Pexidartinib

Umxholo

• Ngaphambi kokuba uthathe i-pexidartinib,
• I-Pexidartinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

I-Pexidartinib inokubangela ukonakala okanye ukusongela ubomi kumngcipheko wesibindi. Tshela ugqirha wakho ukuba ukhe unesifo sesibindi. Tshela ugqirha wakho kunye nosokhemesti malunga namayeza owathathayo ukuze bakwazi ukujonga ukuba ngaba nawaphi na amayeza akho anokunyusa umngcipheko wokuba uya kuphuhlisa umonakalo wesibindi ngexesha lonyango lwakho nge-pexidartinib. Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: ukudinwa kakhulu, ukuncipha kokutya, ukuncipha, isicaphucaphu, ukugabha, ukopha okungaqhelekanga okanye ukugruzuka, ulusu lube luthuthu okanye amehlo, umchamo omnyama tyheli okanye umbala omdaka, isitulo esimthubi , okanye iintlungu kwinxalenye ephezulu yesisu. Ugqirha wakho unokunciphisa idosi yakho ye-pexidartinib okanye ngokusisigxina okanye okwethutyana uyeke unyango lwakho.

Inkqubo ebizwa ngokuba luVavanyo loMngcipheko weTuralio kunye neQhinga lokuNciphisa (i-REMS) isetelwe ukulawula umngcipheko weliyeza. Uya kuba nakho ukufumana i-pexidartinib kuphela ukuba ngaba wena nogqirha omisela amayeza akho ubhalisile yinkqubo. Unokufumana kuphela amayeza kwikhemesti ethatha inxaxheba kule nkqubo. Buza ugqirha wakho ukuba unemibuzo malunga nokuthatha inxaxheba kule nkqubo okanye indlela yokufumana amayeza akho.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola iimvavanyo ezithile zelebhu ngaphambi kwaye ngexesha lonyango lwakho ukuze uqiniseke ukuba kukhuselekile kuwe ukuba uthathe i-pexidartinib kwaye ujonge impendulo yomzimba wakho kunyango.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-pexidartinib kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-pexidartinib.

I-Pexidartinib isetyenziselwa ukunyanga i-tenosynovial giant cell tumors (TGCT; amathumba ngaphakathi okanye ngeenxa zonke kwilungu elinokubangela iintlungu, ukudumba, kunye nokunciphisa intshukumo) kubantu abadala abangenakuphathwa ngokuhlinzwa. I-Pexidartinib ikwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga enokunceda ukuba ithumba linciphe.

I-Pexidartinib iza njengephilisi ukuyithatha ngomlomo. Ihlala ithathwa kabini yonke imihla kwisisu esingenalutho ubuncinci iyure e-1 ngaphambi okanye kwiiyure ezi-2 emva kwesidlo okanye isidlo. Thatha i-pexidartinib malunga nexesha elifanayo (ii) yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-pexidartinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya zonke iifomsile; sukuwavula, uwahlafune, okanye uwaqhekeze.

Ukuba uhlanza emva kokuthatha i-pexidartinib, ungathathi elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-pexidartinib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-pexidartinib, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi zeepexidartinib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: clarithromycin (Biaxin, kwi-Prevpac); ii-antifungals ezithile ezinje nge-itraconazole (Onmel, Sporanox) okanye ketoconazole; enzalutamide (Xtandi); amayeza athile kwintsholongwane kaGawulayo (i-HIV) okanye ifunyenwe isifo se-immunodeficiency syndrome (i-AIDS) efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra), kunye i-saquinavir (i-Invirase); imodafinil (Provigil); nefazodone; ipioglitazone (Actos, eDuetact, eOseni); probenecid (Unobumba); iiproton-pump inhibitors ezinje nge-esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), kunye ne-rabeprazole (AcipHex); irifabutin (Mycobutin); irifampin (Rifadin); amayeza athile okubanjwa njenge-carbamazepine (i-Equetro, iTegretol, iTeril), i-phenobarbital, kunye ne-phenytoin (iDilantin, Phenytek); okanye i-oral steroids efana ne-dexamethasone, i-methylprednisolone (iMedrol) kunye ne-prednisone. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-pexidartinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• ukuba uthatha ii-antacids ezine-magnesium okanye i-aluminium (Maalox, Mylanta, Tums, others), thatha i-antacid iiyure ezingama-2 ngaphambi okanye ubuncinci iiyure ezi-2 emva kokuba uthathe i-pexidartinib.
• ukuba uthatha amayeza okugaya isisu, ukutsha, okanye izilonda ezinje nge-cimetidine (Tagamet), i-famotidine (i-Pepcid, kwi-Duexis), i-nizatidine (i-Axid), okanye i-ranitidine (i-Zantac), thatha ubuncinci iiyure ezili-10 ngaphambi okanye ubuncinci iiyure emva kokuba uthathe i-pexidartinib.
• xelela ugqirha wakho kunye nosokhemisti ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi i-wort yaseSt. Akufanele uthathe i-wort yaseSt.John ngexesha lonyango lwakho nge-pexidartinib.
• xelela ugqirha wakho ukuba ukhe unesifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ukuba ucwangcisa ukuba ngutata womntwana. Ukuba ungumfazi, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango kwaye usebenzise ulawulo lokuzalwa ukukhusela ukukhulelwa ngexesha lonyango lwakho kunye nenyanga e-1 emva kwedosi yakho yokugqibela. Ukuba uyindoda, wena kunye neqabane lakho kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kunye ne-pexidartinib kunye ne-1 iveki emva kwethamo lakho lokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. I-Pexidartinib inokunciphisa ukuzala kwamadoda nabasetyhini. Nangona kunjalo, awufanelanga ukucinga ukuba wena okanye iqabane lakho aninakukhulelwa. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-pexidartinib, biza ugqirha wakho ngokukhawuleza. I-Pexidartinib inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngelixa uthatha i-pexidartinib kunye neveki e-1 emva kwedosi yakho yokugqibela.

Musa ukutya isixa esikhulu segrapefruit okanye usele ijusi yeziqhamo zomdiliya ngelixa uthatha eli yeza.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Pexidartinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• utshintsho lombala weenwele
• utshintsho kwincasa
• ukudinwa
• ukuqhina

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• irhashalala
• ukurhawuzelela
• ukudumba kwezandla, iinyawo, imilenze okanye amaqatha
• iintlungu ezingalweni okanye emilenzeni
• ukudumba ngaphakathi okanye ecaleni kweliso

I-Pexidartinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Musa ukuyisusa i-desiccant (ipakethi encinci ebandakanyiwe namayeza okufunxa ukufuma) kwibhotile, ukuba ibikhona.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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