INeratinib

Umxholo

• Ngaphambi kokuba uthathe i-neratinib,
• I-Neratinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye ezo zidweliswe kwiCandelo LOKUKHUSELEKILEYO, Biza ugqirha ngoko nangoko:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Neratinib isetyenziselwa ukunyanga uhlobo oluthile lomhlaza webele we-receptor-positive (umhlaza webele oxhomekeke kwiihomoni ezinje nge-estrogen ukukhula) kubantu abadala emva konyango nge-trastuzumab (Herceptin) kunye namanye amayeza. I-Neratinib isetyenziswa kunye ne-capecitabine (Xeloda) ukunyanga uhlobo oluthile lomhlaza webele we-receptor-positive okanye umhlaza webele osasazeke kwamanye amalungu omzimba emva konyango ubuncinci ngamanye amayeza. I-Neratinib ikwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

I-Neratinib iza njengecwecwe lokuthatha ngomlomo. Xa i-neratinib ithathwa yodwa ukunyanga umhlaza wamabele, ihlala ithathwa kunye nokutya kube kanye yonke imihla unyaka omnye. Xa i-neratinib ithathwa nge-capecitabine ukunyanga umhlaza webele ophucukileyo okanye umhlaza webele osasazeke kwamanye amalungu omzimba, ihlala ithathwa kube kanye yonke imihla ngokutya ngeentsuku zoku-1 ukuya kwezingama-21 zomjikelo weentsuku ezingama-21 de imeko yakho ibe mbi okanye ukhule iziphumo ebezingalindelekanga ezimandundu. Thatha i-neratinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-neratinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ugqirha wakho unokunciphisa idosi okanye okwexeshana okanye unqumame unyango lwakho lwe-neratinib ngexesha lonyango lwakho. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka uthathe i-neratinib nokuba uziva uphilile. Sukuyeka ukuthatha i-neratinib ungakhange uthethe nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-neratinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-neratinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-neratinib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ii-antibiotics ezithile kubandakanya i-ciprofloxacin (Cipro), i-clarithromycin (i-Biaxin, kwi-Prevpac), i-erythromycin (i-EES, i-E-Mycin, i-Erythrocin), kunye ne-troleandomycin (engasafumanekiyo e-U.S.); ii-antifungals ezithile kubandakanya i-clotrimazole (Mycelex), i-fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), kunye ne-voriconazole (Vfend); Aprepitant (Hlomela); i-bosentan (iTracleer); iibhlokhi ezithile zekhalsiyamu kubandakanya i-diltiazem (Cardizem, Tiazac, abanye) kunye ne-verapamil (Calan, Verelan, abanye); indawo yokuhlala (iTybost); ikhonkco (Vaprisol); crizotinib (Xalkori); icyclosporine (Gengraf, Neoral, Sandimmune); dabigatran (Pradaxa); idigoxin (Lanoxin); idronarone (iMultaq); enzalutamide (Xtandi); i-fexofenadine (Allegra); i-fluvoxamine (iLuvox); idelalisib (iZydelig); imatinib (Gleevec); amayeza athile e-hepatitis C kubandakanya i-boceprevir (engasafumaneki e-U.S., Victrelis), dasabuvir (eViekira Pak), e-ombitasvir (e-Technivie, e-Viekira XR), kunye ne-paritaprevir (e-Technivie, e-Viekira XR); amayeza athile kwintsholongwane kaGawulayo (i-HIV) okanye ifunyenwe isifo se-immunodeficiency syndrome (i-AIDS) kubandakanya i-efavirenz (Sustiva, e-Atripla), elvitegravir (eGenvoya, eStribild), etravirine (Intelence), indinavir (Crixivan), lopinavir (eKaletra), nelfinavir (Viracept), ritonavir (Norvir, eKaletra), saquinavir (Invirase), kunye netipranavir (Aptivus); mitotane (iLysodren); imodafinil (Provigil); nefazodone; Iiproton pump inhibitors ezifana ne-esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), kunye ne-rabeprazole (AcipHex); irifampin (Rifadin, Rimactane, kwiRifater); kunye namayeza athile okubanjwa kubandakanya i-carbamazepine (Carbatrol, Epitol, Tegretol) kunye ne phenytoin (Dilantin, Phenytek). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-neratinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• ukuba uthatha i-antacid, thatha ubuncinci iiyure ezi-3 ngaphambi okanye kwiiyure ezi-3 emva kokuthatha i-neratinib.
• ukuba uthatha i-neratinib kunye nonyango lokuchama, ukubetha kwentliziyo, okanye izilonda (i-H₂ blocker) njenge-cimetidine, i-famotidine (i-Pepcid, kwi-Duexis), i-nizatidine (i-Axid), okanye i-ranitidine (i-Zantac), thatha i-neratinib ubuncinci iiyure ezi-2 ngaphambi okanye ubuncinci iiyure ezili-10 emva kokuthatha i-H₂ blocker.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe unesifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ukuba ucwangcisa ukuba ngutata womntwana. Akufanele ukhulelwe ngelixa uthatha i-neratinib. Ukuba ungowasetyhini, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango kwaye kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kunye ne-neratinib kwaye ubuncinci inyanga emva kokuthatha idosi yokugqibela. Ukuba uyindoda, wena kunye neqabane lakho labasetyhini kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kunye ne-neratinib kwaye niqhubeke iinyanga ezi-3 emva kwedosi yokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba ukhulelwa ngelixa uthatha i-neratinib, biza ugqirha wakho ngokukhawuleza. I-Neratinib inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Akufanele uncelise ngelixa uthatha i-neratinib kwaye ukuya kuthi ga kwinyanga e-1 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba i-neratinib ihlala ibangela urhudo, olunokuba lukhulu. Ugqirha wakho uya kukuxelela ukuba uthathe i-loperamide (Imodium AD), iyeza elichasene nesifo sorhudo, ukuthintela ukomisa (ukulahleka kwamanzi amaninzi emzimbeni wakho) kwiintsuku zokuqala ezingama-56 zonyango lwakho nge-neratinib. Emva kweentsuku ezingama-56 zonyango, ugqirha wakho uya kulungelelanisa idosi yakho ye-loperamide ukuze ube nokuhamba kwamathumbu ayi-1 ukuya kwezi-2 yonke imihla ngelixa uthatha i-neratinib. Ugqirha wakho unokukuxelela ukuba usele into eninzi, wenze utshintsho kwindlela otya ngayo, okanye uthathe amanye amayeza ukulawula urhudo. Biza ugqirha wakho ngokukhawuleza ukuba unesifo sohudo esibuhlungu (ngaphezulu kokuhamba kwamathumbu amabini ngosuku olu-1 okanye urhudo olungayeki) okanye urhudo kunye nobuthathaka, isiyezi, okanye umkhuhlane ngelixa uthatha i-neratinib. Tsalela umnxeba kwangoko ukuba unazo naziphi na kwezi mpawu zilandelayo zokoma: ukoma kakhulu, umlomo owomileyo kunye / okanye ulusu, ukuncipha komchamo, okanye ukubetha kwentliziyo okukhawulezayo.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Neratinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• isisu esibuhlungu
• isilungulela
• ukudumba
• izilonda zomlomo
• Ukuphelelwa ngumdla wokutya
• ukuhla ukusinda
• impumlo iyopha
• iingxaki zenzipho okanye utshintsho
• ukudumba kwezihlunu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye ezo zidweliswe kwiCandelo LOKUKHUSELEKILEYO, Biza ugqirha ngoko nangoko:

• Amehlo atyheli nolusu
• umchamo omnyama
• iintlungu okanye ukungaphatheki kakuhle kwindawo ephezulu yesisu
• ukudinwa
• isicaphucaphu
• ukugabha
• irhashalala
• umkhuhlane, ubunzima bokuchama, iintlungu xa uchama, kunye neminye imiqondiso yosulelo

I-Neratinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• urhudo
• isicaphucaphu
• ukugabha
• isisu esibuhlungu

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-neratinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Nerlynx^®