Simvastatin

Umxholo

• Ngaphambi kokuba uthathe i-simvastatin,
• I-Simvastatin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko okanye ufumane uncedo lonyango olungxamisekileyo.

I-Simvastatin isetyenziswa kunye nokutya, ukwehla kobunzima, kunye nokuzilolonga ukunciphisa umngcipheko wokuhlaselwa sisifo sentliziyo kunye nokufa icala kunye nokunciphisa amathuba okuba kufuneka utyando lwentliziyo kubantu abanesifo sentliziyo okanye abasemngciphekweni wokuhlaselwa sisifo sentliziyo. I-Simvastatin ikwasetyenziselwa ukunciphisa inani lezinto ezinamafutha ezinje nge-low-density lipoprotein (LDL) cholesterol ('' cholesterol engalunganga '') kunye ne-triglycerides egazini kunye nokunyusa inani le-high-density lipoprotein (HDL) cholesterol (' 'cholesterol elungileyo') egazini. I-Simvastatin inokusetyenziselwa ukunciphisa inani le-cholesterol kunye nezinye izinto ezinamafutha egazini ebantwaneni nakwishumi elivisayo abaneminyaka eli-10 ukuya kweli-17 ubudala abane-heterozygous hypercholesterolemia (imeko ezuzwe njengelifa apho i-cholesterol ingenakususwa emzimbeni ngesiqhelo)ISimvastatin ikwiklasi yamayeza abizwa ngokuba yi-HMG-CoA reductase inhibitors (statins). Isebenza ngokunciphisa imveliso ye-cholesterol emzimbeni ukunciphisa inani le-cholesterol elinokwakha kwiindonga zeemithambo kunye nokuvimba ukuhamba kwegazi ukuya entliziyweni, kwingqondo nakwezinye iindawo zomzimba.

Ukuqokelelwa kwecholesterol kunye namafutha ecaleni kweendonga zemithambo yakho (inkqubo eyaziwa njenge-atherosclerosis) inciphisa ukuhamba kwegazi kwaye, ke, unikezelo lweoksijini entliziyweni yakho, kwingqondo nakwamanye amalungu omzimba wakho. Ukwehlisa inqanaba legazi le-cholesterol kunye namafutha nge-simvastatin kubonisiwe ukuthintela isifo sentliziyo, i-angina (iintlungu zesifuba), ukubetha, kunye nokuhlaselwa yintliziyo.

ISimvastatin iza njengecwecwe kunye nokunqunyanyiswa kokuthatha ngomlomo. Iipilisi zihlala zithathwa kanye ngemini ngokuhlwa. Ukunqunyanyiswa kuhlala kuthathwa kanye ngemini ngorhatya kwisisu esingenanto. Thatha i-simvastatin malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-simvastatin ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Shake ukumiswa kakuhle okungenani imizuzwana engama-20 ngaphambi kokusetyenziswa ngakunye.

Ukuba uza kuthatha ukumiswa kwe-simvastatin, musa ukusebenzisa itispuni yasekhaya ukulinganisa idosi yakho. Iispuni zasekhaya azizizo izixhobo zokulinganisa ezichanekileyo, kwaye unokufumana amayeza amaninzi okanye awonelanga xa ulinganisa idosi yakho ngepuni yekhaya. Endaweni yoko, sebenzisa isixhobo sokulinganisa esimakwe kakuhle njengesipuni seyeza okanye isirinji yomlomo. Buza ugqirha wakho okanye usokhemesti ukuba ufuna uncedo lokufumana okanye ukusebenzisa isixhobo sokulinganisa.

Ugqirha wakho unokukuqala kwidosi ephantsi ye-simvastatin kwaye ngokuthe ngcembe yonyuse idosi yakho, hayi ngaphezulu kwesinye kwiiveki ezi-4.

Qhubeka nokuthatha i-simvastatin nokuba uziva uphilile. Sukuyeka ukuthatha i-simvastatin ungakhange uthethe nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-simvastatin,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uyaliwa yi-simvastatin, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi ze-simvastatin okanye ukumiswa ngomlomo. Buza ugqirha wakho okanye usokhemesti uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha amayeza okubola afana ne-itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil) kunye ne-voriconazole (Vfend); i-clarithromycin (i-Biaxin, kwi-Prevpac); amayeza e-cobicistat (Stribild); icyclosporine (Gengraf, Neoral, Sandimmune); idanazol; i-erythromycin (i-EES, i-E-Mycin, i-Erythrocin); gemfibrozil (iLopid); I-HIV protease inhibitors efana ne-atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (eKaletra), nelfinavir (Viracept), ritonavir (Norvir, e Kaletra), saquinavir (Invirase) i-tipranavir (iAptivus); nefazodone; iTelaprevir (Incivek); kunye ne-telithromycin (Ketek). Ugqirha wakho uya kukuxelela ukuba ungathathi i-simvastatin ukuba uthatha la mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amiodarone (Cordarone, Pacerone); iamlodipine (eNorvasc, eCaduet, eLotrel); ii-anticoagulants (’izinciphisi zegazi’) ezifana ne-warfarin (Coumadin, Jantoven); icolchicine (iiColcrys); I-digoxin (iDigitek, iLanoxicaps, iLanoxin); I-diltiazem (iCardizem, iDilacor, iTiazac); idronarone (iMultaq); amanye amayeza athoba i-cholesterol afana ne-fenofibrate (Tricor), lomitapide (Juxtapid), kunye ne-niacin (nicotinic acid, Niacor, Niaspan); I-ranolazine (iRanexa); Kunye neverapamil (Calan, Covera, Isoptin, Verelan). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza anokusebenzisana ne-simvastatin, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba unesifo sesibindi. Ugqirha wakho uya ku-odola uvavanyo lwegazi ukuze abone ukuba isibindi sakho sisebenza njani nokuba awucingi ukuba unesifo sesibindi. Ugqirha wakho uya kukuxelela ukuba ungathathi i-simvastatin ukuba unesifo sesibindi okanye ukuba iimvavanyo zibonisa ukuba unokuba nesi sifo sesibindi.
• xelela ugqirha wakho ukuba usela ngaphezu kwezimbini iziselo ezinxilisayo ngosuku, ukuba uneminyaka engama-65 ubudala okanye ngaphezulu, okanye ukuba ungowaseAsia, ngakumbi ukuba ungumTshayina. Xelela ugqirha wakho ukuba ukhe wanesifo sedlala esingasebenzi kakuhle, isifo seswekile, ukuxhuzula, iintlungu zemisipha okanye ubuthathaka, uxinzelelo lwegazi okanye isifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Akufanele ukhulelwe ngexesha lonyango lwakho nge-simvastatin. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba ukhulelwe ngelixa uthatha i-simvastatin, yeka ukuthatha i-simvastatin kwaye ubize ugqirha ngoko nangoko. ISimvastatin ingonzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Kuya kufuneka ungancancisi ngelixa uthatha i-simvastatin.
• ukuba uyatyandwa, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-simvastatin. Ukuba ulaliswe esibhedlele ngenxa yokulimala kakhulu okanye usulelo, xelela ugqirha okunyangayo ukuba uthatha i-simvastatin.
• buza ugqirha wakho malunga nokusetyenziswa okukhuselekileyo kweziselo ezinxilisayo ngelixa uthatha i-simvastatin. Utywala bunokunyusa umngcipheko weziphumo ebezingalindelekanga ezimandundu.

Yitya ukutya okune-fat-fat, low-cholesterol. Qiniseka ukuba ulandela yonke imithambo kunye nezincomo zokutya ezenziwe ngugqirha wakho okanye ugqirha otya ukutya. Ungandwendwela iNational Cholesterol Education Programme (NCEP) kwiwebhusayithi ukufumana ulwazi olongezelelekileyo malunga nokutya kule http://www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf.

Kunqabe ukusela ijusi ye grapefruit ngelixa uthatha i-simvastatin.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba liphantse lafika ixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yedosi eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Simvastatin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuqhina
• isisu esibuhlungu
• isicaphucaphu
• intloko ebuhlungu
• ukulahleka kwememori okanye ukulibala
• ukudideka
• erhawuzayo okanye ebomvu ulusu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko okanye ufumane uncedo lonyango olungxamisekileyo.

• iintlungu zemisipha, ukuthamba, okanye ubuthathaka kunye okanye ngaphandle komkhuhlane okanye ukunqongophala kwamandla
• umchamo omnyama obomvu
• ukuncipha kokuchama
• ukunqongophala kwamandla, ukudinwa, okanye ubuthathaka
• Ukuphelelwa ngumdla wokutya
• iintlungu kwinxalenye ephezulu yesisu
• mthubi ulusu okanye amehlo
• umchamo omnyama ngombala
• umkhuhlane okanye ukubanda
• ukugungxula
• amadyungudyungu
• irhashalala
• urhwebo
• ukurhawuzelela
• ukudumba kobuso, umqala, ulwimi, imilebe, amehlo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• ubunzima bokuphefumla okanye ukugwinya
• ukudinwa
• intlungu edibeneyo
• uvakalelo ekukhanyeni

Eli yeza linokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Gcina iitafile kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Gcina ukumiswa kubushushu begumbi. Musa ukumisa ngumkhenkce okanye ukumisa efrijini. Qiniseka ukusebenzisa ukumiswa ngaphakathi kweentsuku ezingama-30 zokuvula ibhotile kwaye ulahle naliphi na iyeza eliseleyo emva kweentsuku ezingama-30.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho unoku-odola uvavanyo oluthile lweelebhu ngexesha lonyango lwakho, ngakumbi ukuba uvelisa iimpawu zomonakalo wesibindi.

Ngaphambi kokuba uvavanywe elebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba uthatha i-simvastatin.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• I-Flolipid^®
• IZocor^®

• Isiphelo^® (Equlathe iSimvastatin, iSitagliptin)^¶
• Simcor^® (iqulethe iNiacin, iSimvastatin)
• IVithorin^® (iqulethe i-Ezetimibe, Simvastatin)

^¶ Le mveliso inophawu akusekho kwimarike. Ezinye iindlela ezinokubakho zinokubakho.