Uvavanyo lwe-ACTH

Umxholo

• Uvavanyo lwe-ACTH lwenziwa njani
• Kutheni uvavanyo lwe-ACTH lwenziwa
• Iziphumo zovavanyo ze-ACTH ezinokuthetha ntoni
• Umngcipheko wovavanyo lwe-ACTH
• Yintoni onokuyilindela emva kovavanyo lwe-ACTH

Yintoni uvavanyo lwe-ACTH?

Ihomoni yeAdrenocorticotropic (ACTH) yincindi yedlala eveliswa ngaphambili, okanye ngaphambili, idlala lengqondo kwingqondo. Umsebenzi we-ACTH kukumisela amanqanaba ehomoni ye-steroid cortisol, ekhutshwe kwi-adrenal gland.

I-ACTH ikwabizwa ngokuba yi:

• iadrenocorticotropic hormone
• i-serum adrenocorticotropic hormone
• I-ACTH ethe-ethe-ethe
• icorticotropin
• cosyntropin, eluhlobo lweziyobisi lwe-ACTH

Uvavanyo lwe-ACTH lulinganisa amanqanaba azo zombini i-ACTH kunye ne-cortisol egazini kwaye inceda ugqirha wakho ukuba abhaqe izifo ezinxulunyaniswa ne-cortisol eninzi kakhulu okanye encinci emzimbeni. Izizathu ezinokubangela zezi zifo zibandakanya:

• ukungasebenzi kakuhle kwenzalo okanye iadrenal
• ithumba lelungu lobufazi
• ithumba le-adrenal
• ithumba lemiphunga

Uvavanyo lwe-ACTH lwenziwa njani

Ugqirha wakho unokukucebisa ukuba ungathathi naziphi na iziyobisi ze-steroid ngaphambi kovavanyo lwakho. Oku kunokuchaphazela ukuchaneka kweziphumo.

Uvavanyo luhlala lwenziwa into yokuqala kusasa. Amanqanaba e-ACTH aphezulu kakhulu xa usandula ukuvuka. Ugqirha wakho uya kucwangcisa uvavanyo lwakho kwasekuseni kakhulu.

Amanqanaba e-ACTH avavanywa kusetyenziswa isampulu yegazi. Isampulu yegazi ithathwa ngokutsala igazi emthanjeni, ngesiqhelo ukusuka ngaphakathi kwengqiniba. Ukunika isampulu yegazi kubandakanya la manyathelo alandelayo:

1. Umboneleli wezempilo uqale acoce isiza ngeyeza lokubulala iintsholongwane.
2. Emva koko, baya kusonga ibhanti e-elastic ngengalo yakho. Oku kubangela ukuba umthambo udumbe ligazi.
3. Baza kufaka ngobunono isirinji yenaliti emthanjeni wakho kwaye baqokelele igazi lakho kumbhobho wesirinji.
4. Xa ityhubhu igcwele, inaliti iyasuswa. Ibhendi ye-elastic iyasuswa, kwaye indawo yokugquma igqunywe nge-gauze engenazintsholongwane ukunqanda ukopha.

Kutheni uvavanyo lwe-ACTH lwenziwa

Ugqirha wakho unoku-odola uvavanyo lwegazi lwe-ACTH ukuba uneempawu ze-cortisol eninzi kakhulu okanye encinci. Ezi mpawu zinokwahluka kakhulu komnye umntu kwaye zihlala ziluphawu lweengxaki ezongezelelweyo zempilo.

Ukuba unenqanaba eliphezulu le-cortisol, unokuba:

• ukutyeba kakhulu
• ubuso obujikeleziweyo
• ubuthathaka, ulusu olucekeceke
• Imigca emfusa esiswini
• izihlunu ezibuthathaka
• induna
• inani elonyukayo leenwele zomzimba
• igazi elonyukayo
• amanqanaba aphantsi e-potassium
• inqanaba eliphezulu le-bicarbonate
• amanqanaba aphezulu eswekile
• isifo seswekile

Iimpawu zecortisol ephantsi zibandakanya:

• izihlunu ezibuthathaka
• ukudinwa
• ukuhla ukusinda
• ukwanda kombala wolusu kwiindawo ezingafakwanga lilanga
• Ukuphelelwa ngumdla wokutya
• uxinzelelo lwegazi oluphantsi
• amanqanaba eglucose esezantsi
• amanqanaba esodium ephantsi
• amanqanaba aphezulu e-potassium
• amanqanaba aphezulu e-calcium

Iziphumo zovavanyo ze-ACTH ezinokuthetha ntoni

Amaxabiso aqhelekileyo e-ACTH zii-9 ukuya kwi-52 zeepikgram ngeemililitha. Amaxabiso aqhelekileyo ahluka kancinci kuxhomekeke kwilabhoratri. Ugqirha wakho uza kukuchazela iziphumo zakho zovavanyo.

Inqanaba eliphezulu le-ACTH linokuba luphawu lwe:

• Isifo iAddison
• iadrenal hyperplasia
• Isifo sikaCushing
• ithumba electopic elivelisa i-ACTH
• adrenoleukodystrophy, nto leyo kunqabile kakhulu
• Isifo sikaNelson, esinqabe kakhulu

Inqanaba eliphantsi le-ACTH linokuba luphawu lwe:

• ithumba leadrenal
• Isifo sikaCushing esingaphandle
• hypopituitarism

Ukuthatha amayeza e-steroid kunokubangela amanqanaba asezantsi e-ACTH, ke qiniseka ukuxelela ugqirha wakho ukuba ngaba unayo nayiphi na i-steroids.

Umngcipheko wovavanyo lwe-ACTH

Uvavanyo lwegazi luhlala lunyamezeleka kakuhle. Abanye abantu baneemithambo ezincinci okanye ezinkulu, ezinokwenza ukuba kube nzima ngakumbi ukuthatha isampulu yegazi. Nangona kunjalo, umngcipheko onxulunyaniswa novavanyo lwegazi njengovavanyo lwehomoni ye-ACTH unqabile.

Imingcipheko engaqhelekanga yokutsalwa kwegazi ibandakanya:

• ukopha kakhulu
• intloko elula okanye etyhafayo
• hematoma, okanye ukudityaniswa kwegazi phantsi kolusu
• usulelo kwindawo

Yintoni onokuyilindela emva kovavanyo lwe-ACTH

Ukuchonga izifo ze-ACTH kunokuba nzima kakhulu. Ugqirha wakho unokufuna uku-odola iimvavanyo ezininzi zaselebhu kwaye enze uvavanyo lomzimba ngaphambi kokuba afumane isifo.

Ukulungiselela amathumba okufihla i-ACTH, utyando kuhlala kubonisiwe. Ngamanye amaxesha, iziyobisi ezinje ngecabergoline zinokusetyenziselwa ukuqhelanisa amanqanaba e-cortisol. IHypercortisolism ngenxa yamathumba adrenal ihlala ifuna utyando ngokunjalo.