Inaliti ye-Ixekizumab

Umxholo

• Ngaphambi kokusebenzisa inaliti ye-ixekizumab,
• Inaliti ye-Ixekizumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LOKUKHUSELWA OKUQHELEKILEYO, yeka ukusebenzisa inaliti ye-ixekizumab kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

Inaliti ye-Ixekizumab isetyenziselwa ukunyanga i-plaque psoriasis (isifo solusu apho umbala obomvu, onamaxolo wenza iindawo ezithile zomzimba) kubantu abadala nakubantwana abaneminyaka emi-6 ubudala nangaphezulu abane-psoriasis enzima kakhulu ukuba inganyangwa ngamayeza ndedwa. Isetyenziswa sodwa okanye ngokudibanisa namanye amayeza afana ne-methotrexate (Rasuvo, Trexall, abanye) ukunyanga i-psoriatic arthritis (imeko ebangela iintlungu ezidibeneyo kunye nokudumba kunye nezikali kulusu) kubantu abadala. Inaliti ye-Ixekizumab ikwasetyenziselwa ukunyanga i-ankylosing spondylitis (imeko apho umzimba uhlasela amalungu omqolo kunye nezinye iindawo, kubangela iintlungu kunye nomonakalo odibeneyo) kubantu abadala. Isetyenziselwa ukunyanga i-spondyloarthritis engeyiyo ye-radiographic esebenzayo (imeko apho umzimba uhlasela amalungu omqolo kunye nezinye iindawo ezibangela iintlungu kunye neempawu zokudumba, kodwa ngaphandle kotshintsho olubonwe kwi-x-ray) kubantu abadala, inaliti ye-Ixekizumab kwiklasi yamayeza abizwa ngokuba zii-antibodies ze-monoclonal. Isebenza ngokuthintela isenzo sento ethile yendalo emzimbeni ebangela iimpawu ze-psoriasis.

Inaliti ye-Ixekizumab iza njengesisombululo (ulwelo) kwisirinji ekhethiweyo kunye ne-autoinjector ekhethiweyo yokufaka inaliti (phantsi kolusu). Ukunyanga i-plaque psoriasis kubantu abadala, ihlala inikwa njengezitofu ezimbini zedosi yokuqala, ilandelwe ngenaliti enye rhoqo kwiiveki ezi-2 kwiidosi ezi-6 ezilandelayo, kunye nenaliti enye kwiiveki ezi-4. Ukunyanga i-plaque psoriasis ebantwaneni, ihlala inikezwa njengelinye okanye ezimbini inaliti yedosi yokuqala, kuxhomekeke kubunzima bomntwana, kulandele inaliti enye qho kwiiveki ezi-4. Ukunyanga i-psoriatic arthritis okanye i-ankylosing spondylitis, ihlala inikwa njengezitofu ezimbini zedosi yokuqala, ilandelwe ngenaliti enye rhoqo kwiiveki ezi-4. Ukunyanga i-spondyloarthritis engeyiyo i-radiographic spondyloarthritis, ihlala inikezwa ngenaliti enye kwiiveki ezi-4.

Unokufumana idosi yakho yokuqala yenaliti ye-ixekizumab kwiofisi kagqirha wakho. Ukuba umdala, ugqirha wakho unokukuvumela okanye umkhathaleli ukuba enze inaliti ye-ixekizumab ekhaya emva kwedosi yakho yokuqala. Ukuba unengxaki yokubona okanye yokuva, uya kudinga umnakekeli ukuze akunike inaliti. Ukuba umntwana wakho unobunzima beepawundi ezili-110 (50 kg) okanye ngaphantsi, inaliti ye-ixekizumab kufuneka inikwe kwiofisi kagqirha. Ukuba umntwana wakho unobunzima obungaphezu kweepawundi ezili-110, ugqirha wakho angamvumela umnakekeli ukuba enze inaliti ekhaya. Buza ugqirha wakho okanye usokhemesti akubonise okanye umntu oza kufaka inaliti iyeza ukuba angalitofa njani alilungiselele.

Sebenzisa isirinji nganye okanye i-autoinjector kube kanye kuphela kwaye utofe isisombululo kwisirinji okanye kwi-autoinjector. Lahla iisirinji ezisetyenzisiweyo kunye ne-autoinjector kwisitya esinganyangekiyo. Thetha nogqirha wakho okanye usokhemesti malunga nokusilahla isikhongozeli esinganyangekiyo.

Susa isirinji okanye i-autoinjector efrijini. Yibeke endaweni ethe tyaba ngaphandle kokuyisusa ikepusi yenaliti kwaye uyivumele ifudumele kubushushu begumbi kangangemizuzu engama-30 ngaphambi kokuba ulungele ukutofa amayeza. Sukuzama ukufudumeza amayeza ngokuwatshisa kwimicrowave, ngokuwabeka emanzini ashushu, uwashiye elangeni, okanye ngayo nayiphi na enye indlela.

Sukushukumisa isirinji okanye i-autoinjector equlathe ixekizumab.

Soloko ujonga isisombululo se-ixekizumab ngaphambi kokuyifaka. Jonga ukuba umhla wokuphelelwa awukadluli na kwaye ukuba ulwelo lucacile na okanye lutyheli kancinane. Umbane awunakuba namasuntswana abonakalayo. Sukusebenzisa isirinji okanye i-autoinjector ukuba iqhekeziwe okanye yaphukile, ukuba iphelelwe lixesha okanye iqabile, okanye ukuba ulwelo lunamafu okanye luqulathe amasuntswana amancinci.

Ungatofa inaliti ye-ixekizumab naphina phambi kwamathanga akho (umlenze ongasentla) okanye isisu (isisu) ngaphandle kwenkaba yakho kunye nendawo eyi-intshi enye (2.5 cm) ejikeleze yona. Ukuba unononophelo oza kulifaka iyeza, umva wengalo ephezulu unokusetyenziswa. Ukunciphisa amathuba okuqaqamba okanye ububomvu, sebenzisa indawo eyahlukileyo yenaliti nganye. Musa ukujova kwindawo apho ulusu luthambile, lutyumkileyo, lubomvu, okanye lukhuni okanye apho uneziva okanye ukolula amanqaku. Musa ukufaka i-ixekizumab kwindawo echaphazelekayo yi-psoriasis.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lomguli lomenzi (Isikhokelo seMithi kunye neMiyalelo yokuSebenzisa) xa uqala unyango ngenaliti ye-ixekizumab kwaye ngalo lonke ixesha uzalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukufumana isiKhokelo seMithi, okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi kunye neMiyalelo Ukusetyenziswa.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokusebenzisa inaliti ye-ixekizumab,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-ixekizumab, nawaphi na amanye amayeza, okanye nasiphi na isithako esenziweyo kwisitofu se-ixekizumab. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya oku kulandelayo: carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), cyclosporine (Gengraf, Neoral, Sandimmune), quinidine (eNuedexta), sirolimus (Rapamune), tacrolimus (Astagraf, Envarsus, Prograf) , Kunye ne-warfarin (Coumadin, Jantoven). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokuphinda asebenzisane nenaliti ye-ixekizumab, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba unentsholongwane okanye ukuba unesifo samathumbu esivuthayo (IBD; iqela leemeko ezibangela ukudumba kwenwebu yamathumbu) njengesifo sikaCrohn (imeko apho umzimba uhlasela khona umgca womgudu wokugaya ukutya, obangela iintlungu, urhudo, ukwehla kobunzima bomzimba, kunye nomkhuhlane) okanye ukudumba okwenziwa sisilonda sikabhobhosi (imeko ebangela ukudumba kunye nezilonda kumngxunya wekholoni [amathumbu amakhulu] kunye nomqolo).
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa usebenzisa inaliti ye-ixekizumab, tsalela ugqirha wakho.
• jongana nogqirha wakho ukubona ukuba ufuna ukufumana naluphi na ugonyo. Kubalulekile ukuba zonke izitofu zokugonya zilungele iminyaka yakho ngaphambi kokuqala unyango lwakho ngenaliti ye-ixekizumab. Awunalo ugonyo ngexesha lonyango ngaphandle kokuthetha nogqirha wakho.
• Kuya kufuneka uyazi ukuba inaliti ye-ixekizumab inokunciphisa amandla akho okulwa usulelo kwiibhaktiriya, intsholongwane kunye nefungi kwaye wandise umngcipheko wokuba ufumane usulelo olubi okanye olusongela ubomi. Tshela ugqirha wakho ukuba uhlala ufumana naluphi na uhlobo losulelo okanye ukuba unayo okanye ucinga ukuba unalo naluphi na uhlobo losulelo ngoku. Oku kubandakanya usulelo oluncinci (njengokusikwa okuvulekileyo okanye izilonda), usulelo olufikayo (olufana neherpes okanye izilonda ezibandayo), kunye nosulelo olungapheliyo olungapheliyo. Ukuba ufumana naziphi na kwezi mpawu zilandelayo ngexesha okanye emva nje konyango lwakho ngenaliti ye-ixekizumab, biza ugqirha wakho kwangoko: umkhuhlane, ukubila, okanye ukugodola, iintlungu zemisipha, ukuphefumla okufutshane, ukufudumala, obomvu, okanye ulusu olubuhlungu okanye izilonda emzimbeni wakho, urhudo, iintlungu zesisu, ukuchama rhoqo, okungxamisekileyo, okanye okubuhlungu, okanye ezinye iimpawu zosulelo. Ugqirha wakho unokulibazisa unyango lwakho ngenaliti ye-ixekizumab ukuba unesifo.
• Kuya kufuneka uyazi ukuba ukusebenzisa inaliti ye-ixekizumab kwandisa umngcipheko wokuba uza kuba nesifo sephepha (i-TB; usulelo olubi lwemiphunga), ngakumbi ukuba sele wosulelwe sisifo sephepha kodwa ungenazimpawu zaso. Xelela ugqirha wakho ukuba ukhe wakha okanye wakha wanayo na i-TB, ukuba ngaba wakhe wahlala kwilizwe apho ixhaphake kakhulu i-TB, okanye ukuba ukhe wakufutshane nomntu one-TB. Ugqirha wakho uza kwenza uvavanyo lolusu ukuze abone ukuba unesifo se-TB esingasebenziyo. Ukuba kukho imfuneko, ugqirha wakho uya kukunika amayeza ukunyanga esi sifo ngaphambi kokuba uqale usebenzise inaliti ye-ixekizumab. Ukuba unazo ezi mpawu zilandelayo ze-TB, okanye ukuba uvela kwezi mpawu ngexesha lonyango lwakho, tsalela umnxeba kwangoko: ukukhohlela, ukukhohlela igazi okanye amafinyila, ubuthathaka okanye ukudinwa, ukwehla kobunzima, ukungabi namdla wokutya, ukugodola, umkhuhlane , okanye ukubila ebusuku.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Sebenzisa idosi ephosiweyo kwakamsinya nje emva kokuba uyikhumbule kwaye emva koko uqhubeke neshedyuli yakho yethamo yesiqhelo. Sukusebenzisa idosi ephindwe kabini ukwenza eyilahlekileyo.

Inaliti ye-Ixekizumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• bomvu, urhawuzelele, okanye amehlo anamanzi
• impumlo egobileyo okanye egobayo
• ububomvu okanye iintlungu kwindawo yenaliti
• intlungu zesisu
• urhudo (ngaphandle kwegazi)
• ukuhla ukusinda

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LOKUKHUSELWA OKUQHELEKILEYO, yeka ukusebenzisa inaliti ye-ixekizumab kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

• ndiziva ndidiniwe
• ukudumba kobuso, iinkophe, ulwimi, okanye umqala
• ubunzima bokuginya okanye ukuphefumla
• ukuqina esifubeni okanye emqaleni
• irhashalala
• urhwebo

Inaliti ye-Ixekizumab inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa usebenzisa eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli elingene ukukhusela ekukhanyeni, livale ngci, kwaye lingenakufikelela ebantwaneni. Gcina inaliti ye-ixekizumab kwifriji, kodwa ungayimisi ngumkhenkce. Ukuba kukho imfuneko, unokugcina inaliti ye-ixekizumab kubushushu begumbi ukuya kuthi ga kwiintsuku ezintlanu kwibhokisi yoqobo ukuyikhusela ekukhanyeni. Nje ukuba ugcinwe kubushushu begumbi, musa ukubuyisela inaliti ye-ixekizumab kwifriji. Lahla inaliti ye-ixekizumab ukuba ayisetyenziswanga kwiintsuku ezi-5 kubushushu begumbi.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho.

Ixekizumab autoinjector inamalungu eglasi kwaye kufuneka iphathwe ngononophelo. Ukuba i-autoinjector iwela kwindawo enzima, ungayisebenzisi.

Musa ukuvumela omnye umntu asebenzise amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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