Saquinavir

Umxholo

• Ngaphambi kokuba uthathe i-saquinavir,
• I-Saquinavir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

ISaquinavir isetyenziswa ngokudibene ne-ritonavir (Norvir) kunye namanye amayeza ukunyanga usulelo lwe-immunodeficiency virus (HIV). I-Saquinavir ikudidi lwamayeza abizwa ngokuba zii-protease inhibitors. Isebenza ngokunciphisa inani le-HIV egazini. Nangona i-saquinavir ingayinyangi i-HIV, inokuwanciphisa amathuba akho okuba ne-immunodeficiency syndrome (i-AIDS) kunye nezifo ezinxulumene ne-HIV ezinje ngezifo ezomeleleyo okanye umhlaza. Ukuthatha la mayeza kunye nokwabelana ngesondo okukhuselekileyo nokwenza olunye utshintsho kwindlela yokuphila kunokunciphisa umngcipheko wokuhambisa intsholongwane kagawulayo kwabanye abantu.

I-Saquinavir iza njengecapsule kunye necwecwe lokuthatha ngomlomo. Ihlala ithathwa ngexesha elinye njenge-ritonavir (i-Norvir) amaxesha amabini ngemini kwiiyure ezi-2 emva kwesidlo esipheleleyo. Kungaba lula ukukhumbula ukuthatha i-saquinavir ukuba uyithatha xa utya. Thatha i-saquinavir ngamaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-saquinavir ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; musa ukuhlafuna, okanye ubatyumze.

Ukuba awukwazi ukuginya i-capsule iphelele, ungathatha i-saquinavir ngokuvula i-capsule kwaye udibanise imixholo nesiraphu yeswekile, i-sorbitol, okanye ijam. Ukulungiselela idosi nganye, yongeza iitispuni ezi-3 (i-15 ml) yesiraphu yeswekile, i-sorbitol, okanye ijam kwisitya esingenanto. Vula i-saquinavir capsule kwaye ungeze imixholo kwisitya. Gquba umxube imizuzwana engama-30 ukuya kwengama-60. Ukuba usebenzisa isiraphu ebandayo, i-sorbitol, okanye i-jam, linda umxube ufike kwiqondo lobushushu ngaphambi kokutya. Qiniseka ukuba uwutya wonke umxube ukuze ufumane idosi epheleleyo.

Qhubeka nokuthatha i-saquinavir nokuba uziva uphilile. Sukuyeka ukuthatha i-saquinavir ngaphandle kokuthetha nogqirha wakho. Ukuba uphosa idosi, thatha ngaphantsi kwedosi emiselweyo okanye uyeke ukuthatha i-saquinavir, imeko yakho inokuba nzima ukunyanga.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-saquinavir kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

I-Saquinavir ngamanye amaxesha isetyenziswa kunye ne-ritonavir (Norvir) kunye namanye amayeza ukunceda ukuthintela usulelo kubasebenzi bokhathalelo lwempilo okanye abanye abantu ababesengozini ye-HIV. Thetha nogqirha wakho malunga neengozi zokuthatha la mayeza kwimeko yakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-saquinavir,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-saquinavir, nawaphi na amanye amayeza, i-lactose, okanye ezinye izithako kwiifomsile ze-saquinavir okanye iipilisi. Ugqirha wakho angakuxelela ukuba ungathathi i-saquinavir. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha nawaphi na amayeza alandelayo: alfuzosin (Uroxatral); atazanavir (Reyataz, e-Evotaz); i-clarithromycin (i-Biaxin, kwi-Prevpac); i-clozapine (iClozaril, iFazaclo, iVersacloz); dasatinib (Sprycel); amayeza e-ergot anje nge-dihydroergotamine (iDHE 45, Migranal), i-ergoloid mesylates (Hydergine), ergonovine (Ergotrate), ergotamine (Ergomar, eCafergot, eMigergot, abanye), kunye ne-methylergonovine (Methergine); erythromycin (EES, E-mycin, Erythrocin, abanye); halofantrine; haloperidol (iHaldol); amayeza athile okubetha kwentliziyo okungaqhelekanga afana ne-amiodarone (Nexterone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), flecainide (Tambocor), lidocaine (Xylocaine), propafenone (Rhythmol), kunye nequinidine (eNuedexta); I-lovastatin (Altoprev); ilurasidone (iLatuda); amayeza okugula ngengqondo kunye nesicaphucaphu esifana ne-chlorpromazine, kunye ne-thioridazine; midazolam ngomlomo; ipentamidine (Nebupent, Pentam); ipimozide (Orap); ikwinine (Qualaquin); irifampin (Rifadin, Rimactane, eRifamate, Rifater); sildenafil (kuphela uphawu lweRevatio olusetyenziselwa isifo semiphunga); isimvastatin (iZocor, Flolopid, kwiVytorin); i-sunatinib (uSutent); itacrolimus (Astagraf XL, Envarsus XR, Prograf); ithenda i-triazolam (iHalcion); okanye i-ziprasidone (Geodon). Xelela ugqirha wakho okanye usokhemesti ukuba uthatha i-rilpivirine (Edurant, e-Juluca, Odefsey, Complera) okanye ukuba uyekile ukuyithatha kwezi veki zimbini zidlulileyo. Ugqirha wakho uya kukuxelela ukuba ungathathi i-saquinavir ukuba uthatha elinye okanye ngaphezulu kula mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-anticoagulants ('i-blood thinner') efana ne-warfarin (Coumadin, Jantoven); Izinto zokubulala ezinje nge-itraconazole (i-Onmel, i-Sporanox) kunye ne-ketoconazole benzodiazepines ezinjenge-alprazolam (Xanax), i-clorazepate (iGen-Xene, iTranxene), i-diazepam (iDiastat, iValium) kunye ne-flurazepam; ii-beta blockers ezinje nge-atenolol (Tenormin, kwi-Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, eDutoprol, kwi-Loressor HCT), nadolol (Corgard, eCorzide), kunye nepropranolol (Hemangeol, Inderal, Innopran); i-bosentan (iTracleer); ii-calcium channel blocker ezinje nge-amlodipine (Norvasc, eCaduet, Lotrel, abanye), diltiazem (Cardizem, Cartia, Tiazac, abanye), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), nimodipine (Nymalize ), nisoldipine (Sular), kunye neverapamil (Calan, Verelan, eTarka); amayeza athile athoba i-cholesterol (ii-statins) ezinjenge-atorvastatin (Lipitor, eCaduet); cobicistat (iTybost, eEvotaz, eGenvoya, ePrezcixix, naseStribild); iicorticosteroids ezinjenge betamethasone, budesonide (Entocort, Pulmicort, Uceris, e Symbicort), ciclesonide (Alvesco, Zetonna, Omnaris), dexamethasone, fluticasone (Arnuity Ellipta, Flonase, Flovent, eAdvair, abanye), methylprednisone, Asmana ), prednisone (iRayos), kunye ne-triamcinolone (Kenalog); icolchicine (iiColcrys, iMitigare); idigoxin (Lanoxin); fentanyl (Abstral, Actiq, Duragesic, nabanye); ii-immunosuppressants ezithile ezinje ngecyclosporine (Gengraf, Neoral, Sandimmune), kunye ne-sirolimus (Rapamune); amayeza okunyanga i-HIV okanye i-AIDS kubandakanya indinavir (Crixivan), lopinavir kunye ritonavir (Kaletra), maraviroc (Selzentry), nelfinavir (Viracept), okanye tipranavir nge ritonavir (Aptivus); amayeza athile okubetha kwentliziyo okungaqhelekanga njenge-ibutilide (Corvert), kunye ne-sotalol (iBetapace, iSorine, iSotylize); amayeza okunyanga ukuxhuzula okufana ne-carbamazepine (Carbatrol, Epitol, Tegretol, abanye), phenytoin (Dilantin, Phenytek), kunye ne phenobarbital; imethadone (iDolophine, iMethadose); nefazodone; omeprazole (Prilosec, eYosprela, Zegerid); ezithile ze-phosphodiesterase (PDE5) inhibitors ezinje nge-sildenafil (Viagra), tadalafil (Adcirca, Cialis), kunye ne-vardenafil (Levitra, Staxyn); iquetiapine (iSeroquel); quinupristin kunye nedalfopristin (Synercid); irifabutin (Mycobutin); isalmeterol (iSerevent, eAdvair); kunye ne-tricyclic antidepressants kubandakanya i-amitriptyline, clomipramine (Anafranil), imipramine (Surmontil, Tofranil), kunye ne-maprotiline. Amanye amayeza anokusebenzisana ne-saquinavir, ke qiniseka ukuxelela ugqirha wakho kunye nosokhemesti malunga nawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo okanye oceba ukuzithatha, ngakumbi i-wort yaseSt.
• xelela ugqirha wakho ukuba uyasela okanye wakha wasela izixa ezikhulu zotywala, ukuba wena okanye nabani na kusapho lwakho ukhe unesifo seswekile. Xelela ugqirha wakho ukuba ukhe wabetha ngentliziyo ngendlela engaqhelekanga, i-cholesterol ephezulu okanye i-triglycerides (amafutha egazini); hemophilia (ukuphazamiseka kwegazi); iimeko apho umzimba ungakwazi ukuvelisa ngokwaneleyo i-lactase okanye unganyamezeli i-lactose, okanye isifo sentliziyo okanye sezintso.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ukhulelwa ngelixa uthatha i-saquinavir, biza ugqirha wakho. Akufuneki uncancise ukuba wosulelwe yi-HIV okanye uthatha i-saquinavir.
• Kuya kufuneka uyazi ukuba i-saquinavir inokunciphisa ukusebenza kwezicwangcisi zehomoni (iipilisi zolawulo lokuzalwa, iipatches, iiringi, okanye inaliti). Thetha nogqirha wakho malunga nokusebenzisa enye indlela yolawulo lokuzalwa.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-saquinavir.
• Kuya kufuneka wazi ukuba amanqatha omzimba wakho anganyuka okanye afudukele kwiindawo ezahlukeneyo zomzimba wakho, ezinje ngomqolo wangasentla, intamo (’’ inyathi ’), amabele, kunye nesisu sakho. Ungabona ukulahleka kwamafutha omzimba ebusweni bakho, kwimilenze nakwiingalo.
• Kuya kufuneka uyazi ukuba unokufumana i-hyperglycemia (inyuka kwiswekile esegazini lakho) ngelixa uthatha eli yeza, nokuba awukabinaso isifo seswekile. Xelela ugqirha wakho kwangoko ukuba unayo nayiphi na kwezi mpawu zilandelayo ngelixa uthatha i-saquinavir: ukunxanwa okugqithisileyo, ukuchama rhoqo, ukulamba kakhulu, ukungaboni kakuhle, okanye ubuthathaka. Kubaluleke kakhulu ukubiza ugqirha wakho nje ukuba ube nazo naziphi na ezi mpawu, kuba iswekile ephezulu yegazi enganyangekiyo inokubangela imeko embi ebizwa ngokuba yi ketoacidosis. I-Ketoacidosis inokuba sengozini yobomi ukuba ayinyangwa kwangoko. Iimpawu zeketoacidosis zibandakanya umlomo owomileyo, isicaphucaphu kunye nokugabha, ukuphefumla kancinci, ukuphefumla okunuka iziqhamo kunye nokuncipha kwengqondo.
• Kuya kufuneka uyazi ukuba ngelixa uthatha amayeza ukunyanga usulelo lwe-HIV, amajoni akho omzimba angomelela kwaye aqale ukulwa nezinye izifo ezazisele zisemzimbeni wakho okanye zibangele ezinye iimeko zenzeke. Oku kunokubangela ukuba ukhule iimpawu zolo sulelo okanye iimeko. Ukuba uneempawu ezintsha okanye eziba mandundu emva kokuqala unyango nge-saquinavir, qiniseka ukuxelela ugqirha wakho.

Thetha nogqirha wakho malunga nokutya igrapefruit kunye nokusela ijusi yamagilebhisi ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Saquinavir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• isisu esibuhlungu
• isicaphucaphu
• ukugabha
• ukuqhina
• ukudinwa
• umqolo obuhlungu
• imilebe eyomileyo okanye ulusu
• ifiva

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• irhashalala, ukurhawuzelela, ukudumba kwamehlo, ubuso, umlomo, umqala, okanye imilebe, ukuphefumla nzima okanye ukugwinya
• ukudumba okanye ukuxobuka kolusu
• ukuba tyheli kolusu okanye kwamehlo, ukungabinamdla wokutya, umkhuhlane njengeempawu, ukudinwa kakhulu, umchamo omnyama, izitulo ezinombala okhanyayo, iintlungu kwinxalenye ephezulu yesisu
• utywala, intloko, ukukhanya, ukungahambi kakuhle, okanye ukubetha kwentliziyo, ukuphelelwa amandla

I-Saquinavir inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• intlungu yomqala

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-saquinavir. Ugqirha wakho unokuyalela i-electrocardiogram (i-ECG; uvavanyo olulinganisa umsebenzi wombane entliziyweni) ngaphambi nangexesha lonyango lwakho.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Ingeniso^®