Umbhali: Joan Hall
Umhla Wokudalwa: 1 Eyomdumba 2021
Hlaziya Umhla: 19 Eyenkanga 2024
Anonim
Pharmacology 981 c Chelating Agent Penicillamine Copper Cu wilson disease poisoning kidney cysteine
Ividiyo: Pharmacology 981 c Chelating Agent Penicillamine Copper Cu wilson disease poisoning kidney cysteine

Umxholo

I-Penicillamine isetyenziselwa ukunyanga isifo sikaWilson (imeko ezuzwe njengelifa ebangela ubhedu ukuba yakheke emzimbeni kwaye inokubangela iimpawu ezinzulu) kunye necystinuria (imeko ezuzwe njengelifa enokukhokelela kumatye ezintso). Ikwasetyenziswa ngokudibeneyo nolunye unyango ukunyanga isifo samathambo (imeko apho amajoni omzimba ahlasela amalungu awo, abangela iintlungu, ukudumba, kunye nokuphulukana nomsebenzi) ezingakhange zibengcono emva konyango namanye amayeza. IPenicillamine ikwiklasi yamayeza abizwa ngokuba ziintsimbi ezinzima. Isebenza ukunyanga isifo sikaWilson ngokuzibophelela kubhedu olongezelelekileyo emzimbeni kwaye sisenze ukuba siphume emzimbeni ngomchamo. Isebenza ukunyanga i-cystinuria ngokubophelela kwinto eyenza amatye ezintso kunye nokuthintela ekwakheni nasekwenzeni amatye. Isebenza ukunyanga i-rheumatoid arthritis ngokunciphisa ezinye iintshukumo zomzimba.

I-Penicillamine iza njengecapsule kwaye njengepilisi ukuba uyithathe ngomlomo. Ihlala ithathwa kwisisu esingenalutho ubuncinci iyure enye ngaphambi okanye iiyure ezi-2 emva kwesidlo, kwaye ubuncinci iyure e-1 ngaphambi okanye emva kwako nakuphi na ukutya okanye ubisi. Ukunyanga isifo sikaWilson kunye necystinuria, ipenicillamine ihlala ithathwa amaxesha amane ngosuku. Unyango lwe-rheumatoid arthritis ihlala ithatha kanye ngemini, kodwa kumanqanaba anyukayo, inokuthathwa ukuya kuthi ga kane ngemini. Ugqirha wakho uza kukucebisa ukuba kuya kufuneka uluthathe ixesha elingakanani unyango ngokusekwe kwimeko yakho, ukuba uphendula njani emzimbeni wakho kunyango, kunye naziphi na iziphumo ebezingalindelekanga ohlangabezana nazo. Thatha ipenicillamine malunga nexesha elifanayo (ii) yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha ipenicillamine ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.


Ugqirha wakho uya kuqala ngedosi esezantsi yepenicillamine kwaye ngokuthe ngcembe andise idosi yakho.

Ukunyanga isifo sikaWilson kunye nesifo samathambo kungathatha inyanga enye ukuya kwezintathu okanye nangaphezulu ngaphambi kokuba uve isibonelelo esipheleleyo sepenicillamine. Kuko konke ukusetyenziswa kuyaqhubeka ukuthatha ipenicillamine nokuba uziva uphilile. Sukuyeka ukuthatha ipenicillamine ungakhange uthethe nogqirha wakho, nokuba iimpawu zakho ziya zisiba mbi. Ukuba uyeka ukuthatha i-penicillamine usemngciphekweni okhulayo wokufumana impendulo xa usaqala ukuthatha amayeza kwakhona.

Qiniseka ukuba uxelela ugqirha wakho indlela oziva ngayo ngexesha lonyango lwakho nge penicillamine. Ugqirha wakho unokukuphatha ngamanye amayeza, okanye ulibazise unyango lwakho, ukunciphisa umyinge wakho, okanye uyeke unyango lwakho kuxhomekeke kwiziphumo ozifumanayo.

I-Penicillamine ngamanye amaxesha isetyenziswa njengonyango olulandelayo lwetyhefu emva kokuba iphathwe ngamanye amayeza. Ngamanye amaxesha kusetyenziswa ukunyanga iintlobo ezithile zesifo sesibindi. Thetha nogqirha wakho malunga neengozi zokusebenzisa eli yeza kwimeko yakho.


Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe ipenicillamine,

  • xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-penicillamine, i-penicillin, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi zeepenicillamine okanye iipilisi. Buza usokhemesti wakho uluhlu lwezithako.
  • xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya oku kulandelayo: iikhompawundi zegolide ezinje nge-auranofin (iRidaura) kunye ne-aurothioglucose (Solganol); amayeza antimalarial njenge chloroquine, hydroxychloroquine (Plaquenil); kunye nezinto ezithile zokuzikhusela emzimbeni ezifana ne-azathioprine (Azasan, Imuran), kunye ne-methotrexate (Otrexup, Rasuvo, Trexall, Xatmep). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana nepenicillamine, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
  • ukuba uthatha intsimbi enemveliso, yithathe iiyure ezi-2 ngaphambi okanye nasemva kokuba uthatha ipenicillamine. Ukuba uthatha nawaphi na amanye amayeza, i-antacid, okanye i-zinc enemveliso, thatha iyure e-1 ngaphambi okanye emva kokuba uthathe ipenicillamine.
  • xelela ugqirha wakho ukuba wakhe wanyangwa nge-penicillamine kwixa elidlulileyo kwaye waba nefuthe elibi legazi. Ugqirha wakho uya kukuxelela ukuba ungathathi ipenicillamine kwakhona.
  • xelela ugqirha wakho ukuba ukhe wasabela gwenxa kwiimichiza zegolide, okanye ukuba ukhe unesifo sezintso.
  • xelela ugqirha wakho ukuba ukhulelwe, okanye ukuba ucwangcisa ukukhulelwa. Ukuba ukhulelwa ngelixa uthatha ipenicillamine, biza ugqirha ngokukhawuleza.
  • xelela ugqirha wakho ukuba uncelisa. Akufanele uncancise ngelixa ufumana unyango nge-penicillamine.
  • ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha ipenicillamine.
  • Ugqirha wakho uya kukuxelela ukuba uthathe ipyridoxine (ivithamin B6) ukongeza ngexesha lonyango lwakho nge-penicillamine.

Ukuba unyangwa isifo sikaWilson ugqirha wakho uya kuthi mhlawumbi akucebise ngokutya okukhethekileyo okunezinga eliphantsi lobhedu. Oku kutya kuthintela ukutya okuziinkozo kunye nezongezo zokutya ezicetyiswe ngobhedu, itshokholethi, amandongomane, iqokobhe, amakhowa, isibindi, imolasses, i-broccoli, kunye nolunye ubhedu oluphezulu oluqukethe ukutya. Ugqirha wakho usenokucebisa ukuba usele amanzi anyibilikisiwe okanye ahlaziyekileyo, endaweni yamanzi ompompo aqhelekileyo. Qiniseka ukuba ulandela zonke iingcebiso zokutya ezenziwe ngugqirha wakho.


Ukuba uphathwa nge-cystinuria ugqirha unokucebisa ukutya okhethekileyo okuncinci kwimethionine (uhlobo lweprotein). Nangona kunjalo ukuba ungumntwana okanye ukuba ukhulelwe ugqirha wakho usenokungacebisi oku kutya. Ugqirha wakho uya kuphakamisa ukuba uphuze iziselo ezaneleyo.

Ukuba uphathwa i-rheumatoid arthritis, qhubeka nokutya okuqhelekileyo ngaphandle kokuba ugqirha ukuxelela ngenye indlela.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

IPenicillamine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

  • Ukuphelelwa ngumdla wokutya
  • utshintsho kwindlela izinto ezingcamla ngayo
  • isicaphucaphu
  • ukugabha
  • urhudo
  • intlungu zesisu
  • imibimbi yesikhumba
  • iinzipho utshintsho

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu biza ugqirha ngokukhawuleza:

  • irhashalala, ukurhawuzelela, imihlathi, ukuchitha isikhumba, umkhuhlane, iintlungu ezidibeneyo, okanye i-lymph node
  • Amadyungudyungu abuhlungu okanye arhawuzayo kunye nezilonda kulusu, emlonyeni nakumalungu angasese
  • umkhuhlane, umqala obuhlungu, ingqele, ukopha okungaqhelekanga okanye ukugruzuka
  • ukuphefumla kancinci, ukukhohlela okungachazwanga okanye ukuvutha
  • i-foamy okanye ipinki, ebomvu, emdaka, okanye umchamo onegazi
  • ubuthathaka bemisipha, iinkophe ezijingayo, okanye umbono ophindwe kabini

IPenicillamine inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-penicillamine.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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Ukuhlaziywa kokugqibela-04/15/2018

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