Regorafenib

Umxholo

• Ngaphambi kokuba uthathe i-regorafenib,
• I-Regorafenib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:
• Iimpawu zokudlula ngaphezulu zinokubandakanya:

I-Regorafenib inokubangela ukonakala kwesibindi, okunokuba nzima okanye kusongele ubomi. Xelela ugqirha wakho ukuba ukhe unesifo sesibindi. Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: ukutyheli kwesikhumba okanye amehlo, isicaphucaphu, ukugabha, umchamo omnyama, iintlungu kwindawo ephezulu yesisu, ukudinwa kakhulu, ukopha okungaqhelekanga okanye ukugruzuka , Ukuphelelwa ngumdla wokutya, iimpawu ezifana nomkhuhlane, okanye utshintsho kwindlela olala ngayo.

Gcina lonke ixesha lokuqeshwa elabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ngaphambi nangexesha lonyango lwakho ukuze uqiniseke ukuba kukhuselekile kuwe ukuba uthathe i-regorafenib kwaye ujonge impendulo yomzimba wakho kunyango.

I-Regorafenib isetyenziselwa ukunyanga umhlaza wekolon kunye nomhlaza (umhlaza oqala emathunjini amakhulu okanye i-rectum) ethe yasasazeka kwamanye amalungu omzimba wabantu abangakhange banyangwe ngempumelelo ngamanye amayeza. Isetyenziselwa ukunyanga amathumbu esisu esiswini (GIST; uhlobo lwethumba elikhula esiswini, emathunjini [emathunjini], okanye kumqala [ityhubhu edibanisa umqala nesisu]) kubantu abangakhange banyangwe ngokuphumelelayo amayeza. I-Regorafenib ikwasetyenziselwa ukunyanga i-hepatocellular carcinoma (HCC; uhlobo lomhlaza wesibindi) kubantu ababephathwa ngaphambili nge-sorafenib (Nexafar). I-Regorafenib ikudidi lwamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

Regorafenib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa ngesidlo esinamafutha asezantsi (esiqulathe ngaphantsi kweekhalori ezingama-600 kunye neekhalori ezingaphantsi kwama-30% kumanqatha) kube kanye ngemini kangangeeveki ezi-3 emva koko weqe iveki enye. Eli xesha lonyango libizwa ngokuba ngumjikelo, kwaye umjikelo unokuphindwa ixesha elide ucebisa ngalo ugqirha. Thatha i-regorafenib ngaxeshanye yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-regorafenib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ugqirha wakho unokunciphisa idosi ye-regorafenib okanye akuxelele ukuba uyeke ukuthatha i-regorafenib kangangexesha elithile ngexesha lonyango lwakho. Oku kuya kuxhomekeka ekubeni lisebenza njani na iyeza kunye naziphi na iziphumo ebezingalindelekanga onokuzifumana. Qhubeka nokuthatha i-regorafenib nokuba uziva uphilile. Sukuyeka ukuthatha i-regorafenib ngaphandle kokuthetha nogqirha wakho.

I-Regorafenib ayifumaneki kwiivenkile ezithengisa iimpahla. Amayeza akho aya kuthunyelwa ngeposi kuwe okanye kugqirha wakho kwikhemesti ekhethekileyo. Buza ugqirha wakho ukuba unemibuzo malunga nokuba uza kuwafumana njani amayeza akho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-regorafenib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-regorafenib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-regorafenib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo, ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ii-anticoagulants ('' blood thinner '') ezifana ne-warfarin (Coumadin, Jantoven); amayeza athile okubola anje nge-itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), kunye ne-voriconazole (Vfend); amayeza athile okubanjwa afana ne-carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital, kunye ne phenytoin (Dilantin, Phenytek); atorvastatin (Lipitor, kwiCaduet); i-clarithromycin (i-Biaxin, kwi-Prevpac); ifluvastatin (Lescol); irinotecan (Camptosar); imethotrexate (Otrexup, Rasuvo, Trexall); irifampin (Rifadin, Rifamate, kwiRifater); okanye telithromycin (Ketek). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort. Akufanele uthathe i-wort yaseSt.John ngelixa uthatha i-regorafenib.
• xelela ugqirha wakho ukuba unenxeba elingapholiyo okanye ukuba ukhe wanengxaki yokopha, uxinzelelo oluphezulu lwegazi, iintlungu esifubeni, okanye intliziyo, isifo sezintso okanye sesibindi. Xelela ugqirha wakho ukuba kutshanje uye wahlinzwa.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ungumfazi, akufanele ukhulelwe ngelixa uthatha i-regorafenib kunye neenyanga ezi-2 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba uyindoda, wena neqabane lakho labasetyhini kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kwaye niqhubeke nokusebenzisa ulawulo lokuzalwa kangangeenyanga ezi-2 emva kwedosi yokugqibela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-regorafenib, biza ugqirha wakho. I-Regorafenib inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncancise ngexesha lonyango lwakho kunye ne-regorafenib kunye nokuya kuthi ga kwiiveki ezi-2 emva kwedosi yokugqibela.
• ukuba wenza utyando, kubandakanya nonyango lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-regorafenib. Ugqirha wakho mhlawumbi uza kukuxelela ukuba uyeke ukuthatha i-regorafenib ubuncinci iiveki ezi-2 ngaphambi kotyando lwakho. Ugqirha wakho uya kukuxelela xa kukhuselekile ukuba uqale ukuthatha i-regorafenib kwakhona emva kotyando lwakho.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphosa idosi ye-regorafenib, thabatha idosi ephosiweyo kwakamsinya nje emva kokuba uyikhumbule ngalo mhla. Musa ukuthatha iidosi ezimbini ngosuku olunye ukwenza enye ephosiweyo.

I-Regorafenib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukudinwa
• ubuthathaka
• Ukuphelelwa ngumdla wokutya
• urhudo
• ukudumba, iintlungu, kunye nokuba bomvu kwebala lomlomo wakho okanye lomqala
• ukuhla ukusinda
• Ukudakumba okanye olunye utshintsho kwisandi selizwi lakho

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• iintlungu zesifuba
• ukuqhawukelwa ngumphefumlo
• ukuphuma ngokungaqhelekanga kwilungu lobufazi okanye ukucaphuka
• ukutshisa okanye iintlungu xa uchama
• isiyezi okanye uziva utyhafile
• umkhuhlane, ukukhohlela, umqala obuhlungu, Ukugodola kunye neminye imiqondiso yosulelo
• ukudumba kwesisu
• umkhuhlane ophezulu
• Ukugodola
• urhudo oluqatha
• intloko ebuhlungu
• ukuxhuzula
• ukudideka
• utshintsho kumbono
• umlomo owomileyo, iicramps, okanye ukunciphisa ukuchama
• ububomvu, iintlungu, amanxeba, ukopha, okanye ukudumba ezintendeni zezandla zakho okanye kwiinyawo zakho
• irhashalala
• Igazi okanye ukugabha okubonakala ngathi yindawo yekhofi
• umchamo opinki okanye omdaka
• ebomvu okanye emnyama izitulo
• ukukhohlela igazi okanye amahlwili egazi
• ukuphuma kwegazi okunzima ngokungaqhelekanga (amaxesha)
• ukopha okungaqhelekanga kwilungu lobufazi
• iimpumlo zeempumlo rhoqo

I-Regorafenib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Musa ukubeka iipilisi kwezinye izikhongozeli, ezinje ngeebhokisi zepilisi zemihla ngemihla okanye ngeveki, kwaye ungayisusi i-desiccant (into eyomisayo) kwisitya. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Lahla naziphi na iipilisi ezingasetyenziswanga kwiiveki ezisi-7 emva kokuba ibhotile ivulwe kuqala.

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• irhashalala okanye olunye utshintsho lolusu
• Ukutshintsha kwelizwi okanye ukungxola
• urhudo
• ukudumba ngaphakathi kwempumlo okanye emlonyeni
• umlomo owomileyo
• ukunciphisa ukutya
• ukudinwa

Gcina lonke ixesha lokudibana nogqirha wakho. Ugqirha wakho uya kujonga uxinzelelo lwegazi ngaphambi kokuba uqale ukuthatha i-regorafenib kwaye rhoqo ngexesha lonyango lwakho.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Stivarga^®