Pralsetinib

Umxholo

• Ngaphambi kokuba uthathe i-pralsetinib,
• I-Pralsetinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye ezo zidweliswe kwiZIKHUSELEKO EZIZODWA, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

I-Pralsetinib isetyenziselwa ukunyanga uhlobo oluthile lomhlaza wamaphaphu ongekho kwiseli encinci (i-NSCLC) kubantu abadala abasasazeke kwamanye amalungu omzimba. Isetyenziselwa ukunyanga uhlobo oluthile lomhlaza wedlala lengqula kubantu abadala nakubantwana abaneminyaka eli-12 ubudala nangaphezulu esiya sisiba mandundu okanye sinwenwele kwamanye amalungu omzimba. I-Pralsetinib isetyenziselwa ukunyanga uhlobo oluthile lomhlaza wedlala lengqula kubantu abadala nakubantwana abaneminyaka eli-12 ubudala nangaphezulu oluya lusiba mandundu okanye olusele lwasasazeka kwamanye amalungu omzimba kwaye alunakuphathwa nge-iodine ene-radioactive. I-Pralsetinib ikudidi lwamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo sento ethile yendalo enokubakho enokufuneka ukunceda iiseli zomhlaza zande.

I-Pralsetinib iza njengepilisi yokuthatha ngomlomo. Ihlala ithathwa kanye yonke imihla kwisisu esingenanto, ubuncinci iiyure ezi-2 ngaphambili kwaye ubuncinci iyure enye emva kwesidlo. Thatha i-pralsetinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-pralsetinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba uyagabha emva kokuthatha i-pralsetinib, musa ukuthatha elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho anganciphisa umthamo wakho okanye ayeke unyango lwakho okwethutyana okanye ngokusisigxina ukuba uneziphumo ebezingalindelekanga ezithile. Qiniseka ukuba uxelela ugqirha wakho indlela oziva ngayo ngexesha lonyango lwakho nge-pralsetinib.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-pralsetinib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-pralsetinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi zeepalsalib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amayeza okubulala ukubola kubandakanya itraconazole (Onmel, Sporanox) kunye ne ketoconazole; i-clarithromycin (kwi-Biaxin); amayeza athile e-HIV afana ne-efavirenz (Sustiva, e-Atripla, Symfi), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e-Kaletra, Viekira Pak), kunye ne-saquinavir (i-Invirase); i-oxcarbazepine (iOxtellar XR, iTrileptal); phenobarbital; phenytoin (iDilantin, iPhenytek); ipioglitazone (iActos, eOseni, iDuetact); irifabutin (Mycobutin); kunye nerifampin (Rifadin, Rimactane, eRifater). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba unengxaki yokuphefumla okanye yokuphefumla ngaphandle komhlaza wemiphunga, iingxaki zokopha, uxinzelelo lwegazi oluphezulu, okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ukuba ucwangcisa ukuba notata umntwana. I-Pralsetinib inokuphazamisa ukusebenza kwezicwangcisi zehomoni (iipilisi zolawulo lokuzalwa, iipatches, iiringi, ukufakelwa, okanye inaliti), ngenxa yoko akufuneki uzisebenzise njengeyona ndlela yakho yolawulo lokuzalwa ngexesha lonyango lwakho. Kuya kufuneka usebenzise indlela yokuzalwa engeyiyo ihomoni enje ngendlela yothintelo (isixhobo esivimba isidoda ukuba singene esibelekweni esifana nekhondom okanye uvalo). Buza ugqirha wakho ukuba akuncede ukhethe indlela yolawulo lokuzalwa eya kukusebenzela. Ukuba ungowasetyhini, kuya kufuneka ukuba ube novavanyo lokukhulelwa ngaphambi kokuba uqale unyango, kwaye kuya kufuneka usebenzise ulawulo lokuzalwa olungenalo ihomoni ukukhusela ukukhulelwa ngexesha lonyango kunye nakwiiveki ezi-2 emva kwethamo lakho lokugqibela. Ukuba uyindoda kwaye iqabane lakho linokukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ukuthintela ukukhulelwa ngexesha lonyango lwakho kunye neveki e-1 emva kwedosi yakho yokugqibela. Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini; Nangona kunjalo, akufuneki ucinge ukuba awungekhe ukhulelwe okanye awungekhe umithise omnye umntu. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-pralsetinib, biza ugqirha wakho. I-Pralsetinib inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Akufanele uncelise ngelixa uthatha i-pralsetinib kunye neveki e-1 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-pralsetinib.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-pralsetinib. Ugqirha wakho angakuxelela ukuba ungathathi pralsetinib kwiintsuku ezi-5 ngaphambi kotyando lwakho kwaye uza kukuxelela ukuba uqale nini ukuthatha amayeza kwakhona.
• Kuya kufuneka uyazi ukuba uxinzelelo lwegazi lwakho lunokunyuka ngexesha lonyango lwakho nge-pralsetinib. Ugqirha wakho uza kujonga uxinzelelo lwegazi ngononophelo, kwaye unokuyalela amayeza ukunyanga uxinzelelo lwegazi oluphezulu ukuba luyakhula.
• Kuya kufuneka uyazi ukuba unokuba ne-tumor lysis syndrome (i-TLS; imeko ebangelwa kukuwohloka okukhawulezayo kweeseli zomhlaza ezinokubangela ukusilela kwezintso kunye nezinye iingxaki) ngexesha lonyango lwakho nge-pralsetinib. Ukukunceda ukunciphisa umngcipheko wokufumana i-TLS, ugqirha wakho unokucela ukuba usele amanzi ngaphambi nangexesha lonyango lwakho, kwaye ngalo lonke ixesha idosi yakho inyukile. Ukongeza, ugqirha wakho uya kukunika amayeza oza kuwathatha ngaphambi kokuqala kwaye ngexesha lonyango lwakho ukunceda ukuthintela eli cala. Ukuba unazo naziphi na kwezi mpawu zilandelayo ze-TLS, biza ugqirha ngoko nangoko: umkhuhlane, ukugodola, isicaphucaphu, ukugabha, ukudideka, ukuphefumla kancinci, ukuxhuzula, ukubetha kwentliziyo okungaqhelekanga, umchamo omnyama okanye onamafu, ukudinwa okungaqhelekanga, okanye umsipha okanye iintlungu.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo kwangolo suku lunye nje ukuba uyikhumbule. Emva koko, qhubeka neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Pralsetinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuqhina
• urhudo
• umlomo owomileyo
• iintlungu zemisipha okanye zethambo
• ukudumba kwezandla, amaqatha okanye iinyawo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye ezo zidweliswe kwiZIKHUSELEKO EZIZODWA, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• ukudideka, intloko ebuhlungu, ukuphefumla kancinci, isiyezi, okanye iintlungu esifubeni
• umkhuhlane, ukuphefumla kancinci, okanye ukukhohlela
• ulusu olukhanyayo, ukudinwa, okanye ukuphefumla okufutshane
• ubumthubi besikhumba okanye amehlo, umchamo omnyama, ukuphuma kwegazi okanye ukugruzuka ngokulula kunesiqhelo, ukuphelelwa ngumdla, ukuncipha kwamandla, okanye iintlungu kwicala lasekunene lesisu
• izitulo ezimnyama kunye nokulinda
• Igazi elibomvu ilindle
• ukugabha okunegazi
• ukugabha okubonakala ngathi yindawo yekofu
• ukhohlela igazi
• ukopha okungaqhelekanga okanye ukugruzuka
• ukopha okungaqhelekanga kwilungu lobufazi
• ukopha rhoqo
• Ukozela, ukudideka, intloko ebuhlungu, okanye kunzima ukuthetha

I-Pralsetinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola uvavanyo lwelebhu ngaphambi kokuba unyango lwakho lufumanise ukuba umhlaza wakho unganyangwa nge-pralsetinib. Ugqirha wakho uya ku-odola iimvavanyo ezithile zelebhu ngaphambi, ngexesha, nasemva konyango lwakho ukujonga impendulo yomzimba wakho kwi-pralsetinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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