Inalitigene yeTalimogene Laherparepvec

Umxholo

• Ngaphambi kokufumana inalitigene laherparepvec inaliti,
• Inalitigene laherparepvec inaliti inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye ezo zidweliswe kwiCandelo LOKUKHUSELEKILEYO, Biza ugqirha ngoko nangoko:

Inalitigene laherparepvec inaliti isetyenziselwa ukunyanga imelanoma ethile (uhlobo lomhlaza wolusu) amathumba angenakususwa ngotyando okanye abuye emva kokuba ephathwe ngotyando. I-Talimogene laherparepvec ikudidi lwamayeza abizwa ngokuba ziintsholongwane ze-oncolytic. Yindlela ebuthathaka kunye notshintsho yeHerpes Simplex Virus Type I (HSV-1 ’cold virus virus’) esebenza ngokunceda ekubulaleni iiseli zomhlaza.

Inaliti ye-Talimogene laherparepvec yeza njengokumiswa (ulwelo) ukuze kutofwe ngugqirha okanye ngumongikazi kwiofisi yezonyango. Ugqirha wakho uya kulifaka iyeza ngqo kwizilonda ezisesikhumbeni sakho, ngaphantsi kwesikhumba sakho, okanye kwii-lymph node zakho. Uyakufumana unyango lwesibini emva kweeveki ezintathu emva konyango lokuqala, kwaye emva kweeveki ezi-2 emva koko. Ubude bonyango buxhomekeke kwindlela ophendula ngayo amathumba kunyango. Ugqirha wakho akanakho ukujova zonke izidumbu kutyelelo ngalunye.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-talimogene laherparepvec kwaye ngalo lonke ixesha ufumana inaliti. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inalitigene laherparepvec inaliti,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-talimogene laherparepvec, nawaphi na amanye amayeza, okanye nasiphi na isithako esikuyo isitofu se-talimogene laherparepvec. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha nawaphi na amayeza enza buthathaka amajoni akho omzimba afana ne-antithymocyte globulin (Atgam, Thymoglobulin), azathioprine (Azasan, Imuran), basiliximab (Simulect), belatacept (Nulojix), belimumab (Benlysta), cortisone, cyclosporine ( Gengraf, Neoral, Sandimmune), dexamethasone, fludrocortisone, methotrexate (Otrexup, Rasuvo, Trexall), methylprednisolone (Depo-medrol, Medrol, Solu-medrol), mycophenolate mofetil (Cellcept), prednisolone (Flopred, Orapred, Pediapred Rayos), sirolimus (Rapamune), kunye netacrolimus (Astagraf XL, Prograf, Envarsus XR). Uninzi lwamanye amayeza anokuwenza buthathaka amajoni akho omzimba, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu. Ugqirha wakho uya kukuxelela ukuba ungafumani talimogene laherparepvec ukuba uthatha elinye okanye ngaphezulu kula mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zilandelayo: naliphi na iyeza le-antiviral njengeacyclovir (Sitavig, Zovirax), cidofovir, docosanol (Abreva), famciclovir (Famvir), foscarnet (Foscavir), ganciclovir (Cytovene), penciclovir (Denavir), trifluridine I-Viroptic), i-valacyclovir (iValtrex), kunye ne-valganciclovir (iValcyte). La mayeza anokuchaphazela indlela esebenza ngayo i-talimogene laherparepvec.
• xelela ugqirha wakho ukuba ukhe waba neleukemia (umhlaza weeseli ezimhlophe zegazi), i-lymphoma (umhlaza wenxalenye yenkqubo yamajoni omzimba), intsholongwane kaGawulayo (i-HIV), ufumene isifo se-immunodeficiency syndrome (i-AIDS), okanye enye imeko oko kubangela amajoni omzimba athathaka. Ugqirha wakho ngekhe afune ukuba ungafumani inalitigene laherparepvec inaliti.
• xelela ugqirha wakho ukuba ukhe wakha wanyangwa ngemitha kwindawo yamathumba e-melanoma, i-myeloma ezininzi (umhlaza weeseli ze-plasma kumongo wethambo), naluphi na uhlobo lwesifo sokuzimela komzimba (iimeko apho amajoni omzimba ahlasela iindawo ezinempilo umzimba kwaye ubangele iintlungu, ukudumba, kunye nomonakalo), okanye ukuba unonxibelelwano olusondeleyo nomntu okhulelweyo okanye onamajoni omzimba abuthathaka.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Akufanele ukhulelwe ngexesha lonyango lwakho ngenalitigene laherparepvec inaliti. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba ukhulelwa ngelixa ufumana inalitigene laherparepvec inaliti, tsalela umnxeba kwangoko. Inalitigene laherparepvec inaliti inokulimaza umbungu.
• Kuya kufuneka uyazi ukuba inalitigene laherparepvec inaliti inentsholongwane enokuthi isasaze kwaye yosulele abanye abantu. Kuya kufuneka ulumke ukogquma zonke iindawo zenaliti ngeebhandeji ezingangeni moya nezingangeni manzi okungenani iveki enye emva konyango ngalunye, okanye ixesha elide ukuba indawo yenaliti iyaphuma. Ukuba ii-bandage ziyakhulula okanye ziyawa, qiniseka ukuzitshintsha kwangoko. Kuya kufuneka usebenzise irabha okanye iiglavu zelatex xa ubopha ibanda kwiindawo zokufaka inaliti. Kuya kufuneka uqiniseke ukuba ubeke zonke izinto zokucoca, iiglavu kunye neebhandeji ezazisetyenziselwa indawo yenaliti kwingxowa yeplastiki etywiniweyo kwaye uyilahle emgqomeni.
• akufuneki ubambe okanye ukrwempe iisayithi zokutofa okanye ii-bandage. Oku kunokusasaza intsholongwane kumayeza e-talimogene laherparepvec kwamanye amalungu omzimba wakho. Abantu abakungqongileyo kufuneka balumke bangadibani ngqo neendawo zakho zokutofa, iibhandeji, okanye ulwelo lomzimba. Biza ugqirha wakho ngokukhawuleza ukuba wena, okanye nabani na okujikelezileyo, uvelisa imiqondiso yosulelo lwe-herpes; iintlungu zamehlo, ukuba bomvu, okanye ukukrazula; ukungaboni kakuhle; uvakalelo ekukhanyeni; ubuthathaka kwiingalo okanye emilenzeni; ukozela kakhulu; okanye ukudideka kwengqondo.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Inalitigene laherparepvec inaliti inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukudinwa okungaqhelekanga
• isicaphucaphu
• ukugabha
• urhudo
• ukuqhina
• intlungu zesisu
• intloko ebuhlungu
• isiyezi
• ukuhla ukusinda
• owomileyo, oqhekekileyo, ukurhawuzelela, ukutsha kolusu
• intlungu yesihlunu okanye edibeneyo
• iintlungu ezingalweni okanye emilenzeni
• ukunyanga okucothisiweyo kweendawo zenaliti
• iintlungu kwiindawo zenaliti

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye ezo zidweliswe kwiCandelo LOKUKHUSELEKILEYO, Biza ugqirha ngoko nangoko:

• ukuphefumla kancinci okanye ezinye iingxaki zokuphefumla
• ukukhohlela
• ipinki, umbala wecola, okanye umchamo onogwebu
• ukudumba kobuso, izandla, iinyawo, okanye isisu
• ukulahleka kombala kulusu lwakho, iinwele, okanye amehlo
• ukufudumala, obomvu, ukudumba, okanye isikhumba esibuhlungu malunga nendawo yenaliti
• umkhuhlane, umqala obuhlungu, ingqele, okanye ezinye iimpawu zosulelo
• izicwili ezifileyo okanye izilonda ezivulekileyo kumathumba afakiweyo

Inalitigene laherparepvec inaliti inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho.

Buza usokhemesti wakho ukuba unayo nayiphi na imibuzo onayo malunga nenalitigene laherparepvec inaliti.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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