ILumacaftor kunye neIvacaftor

Umxholo

• Ngaphambi kokuba uthathe i-lumacaftor kunye ne-ivacaftor,
• ILumacaftor kunye ne-ivacaftor zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:
• Iimpawu zokudlula ngaphezulu zinokubandakanya:

I-Lumacaftor kunye ne-ivacaftor isetyenziselwa ukunyanga iintlobo ezithile ze-cystic fibrosis (isifo esizelwe sisidala esibangela iingxaki ngokuphefumla, ukwetyisa, kunye nokuzala) kubantu abadala nakubantwana abaneminyaka emi-2 ubudala nangaphezulu. I-Lumacaftor ikudidi lwamayeza abizwa ngokuba yi-cystic fibrosis transmembrane conductance regulator (CFTR) yokulungisa. I-Ivacaftor ikudidi lwamayeza abizwa ngokuba yi-cystic fibrosis transmembrane conductance regulator (CFTR) potentiators.Omabini la mayeza asebenza ngokuphucula ukusebenza kweprotein emzimbeni ukunciphisa ukwakhiwa kwe-mucus eshinyeneyo emiphungeni kunye nokuphucula ezinye iimpawu ze-cystic fibrosis.

Indibaniselwano ye-lumacaftor kunye ne-ivacaftor iza njengecwecwe kwaye njengegranules emayithathwe ngomlomo. Ihlala ithathwa ngokutya okunamafutha kabini ngemini, ngaphandle kweeyure ezili-12. Thatha i-lumacaftor kunye ne-ivacaftor kumaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-lumacaftor kunye ne-ivacaftor ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukulungiselela idosi ye-lumacaftor kunye ne-ivacaftor granules, xuba yonke ipakethi yegranu kwitispuni ye-1 (5 ml) yokutya okuthambileyo okanye ulwelo (kubanda okanye kubushushu begumbi) njenge yoghurt, applesauce, pudding, ubisi okanye ijusi. Thatha wonke umxube ngaphakathi kweyure e-1 yokuxuba iigraanu kunye nokutya okanye ulwelo.

Thatha i-lumacaftor kunye ne-ivacaftor enokutya okunamafutha okufana namaqanda, iiavokhado, amandongomane, ibhotolo, ibhotolo yamandongomane, itshizi pizza, ubisi olupheleleyo kunye nezinye iimveliso zobisi ezinje ngeshizi kunye neyogathi enamafutha. Thetha nogqirha wakho malunga nokunye ukutya okunamafutha okutya kunye ne-lumacaftor kunye ne-ivacaftor.

I-Lumacaftor kunye ne-ivacaftor ilawula i-cystic fibrosis kodwa ayiyinyangi. Qhubeka uthathe i-lumacaftor kunye ne-ivacaftor nokuba uziva uphilile. Sukuyeka ukuthatha i-lumacaftor kunye ne-ivacaftor ngaphandle kokuthetha nogqirha wakho.

Ukuba awuyithathi i-lumacaftor kunye ne-ivacaftor kangangeentsuku ezisi-7 okanye ngaphezulu, ungaqali ukuyithatha kwakhona ungakhange uthethe nogqirha wakho. Ugqirha wakho unokufuna ukutshintsha idosi yakho yolu nyango okanye amanye amayeza owathathayo.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-lumacaftor kunye ne-ivacaftor,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-lumacaftor kunye ne-ivacaftor, nawaphi na amanye amayeza, okanye nasiphi na isithako esenziwe kwi-lumacaftor kunye ne-ivacaftor tablets okanye iigranu. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhalwanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-antitifungal ezifana ne-itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), kunye ne-voriconazole (Vfend); ii-antibiotics ezithile ezifana ne-clarithromycin (i-Biaxin, kwi-Prevpac), i-erythromycin (i-EES, i-Erythrocin, i-Eryped, ezinye), i-rifabutin (i-Mycobutin) kunye ne-rifampin (i-Rifadin, i-Rifamate, i-Rifater, i-Rimactane); amayeza athile eswekile efana ne-chlorpropamide (i-Diabinese), i-glimepiride (i-Amaryl, kwi-Duetact), i-glipizide (i-Glucotrol), i-glyburide (i-Diabeta, i-Glynase, kwi-Glucovance), i-repaglinide (i-Prandin), i-tolazamide kunye ne-tolbutamide; idigoxin (Lanoxin); ibuprofen (Advil, Motrin, kwiVicoprofen); ii-immunosuppressants ezithile ezinjenge-cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune) kunye ne-tacrolimus (Astagraf, Prograf); midazolam; imontelukast (Singulair); imethylprednisolone (iMedrol); uqikelelo (iRayos); iiproton pump inhibitors (ii-PPIs) ezithile ezinje nge-esomeprazole (Nexium, eVimovo), lansoprazole (Prevacid, Prevpac), kunye ne-omeprazole (Prilosec, eZegerid); i-ranitidine (iZantac); amayeza athile okubanjwa afana ne-carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, kunye ne phenytoin (Dilantin, Phenytek); ezithile ezikhethiweyo ze-serotonin reuptake inhibitors (ii-SSRIs) ezinje nge-citalopram (Celexa), escitalopram (Lexapro), kunye ne-sertraline (Zoloft); i-triazolam (iHalcion); kunye ne-warfarin (Coumadin, Jantoven). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-lumacaftor kunye ne-ivacaftor, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort. Ugqirha wakho usenokukuxelela ukuba ungathathi iwort yaseSt.John ngelixa uthatha i-lumacaftor kunye ne-ivacaftor.
• xelela ugqirha wakho ukuba ukhe wanengxaki yokuphefumla okanye yeemeko, ukufakelwa ilungu, okanye isibindi okanye isifo sezintso.
• Kuya kufuneka uyazi ukuba i-lumacaftor kunye ne-ivacaftor zinokunciphisa ukusebenza kwezicwangcisi zehomoni (iipilisi zolawulo lokuzalwa, iipatches, iiringi, inaliti, ukufakelwa, okanye izixhobo zesisu). Thetha nogqirha wakho ngezinye iindlela zolawulo lokuzalwa eziza kukusebenzela ngelixa uthatha i-lumacaftor kunye ne-ivacaftor.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwe ngelixa uthatha i-lumacaftor kunye ne-ivacaftor, tsalela ugqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba ukhumbula idosi ephosiweyo kwisithuba seeyure ezingama-6 zexesha owawucwangciselwe ukulithatha, thatha idosi ephosiweyo ngoko nangoko. Nangona kunjalo, ukuba ngaphezulu kweeyure ezingama-6 zidlulile ukusukela kwixesha oqhele ukuthatha ngalo i-lumacaftor kunye ne-ivacaftor, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

ILumacaftor kunye ne-ivacaftor zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuqhawukelwa ngumphefumlo
• ukuqina kwesifuba okanye iintlungu
• iingxaki zokuphefumla
• urhudo
• irhasi
• ukudinwa kakhulu
• irhashalala
• ngokungahambi kakuhle, ukuphoswa, ubunzima okanye amaxesha abuhlungu okuya exesheni, ngakumbi kubafazi abathatha izinto zokucwangcisa zehomoni
• ukuphuma empumlweni, ukuthimla, ukukhohlela, umqala obuhlungu, okanye iimpawu ezifana nomkhuhlane
• umqala obuhkungu
• impumlo egobileyo okanye egobayo
• intloko ebuhlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• isicaphucaphu
• ukugabha
• Ukuphelelwa ngumdla wokutya
• iintlungu kwinxalenye ephezulu yesisu
• umchamo omnyama
• ukudideka
• mthubi ulusu okanye amehlo

I-Lumacaftor kunye ne-ivacaftor kunokubangela isifo samehlo (ukugcwala kwelensi yamehlo enokubangela iingxaki zombono) kubantwana nakwishumi elivisayo. Abantwana kunye nolutsha oluthatha i-lumacaftor kunye ne-ivacaftor kufuneka babone ugqirha wamehlo ngaphambi nangexesha lonyango lwabo. Thetha nogqirha womntwana wakho malunga neengozi zokunika i-lumacaftor kunye ne-ivacaftor emntwaneni wakho.

ILumacaftor kunye ne-ivacaftor kunokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• intloko ebuhlungu
• irhashalala

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukuze ubone ukuba imeko yakho inokunyangwa nge-lumacaftor kunye ne-ivacaftor njengoko kufanelekile ukuba isetyenziswe kuphela kubantu abanemfuza ethile. Ugqirha wakho uya ku-odola kuvavanyo lwamehlo kunye novavanyo oluthile lwelebhu ngaphambi kwaye ngexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-lumacaftor nakwi-ivacaftor. Uxinzelelo lwegazi kufuneka luhlolwe rhoqo ngelixa uthatha la mayeza.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Orkambi^®