I-Darunavir, iCobicistat, i-Emtricitabine, kunye neTenofovir

Umxholo

• Ngaphambi kokuba uthathe i-darunavir, i-cobicistat, i-emtricitabine, kunye ne-tenofovir,
• IDarunavir, icobicistat, emtricitabine, kunye ne-tenofovir zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kumacandelo ESILUMKISO ESIBALULEKILEYO OKANYE AMANYATHELO ATHILE, biza ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

I-Darunavir, i-cobicistat, i-emtricitabine, kunye ne-tenofovir akufuneki zisetyenziselwe ukunyanga usulelo lwentsholongwane ye-hepatitis B (HBV; usulelo lwesibindi oluqhubekayo). Xelela ugqirha wakho ukuba unayo okanye ucinga ukuba unayo i-HBV. Ugqirha wakho angakuvavanya ukuze ubone ukuba unayo i-HBV ngaphambi kokuba uqale kwaye ngexesha lonyango lwakho nge-darunavir, cobicistat, emtricitabine, kunye ne-tenofovir. Ukuba unayo i-HBV kwaye uthatha i-darunavir, i-cobicistat, i-emtricitabine kunye ne-tenofovir, imeko yakho inokuba mandundu mandundu xa uyeka ukuthatha eli yeza. Ugqirha wakho uya kukuvavanya kwaye a-odole uvavanyo lweelebhu rhoqo kwiinyanga ezininzi emva kokuba uyekile ukuthatha eli yeza ukubona ukuba i-HBV yakho iye yanda.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-darunavir, cobicistat, emtricitabine, kunye ne-tenofovir.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-darunavir, i-cobicistat, i-emtricitabine kunye ne-tenofovir.

Indibaniselwano ye-darunavir, i-cobicistat, i-emtricitabine, kunye ne-tenofovir isetyenziselwa ukunyanga usulelo lwe-immunodeficiency virus (HIV) kubantu abadala nakubantwana abanobunzima obungama-88 eekhilogram (40 kg) abangakhange banyangwe ngamanye amayeza e-HIV okanye ukubuyisela amayeza kubantu abathile sele bethatha amayeza e-HIV. Indibaniselwano yedarunavir, icobicistat, emtricitabine, kunye ne-tenofovir ikudidi lwamayeza abizwa ngokuba zii-antivirals. Umsebenzi weDarunavir, emtricitabine, kunye ne-tenofovir ngokunciphisa inani le-HIV egazini. ICobicistat inceda ukugcina i-darunavir emzimbeni ixesha elide ukuze amayeza abe nefuthe elikhulu. Nangona indibaniselwano ye-darunavir, i-cobicistat, i-emtricitabine, kunye ne-tenofovir zingayi kuyinyanga i-HIV, la mayeza angalinciphisa ithuba lakho lokufumana isifo se-immunodeficiency syndrome (i-AIDS) kunye nezifo ezinxulumene ne-HIV ezinje ngezifo ezinzulu okanye umhlaza. Ukuthatha la mayeza kunye nokwabelana ngesondo okukhuselekileyo nokwenza olunye utshintsho kwindlela yokuphila kunokunciphisa umngcipheko wokudlulisela intsholongwane kagawulayo kwabanye abantu.

Indibaniselwano yedarunavir, icobicistat, emtricitabine, kunye ne-tenofovir iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kunye nokutya kanye ngemini. Thatha i-darunavir, i-cobicistat, i-emtricitabine, kunye ne-tenofovir ngexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-darunavir, cobicistat, emtricitabine, kunye ne-tenofovir ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba unengxaki yokuginya amacwecwe, ungowahlulahlula ube ngamacwecwe amabini ngokusika ithebhulethi. Thatha amacwecwe okwahlulahlula emva kokuwasika. Sukuzigcina ukuze zisetyenziselwe ixesha elizayo.

Indibaniselwano yedarunavir, icobicistat, emtricitabine, kunye ne-tenofovir iyanceda ukulawula usulelo lwe-HIV kodwa ayiyinyangi. Qhubeka uthathe i-darunavir, i-cobicistat, i-emtricitabine, kunye ne-tenofovir nokuba uziva uphilile. Sukuyeka ukuthatha i-darunavir, i-cobicistat, i-emtricitabine, kunye ne-tenofovir ngaphandle kokuthetha nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-darunavir, i-cobicistat, i-emtricitabine, kunye ne-tenofovir,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-darunavir, i-cobicistat, i-emtricitabine, kunye ne-tenofovir, nawaphi na amanye amayeza, amayeza e-sulfa, okanye ezinye izithako ezikwi-darunavir, i-cobicistat, i-emtricitabine kunye neepilisi ze-tenofovir. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha nawaphi na amayeza alandelayo: alfuzosin (Uroxatral); carbamazepine (Carbatrol, Epitol, Tegretol, nabanye); i-cisapride (Propulsid) (ayifumaneki e-U.S.); colchicine (Colcyrs, Mitigare) kubantu abanezintso okanye isifo sesibindi; idronarone (iMultaq); elbasvir kunye negrazoprevir (Zepatier); amayeza e-ergot anje nge-dihydroergotamine (iDHE 45, Migranal), ergotamine (Ergomar, eCafergot, eMigergot), kunye ne-methylergonovine (Methergine); ivabradine (Corlanor); lomitapide (Juxtapid); I-lovastatin (Altoprev); ilurasidone (iLatuda); midazolam ngomlomo; naloxegol (Movantik); phenobarbital; phenytoin (iDilantin, iPhenytek); ipimozide (Orap); I-ranolazine (iRanexa); irifampin (Rifadin, Rimactane, eRifamate, eRifater); I-wort yaseSt. i-sildenafil (i-Revatio kuphela, uphawu olusetyenziselwa isifo semiphunga); isimvastatin (Simcor, Zocor, kwiVytorin); okanye i-triazolam (Halcion). Ugqirha wakho uyakukuxelela ukuba ungathathi i-darunavir, i-cobicistat, i-emtricitabine, kunye ne-tenofovir ukuba uthatha elinye okanye ngaphezulu kula mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: aminoglycoside antibiotics njenge-gentamicin; amayeza antifungal anjenge-isavuconazonium (Cresemba), itraconazole (Onmel, Sporanox), ketoconazole, kunye ne-voriconazole (Vfend); amayeza antiviral anje ngeacyclovir (Sitavig, Zovirax), cidofovir, ganciclovir (Cytovene, Valcyte), valacyclovir (Valtrex), kunye valganciclovir (Valcyte); I-antibiotics efana ne-clarithromycin (i-Biaxin, kwi-PrevPac), i-erythromycin (i-E.E.S, i-Eryc, i-Ery-Tab), kunye ne-telithromycin (ayisekho e-U.S., Ketek); apixaban (uEliquis); artemether kunye ne-lumefantrine (Coartem); i-aspirin kunye nezinye iyeza ezichasayo (i-NSAIDs) ezinje nge-ibuprofen (Advil, Motrin) kunye ne-naproxen (Aleve, Naprosyn); i-benzodiazepines efana ne-clonazepam (iKlonopin), i-diazepam (i-Diastat, iValium), i-estazolam, i-flurazepam, i-midazolam inikwe ngaphakathi (emthanjeni), kunye ne-zolpidem (Ambien, Zolpmist); iibhloko ze-beta ezinje nge-arvedilol (Coreg), metoprolol (Lopressor, Toprol-XL, in Dutoprol), kunye ne-timolol; i-bosentan (iTracleer); buprenorphine (Belbuca, Buprenex, nabanye); buprenorphine kunye naloxone (Bunavail, Suboxone); buspirone; iicalcium block blockers ezinje ngeamlodipine (Norvasc), diltiazem (Cardizem, Diltzac, Tiazac, others), felodipine, nifedipine (Adalat CC, Afeditab CR, Procardia), kunye neverapamil (Calan, Verelan, eTarka); icarvedilol (iCoreg); cholesterol-ukunciphisa amayeza (ii-statins) ezinje nge-atorvastatin (Lipitor, eCaduet), fluvastatin (Lescol), pitavastatin (Livalo), pravastatin (Pravachol), kunye ne rosuvastatin (Crestor); dasatinib (Sprycel); amayeza oxinzelelo anje nge-amitriptyline, desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Brisdelle, Paxil, Pexeva), sertraline (Zoloft), kunye ne-trazodone; idigoxin (Lanoxin); eslicarbazepine (Aptiom); i-everolimus (i-Afinitor, iZortress); fentanyl (iDuragesic, iSysys); ifesoterodine (Toviaz); irinotecan (Camptosar); amayeza okubetha kwentliziyo ngokungaqhelekanga njenge-amiodarone (Nexterone, Pacerone), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), kunye nequinidine (eNuedexta); amayeza athintela amajoni omzimba anje ngecyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), kunye netacrolimus (Prograf); imethadone (iMethadose); I-nilotinib (iTasigna); izinto zokucwangcisa ngomlomo (’iipilisi zoqingqo-nzala); oxcarbazepine (iTrileptal); iOxycodone (Xtampza, ePercodan); iperphenazine; iquetiapine (iSeroquel); i-phosphodiesterase (PDE5) inhibitors ezinje nge-avanafil (Stendra), avanafil (Stendra); sildenafil (Viagra), tadalafil (Adcirca, Cialis), kunye ne-vardenafil (Levitra, Staxyn); irifabutin (Mycobutin); irifapentine (Priftin); irisperidone (iRisperdal); irivaroxaban powder (Xarelto); isalmeterol (iSerevent, eAdvair); simeprevir (iOlysio; ayisasebenzi e-US); i-solifenacin (Vesicare); I-steroids yomlomo okanye i-inhaled efana ne-betamethasone, i-budesonide (i-Pulmicort), i-ciclesonide (i-Alvesco, i-Omnaris, i-Zetonna) i-dexamethasone, i-fluticasone (i-Flonase, i-Flovent, e-Advair), i-methylprednisolone, i-mometasone (i-Asmanex, i-Dulera) kunye ne-triamcinolone; thioridazine; ticagrelor (Brilinta); iTramadol (iConzip, i-Ultram); vinblastine; vincristine; kunye ne-warfarin (Coumadin, Jantoven). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-darunavir, cobicistat, emtricitabine, kunye ne-tenofovir, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba ukhe okanye wakha wanemiqathango ekhankanyiweyo kwicandelo LESILUMKISO ELIBALULEKILEYO, naluphi na uhlobo losulelo olungapheliyo okanye oluza ludlule njengesifo sephepha (i-TB; uhlobo losulelo lwemiphunga) okanye i-cytomegalovirus (i-CMV; usulelo lwentsholongwane olunokubangela iimpawu kwizigulana ezinamajoni omzimba abuthathaka); isifo seswekile; haemophilia (isifo apho igazi aligugi ngesiqhelo); okanye isibindi okanye isifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ukhulelwe ngelixa uthatha i-darunavir, i-cobicistat, i-emtricitabine, kunye ne-tenofovir, tsalela ugqirha wakho.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncancise xa wosulelwe yi-HIV okanye ukuba uthatha i-darunavir, i-cobicistat, i-emtricitabine kunye ne-tenofovir.
• Kuya kufuneka wazi ukuba amanqatha omzimba wakho anganyuka okanye afudukele kwiindawo ezahlukeneyo zomzimba wakho, ezinje ngomqolo wangasentla, intamo (’’ inyathi ’), amabele, kunye nesisu sakho. Ungabona ukulahleka kwamafutha omzimba ebusweni bakho, kwimilenze nakwiingalo.
• Kuya kufuneka uyazi ukuba ngelixa uthatha amayeza ukunyanga usulelo lwe-HIV, amajoni akho omzimba angomelela kwaye aqale ukulwa nezinye izifo ezazisele zisemzimbeni wakho. Oku kunokubangela ukuba ube neempawu zolu sulelo. Ukuba uneempawu ezintsha okanye eziba mandundu ngexesha lonyango lwakho nge-darunavir, cobicistat, emtricitabine, kunye ne-tenofovir, qiniseka ukuxelela ugqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

IDarunavir, icobicistat, emtricitabine, kunye ne-tenofovir zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• intloko ebuhlungu
• isisu esibuhlungu
• irhasi

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kumacandelo ESILUMKISO ESIBALULEKILEYO OKANYE AMANYATHELO ATHILE, biza ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

• umchamo omnyama omthubi okanye omdaka; ukukhanya okukhanyayo; ukuphelelwa ngumdla wokutya; isicaphucaphu; ukugabha; ilungelo lendawo engaphezulu yesisu; okanye ulusu olutyheli okanye amehlo
• ukonyuka okanye ukuncipha kokuchama
• ubuthathaka; iintlungu zemisipha; ukuphefumla kancinci okanye ukuphefumla ngokukhawuleza; isisu esibuhlungu isicaphucaphu nokugabha; izandla ezibandayo okanye eziluhlaza kunye neenyawo; isiyezi, intloko emhlophe; okanye ukubetha kwentliziyo okukhawulezayo okanye okungaqhelekanga
• umqala obuhkungu; ifiva; Ukugodola; ukukhohlela; kunye neminye imiqondiso yosulelo
• irhashalala okanye irhashalala okanye enye yezi zinto zilandelayo: umkhuhlane, izihlunu okanye amalungu adibeneyo, amehlo abomvu okanye adumbileyo, iblisters okanye isikhumba esikhulayo, izilonda zomlomo, okanye ukudumba kobuso okanye intamo.

IDarunavir, icobicistat, emtricitabine, kunye ne-tenofovir inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Sukuzisusa izikhwama ze-desiccant (zomisa) kwi-container.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina ubonelelo lwe darunavir, cobicistat, emtricitabine, kunye ne tenofovir ngesandla. Sukulinda de uphelelwe ngamayeza ukuze uphinde uzalise amayeza akho.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Symtuza^®