Midostaurin

Umxholo

• Ngaphambi kokuba uthathe i-midostaurin,
• I-Midostaurin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Midostaurin isetyenziswa namanye amachiza e-chemotherapy ukunyanga iintlobo ezithile ze-leukemia ye-myeloid (AML; uhlobo lomhlaza weeseli ezimhlophe zegazi). I-Midostaurin ikwasetyenziselwa iintlobo ezithile ze-mastocytosis (ukuphazamiseka kwegazi apho kukho iiseli zemasti ezininzi kakhulu [uhlobo oluthile lweseli emhlophe yegazi]). I-Midostaurin ikwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukunqanda ukusasazeka kwemasti kunye neeseli zomhlaza.

I-Midostaurin iza njengecapsule ukuyithatha ngomlomo. Ihlala ithathwa ngokutya kabini ngemini. Thatha i-midostaurin ngeenxa zonke ngamaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-midostaurin ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya zonke iifomsile; sukuzivula okanye uzityumze.

Ukuba uyagabha emva kokuthatha i-midostaurin, sukuthatha elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho unokunciphisa idosi ye-midostaurin okanye akuxelele ukuba uyeke ukuthatha i-midostaurin kangangexesha elithile okanye ngokusisigxina ngexesha lonyango lwakho. Oku kuxhomekeke kwiziphumo ebezingalindelekanga onazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka uthatha i-midostaurin nokuba uziva uphilile. Ungayeki ukuthatha i-midostaurin ngaphandle kokuthetha nogqirha wakho.

Ugqirha wakho unokukuxelela ukuba uthathe amayeza ukuthintela isicaphucaphu kunye nokugabha ngaphambi kwethamo ngalinye le-midostaurin.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-midostaurin,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-midostaurin, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwii-capsules ze-midostaurin. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: boceprevir (ayisafumaneki e-U.S. Victrelis); carbamazepine (Carbatrol, Equetro, Tegretol, nabanye); i-clarithromycin (i-Biaxin, kwi-Prevpac); diltiazem (Cardizem, Cartia, Tiazac, nabanye); enzalutamide (Xtandi); idelalisib (iZydelig); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); amayeza asetyenziselwa ukunyanga intsholongwane kaGawulayo (i-HIV) efana ne-cobicistat (Tybost, e-Evotaz, e-Genvoya, e-Prezcobix, e-Stribild), elvitegravir (Vitekta), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, e Kaletra , eTechnivie, eViekira), saquinavir (Invirase) kunye netipranavir (Aptivus); mitotane (iLysodren); nefazodone; phenytoin (iDilantin, iPhenytek); i-posaconazole (Noxafil); irifampin (Rifadin, Rimactane, eRifamate, eRifater); i-troleandomycin (ayifumaneki e-U.S.); kunye ne-voriconazole (Vfend). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-midostaurin, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe wabethwa yintliziyo ngendlela engaqhelekanga, ukwandiswa kweQT (ingxaki yentliziyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe), imiphunga, isibindi, okanye isifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ungumfazi, akufanele ukhulelwe ngelixa uthatha i-midostaurin kunye neenyanga ezi-4 emva kwedosi yakho yokugqibela. Kuya kufuneka ukuba ube novavanyo lokukhulelwa olubi ngaphakathi kweentsuku ezisi-7 ngaphambi kokuba uqale ukuthatha i-midostaurin. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba uyindoda, wena kunye neqabane lakho labasetyhini kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kwaye niqhubeke nokusebenzisa ulawulo lokuzalwa kwiinyanga ezi-4 emva kwedosi yenu yokugqibela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-midostaurin, tsalela ugqirha ngokukhawuleza. I-Midostaurin inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngelixa uthatha i-midostaurin kunye neenyanga ezi-4 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini.

Thetha nogqirha wakho malunga nokutya igrapefruit kunye nokusela ijusi yamagilebhisi ngelixa uthatha eli yeza.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Midostaurin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• urhudo
• intloko ebuhlungu
• impumlo
• ukudinwa
• ubuthathaka
• isiyezi
• ukuqhina
• Iimpawu
• ukwanda kokubila
• isisu esibuhlungu
• amabala amhlophe okanye izilonda emilebeni okanye emlonyeni nasemqaleni
• ukudumba kwezandla, iinyawo, amaqatha okanye imilenze esezantsi
• umqolo, ithambo, ilungu, ilungu lomzimba, okanye iintlungu zemisipha
• ubunzima bokulala okanye ukulala

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• umkhuhlane, ukukhohlela, umqala obuhlungu, Ukugodola kunye neminye imiqondiso yosulelo
• ukukhawuleza kwentliziyo, ukungahambi kakuhle, okanye ukubetha kwentliziyo
• ukuqhawukelwa ngumphefumlo
• iintlungu zesifuba
• ukugungxula
• ukudumba kwemilebe, ulwimi, okanye umqala
• ubunzima bokuphefumla okanye ukugwinya
• urhwebo
• irhashalala
• ukurhawuzelela
• ukukhwehlela okutsha okanye okuya kusiba mandundu
• ukuvutha
• Igazi okanye ukugabha okubonakala ngathi yindawo yekhofi
• ukopha okungaqhelekanga okanye ukugruzuka
• ukutshisa okanye iintlungu xa uchama

I-Midostaurin inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho unokuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-midostaurin.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Rydapt^®