Inaliti yeNusinersen

Umxholo

• Ngaphambi kokuba uthathe inaliti ye-nusinersen,
• Inaliti yeNusinersen inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

Inaliti ye-Nusinersen isetyenziselwa unyango lwe-spinal muscular atrophy (imeko ezuzwe njengelifa elinciphisa amandla emisipha kunye nokuhamba) kwiintsana, abantwana kunye nabantu abadala. Inaliti yeNusinersen ikudidi lwamayeza abizwa ngokuba yi-antisense oligonucleotide inhibitors. Isebenza ngokwandisa isixa seproteyini ethile eyimfuneko kwimisipha kunye nemithambo-luvo ukuze isebenze ngokwesiqhelo.

Inaliti yeNusinersen iza njengesisombululo (ulwelo) sokujova ngaphakathi (kwisithuba esigcwele ulwelo somjelo womqolo). Inaliti yeNusinersen inikwa ngugqirha kwiofisi yezonyango okanye eklinikhi. Ihlala inikwa njengeedosi zokuqala ezi-4 (kanye qho emva kweeveki ezimbini kwiidosi zokuqala ezi-3 kwaye kwakhona kwiintsuku ezingama-30 emva kwethamo lesithathu) emva koko kunikwa kube kanye kwiinyanga ezi-4 emva koko.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe inaliti ye-nusinersen,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-nusinersen, nawaphi na amanye amayeza, okanye nasiphi na isithako senaliti ye-nusinersen. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe unesifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa ufumana inaliti ye-nusinersen, tsalela ugqirha wakho.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba ufumana inaliti ye-nusinersen.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphoswa idinga lokufumana inaliti ye-nusinersen, tsalela ugqirha ngoko nangoko ukuze ubeke kwakhona idinga lakho. Ugqirha wakho uya kuthi akuxelele ukuba uqalise kwakhona ishedyuli yakho yangaphambili ukuze ufumane inaliti ye-nusinersen, ubuncinci iintsuku ezili-14 phakathi kwamayeza e-4 okuqala kunye neenyanga ezi-4 phakathi kweedosi zamva.

Inaliti yeNusinersen inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuqhina
• irhasi
• ukuhla ukusinda
• intloko ebuhlungu
• ukugabha
• umqolo obuhlungu
• ukuwa
• ukuvuza okanye impumlo efakiweyo, ukuthimla, umqala obuhlungu
• ubuhlungu bendlebe, umkhuhlane, okanye ezinye iimpawu zosulelo lwendlebe
• ifiva

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• ukopha okungaqhelekanga okanye ukugruzuka
• ukuncipha kokuchama; umchamo omphunga, opinki, okanye omdaka ngombala; ukudumba ezandleni, ebusweni, iinyawo okanye isisu
• Ukuchama rhoqo, okungxamisekileyo, okunzima, okanye okubuhlungu
• ukukhohlela, ukuphefumla kancinci, umkhuhlane, ukubanda

Inaliti yeNusinersen inokucothisa ukukhula kosana. Ugqirha womntwana wakho uya kujonga ukukhula kwakhe ngononophelo. Thetha nogqirha womntwana wakho ukuba unenkxalabo malunga nokukhula komntwana wakho ngelixa efumana la mayeza.

Inaliti yeNusinersen inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola iilebhu ezithile ngaphambi kokuqala unyango, ngaphambi kokuba ufumane idosi nganye, kwaye njengoko kufuneka ngexesha lonyango ukujonga impendulo yomzimba wakho kwisitofu senusinersen.

Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nenaliti ye-nusinersen.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Ispinraza^®