Imethotrexate

Umxholo

• Ngaphambi kokuba uthathe i-methotrexate,
• I-Methotrexate inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

I-Methotrexate inokubangela iziphumo ezibi kakhulu, ezisongela ubomi. Kuya kufuneka uthathe i-methotrexate kuphela ukunyanga umhlaza okanye ezinye iimeko ezinzima kakhulu kwaye ezingenakunyangwa ngamanye amayeza. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-methotrexate kwimeko yakho.

Xelela ugqirha wakho ukuba ukhe wakha wanamanzi amaninzi kwisisu sakho okanye kwindawo ejikeleze imiphunga yakho kwaye ukuba ukhe unesifo sezintso. Xelela ugqirha wakho ukuba uthatha ii-nonsteroidal anti-inflammatory drug (NSAIDs) ezinje nge-aspirin, choline magnesium trisalicylate (Tricosal, Trilisate), ibuprofen (Advil, Motrin), magnesium salicylate (Doan's), naproxen (Aleve, Naprosyn), okanye isalali. Ezi meko kunye namayeza anokunyusa umngcipheko wokuba uya kuba nemiphumo emibi ye-methotrexate. Ugqirha wakho uya kukujonga ngononophelo kwaye unokufuna ukukunika idosi esezantsi ye-methotrexate okanye uyeke unyango lwakho nge-methotrexate.

I-Methotrexate inokubangela ukwehla kwenani leeseli zegazi ezenziwe ngumongo wethambo lakho. Tshela ugqirha wakho ukuba unayo okanye wakhe wanenani eliphantsi lalo naluphi na uhlobo lweeseli zegazi okanye nayiphi na ingxaki ngeeseli zakho zegazi. Fowunela ugqirha ngokukhawuleza ukuba unazo naziphi na kwezi mpawu: umqala obuhlungu, ukugodola, umkhuhlane, okanye ezinye iimpawu zosulelo; ukugruzuka okanye ukopha okungaqhelekanga; ukudinwa okugqithisileyo; ulusu oluthuthu; okanye ukuphefumla okufutshane.

I-Methotrexate inokubangela ukonakala kwesibindi, ngakumbi xa ithathwa ixesha elide. Ukuba usela okanye wakha wasela utywala kakhulu okanye ukuba unesifo sesibindi, ugqirha unokukuxelela ukuba ungathathi i-methotrexate ngaphandle kokuba unesifo somhlaza esisongela ubomi kuba kukho umngcipheko omkhulu wokuba phuhlisa ukonakala kwesibindi. Umngcipheko wokuba uhlakulele umonakalo wesibindi unokuphakama xa ukhulile, ukhuluphele, okanye unesifo sikashukela. Tshela ugqirha wakho ukuba ngaba uthatha nawaphi na amayeza alandelayo: iacitretin (Soriatane), azathioprine (Imuran), isotretinoin (Accutane), sulfasalazine (Azulfidine), okanye tretinoin (Vesanoid). Buza ugqirha wakho malunga nokusetyenziswa okukhuselekileyo kotywala ngelixa uthatha i-methotrexate. Biza ugqirha wakho kwangoko ukuba unazo naziphi na kwezi mpawu zilandelayo: isicaphucaphu, ukudinwa kakhulu, ukungabikho kwamandla, ukungabi namdla, iintlungu kwindawo ephezulu yesisu, ukuba tyheli kolusu okanye amehlo, okanye iimpawu ezinje ngomkhuhlane. Ugqirha wakho unoku-odola i-biopsies yesibindi (ukususwa kwesiqwengana sesicwili sesibindi ukuze kuvavanywe elebhu) ngaphambi nangexesha lonyango lwakho nge-methotrexate.

I-Methotrexate inokubangela umonakalo wemiphunga. Tshela ugqirha wakho ukuba unayo okanye wakhe waba nesifo semiphunga. Biza ugqirha wakho ngokukhawuleza ukuba unazo naziphi na kwezi mpawu zilandelayo: ukukhohlela owomileyo, umkhuhlane, okanye ukuphefumla kancinci.

I-Methotrexate inokubangela umonakalo kumngxunya womlomo wakho, isisu, okanye amathumbu. Xelela ugqirha wakho ukuba ukhe wanesilonda esiswini okanye ulcerative colitis (imeko ebangela ukudumba kunye nezilonda kumngxunya wekholoni [amathumbu amakhulu] kunye ne-rectum). Ukuba unazo naziphi na kwezi mpawu zilandelayo, yeka ukuthatha i-methotrexate kwaye ubize ugqirha ngoko nangoko: izilonda zomlomo, urhudo, mnyama, ukulinda, okanye izitulo ezinegazi, okanye ukugabha okunegazi okanye okujongeka njengendawo yekofu.

Ukuthatha i-methotrexate kunokunyusa umngcipheko wokuba uphuhlise i-lymphoma (umhlaza oqala kwiiseli zomzimba). Ukuba uhlakulela i-lymphoma, inokuhamba ngaphandle kwonyango xa uyeka ukuthatha i-methotrexate, okanye kunokufuna unyango nge-chemotherapy.

Ukuba uthatha i-methotrexate ukunyanga umhlaza, unokuhlakulela iingxaki ezithile njengoko i-methotrexate isebenza ukutshabalalisa iiseli zomhlaza. Ugqirha wakho uya kukujonga ngononophelo kwaye azinyange ezi ngxaki ukuba zinokwenzeka.

I-Methotrexate inokubangela ulusu olunobuzaza okanye olusongela ubomi. Ukuba uhlangabezana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: umkhuhlane, irhashalala, iblister, okanye isikhumba esikhulayo.

I-Methotrexate inokuwunciphisa umsebenzi wamajoni akho omzimba, kwaye unokuba nosulelo olubi. Tshela ugqirha wakho ukuba unayo nayiphi na intsholongwane kwaye unayo okanye unayo nayiphi na imeko echaphazela amajoni akho omzimba. Ugqirha wakho unokukuxelela ukuba akufuneki uthathe i-methotrexate ngaphandle kokuba unomdlavuza osongela ubomi. Ukuba ufumana iimpawu zosulelo ezinje ngomqala obuhlungu, ukukhohlela, umkhuhlane, okanye ukugodola, tsalela umnxeba kwangoko.

Ukuba uthatha i-methotrexate ngelixa uphathwa ngonyango lwe-radiation kumhlaza, i-methotrexate inokunyusa umngcipheko wokuba unyango lwe-radiation luza kubangela ukonakala kulusu lwakho, amathambo, okanye amanye amalungu omzimba wakho.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ngaphambi, ngexesha, nasemva konyango lwakho ukujonga impendulo yomzimba wakho kwimethotrexate kunye nokunyanga iziphumo ebezingalindelekanga ngaphambi kokuba zibe nzima.

Tshela ugqirha wakho ukuba wena okanye iqabane lakho ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ungumfazi, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale ukuthatha i-methotrexate. Sebenzisa indlela ethembekileyo yolawulo lokuzalwa ukuze wena okanye iqabane lakho lingakhulelwa ngexesha okanye kungekudala emva konyango. Ukuba uyindoda, wena neqabane lakho labasetyhini kufuneka niqhubeke nokusebenzisa ulawulo lokuzalwa kangangeenyanga ezi-3 emva kokuba uyeke ukuthatha imethotrexate. Ukuba ungumfazi, kuya kufuneka uqhubeke nokusebenzisa uzalo de ube nokuya exesheni emva kokuba uyekile ukuthatha i-methotrexate. Ukuba wena okanye iqabane lakho ukhulelwe, biza ugqirha wakho ngokukhawuleza. I-Methotrexate inokubangela ingozi okanye ukufa kwimveku.

I-Methotrexate isetyenziselwa ukunyanga i-psoriasis (isifo solusu apho umbala obomvu, onamaxolo wenza iindawo ezithile zomzimba) ezingenakulawulwa lolunye unyango. I-Methotrexate ikwasetyenziswa kunye nokuphumla, unyango lomzimba, kwaye ngamanye amaxesha amanye amayeza okunyanga isifo samathambo (RA; imeko apho umzimba uhlasela amalungu ayo, ubangela iintlungu, ukudumba, kunye nokuphulukana nomsebenzi) ongenakulawulwa amanye amayeza. I-Methotrexate ikwasetyenziselwa ukunyanga iintlobo ezithile zomhlaza kubandakanya umhlaza oqala kwizicwili ezithi zijikeleze iqanda elichumileyo esibelekweni, umhlaza wamabele, umhlaza wemiphunga, umhlaza othile wentloko nentamo, iintlobo ezithile ze-lymphoma, kunye neleukemia (umhlaza oko kuqala kwiiseli ezimhlophe zegazi). I-Methotrexate ikudidi lwamayeza abizwa ngokuba zii-antimetabolites. IMethotrexate inyanga umhlaza ngokunciphisa ukukhula kweeseli zomhlaza. IMethotrexate inyanga i-psoriasis ngokunciphisa ukukhula kweeseli zolusu ukuyeka isikali ekubeni senziwe. I-Methotrexate inokunyanga isifo samathambo ngokunciphisa umsebenzi wamajoni omzimba.

IMethotrexate iza njengecwecwe lokuthatha ngomlomo. Ugqirha wakho uza kukuxelela ukuba kufuneka uthathe kangaphi imethotrexate. Ishedyuli ixhomekeke kwimeko onayo nakwindlela umzimba wakho uphendula ngayo kunyango.

Ugqirha wakho unokukuxelela ukuba uthathe i-methotrexate kwishedyuli ejikelezayo etshintsha iintsuku ezininzi xa uthatha i-methotrexate ngeentsuku okanye iiveki ezininzi xa ungathathi amayeza. Landela le miyalelo ngononophelo kwaye ubuze ugqirha wakho okanye usokhemesti ukuba awazi ukuba ulithatha nini na iyeza lakho.

Ukuba uthatha i-methotrexate ukunyanga i-psoriasis okanye i-rheumatoid arthritis, ugqirha wakho unokukuxelela ukuba uthathe amayeza kanye ngeveki. Naka ingqalelo kwizikhokelo zikagqirha wakho. Abanye abantu ngempazamo bathathe i-methotrexate kanye yonke imihla endaweni yokuba kanye ngeveki babe neziphumo ebezingalindelekanga ezibi okanye bafe.

Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-methotrexate ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba uthatha i-methotrexate ukunyanga i-psoriasis okanye i-rheumatoid arthritis, ugqirha wakho unokukuqala kwidosi ephantsi yonyango kwaye ngokuthe ngcembe wandise idosi yakho. Landela le miyalelo ngononophelo.

Ukuba uthatha i-methotrexate ukunyanga isifo samathambo, kungathatha iiveki ezi-3 ukuya kwezi-6 ukuze iimpawu zakho ziqale ukuphucula, kunye neeveki ezili-12 okanye ngaphezulu ukuze uve isibonelelo se-methotrexate. Qhubeka nokuthatha i-methotrexate nokuba uziva uphilile. Sukuyeka ukuthatha i-methotrexate ngaphandle kokuthetha nogqirha wakho.

I-Methotrexate ngamanye amaxesha isetyenziselwa ukunyanga isifo sikaCrohn (imeko apho amajoni omzimba ahlasela khona umgca wokugaya ukutya, abangela iintlungu, urhudo, ukwehla kobunzima kunye nomkhuhlane), multiple sclerosis (MS; imeko apho amajoni omzimba ahlasela imithambo-luvo, kubangela ubuthathaka, ukuba ndindisholo, ukuphulukana nokulungelelaniswa kwezihlunu, kunye neengxaki zombono, intetho, kunye nolawulo lwesinyi), kunye nezinye izifo ezizimela komzimba (iimeko ezithi zikhule xa amajoni omzimba ehlasela iiseli ezisempilweni emzimbeni ngempazamo). Buza ugqirha wakho malunga nomngcipheko wokusebenzisa eli yeza kwimeko yakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-methotrexate,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-methotrexate, nawaphi na amanye amayeza, okanye nasiphi na isithako kwiipilisi ze-methotrexate. Buza ugqirha wakho okanye usokhemesti uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ngokukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nayo nayiphi na kwezi zilandelayo: folic acid (ifumaneka yodwa okanye isithako kwezinye iivithamini); amanye amayeza e-rheumatoid arthritis; phenytoin (Dilantin); probenecid (iBenemid); i-sulfonamides efana ne-co-trimoxazole (Bactrim, Septra), sulfadiazine, sulfamethizole (Urobiotic), kunye ne-sulfisoxazole (Gantrisin); kunye ne-theophylline (Theochron, Theolair). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe wakha wanayo nayiphi na imiqathango ekhankanywe kwicandelo LESILUMKISO ESIBALULEKILEYO okanye kwinqanaba elisezantsi legazi.
• musa ukuncancisa xa uthatha i-methotrexate.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-methotrexate.
• cwangcisa ukuthintela ukukhanya kwelanga ngokungeyomfuneko okanye ixesha elide okanye ukukhanya kwe-ultraviolet (iibhedi zokutsala kunye nezibane zelanga) kwaye unxibe iimpahla zokuzikhusela, iiglasi zelanga kunye nescreen selanga. IMethotrexate inokwenza ulusu lwakho lubuthathaka kwilanga okanye ekukhanyeni kwelanga. Ukuba une-psoriasis, izilonda zakho zinokuba mbi ngakumbi xa uveza ulusu lwakho elangeni ngelixa uthatha i-methotrexate.
• awunalo ugonyo ngexesha lonyango lwakho nge-methotrexate ngaphandle kokuthetha nogqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Methotrexate inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isiyezi
• ukozela
• intloko ebuhlungu
• Iintsini ezidumbileyo
• ukunciphisa ukutya
• amehlo abomvu
• ukulahleka kweenwele

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

• ukungaboni kakuhle okanye ukulahleka kombono ngesiquphe
• ukuxhuzula
• ukudideka
• ubuthathaka okanye ubunzima bokuhambisa elinye okanye omabini amacala omzimba
• ukulahleka kwengqondo

I-Methotrexate inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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