Siponimod

Umxholo

• Ngaphambi kokuba uthathe i-siponimod,
• I-Siponimod inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Siponimod isetyenziselwa ukukhusela iziqendu zeempawu kunye nokucotha ukwanda kokukhubazeka kubantu abadala abaneendlela zokubuyela umva (ikhosi yesifo apho iimpawu zivela khona amaxesha ngamaxesha) zesifo se-multiple sclerosis (MS; isifo apho iimbilini zingasebenzi kakuhle kwaye abantu banokufumana ubuthathaka, ukuba ndindisholo, ukuphulukana nokulungelelaniswa kwezihlunu, kunye neengxaki zombono, intetho, kunye nolawulo lwesinyi). I-Siponimod ikwiklasi yamayeza abizwa ngokuba yi-sphingosine l-phosphate receptor modulators. Isebenza ngokunciphisa isenzo samaseli omzimba anokubangela ukonakala kwentliziyo.

I-Siponimod iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye ngemini kunye okanye ngaphandle kokutya. Thatha i-siponimod malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-siponimod ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ugqirha wakho uya kuqala ngedosi esezantsi ye-siponimod kwaye ngokuthe ngcembe andise idosi yakho kwiintsuku zokuqala ezi-4 okanye ezi-5,

I-Siponimod inokubangela ukuba ukubetha kwentliziyo kucothe, ngakumbi kwiiyure zokuqala ezi-6 emva kokuba uthathe idosi yakho yokuqala. Uya kufumana i-electrocardiogram (i-ECG; uvavanyo olurekhoda umsebenzi wombane wentliziyo) ngaphambi kokuba uthathe idosi yakho yokuqala kwaye kwakhona emva kweeyure ezingama-6 emva kokuba uthathe idosi. Uya kuthatha idosi yakho yokuqala yesiponimod kwiofisi kagqirha wakho okanye kwelinye iziko lonyango. Kuya kufuneka uhlale kwindawo yonyango ubuncinci iiyure ezingama-6 emva kokuba uthathe amayeza ukuze ube nokubekwa esweni. Ungadinga ukuhlala kwiziko lonyango ixesha elingaphezulu kweeyure ezingama-6 okanye ubusuku bonke ukuba unemiqathango ethile okanye uthatha amayeza athile anyusa umngcipheko wokuba ukubetha kwentliziyo yakho kucothe okanye ukuba ukubetha kwentliziyo yakho kuhamba kancinci kunokuba bekulindelwe okanye kuyaqhubeka ukucotha emva kwe-6 yokuqala iiyure. Kuya kufuneka ukuba uhlale kwiziko lonyango ubuncinci iiyure ze-6 emva kokuba uthathe idosi yakho yesibini ukuba ukubetha kwentliziyo yakho kunciphisa kakhulu xa uthatha idosi yakho yokuqala. Tshela ugqirha wakho ukuba unesiyezi, udiniwe, iintlungu zesifuba, okanye ukubetha kwentliziyo okungahambi kakuhle nangaliphi na ixesha nonyango lwakho.

I-Siponimod inokunceda ukulawula i-multiple sclerosis kodwa ayiyi kuyinyanga. Ungayeki ukuthatha i-siponimod ngaphandle kokuthetha nogqirha wakho. Ukuba awuyithathi i-siponimod usuku olu-1 okanye ngaphezulu ngeentsuku zokuqala ezi-4 okanye ezi-5 zonyango okanye kangangeentsuku ezi-4 okanye nangaphezulu emva kweveki yokuqala yonyango, thetha nogqirha wakho ngaphambi kokuba uqale kwakhona. Unokufumana ukubetha kwentliziyo okucothayo xa uqala ukuthatha i-siponimod kwakhona, ke kuyakufuneka uqalele kwakhona amayeza kwidosi esezantsi kwiofisi kagqirha wakho kwaye ngokuthe ngcembe wandise idosi ngaphezulu kweentsuku ezi-4 okanye ezi-5.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-siponimod kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-siponimod,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-siponimod nawaphi na amanye amayeza, okanye nasiphi na isithako kwiipilisi ze-siponimod. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: alemtuzumab (Campath, Lemtrada); amiodarone (Nexterone, iPacerone); ii-beta-blockers ezinjenge-atenolol (Tenormin, in Tenoretic), carteolol, labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, in Dutoprol, in Lopressor HCT), nadolol (Corgard, eCorzide), nebivolol (Bystolic, in Byvalson ), Ipropranolol (Inderal LA, Innopran XL), kunye netimolol; carbamazepine (Carbatrol, Equetro, Tegretol, nabanye); idigoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, nabanye); efavirenz (Sustiva, eAtripla, eSymfi); i-fluconazole (iDiflucan); ivabradine (Corlanor); imodafinil (Provigil); ukuvelisa; quinidine (kwiNuedexta); rifampin (Rifadin, Rimactane, eRifamate, abanye); i-sotalol (iBetapace, iSorine, iSotylize); kunye neverapamil (Calan, Verelan, eTarka). Ndixelele ugqirha ukuba uthatha nawaphi na amayeza alandelayo, okanye ukuba ukhe wawathatha ngaphambili: ii-corticosteroids ezinje nge-dexamethasone, methylprednisolone (Medrol), kunye ne-prednisone (iRayos); amayeza omhlaza; kunye namayeza okwenza buthathaka okanye ukulawula amajoni omzimba anjenge-glatiramer acetate (iCopaxone, iGlatopa) kunye ne-interferon beta (iBetaseron, i-Extavia, iPlegridy). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-siponimod, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba ukhe wanayo okanye unayo nayiphi na kwezi meko kwiinyanga ezintandathu ezidlulileyo: isifo sentliziyo, i-angina (iintlungu zesifuba), ukubetha okanye ukubetha kwentliziyo, okanye ukusilela kwentliziyo. Xelela ugqirha wakho ukuba unesingqisho sentliziyo esingaqhelekanga. Ugqirha wakho unokukuxelela ukuba ungathathi i-siponimod.
• xelela ugqirha wakho ukuba wakhe wawa isiqaqa, wahlaselwa sisifo sentliziyo, wabethwa sistroke, okanye wabethwa kancinci; ukuba ngoku unefiva okanye ezinye iimpawu zosulelo okanye ukuba unesifo esifikayo nesiphelayo okanye esingapheliyo; kwaye ukuba ukhe unesifo seswekile; ubuthongo bokulala (imeko apho uyeke kancinci ukuphefumla amaxesha amaninzi ebusuku) okanye ezinye iingxaki zokuphefumla; igazi elonyukayo; uveitis (ukudumba kwamehlo) okanye ezinye iingxaki zamehlo; ukubetha kwentliziyo kancinci; umhlaza wolusu, okanye isifo sentliziyo okanye sesibindi. Xelela ugqirha wakho ukuba usandula ukufumana iyeza lokugonya.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa, okanye uncelisa. Kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kwaye ubuncinci kwiintsuku ezili-10 emva kwedosi yakho yokugqibela. Ukuba ukhulelwa ngelixa uthatha i-siponimod okanye kwiintsuku ezili-10 emva kwedosi yakho yokugqibela, tsalela ugqirha wakho.
• awunalo ugonyo lweveki e-1 ngaphambi kokuba uqale unyango lwakho nge-siponimod, ngexesha lonyango lwakho, okanye kwinyanga e-1 emva kwedosi yakho yokugqibela ngaphandle kokuthetha nogqirha wakho. Thetha nogqirha wakho malunga nokugonywa onokufuna ukukufumana ngaphambi kokuba uqale unyango lwakho nge-siponimod.
• xelela ugqirha wakho ukuba awuzange ube nayo irhashalala kwaye awulifumani iyeza lokugonya irhashalala. Ugqirha wakho angayalela uvavanyo lwegazi ukuze abone ukuba ubonakalisiwe na kumbungu wenkukhu. Unokufuna ukufumana isitofu sokugonya irhashalala uze ulinde inyanga e-1 ngaphambi kokuba uqale unyango lwakho nge-siponimod.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye ubize ugqirha ngaphambi kokuba uthathe idosi elandelayo. Ungadinga ukubekwa esweni njengoko uqala kwakhona amayeza akho kwidosi esezantsi kwaye njengoko idosi inyuka kancinci ngaphezulu kweentsuku ezi-4 okanye ezi-5. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Siponimod inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ubuthathaka
• iintlungu ezingalweni, emilenzeni, ezandleni, okanye ezinyaweni
• urhudo
• intloko ebuhlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• ukubetha kwentliziyo kancinci
• umqala obuhlungu, iintlungu zomzimba, umkhuhlane, Ukugodola, ukukhohlela, kunye neminye imiqondiso yosulelo kwaye kunyango ukuya kuthi ga kwinyanga e-1 emva konyango lwakho
• intloko ebuhlungu, ukuqina kwentamo, umkhuhlane, ubuntununtunu ekukhanyeni, isicaphucaphu, okanye ukudideka ngexesha lonyango ukuya kuthi ga kwinyanga e-1 emva konyango lwakho
• intloko ebukhali ngesiquphe, ukudideka, utshintsho kumbono, okanye ukuxhuzula
• ukufiphala, izithunzi, okanye indawo engaboniyo kumbono wombono wakho; uvakalelo ekukhanyeni; umbala ongaqhelekanga kumbono wakho okanye ezinye iingxaki zombono
• ubuthathaka kwelinye icala lomzimba okanye ubucukubhede beengalo okanye imilenze eya isiba mandundu ngokuhamba kwexesha; utshintsho kwindlela ocinga ngayo, kwimemori, okanye kulungelelwano; ukudideka okanye utshintsho kubuntu; okanye ukuphelelwa ngamandla
• okutsha okanye okuya kusiba mandundu nokuphefumla okufutshane
• isicaphucaphu, ukugabha, ukungabinamdla wokutya, iintlungu esiswini, ubumthubi besikhumba okanye amehlo, okanye umchamo omnyama

I-Siponimod inokunyusa umngcipheko wokuba nomhlaza wolusu. Thetha nogqirha wakho malunga nemingcipheko yokuthatha la mayeza.

Ukunyuka ngokukhawuleza kweziqendu zeempawu ze-MS kunye nokunyuka kokukhubazeka kwenzeka emva kokuyeka ukuthatha i-siponimod. Tshela ugqirha wakho ukuba ngaba iimpawu zakho ze-MS ziya zisiba mbi emva kokuyeka i-siponimod.

I-Siponimod inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Gcina izikhongozeli ezingavulwanga zeliyeza kwisibandisi. Iipakethe zeblister ezivuliweyo kunye neebhotile zinokugcinwa kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela) kangangexesha elithile. Iipakethe zeblister ezivuliweyo zinokugcinwa kubushushu begumbi ukuya kwiveki e-1 emva kokusetyenziswa kokuqala. Iibhotile ezivuliweyo zinokugcinwa kubushushu begumbi ukuya kwinyanga e-1 emva kokusetyenziswa kokuqala.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• ukubetha kwentliziyo okucothayo okanye okungaqhelekanga

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola iimvavanyo ezithile zelebhu, iimviwo zamehlo, kwaye uya kubeka esweni uxinzelelo lwegazi ngaphambi nangexesha lonyango lwakho ukuze uqiniseke ukuba kukhuselekile ukuba uqale ukuthatha okanye uqhubeke nokuthatha i-siponimod.

Ngaphambi kokuba uvavanywe elebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba uthatha i-siponimod.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• UMayzent^®