Inaliti yeGemtuzumab Ozogamicin

Umxholo

• Phambi kokufumana inaliti ye-gemtuzumab ozogamicin,
• Inaliti yeGemtuzumab ozogamicin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

Inaliti ye-Gemtuzumab ozogamicin inokubangela ukonakala okanye ukusongela ubomi kwesibindi, kubandakanya isifo se-hepatic veno-occlusive (VOD; imithambo yegazi evaliweyo ngaphakathi kwesibindi). Tshela ugqirha wakho ukuba ukhe unesifo sesibindi okanye une-hematopoietic stem-cell transplant (HSCT; inkqubo etshintsha umongo wethambo onesifo somongo wethambo). Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: ukutyeba ngokukhawuleza, iintlungu okanye ukudumba kwinxalenye ephezulu yesisu, ukuba tyheli kolusu okanye amehlo, isicaphucaphu, ukugabha, umchamo omnyama, okanye ukudinwa okugqithisileyo.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ngaphambi, ngexesha, nasemva konyango lwakho ukujonga impendulo yomzimba wakho kwi-gemtuzumab ozogamicin injection.

Thetha nogqirha wakho malunga nomngcipheko wokuthatha inaliti ye-gemtuzumab ozogamicin.

Inaliti ye-Gemtuzumab ozogamicin isetyenziswa yodwa okanye ngokudibeneyo namanye amayeza e-chemotherapy ukunyanga uhlobo oluthile lwe-myeloid leukemia (AML; uhlobo lomhlaza oqala kwiiseli ezimhlophe zegazi) kubantu abadala nakubantwana kwinyanga eyi-1 ubudala nangaphezulu ababesandula ukubakhona ufumaneke unalo mhlaza. Isetyenziselwa sodwa ukunyanga uhlobo oluthile lwe-AML kubantu abadala nakubantwana abaneminyaka emi-2 ubudala nangaphezulu abanomhlaza owandayo ngexesha okanye emva konyango ngamanye amayeza e-chemotherapy. Inaliti yeGemtuzumab ozogamicin ikudidi lwamayeza abizwa ngokuba ngamachiza omzimba omzimba. Isebenza ngokunceda ekubulaleni iiseli zomhlaza.

Inaliti ye-Gemtuzumab ozogamicin iza njengomgubo wokudityaniswa nolwelo kwaye inikezwe ngenaliti okanye nge-catheter ebekwe emthanjeni. Ihlala itofwe kancinci kwisithuba seeyure ezi-2. Ugqirha wakho uza kukuxelela ukuba uza kuyifumana kangaphi inaliti ye-gemtuzumab ozogamicin. Ishedyuli yokulinganisa ixhomekeke ekubeni uphathwa ngamanye amayeza e-chemotherapy, ukuba umhlaza wakho wawunyangwa ngaphambili, kunye nendlela umzimba wakho uphendula ngayo kunyango.

Inaliti ye-Gemtuzumab ozogamicin inokubangela ukusabela okunobuzaza okanye okusongela ubomi ngexesha lokufakwa kunye nasemva komhla. Uya kufumana amayeza athile ukunceda ukuthintela impendulo ngaphambi kokuba ufumane idosi nganye yegemtuzumab ozogamicin. Ugqirha okanye umongikazi uya kukujonga ngokusondeleyo ngelixa ufumana ukumiliselwa kwaye kungekudala emva kokufakwa ukuze uqiniseke ukuba awunampendulo imbi kunyango. Xelela ugqirha wakho okanye umongikazi kwangoko ukuba unazo naziphi na kwezi mpawu zilandelayo ezinokuthi zenzeke ngexesha okanye ngaphakathi kweeyure ezingama-24 emva kokufakwa: irhashalala, umkhuhlane, ukugodola, ukubetha kwentliziyo okukhawulezayo, ukudumba ulwimi okanye umqala, ukuphefumla kancinci okanye ukuphefumla nzima.

Ugqirha wakho unokucothisa ukumiliselwa kwakho, ukulibaziseka, okanye uyeke unyango lwakho ngenaliti ye-gemtuzumab ozogamicin, okanye ukunyanga ngamayeza ongezelelweyo kuxhomekeke kwimpendulo yakho kunyango kunye naziphi na iziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha nasemva konyango lwakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Phambi kokufumana inaliti ye-gemtuzumab ozogamicin,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-gemtuzumab ozogamicin, nawaphi na amanye amayeza, okanye naziphi na izithako kwiinaliti ye-gemtuzumab ozogamicin. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukukhankanya nayiphi na kwezi zilandelayo: amiodarone (Cordarone, Nexterone, Pacerone), anagrelide (Agrylin), chloroquine, chlorpromazine, cilostazol, citalopram (Celexa), disopyramide (Norpace), dofetilide (Tikosyn), donepezil (Aricept, in Namzar ), dronedarone (Multaq), escitalopram (Lexapro), flecainide (Tambocor), fluconazole (Diflucan), haloperidol (Haldol), ibutilide (Corvert), methadone (Methadose, Dolophine), ondansetron (Zuplenz, Sofran), pimozide , procainamide, quinidine (eNuedexta), sotalol (iBetapace, iSorine, iSotylize), kunye ne-thioridazine. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokuphinda asebenzisane nenaliti ye-gemtuzumab ozogamicin, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba wena okanye nabani na kusapho lwakho une-QT syndrome (imeko eyonyusa umngcipheko wokuba nesifo sentliziyo esingaqhelekanga esinokubangela ukuba utyhafile okanye usweleke ngesiquphe), okanye ukuba ubunayo okanye ubukhe kunamanqanaba aqhelekileyo esodiyam, potasium, ikhalsiyam, okanye imagniziyam egazini lakho.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ucwangcise ukuba ngutata womntwana. Akufanele ukhulelwe ngelixa ufumana inaliti yegemtuzumab ozogamicin. Uya kudinga uvavanyo lokukhulelwa olubi ngaphambi kokuba uqale ukufumana eli yeza. Sebenzisa ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho ngenaliti ye-gemtuzumab ozogamicin kunye neenyanga ezi-6 emva kwedosi yakho yokugqibela. Ukuba uyindoda kwaye iqabane lakho linokukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho kunye neenyanga ezi-3 emva kwedosi yakho yokugqibela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa ufumana inaliti yegemtuzumab ozogamicin, tsalela ugqirha wakho.
• xelela ugqirha wakho ukuba uncelisa. Akufanelanga ukuncancisa ngelixa ufumana inaliti ye-gemtuzumab ozogamicin, kunye nenyanga e-1 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini. Thetha nogqirha wakho malunga neengozi zokufumana i-gemtuzumab ozogamicin.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Inaliti yeGemtuzumab ozogamicin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• irhashalala
• urhudo
• ukuqhina
• isicaphucaphu
• ukugabha
• intloko ebuhlungu
• intlungu
• iintlungu, ukudumba, okanye izilonda emlonyeni okanye emqaleni

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• ukopha okungaqhelekanga okanye ukuqina
• ukukhwehlela, ukuphefumla kancinci, okanye ukuphefumla nzima
• ukubetha kwentliziyo ngokukhawuleza
• umkhuhlane, ingqele, umqala obuhlungu, okanye ezinye iimpawu zosulelo

Inaliti ye-Gemtuzumab ozogamicin inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Imylotarg^®