Ponesimod

Umxholo

• I-Ponesimod isetyenziselwa ukuthintela iziqendu zeempawu kunye nokucothisa ukuwohloka kokukhubazeka kubantu abadala ababuyela umva kwifom ye-multiple sclerosis (MS; isifo apho imithambo-luvo ingasebenzi kakuhle kwaye abantu banokufumana ubuthathaka, ukuphazamiseka, ukuphulukana nokulungelelaniswa kwemisipha, kunye iingxaki ngombono, intetho, kunye nolawulo lwesinyi), kubandakanya: I-Ponesimod ikudidi lwamayeza abizwa ngokuba yi-sphingosine l-phosphate receptor modulators. Isebenza ngokunciphisa isenzo samaseli omzimba anokubangela ukonakala kwentliziyo.
• Ngaphambi kokuba uthathe i-ponesimod,
• I-Ponesimod inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
• Iimpawu zokudlula ngaphezulu zinokubandakanya:

I-Ponesimod isetyenziselwa ukuthintela iziqendu zeempawu kunye nokucothisa ukuwohloka kokukhubazeka kubantu abadala ababuyela umva kwifom ye-multiple sclerosis (MS; isifo apho imithambo-luvo ingasebenzi kakuhle kwaye abantu banokufumana ubuthathaka, ukuphazamiseka, ukuphulukana nokulungelelaniswa kwemisipha, kunye iingxaki ngombono, intetho, kunye nolawulo lwesinyi), kubandakanya: I-Ponesimod ikudidi lwamayeza abizwa ngokuba yi-sphingosine l-phosphate receptor modulators. Isebenza ngokunciphisa isenzo samaseli omzimba anokubangela ukonakala kwentliziyo.

• Isifo esizimeleyo kwiklinikhi (i-CIS; isiqhelo sesibonakaliso sokuqala se-nerve esihlala ubuncinci iiyure ezingama-24),
• Isifo esibuyisayo (isifo sesifo apho isifo sivela khona amaxesha ngamaxesha),
• isifo esikwesibini esiqhubekayo (kamva kwinqanaba lesifo kunye nokuqhubeka kokubi kweempawu.)

I-Ponesimod iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye ngemini kunye okanye ngaphandle kokutya. Thatha i-ponesimod ejikeleze ixesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-ponesimod ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ugqirha wakho uya kukuqala ngedosi esezantsi yeponesimod kwaye ngokuthe ngcembe andise idosi yakho kwiintsuku ezili-15 zokuqala.

I-Ponesimod inokubangela ukuba ukubetha kwentliziyo kucothe, ngakumbi kwiiyure zokuqala ze-4 emva kokuba uthathe idosi yakho yokuqala. Uya kuthatha idosi yakho yokuqala yeponesimod kwiofisi kagqirha wakho okanye kwelinye iziko lonyango. Uya kufumana i-electrocardiogram (i-ECG; uvavanyo olurekhoda umsebenzi wombane wentliziyo) ngaphambi kokuba uthathe idosi yakho yokuqala kwaye kwakhona emva kweeyure ezingama-4 emva kokuba uthathe idosi. Uya kudinga ukuhlala kwindawo yonyango ubuncinci iiyure ze-4 emva kokuba uthathe amayeza ukuze ube nokubekwa esweni. Unokufuna ukuhlala kwiziko lonyango ixesha elingaphezulu kweeyure ezi-4 okanye ubusuku bonke ukuba unemiqathango ethile okanye uthatha amayeza athile anyusa umngcipheko wokuba ukubetha kwentliziyo yakho kucothe okanye ukuba ukubetha kwentliziyo yakho kuhamba kancinci kunokuba bekulindelwe okanye kuyaqhubeka ukucotha emva kwe-4 yokuqala. iiyure. Kuya kufuneka ukuba uhlale kwiziko lonyango ubuncinci iiyure ze-4 emva kokuba uthathe idosi yakho yesibini ukuba ukubetha kwentliziyo yakho kunciphisa kakhulu xa uthatha idosi yakho yokuqala. Tshela ugqirha wakho ukuba unesiyezi, udiniwe, iintlungu zesifuba, okanye ukubetha kwentliziyo okungahambi kakuhle nangaliphi na ixesha nonyango lwakho.

I-Ponesimod inokunceda ukulawula i-multiple sclerosis kodwa ayiyi kuyinyanga. Ungayeki ukuthatha i-ponesimod ngaphandle kokuthetha nogqirha wakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-ponesimod kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-ponesimod,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-ponesimod, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-ponesimod. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: alemtuzumab (Campath, Lemtrada); amiodarone (Nexterone, iPacerone); ii-beta-blockers ezinjenge-atenolol (Tenormin, kwi-Tenoretic), i-carteolol, i-labetalol (i-Trandate), i-metoprolol (i-Lopressor, i-Toprol-XL, kwi-Dutoprol, kwi-Lopressor HCT), nadolol (Corgard, eCorzide), nebivolol (Bystolic, e-Byvalson ), Ipropranolol (Inderal LA, Innopran XL), sotalol (iBetapace, iSorine, iSotylize) kunye netimolol; carbamazepine (Carbatrol, Equetro, Tegretol, nabanye); idigoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, nabanye); imodafinil (Provigil); phenytoin (Dilantin); ukuvelisa; quinidine (kwiNuedexta); rifampin (Rifadin, Rimactane, eRifamate, abanye); kunye neverapamil (Calan, Verelan, eTarka). Xelela ugqirha wakho ukuba uthatha nawaphi na amayeza alandelayo, okanye ukuba uwathathe ngaphambili: ii-corticosteroids ezinje nge-dexamethasone, methylprednisolone (Medrol), kunye ne-prednisone (iRayos); amayeza omhlaza; kunye namayeza okwenza buthathaka okanye ukulawula amajoni omzimba anjenge-glatiramer acetate (iCopaxone, iGlatopa) kunye ne-interferon beta (iBetaseron, i-Extavia, iPlegridy). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-ponesimod, ke qiniseka ukuxelela ugqirha wakho malunga nawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba ukhe wanayo okanye unayo nayiphi na kwezi meko kwiinyanga ezintandathu ezidlulileyo: isifo sentliziyo, i-angina (iintlungu zesifuba), ukubetha okanye ukubetha kwentliziyo, okanye ukusilela kwentliziyo. Xelela ugqirha wakho ukuba unesingqisho sentliziyo esingaqhelekanga okanye iintlobo ezithile zebhloko yentliziyo, ngaphandle kokuba une-pacemaker. Ugqirha wakho unokukuxelela ukuba ungathathi i-ponesimod.
• xelela ugqirha wakho ukuba unefiva okanye usulelo okanye ukuba unesifo esiza kwaye sihamba okanye esingahambiyo. Kwakhona xelela ugqirha wakho ukuba ukhe wahlaselwa sisifo sentliziyo, ukubetha, ukubetha kancinci, isifo seswekile, ukuphefumla xa ulala (imeko apho uyeke khona ukuphefumla amaxesha amaninzi ebusuku) okanye ezinye iingxaki zokuphefumla, uxinzelelo lwegazi, uveitis (ukudumba kwamehlo) okanye ezinye iingxaki zamehlo, umhlaza wolusu, okanye isifo sentliziyo okanye sesibindi. Xelela ugqirha wakho ukuba une-QT syndrome ende (imeko eyonyusa umngcipheko wokuba nokubetha kwentliziyo okungaqhelekanga, okunokubangela ukuba utyhafe okanye ukufa ngesiquphe), isingqi sentliziyo esingaqhelekanga, okanye ukuba usandula ukufumana iyeza.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa, okanye uncelisa.Kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kwaye ubuncinci iveki enye emva kwedosi yakho yokugqibela. Ukuba ukhulelwa ngelixa uthatha i-ponesimod okanye kwisithuba seveki enye emva kwethamo lakho lokugqibela, tsalela ugqirha wakho. I-Ponesimod inokulimaza umbungu.
• awunalo ugonyo kwinyanga e-1 ngaphambi kokuba uqale unyango lwakho nge-ponesimod, ngexesha lonyango lwakho, kunye ne-1 ukuya kwiiveki ezi-2 emva kwedosi yakho yokugqibela ungakhange uthethe nogqirha wakho. Thetha nogqirha wakho malunga nokugonywa onokufuna ukukufumana ngaphambi kokuba uqale unyango lwakho nge-ponesimod.
• xelela ugqirha wakho ukuba awuzange ube nayo irhashalala kwaye awulifumani iyeza lokugonya irhashalala. Ugqirha wakho angayalela uvavanyo lwegazi ukuze abone ukuba ubonakalisiwe na kumbungu wenkukhu. Unokufuna ukufumana isitofu sokugonya irhashalala uze ulinde iiveki ezi-4 ngaphambi kokuba uqale unyango lwakho nge-ponesimod.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uyaphoswa ziintsuku ezi-1 ukuya kwezi-3 zeponesimod Ngexesha lokungeniswa (i-14-day starter pack), thabatha ithebhulethi ephosiweyo ngokukhawuleza nje ukuba ukhumbule kwaye uqhubeke nonyango lwakho ngokuthatha ithebhulethi enye ngosuku kwipakethe yokuqalisa njengoko bekucwangcisiwe. Ukuba uyaphoswa kukuthatha iintsuku ezi-4 okanye nangaphezulu zilandelelana kweponesimod Ngexesha lokungeniswa (i-14-day starter pack), fowunela ugqirha wakho njengoko uza kufuneka uqale unyango kwakhona nge-14-pack starter pack. Ukuba uneemeko ezithile zentliziyo, unokufuna ukubekwa esweni ngugqirha wakho ubuncinci iiyure ze-4 xa uthatha idosi yakho elandelayo.

Ukuba uyaphoswa ziintsuku ezi-1 ukuya kwezi-3 zeponesimod emva kwexesha lokubambisa (idosi yokugcina) thabatha ithebhulethi ephosiweyo ngokukhawuleza nje ukuba ukhumbule kwaye uqhubeke nonyango lwakho. Ukuba uyaphoswa kukuthatha iintsuku ezi-4 okanye ngaphezulu ngokulandelelana kweponesimod emva kwexesha lokubambisa (idosi yokugcina), fowunela ugqirha wakho njengoko uzakufuna ukuqala kwakhona unyango nge-14-pack starter pack. Ukuba uneemeko ezithile zentliziyo, unokufuna ukubekwa esweni ngugqirha wakho ubuncinci iiyure ze-4 xa uthatha idosi yakho elandelayo.

I-Ponesimod inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isiyezi
• ukukhohlela
• iintlungu ezandleni okanye ezinyaweni

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ukubetha kwentliziyo kancinci
• umqala obuhlungu, ukuphefumla kancinci, iintlungu zomzimba, umkhuhlane, ukutshisa ngokuchama, ukugodola, ukukhohlela, kunye neminye imiqondiso yosulelo ngexesha lonyango kwaye ukuya kuthi ga kwiiveki ezi-1 ukuya kwezi-2 emva konyango lwakho
• ubuthathaka kwelinye icala lomzimba okanye ubucukubhede beengalo okanye imilenze eya isiba mandundu ngokuhamba kwexesha; utshintsho kwindlela ocinga ngayo, kwimemori, okanye kulungelelwano; ukudideka okanye utshintsho kubuntu; okanye ukuphelelwa ngamandla
• ukufiphala, izithunzi, okanye indawo engaboniyo kumbono wombono wakho; uvakalelo ekukhanyeni; umbala ongaqhelekanga kumbono wakho okanye ezinye iingxaki zombono
• isicaphucaphu, ukugabha, ukungabinamdla wokutya, iintlungu esiswini, ubumthubi besikhumba okanye amehlo, okanye umchamo omnyama
• okutsha okanye okuya kusiba mandundu nokuphefumla okufutshane

I-Ponesimod inokunyusa umngcipheko wokuba nomhlaza wolusu. Tshela ugqirha wakho ukuba unalo naluphi na utshintsho kwimole esele ikho; indawo entsha emnyama esikhumbeni; izilonda ezingapholiyo; Ukukhula kwesikhumba sakho njengebhampu enokuthi ikhanye, ipear emhlophe, ibala lolusu, okanye ipinki, okanye naluphi na utshintsho kolusu lwakho. Ugqirha wakho kufuneka ahlole ulusu lwakho ukuba kukho naluphi na utshintsho ngexesha lonyango nge-ponesimod. Nciphisa ixesha olichitha elangeni nakwisibane se-ultraviolet (UV). Nxiba impahla yokuzikhusela kwaye usebenzise i-sunscreen enezinto eziphezulu zokukhusela ilanga. Thetha nogqirha wakho malunga nemingcipheko yokuthatha la mayeza.

I-Ponesimod inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Ukuba amayeza akho eza nepakethi ye-desiccant (ipakethi encinci enezinto ezifunxa ukufuma ukugcina iyeza lomile), yishiye ipakethi ebhotileni kodwa ulumke ungaginyeki.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• ukubetha kwentliziyo okucothayo okanye okungaqhelekanga

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu kunye novavanyo lwemehlo, kwaye uya kubeka esweni uxinzelelo lwegazi ngaphambi kwaye ngexesha lonyango lwakho ukuze uqiniseke ukuba kukhuselekile kuwe ukuba uqale ukuthatha okanye uqhubeke nokuthatha i-ponesimod.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Ngamandla^®