Dapagliflozin

Umxholo

• Ngaphambi kokuba uthathe i-dapagliflozin,
• Eli yeza linokubangela utshintsho kwiswekile yegazi lakho. Kuya kufuneka uyazi iimpawu zeswekile esezantsi kunye ephezulu yegazi kwaye wenzeni ukuba unayo le miqondiso.
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:
• Ukuba ufumana naziphi na kwezi mpawu zilandelayo, yeka ukuthatha i-dapagliflozin kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:
• Ukuba ufumana naziphi na kwezi mpawu zilandelayo ze-ketoacidosis, yeka ukuthatha i-dapagliflozin kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo. Ukuba kunokwenzeka, jonga ietoni kumchamo wakho ukuba unempawu, nokuba iswekile yegazi lakho ingaphantsi kwama-250 mg / dL:

I-Dapagliflozin isetyenziswa kunye nokutya kunye nokuzilolonga, kwaye ngamanye amaxesha ngamanye amayeza, ukwehlisa amanqanaba eswekile yegazi kubantu abadala abanesifo seswekile sesi-2 (imeko apho iswekile yegazi iphezulu kakhulu kuba umzimba awuvelisi okanye usebenzise i-insulin ngesiqhelo). I-Dapagliflozin ikwasetyenziselwa ukunciphisa umngcipheko wokufuna ukulaliswa esibhedlele ngenxa yokusilela kwentliziyo kubantu abadala abanesifo seswekile sesi-2 kunye nesifo sentliziyo kunye nesifo semithambo yegazi okanye abanezinto ezinobungozi obuninzi ekuphuhliseni isifo sentliziyo kunye negazi. I-Dapagliflozin ikwasetyenziswa kubantu abadala abanokusilela kwentliziyo ukunciphisa umngcipheko wokufuna ukulaliswa esibhedlele kunye nokufa ngenxa yesifo sentliziyo kunye nesifo semithambo yegazi. I-Dapagliflozin ikudidi lwamayeza abizwa ngokuba yi-sodium-glucose co-transporter 2 (SGLT2) inhibitors. Yehlisa iswekile yegazi ngokubangela ukuba izintso zisuse iswekile eninzi kumchamo. I-Dapagliflozin ayisetyenziswanga ukunyanga uhlobo lweswekile 1 (imeko apho umzimba ungayivelisi i-insulin kwaye, ngenxa yoko, ayinakho ukulawula isixa seswekile esegazini) okanye isifo seswekile ketoacidosis (imeko enzulu enokuthi ikhule ukuba iswekile ephezulu yegazi ayinyangwa. ).

Ixesha elingaphezulu, abantu abanesifo seswekile kunye neswekile ephezulu yegazi banokuba neengxaki ezinzulu okanye ezisongela ubomi, kubandakanya isifo sentliziyo, ukubetha, iingxaki zezintso, ukonakala kwemithambo-luvo kunye neengxaki zamehlo. Ukuthatha i-dapagliflozin, ukwenza utshintsho kwindlela yokuphila (umzekelo, ukutya, ukwenza umthambo, ukuyeka ukutshaya), kunye nokujonga iswekile yegazi rhoqo kunokunceda ukulawula isifo seswekile kunye nokuphucula impilo yakho. Olu nyango lunokunciphisa amathuba akho okuhlaselwa sisifo sentliziyo, ukubetha, okanye ezinye iingxaki ezinxulumene nesifo seswekile ezinje ngokusilela kwezintso, ukulimala kwentliziyo (ukubindeka, imilenze ebandayo okanye iinyawo; ukunciphisa amandla ezesondo kumadoda nabasetyhini), iingxaki zamehlo, kubandakanya notshintsho okanye ukulahleka kombono, okanye isifo seentsini. Ugqirha wakho kunye nabanye ababoneleli ngempilo bayakuthetha nawe ngeyona ndlela yokulawula isifo sakho seswekile.

I-Dapagliflozin iza njengecwecwe lokuthatha ngomlomo. Kuthathwa rhoqo kunye okanye ngaphandle kokutya kanye ngemini kusasa. Thatha i-dapagliflozin malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-dapagliflozin kanye njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ugqirha wakho unokukuqala kwidosi esezantsi yedapagliflozin kwaye wandise idosi yakho xa kufuneka njalo.

I-Dapagliflozin ilawula uhlobo lwe-2 yeswekile kodwa ayiyinyangi. Qhubeka uthathe i-dapagliflozin nokuba uziva uphilile. Sukuyeka ukuthatha i-dapagliflozin ngaphandle kokuthetha nogqirha wakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-dapagliflozin kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukufumana isiKhokelo seyeza.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-dapagliflozin,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-dapagliflozin, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi ze-dapagliflozin. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-angiotensin-converting enzyme (ACE) inhibitors enjenge benazepril (Lotensin, eLotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc, Uniretic), perindopril (Aceon, ePrestalia), ramipril (Altace), kunye netrandolapril (Mavik, eTarka); ii-angiotensin receptor blockers (ARB) ezinje nge-azilsartan (Edarbi, e-Edarbyclor), i-candesartan (Atacand, e-Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, eAvalide), losartan (Cozaar, e-Hyzaar), olmesartan (Benicar, eAzor, kwiBenicar HCT, eTribenzor), telmisartan (Micardis, eMicardis HCT, eTwynsta); i-aspirin kunye nezinye iyeza ezichasayo (i-NSAIDS) ezinje nge-ibuprofen (Advil, Motrin) kunye ne-naproxen (Aleve, Naprosyn); amayeza eswekile afana ne-glimepiride (Amaryl, kwi-Duetact), glipizide (Glucotrol), glyburide (DiaBeta, Glynase), repaglinide (Prandin, Prandimet), kunye ne-tolbutamide; umchamo ('iipilisi zamanzi'); kunye ne-insulin.
• xelela ugqirha wakho ukuba unedialysis kwaye ukhe unesifo sezintso. Ugqirha wakho unokukuxelela ukuba ungathathi i-dapagliflozin.
• xelela ugqirha wakho ukuba uhlala usela utywala okanye ngamanye amaxesha usela izixa ezikhulu zotywala ngexesha elifutshane (ukuzinkcinkca ngotywala) okanye ukuba utya ukutya okunesodiyamu ephantsi. Xelela ugqirha wakho ukuba ngaba ukhe wasilela kwentliziyo, isifo sepancreatic kubandakanya i-pancreatitis (ukudumba kwepancreas) okanye uqhaqho olwenziwe kwi-pancreas, usulelo lwe-urinary tract okanye iingxaki zokuchama, uxinzelelo lwegazi oluphantsi, usulelo lwegwele kwindawo yesini, isifo sezintso okanye sesibindi. Ukuba uyindoda, xelela ugqirha wakho ukuba awuzange waluswe. Xelela ugqirha wakho, ukuba ngaba utya kancinci ngenxa yokugula, utyando okanye utshintsho kwindlela otya ngayo, okanye kutshanje urhudo, ukugabha, ubungaseli manzi ngokwaneleyo, ubuselangeni ixesha elide, okanye ubebile kakhulu, ezinokubangela ukuphelelwa ngamanzi emzimbeni (ukulahleka kwamanzi amaninzi emzimbeni).
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Musa ukuncancisa ngelixa uthatha i-dapagliflozin. Ukuba ukhulelwe ngelixa uthatha i-dapagliflozin, tsalela ugqirha wakho.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-dapagliflozin. Ugqirha wakho uya kukuxelela ukuba uyeke ukuthatha i-dapagliflozin ubuncinci kwiintsuku ezi-3 ngaphambi kotyando.
• utywala kunokubangela utshintsho iswekile yegazi. Buza ugqirha wakho malunga nokusetyenziswa okukhuselekileyo kotywala ngelixa uthatha i-dapagliflozin.
• Kuya kufuneka uyazi ukuba i-dapagliflozin inokubangela ukuba ube nesiyezi, ukuba nentloko elula, kunye nokuphelelwa ngamandla xa usukuma ngokukhawuleza kwindawo olele kuyo. Ukuba unale ngxaki, tsalela umnxeba ugqirha wakho. Le ngxaki ixhaphake kakhulu xa uqala ukuthatha i-dapagliflozin. Ukuthintela le ngxaki, phuma kancinci ebhedini, uphumle iinyawo zakho phantsi imizuzu embalwa ngaphambi kokuba ume.
• buza ugqirha wakho ukuba wenzeni ukuba uyagula, uhlasele usulelo okanye umkhuhlane, amava oxinzelelo angaqhelekanga, okanye wenzakele. Ezi meko zinokuchaphazela iswekile yegazi kunye nenani le-dapagliflozin onokuyifuna.

Qiniseka ukuba ulandela yonke imithambo kunye nezincomo zokutya ezenziwe ngugqirha wakho okanye ugqirha otya ukutya. Kubalulekile ukutya ukutya okusempilweni nokuzilolonga rhoqo.

Landela imiyalelo kagqirha wakho malunga nokusela ngokwaneleyo ulwelo imini yonke ngelixa ukule nyango.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Eli yeza linokubangela utshintsho kwiswekile yegazi lakho. Kuya kufuneka uyazi iimpawu zeswekile esezantsi kunye ephezulu yegazi kwaye wenzeni ukuba unayo le miqondiso.

I-Dapagliflozin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuchama kakhulu, kubandakanya nasebusuku
• ukwanda kokoma

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• Ukuchama rhoqo, okungxamisekileyo, okutshisayo, okanye okubuhlungu
• umchamo onamafu, obomvu, opinki, okanye omdaka
• umchamo onukayo
• ukuncipha kwenani lomchamo
• intlungu ye-pelvic okanye ye-rectal
• (kwabasetyhini) ivumba lobufazi, ukuphuma okumhlophe okanye okumthubi (kusenokuba namathambo okanye kujongeka njengekhitshi), okanye ukurhawuzelela kwilungu lobufazi
• (emadodeni) ukuba bomvu, ukurhawuzelela, okanye ukudumba kwelungu lobudoda; irhashalala kwilungu lobudoda; ukukhutshwa okungcolileyo kwilungu lobudoda; okanye iintlungu kulusu olujikeleze ipipi
• uziva udiniwe, ubuthathaka, okanye ungonwabanga; kunye nomkhuhlane kunye nentlungu, ukuthamba, ubomvu, kunye nokudumba kwamalungu esini okanye indawo phakathi kwamalungu esini kunye nethanga
• ukudumba kwemilenze okanye iinyawo

Ukuba ufumana naziphi na kwezi mpawu zilandelayo, yeka ukuthatha i-dapagliflozin kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

• irhashalala
• urhwebo
• ukurhawuzelela
• ubunzima bokuphefumla okanye ukugwinya
• ukudumba kobuso, umqala, ulwimi, imilebe, umlomo, okanye amehlo
• ukudinwa

Ukuba ufumana naziphi na kwezi mpawu zilandelayo ze-ketoacidosis, yeka ukuthatha i-dapagliflozin kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo. Ukuba kunokwenzeka, jonga ietoni kumchamo wakho ukuba unempawu, nokuba iswekile yegazi lakho ingaphantsi kwama-250 mg / dL:

• isicaphucaphu
• ukugabha
• indawo yesisu
• ukudinwa
• ubunzima bokuphefumla

I-Dapagliflozin inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuthi aodole iimvavanyo ezithile zaselebhu ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-dapagliflozin.

Amanqanaba eswekile yegazi lakho kufuneka atshekishwe rhoqo ukumisela impendulo yakho kwi-dapagliflozin. Ugqirha wakho uya kuyalela ezinye iimvavanyo zelebhu, kubandakanya i-hemoglobin eglycosylated (HbA1c), ukujonga impendulo yakho kwi-dapagliflozin. Ugqirha wakho uya kukuxelela nendlela yokujonga impendulo yakho kolu nyango ngokulinganisa amanqanaba eswekile yegazi lakho ekhaya. Landela le miyalelo ngononophelo.

Ngaphambi kokuba uvavanywe elebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba uthatha i-dapagliflozin. Ngenxa yendlela la mayeza asebenza ngayo, umchamo wakho unokuvavanya ukuba une-glucose.

Kufuneka usoloko unxibe isacholo esichaza isifo seswekile ukuze uqiniseke ukuba ufumana unyango olufanelekileyo ngexesha likaxakeka.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Farxiga^®

• Qtern^® (Equlathe iDapagliflozin, Saxagliptin)
• Qternmet^® XR (equlathe iDapagliflozin, Metformin, Saxagliptin)
• Xigduo^® XR (equlathe iDapagliflozin, Metformin)