Umbhali: Marcus Baldwin
Umhla Wokudalwa: 17 Isilimela 2021
Hlaziya Umhla: 19 Eyenkanga 2024
Anonim
Treatment of Alzheimer’s Disease - Galantamine, Rivastigmine, and Donepezil
Ividiyo: Treatment of Alzheimer’s Disease - Galantamine, Rivastigmine, and Donepezil

Umxholo

IGalantamine isetyenziselwa ukunyanga iimpawu zesifo i-Alzheimer's (AD; isifo sobuchopho esitshabalalisa kancinci inkumbulo kunye nokukwazi ukucinga, ukufunda, ukunxibelelana nokuphatha imisebenzi yemihla ngemihla). IGalantamine ikwiklasi yamayeza abizwa ngokuba yi-acetylcholinesterase inhibitors. Isebenza ngokwandisa inani lezinto ezithile zendalo kwingqondo ezifunekayo kwimemori nasekucingeni. IGalantamine inokuphucula ukukwazi ukucinga nokukhumbula okanye ukucothisa ilahleko kwezi zinto kubantu abane-AD. Nangona kunjalo, i-galantamine ayizukuyinyanga i-AD okanye ithintele ukuphulukana nobuchule bengqondo ngexesha elizayo.

IGalantamine iza njengecwecwe, ukukhutshwa okwandisiweyo (ukusebenza ixesha elide), kunye nesisombululo (ulwelo) ukuthatha ngomlomo. Amacwecwe kunye nolwelo zihlala zithathwa kabini ngemini, ngakumbi ukutya kwasekuseni nangokuhlwa. Iifomsile zokukhululwa ezandisiweyo zihlala zithathwa kanye ngemini kusasa. Thatha i-galantamine malunga nexesha elifanayo (ii) yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-galantamine kanye njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho. Awunakufane ube neziphumo ebezingalindelekanga zegalantamine ukuba ulandela ngqo ishedyuli yedosi emiselweyo ngugqirha wakho.


Ginya zonke iipilisi ezikhutshiweyo; ungawaphuli okanye uwahlafune.

IGalantamine inokucaphukisa isisu sakho, ngakumbi ekuqaleni konyango lwakho. Thatha i-galantamine ngokutya kwaye usele iiglasi zamanzi ezi-6 ukuya kwezi-8 yonke imihla. Oku kunokunciphisa amathuba okuba ube nesisu esibuhlungu ngexesha lonyango lwakho.

Ugqirha wakho uya kukuqala ngedosi esezantsi yegalantamine kwaye ngokuthe ngcembe uyonyuse idosi yakho, hayi rhoqo rhoqo kube kanye kwiiveki ezi-4.

Qhubeka nokuthatha i-galantamine nokuba uziva uphilile. Sukuyeka ukuthatha i-galantamine ungakhange uthethe nogqirha wakho. Ukuba uyeka ukuthatha i-galantamine kangangeentsuku ezimbalwa okanye nangaphezulu, tsalela umnxeba ugqirha wakho ngaphambi kokuba uqale ukuthatha i-galantamine kwakhona. Ugqirha wakho uya kuthi akuxelele ukuba uqale ngedosi esezantsi yegalantamine kwaye ngokuthe ngcembe wandise idosi yakho kwithamo obukade ulithatha.

Ngaphambi kokuba uthathe isisombululo somlomo segalantamine okokuqala ngqa, funda imiyalelo ebhaliweyo eza nayo. Buza ugqirha wakho okanye usokhemesti akubonise indlela yokusithatha isisombululo somlomo. Ukuthatha isisombululo somlomo, landela la manyathelo:

  1. Vula ikepusi engqina ubungqina bomntwana ngokutyhala ikephu ezantsi ngelixa uyijikela ngasekhohlo. Susa isiciko.
  2. Tsala ipipette (ityhubhu oyisebenzisayo ukulinganisa idosi yegalantamine) kwimeko yayo.
  3. Beka ipipette ngokupheleleyo kwibhotile yegalantamine.
  4. Ngelixa ubambe iringi esezantsi yombhobho, tsala ipipette plunger ukuya kuphawu olubonisa idosi ugqirha oyimiselweyo.
  5. Bamba iringi esezantsi yombhobho kwaye ususe umbhobho kwibhotile. Lumka ungatyhaleli isijula ​​ngaphakathi.
  6. Lungisa ii-ounces ezi-3 ukuya kwezi-4 (malunga ne-1/2 yekomityi [ezingama-90 ukuya kwi-120 milliliters]) zaso nasiphi na isiselo esinxilisayo. Khuphela lonke iyeza kwibhotile ukuya kwisiselo ngokutyhala iplastikhi kuyo yonke indlela.
  7. Khuthaza kakuhle isiselo.
  8. Sela wonke umxube kwangoko.
  9. Beka isiciko seplastiki kwibhotile yegalantamine kwaye ujike ikepusi ngasekunene ukuvala ibhotile.
  10. Yipule ipipette engenanto ngokubeka isiphelo sayo esivulekileyo kwiglasi yamanzi, ukhuphe iplunger, kwaye uyityhale ngaphakathi ukuze isuse amanzi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.


Ngaphambi kokuba uthathe i-galantamine,

  • xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-galantamine, nawaphi na amanye amayeza, okanye naziphi na izinto ezingasebenziyo kwiipilisi zegalantamine, isisombululo, okanye iipilisi ezandisiweyo. Buza usokhemesti wakho uluhlu lwezinto ezingasebenziyo.
  • xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ambenonium chloride (Mytelase); umgca we-amitriptyline (Elavil); amayeza anticholinergic afana neatropine (Atropen, Sal-Tropine), belladonna (eDonnatal, Bellamine, Bel-Tabs, abanye); benztropine (Cogentin), biperiden (Akineton); clidinium (eLibrax), dicyclomine (Bentyl), glycopyrrolate (Robinul), hyoscyamine (Cytospaz-M, Levbid, Levsin), ipratropium (Atrovent, in Combivent), oxybutynin (Ditropan), procyclidine (Kemadrin), propantheine Pro-pro ), scopolamine (Scopace, Transderm-Scop), tiotropium (Spiriva), tolterodine (Detrol), kunye trihexyphenidyl; izinto ezithile zokubulala ukungunda ezifana ne-fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), kunye ne-voriconazole (Vfend); i-aspirin okanye ezinye iziyobisi ezichasayo (i-NSAIDs) ezinje nge-ibuprofen (Advil, Motrin) kunye ne-naproxen (Aleve, Naprosyn); i-bethanechol (i-Urecholine); i-cevimeline (i-Evoxac); cimetidine (iTagamet); i-clarithromycin (i-Biaxin, kwi-Prevpac); idigoxin (Lanoxin); ifluoxetine (Prozac, Sarafem); i-fluvoxamine (iLuvox); amayeza entliziyo; nefazodone; neostigmine (Prostigmin); amanye amayeza esi sifo sika-Alzheimer; amayeza e-HIV (okanye i-HIV) okanye i-immunodeficiency syndrome (i-AIDS); amayeza kuxinzelelo lwegazi; paroxetine (Paxil); pyridostigmine (Mestinon); kunye nequinidine (Quinidex). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
  • xelela ugqirha wakho ukuba ukhe wanesifo sombefu okanye nasiphi na isifo semiphunga; iprotrate eyandisiweyo; izilonda; ukuxhuzula; ukubetha kwentliziyo ngokungaqhelekanga; okanye intliziyo, isifo, okanye isifo sesibindi.
  • xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa uthatha i-galantamine, tsalela ugqirha wakho.
  • ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-galantamine.
  • Kuya kufuneka uyazi ukuba i-galantamine inokukwenza wozele. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.
  • khumbula ukuba utywala bunokongeza ukozela okubangelwa leli yeza.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.


Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

IGalantamine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

  • isicaphucaphu
  • ukugabha
  • urhudo
  • Ukuphelelwa ngumdla wokutya
  • isisu esibuhlungu
  • isilungulela
  • ukuhla ukusinda
  • ukudinwa kakhulu
  • isiyezi
  • ulusu oluthuthu
  • intloko ebuhlungu
  • ukungcangcazela kwelungu lomzimba ongenakulilawula
  • ukudakumba
  • ubunzima bokulala okanye ukulala
  • impumlo enemifinya

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ezi mpawu zilandelayo aziqhelekanga, kodwa ukuba ufumana enye yazo, tsalela ugqirha ngokukhawuleza:

  • ubunzima bokuchama
  • igazi kumchamo
  • intlungu okanye ukutshisa xa uchama
  • ukuxhuzula
  • ukubetha kwentliziyo
  • isiqaqa
  • ukuqhawukelwa ngumphefumlo
  • izitulo ezimnyama kunye nokulinda
  • igazi elibomvu kwizitulo
  • ukugabha okunegazi
  • ukugabha okujongeka njengendawo yekofu

IGalantamine inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).Musa ukubanda.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

  • ubuthathaka bemisipha okanye ukuxhuzula
  • isicaphucaphu
  • ukugabha
  • isisu esiswini
  • ukuvuza amathe
  • Amehlo aneenyembezi
  • ukwanda komchamo
  • kufuneka ubenentshukumo yamathumbu
  • ukubila
  • icothisile, ikhawuleze, okanye ibethe intliziyo ngendlela engaqhelekanga
  • intloko elula
  • isiyezi
  • isiqaqa
  • ukuphefumla okucothayo
  • Ukuwa
  • ukulahleka kwengqondo
  • ukuxhuzula
  • umlomo owomileyo
  • iintlungu zesifuba
  • ukubona izinto ezingekhoyo (ukubona izinto okanye ukuva amazwi angabikho)

Gcina lonke ixesha lokudibana nogqirha wakho.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

  • URazadyne® (ngaphambili ibifumaneka njengeReminyl®)
  • URazadyne® ER
Ukuhlaziywa kokugqibela-03/15/2020

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