Inaliti ye-Axicabtagene Ciloleucel

Umxholo

• Ngaphambi kokufumana inaliti ye-axicabtagene ciloleucel,
• I-Axicabtagene ciloleucel inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

Inaliti ye-Axicabtagene ciloleucel inokubangela ukusabela okunobungozi okanye okusongela ubomi okubizwa ngokuba yi-cytokine release syndrome (CRS). Ugqirha okanye umongikazi uya kukujonga ngononophelo ngexesha lokufakwa kwakho kunye ubuncinci iiveki ezi-4 emva koko. Tshela ugqirha wakho ukuba unesifo esivuthayo okanye ukuba unayo okanye ucinga ukuba unalo naluphi na uhlobo losulelo ngoku. Uya kunikwa amayeza kwimizuzu engama-60 ngaphambi kokufakwa kwakho ukunceda ukuthintela iimpendulo kwi-axicabtagene ciloleucel. Ukuba uhlangabezana naziphi na kwezi mpawu zilandelayo ngexesha nasemva kokufakwa, xelela ugqirha ngoko nangoko: umkhuhlane, ukugodola, ukukhawuleza kwentliziyo okanye ukubetha kwentliziyo, ukugungqa, urhudo, ukudinwa, ukuba buthathaka, ukuphefumla nzima, ukuphefumla kancinci, ukudideka, isicaphucaphu, ukugabha, isiyezi , okanye intloko elula.

Inaliti ye-Axicabtagene ciloleucel inokubangela ukusabela okubukhali okanye okusongela ubomi. Ezi mpendulo zinokwenzeka emva konyango nge-axicabtagene ciloleucel. Tshela ugqirha wakho ukuba ukhe waxhuzula, wabethwa yistroke, okanye waphulukana nenkumbulo. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, xelela ugqirha ngoko nangoko: intloko ebuhlungu, isiyezi, ubunzima bokulala okanye ukulala, ukungazinzi, ukudideka, ixhala, ukungcangcazela okungalawulekiyo komzimba, ukulahleka kwengqondo, ukuphazamiseka, ukuxhuzula, ukulinganisela, ukuqonda ubunzima, okanye ukuthetha nzima.

Inaliti ye-Axicabtagene ciloleucel ifumaneka kuphela ngenkqubo ekhethekileyo yokuhambisa ngenxa yomngcipheko weCRS kunye neetyhefu ze-neurological. Unokufumana amayeza kugqirha nakwiziko lokhathalelo lwempilo oluthatha inxaxheba kule nkqubo. Buza ugqirha wakho ukuba unemibuzo malunga nale nkqubo.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango ngeaxicabtagene ciloleucel. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Inaliti ye-Axicabtagene ciloleucel isetyenziselwa ukunyanga uhlobo oluthile lwe-non-Hodgkin's lymphoma (umhlaza oqala kwiiseli ezimhlophe zegazi ezihlala zilwa nosulelo) olubuyileyo okanye olungaphenduliyo kolunye unyango (abantu) esele bephethwe ubuncinci amanye amayeza amabini e-chemotherapy. Inaliti ye-Axicabtagene ciloleucel ikudidi lwamayeza abizwa ngokuba yi-autologous cellular immunotherapy, uhlobo lonyango olulungiselelwe kusetyenziswa iiseli ezivela kwigazi lesigulana. Isebenza ngokubangela amajoni omzimba (iqela leeseli, izicwili, kunye namalungu akhusela umzimba ekuhlaselweni ziintsholongwane, iintsholongwane, iiseli zomhlaza, kunye nezinye izinto ezibangela izifo) ukuba zilwe neeseli zomhlaza.

Inaliti ye-Axicabtagene ciloleucel iza njengokumiswa (ulwelo) ukuze kufakwe ngaphakathi (emthanjeni) ngugqirha okanye ngumongikazi kwiofisi kagqirha okanye kwiziko lokumnika. Ihlala inikwa ngaphezulu kwesithuba semizuzu engama-30 njengedosi yexesha elinye. Ngaphambi kokuba ufumane idosi yakho ye-axicabtagene ciloleucel, ugqirha wakho okanye umongikazi uya kulawula amanye amayeza e-chemotherapy ukulungiselela umzimba wakho ukuba ufumane i-axicabtagene ciloleucel.

Phambi kokuba unikwe inaliti ye-axicabtagene ciloleucel inaliti, isampuli yeeseli zakho ezimhlophe zegazi ziya kuthathwa kwiziko lokuqokelela iiseli kusetyenziswa inkqubo ebizwa ngokuba yileukapheresis (inkqubo esusa iiseli ezimhlophe zegazi emzimbeni). Ngenxa yokuba eli yeza lenziwa kwiiseli zakho, kufuneka unikwe wena kuphela. Kubalulekile ukuba ufike ngexesha kwaye ungaphoswa kukuqokelelwa (okanye) kokuqokelelwa kweeselfowuni okanye ukufumana idosi yonyango. Kuya kufuneka ucwangcise ukuhlala kufutshane nalapho ufumene unyango lwakho lwe-axicabtagene ciloleucel ubuncinci iiveki ezi-4 emva kwedosi yakho. Umboneleli wakho wezononophelo lwempilo uya kujonga ukuba unyango lwakho luyasebenza na kwaye akubeke esweni naziphi na iziphumo ebezingalindelekanga ezinokubakho. Thetha nogqirha wakho malunga nendlela yokulungiselela i-leukapheresis kunye nento onokuyilindela ngexesha nasemva kwenkqubo.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-axicabtagene ciloleucel,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-axicabtagene ciloleucel, i-gentamicin, nawaphi na amanye amayeza, i-dimethyl sulfoxide (i-DMSO), okanye ezinye izithako kwiinaliti ze-axicabtagene ciloleucel. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ii-steroids ezinje nge-dexamethasone, methylprednisolone (Medrol), prednisolone, kunye ne-prednisone (iRayos). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe wanengxaki yokuphefumla okanye imiphunga, izintso, intliziyo, okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Kuya kufuneka ukuba ube kuvavanyo lokukhulelwa ngaphambi kokuba uqale unyango lwe-axicabtagene ciloleucel. Ukuba ukhulelwa ngelixa ufumana inaliti ye-axicabtagene ciloleucel, tsalela umnxeba kwangoko.
• Kuya kufuneka uyazi ukuba inaliti ye-axicabtagene ciloleucel inokukwenza wozele kwaye ubangele ukudideka, ubuthathaka, isiyezi, ukuxhuzula, kunye neengxaki zokulungelelanisa. Musa ukuqhuba imoto okanye usebenzise oomatshini ubuncinci iiveki ezi-8 emva kwethamo lakho le-axicabtagene ciloleucel.
• musa ukunikela ngegazi, amalungu, izicwili, okanye iiseli zokufakelwa emva kokuba ufumene inaliti ye-axicabtagene ciloleucel.
• jongana nogqirha wakho ukubona ukuba ufuna ukufumana naluphi na ugonyo. Awunalo naluphi na ugonyo ngaphandle kokuthetha nogqirha wakho ubuncinci iiveki ezi-6 ngaphambi kokuqala unyango lwe-chemotherapy, ngexesha lonyango lwe-axicabtagene ciloleucel, de ugqirha akuxelele ukuba amajoni akho omzimba abuyile.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphosa ixesha lokuqokelela iiseli zakho, kuya kufuneka ubize ugqirha wakho kunye neziko lokuqokelela kwangoko. Ukuba uphosa ixesha lokuqeshwa ukuze ufumane idosi yakho ye-axicabtagene ciloleucel, kuya kufuneka ubize ugqirha ngoko nangoko.

I-Axicabtagene ciloleucel inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuqhina
• isisu esibuhlungu
• umqolo obuhlungu
• intlungu edibeneyo okanye yemisipha
• umlomo owomileyo
• Ukuphelelwa ngumdla wokutya
• ukuhla ukusinda

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

• igazi kumchamo
• ukopha ngokulula kunesiqhelo
• umkhuhlane, umqala obuhlungu, ingqele, okanye ezinye iimpawu zosulelo
• Ukuncipha kokuchama rhoqo okanye isixa
• ulusu oluthuthu
• ukudinwa
• ukudumba kwamehlo, ubuso, imilebe, ulwimi, umqala, iingalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• kunzima ukugwinya
• irhashalala
• urhwebo
• ukurhawuzelela

Inaliti ye-Axicabtagene ciloleucel inokunyusa umngcipheko wokuvela komhlaza othile. Thetha nogqirha wakho malunga neengozi zokufumana eli yeza.

I-Axicabtagene ciloleucel inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina lonke ixesha lokudibana nogqirha wakho, indawo yokuqokelela iiseli, kunye nelabhoratri. Ugqirha wakho unoku-odola iimvavanyo ezithile zelebhu ngaphambi, ngexesha, nasemva konyango lwakho ukujonga impendulo yomzimba wakho kwisitofu se-axicabtagene ciloleucel.

Ngaphambi kokuba uvavanywe elebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba ufumana inaliti ye-axicabtagene ciloleucel. Eli yeza linokuchaphazela iziphumo zovavanyo oluthile lwelabhoratri.

Buza usokhemesti wakho ukuba unayo nayiphi na imibuzo onayo malunga nenaliti ye-axicabtagene ciloleucel.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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