Tezacaftor kunye ne-Ivacaftor

Umxholo

• Ngaphambi kokuba uthathe i-tezacaftor kunye ne-ivacaftor,
• I-Tezacaftor kunye ne-ivacaftor zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, yeka ukuthatha i-tezacaftor kunye ne-ivacaftor kwaye ubize ugqirha ngoko nangoko:

Indibaniselwano yetezacaftor kunye ne-ivacaftor isetyenziswa kunye ne-ivacaftor ukunyanga iintlobo ezithile ze-cystic fibrosis (isifo esizalwe naso esibangela iingxaki ngokuphefumla, ukwetyisa, kunye nokuzala) kubantu abadala nakubantwana abaneminyaka emi-6 ubudala nangaphezulu. I-Tezacaftor kunye ne-ivacaftor kufuneka zisetyenziswe kuphela kubantu abanemveliso ethile yobume. Ugqirha wakho unokuyalela uvavanyo lwegazi ukukunceda uthathe isigqibo sokuba ngaba eliyeza lilungile na kuwe. I-Tezacaftor ikudidi lwamayeza abizwa ngokuba yi-cystic fibrosis transmembrane conductance regulator (CFTR) yokulungisa. I-Ivacaftor ikudidi lwamayeza abizwa ngokuba yi-cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. Omabini la mayeza asebenza ngokuphucula ukusebenza kweprotein emzimbeni ukunciphisa ukwakhiwa kwe-mucus eshinyeneyo emiphungeni kunye nokuphucula ezinye iimpawu ze-cystic fibrosis.

Umdibaniso we tezacaftor kunye ne-ivacaftor kunye ne-ivacaftor uza njengeepilisi ezizakuthathwa ngomlomo. Eli yeza liza kwiphakheji eneeveki ezi-4 zonyango. Idosi nganye yemihla ngemihla ineentlobo ezahlukeneyo zamacwecwe: ithebhulethi enye yindibaniselwano ye-tezacaftor kunye ne-ivacaftor kunye nenye ithebhulethi yi-ivacaftor. Thatha i-tezacaftor kunye ne-ivacaftor (icwecwe elityheli eli-1) rhoqo kusasa ngokutya okunamafutha kunye ne-ivacaftor (icwecwe eliblue eli-1) rhoqo ngokuhlwa ngokutya okunamafutha, ukwahlukana iiyure ezili-12. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha la mayeza ngokuchanekileyo. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Thatha indibaniselwano yetizacaftor kunye ne-ivacaftor kunye ne-ivacaftor enokutya okunamafutha okufana namaqanda, ibhotolo, amantongomane, ibhotolo yamandongomane, itshizi pizza, kunye neemveliso zobisi olupheleleyo (ezinje ngobisi olupheleleyo, itshizi, kunye neyogathi). Thetha nogqirha wakho malunga nokunye ukutya okunamafutha okutya nala mayeza.

Umdibaniso we tezacaftor kunye ne-ivacaftor kunye ne-ivacaftor usebenza ukulawula i-cystic fibrosis, kodwa ayiyinyangi. Qhubeka nokuthatha la mayeza nokuba uziva uphilile. Sukuyeka ukuthatha la mayeza ungakhange uthethe nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-tezacaftor kunye ne-ivacaftor,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-tezacaftor, i-ivacaftor, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwi-tezacaftor kunye ne-ivacaftor kunye neepilisi ze-ivacaftor. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, othabathayo okanye oceba ukuthatha Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ii-antibiotics ezithile ezifana ne-clarithromycin (i-Biaxin, kwi-PrevPac), i-erythromycin (i-EES, i-E-Mycin, i-Ery-Tab, i-Erythrocin), kunye ne-telithromycin (Ketek); ii-antifungals ezithile ezinjenge fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), kunye ne voriconazole (Vfend); icyclosporine (Gengraf, Neoral, Sandimmune); idigoxin (Lanoxin); i-everolimus (i-Afinitor, iZortress); amayeza athile okubanjwa njenge-carbamazepine (Carbatrol, Epitol, Tegretol, abanye), phenobarbital, kunye phenytoin (Dilantin, Phenytek); irifabutin (Mycobutin); irifampin (Rifadin, eRifamate, eRifater, eRimactane); i-sirolimus (iRapamune); okanye itacrolimus (Astagraf, Prograf). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-tezacaftor kunye ne-ivacaftor, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort. Ugqirha wakho usenokukuxelela ukuba ungathathi iwort yaseSt. John ngelixa uthatha indibaniselwano ye-tezacaftor kunye ne-ivacaftor kunye ne-ivacaftor.
• xelela ugqirha wakho ukuba ukhe unesifo sezintso okanye sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa uthatha indibaniselwano ye-tezacaftor kunye ne-ivacaftor kunye ne-ivacaftor, tsalela ugqirha wakho.
• Kuya kufuneka uyazi ukuba la mayeza anokukwenza wozele. Sukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela ekuchaphazela ngayo la mayeza.

Musa ukuyitya i-grapefruit okanye ii-orenji ze-Seville okanye usele ijusi ye-grapefruit ngelixa uthatha la mayeza.

Ukuba ukhumbula idosi ephosiweyo yethebhulethi ngaphakathi kweeyure ezingama-6 zexesha obucwangciselwe ukuyithatha, thatha idosi ephosiweyo kwangoko kunye nokutya okunamafutha. Nangona kunjalo, ukuba ngaphezulu kweeyure ezingama-6 zidlulile ukusukela kwixesha elimiselweyo lokuthatha nokuba yeyiphi ithebhulethi, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Tezacaftor kunye ne-ivacaftor zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• ukuxinana kwempumlo
• isiyezi

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, yeka ukuthatha i-tezacaftor kunye ne-ivacaftor kwaye ubize ugqirha ngoko nangoko:

• mthubi ulusu okanye amehlo
• Ukuphelelwa ngumdla wokutya
• isicaphucaphu
• ukugabha
• izitulo ezimhlophe
• isisu esibuhlungu
• umchamo omnyama

I-Tezacaftor kunye ne-ivacaftor zinokubangela isifo samehlo (ukugcwala kwelensi yamehlo enokubangela iingxaki zombono) kubantwana nakwishumi elivisayo. Abantwana kunye nolutsha oluthatha i-tezacaftor kunye ne-ivacaftor kufuneka babone ugqirha wamehlo ngaphambi nangexesha lonyango lwabo. Thetha nogqirha womntwana wakho malunga neengozi zokunika i-tezacaftor kunye ne-ivacaftor emntwaneni wakho.

I-Tezacaftor kunye ne-ivacaftor zinokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola uvavanyo lwamehlo (lwabantwana nabakwishumi elivisayo) kunye novavanyo oluthile lwelebhu ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwitezacaftor nakwivacaftor.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Symdeko^®