I-Avatrombopag

Umxholo

• Ngaphambi kokuba uthathe i-avatrombopag,
• I-Avatrombopag inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu biza ugqirha ngokukhawuleza:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Avatrombopag isetyenziselwa ukunyanga i-thrombocytopenia (inani eliphantsi leeplatelets [uhlobo lweeseli zegazi ezifunekayo ekunqandeni igazi]) kubantu abanezifo zesibindi ezingapheliyo (eziqhubekayo) ezicwangciselwe ukuba nenkqubo yezonyango okanye yamazinyo ukunceda ukuthintela ukopha. Isetyenziselwa ukunyanga i-thrombocytopenia kubantu abane-immune thrombocytopenia engapheliyo (i-ITP; imeko eqhubekayo enokubangela ukugruzuka okanye ukopha okungaqhelekanga ngenxa yenani eliphantsi ngokungaqhelekanga leeplatelets egazini) abangakhange bancedwe ngolunye unyango. I-Avatrombopag ikudidi lwamayeza abizwa ngokuba yi-thrombopoietin (TPO) receptor agonists. Isebenza ngokubangela ukuba umzimba uvelise iiplatelets ezininzi.

I-Avatrombopag iza njengecwecwe lokuthatha ngomlomo. Unyango lwe-thrombocytopenia kubantu abanezifo ezingapheliyo zesibindi ezicwangciselwe ukuba zibe nenkqubo, zihlala zithathwa ngokutya kube kanye ngemini kangangeentsuku ezintlanu, ukuqala kwiintsuku ezili-10 ukuya kwezi-13 ngaphambi kwenkqubo. Unyango lwe-thrombocytopenia kubantu abane-ITP, ihlala ithathwa kube kanye yonke imihla kunye nokutya ixesha elide njengoko kuyalelwe. Thatha i-avatrombopag malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-avatrombopag ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-avatrombopag,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-avatrombopag, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-avatrombopag. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qinisekisa ukukhankanya nayiphi na kwezi zilandelayo: amiodarone (Nexterone, Pacerone); Aprepitant (Hlomela); ii-antifungals ezithile ezifana ne-fluconazole, itraconazole (Onmel, Sporanox), ketoconazole, okanye voriconazole (Vfend); icarbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); i-clarithromycin (i-Biaxin, kwi-Prevpac); idiltiazem (Cardizem, Cartia, Diltzac, Taztia); enzalutamide (Xtandi); i-erythromycin (i-EES, i-Erythrocin, abanye; amayeza athile okunyanga i-HIV njenge-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), okanye nevirapine (Viramune); phenobarbital; phenytoin (Dilantin, Phenytut); Mycobutin); rifampin (Rifadin, Rimactane, eRifamate, eRifater); ritonavir (Norvir, e Kaletra, abanye), okanye saquinavir (Invirase); nefazodone; kunye ne-verapamil (Calan, Covera, Verelan). Nge-avatrombopag, ke qiniseka ukuxelela ugqirha wakho malunga nawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu Ugqirha wakho kusenokufuneka ukuba atshintshe amayeza akho okanye akujonge ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe wahlanjwa ligazi, okanye imeko yemfuza enokubangela amahlwili egazi.
• xelela ugqirha wakho ukuba ukhulelwe, okanye ucwangcise ukukhulelwa. Ukuba ukhulelwa ngelixa uthatha i-avatrombopag, tsalela umnxeba ugqirha wakho.
• xelela ugqirha wakho ukuba uncelisa. Ugqirha wakho uya kukuxelela ukuba ungancancisi ngexesha lonyango lwakho kunye nakwiiveki ezi-2 emva kwedosi yakho yokugqibela.

Sukutya igrapefruit okanye usele ijusi yeziqhamo xa usebenzisa eli yeza.

Ukuba uthatha i-avatrombopag ukunyanga i-thrombocytopenia ngaphambi nje kwenkqubo, thatha idosi ephosiweyo kwakamsinya nje emva kokuba uyikhumbule. Ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo, kodwa qiniseka ukugqiba ukuthatha onke amayeza (nokuba awathathwanga iintsuku ezi-5 zilandelelana). Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Ukuba uthatha i-avatrombopag ukunyanga i-immune thrombocytopenia engapheliyo, thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Avatrombopag inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukudinwa kakhulu
• intloko ebuhlungu
• ukuphuma kweempumlo okanye ukopha kweentsini
• intlungu edibeneyo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu biza ugqirha ngokukhawuleza:

• idumbile, ibuhlungu, ibomvu, okanye umlenze othambileyo
• ukuphefumla kancinci, umkhuhlane, ukukhohlela, iintlungu esifubeni, okanye ukubetha kwentliziyo okukhawulezayo
• isisu esibuhlungu okanye ukuthamba
• ukudumba kwezandla okanye iinyawo

I-Avatrombopag inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• idumbile, ibuhlungu, ibomvu okanye umlenze othambileyo
• ukuphefumla kancinci, ukukhohlela, iintlungu esifubeni, ukubetha kwentliziyo okukhawulezayo
• isisu esibuhlungu okanye ukuthamba

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ngaphambi kokuba uqale unyango ukuze uthathe isigqibo sedosi yakho ye-avatrombopag nangomhla wenkqubo.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Doptelet^®