I-Ajovy (fremanezumab-vfrm)

Umxholo

• Yintoni u-Ajovy?
• Uhlobo olutsha lweziyobisi
• Ukusebenza ngempumelelo
• Ajovy generic
• Sebenzisa u-Ajovy
• Ajovy ngenxa yentloko ebuhlungu
• Ukusebenza kwentloko ye-migraine
• Iziphumo ebezingalindelekanga zika-Ajovy
• Iziphumo eziqhelekileyo ezichaphazelekayo
• Iziphumo ebezingalindelekanga ezimandundu
• Ukuphendula ngokuchaseneyo
• Iziphumo ebezingalindelekanga zexesha elide
• Enye indlela eya ku-Ajovy
• Abachasi be-CGRP
• Ajovy vs. namanye amachiza
• Ajovy vs Aimovig
• Ajovy vs. Ubundlobongela
• Ajovy vs.Botox
• Iindleko zeAjovy
• Uncedo lwezezimali
• Umthamo we-Ajovy
• Iifom zamachiza kunye namandla
• Umyinge wokuthintela intloko ebuhlungu
• Kuthekani ukuba ndiphose idosi?
• Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?
• Ungamthatha njani u-Ajovy
• Ungayifaka njani inaliti
• Ixesha
• Ukuthatha iAjovy ngokutya
• Isebenza njani iAjovy
• Kuthatha ixesha elingakanani ukusebenza?
• Ajovy kunye notywala
• Unxibelelwano ngoAjovy
• Ajovy kunye nokukhulelwa
• Ajovy kunye nokuncancisa
• Imibuzo eqhelekileyo malunga no-Ajovy
• Ngaba iAjovy ingasetyenziselwa ukunyanga intloko ebuhlungu?
• Wahluke njani u-Ajovy kwezinye iziyobisi ze-migraine?
• Ngaba iAjovy iyayinyanga intloko ebuhlungu?
• Ukuba ndithatha iAjovy, ndingayeka ukuthatha amanye amayeza am okuthintela?
• Ukugqithisa iAjovy
• Iimpawu libanda
• Kufuneka wenze ntoni xa uthe wagqithisa?
• Izilumkiso zika-Ajovy
• Ukuphelelwa nguAjovy

Yintoni u-Ajovy?

I-Ajovy ligama lonyango elisebenzisa amayeza elisetyenziselwa ukuthintela iintlungu kubantu abadala. Kuza njengesirinji ekhethiweyo. Unokuzijoba ngokwakho u-Ajovy, okanye ufumane inaliti ye-Ajovy evela kumboneleli wezempilo kwiofisi kagqirha wakho. U-Ajovy unokujova inyanga nenyanga okanye ngekota (kanye qho kwiinyanga ezintathu).

I-Ajovy iqulethe ichiza le-fremanezumab, elilelona linye lomzimba. I-anti-monoclonal antibody luhlobo lweziyobisi olwenziwe kwiiseli zomzimba zokuzikhusela. Isebenza ngokuthintela ezinye zeeproteni zomzimba wakho ekusebenzeni. I-Ajovy inokusetyenziselwa ukunqanda zombini iintlungu ze-episodic kunye ezingapheliyo zentloko.

Uhlobo olutsha lweziyobisi

I-Ajovy yinxalenye yodidi olutsha lwamachiza abizwa ngokuba yi-calcitonin enxulumene ne-peptide (CGRP) echasene ne-gene. La machiza ngamayeza okuqala enziwe ukuthintela iintlungu zentloko.

Ulawulo lwezoKutya kunye neDrug (FDA) lwaphumeza iAjovy ngoSeptemba 2018. UAjovy wayelichiza lesibini kwiklasi ye-CGRP echasene ne-FDA evunyiweyo yokunceda ukuthintela iintlungu zentloko.

Kukho ezinye ezimbini ezichasayo ze-CGRP ezikhoyo. La machiza abizwa ngokuba yi-Emgality (galcanezumab) kunye ne-Aimovig (erenumab). Kukho umchasi wesine we-CGRP obizwa ngokuba yi-eptinezumab naye ofundwayo. Kulindeleke ukuba yamkelwe yi-FDA kwixa elizayo.

Ukusebenza ngempumelelo

Ukufunda ngokusebenza kwe-Ajovy, jonga icandelo elithi "Ajovy uses" apha ngezantsi.

Ajovy generic

I-Ajovy ifumaneka kuphela njengonyango lwegama lophawu. Okwangoku ayifumaneki ngendlela eqhelekileyo.

I-Ajovy iqulethe ichiza i-fremanezumab, ekwabizwa ngokuba yi-fremanezumab-vfrm. Isizathu esithi "-vfrm" sibonakala esiphelweni segama kukubonisa ukuba iyeza lahlukile kumayeza afanayo anokwenziwa kwixesha elizayo. Ezinye ii-antibodies ze-monoclonal zithiwe ngendlela efanayo.

Sebenzisa u-Ajovy

Ulawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) luvuma amayeza amiselweyo anje ngeAjovy ukunyanga okanye ukuthintela iimeko ezithile.

Ajovy ngenxa yentloko ebuhlungu

I-FDA ivume i-Ajovy ukunceda ukukhusela i-migraine entloko kubantu abadala. Ezi ntloko zinzima. Ziyeyona mpawu ephambili ye-migraine, eyimeko ye-neurological. Ubuntununtunu bokukhanya kunye nesandi, isicaphucaphu, ukugabha, kunye nengxaki yokuthetha zezinye iimpawu ezinokuthi zenzeke ngentloko ebuhlungu.

U-Ajovy uvunyiwe ukukhusela zombini iintloko ezingapheliyo kunye neepisodic migraine. I-International Headache Society ithi abantu abane-episodic migraine headaches banamava angaphantsi kwe-15 migraine okanye iintsuku zentloko inyanga nenyanga. Abantu abaneentloko ezingapheliyo ze-migraine, kwelinye icala, banamava e-15 okanye ngaphezulu kweentsuku zentloko nganye ngenyanga ngaphezulu kweenyanga ezi-3. Kwaye ubuncinci i-8 yezi ntsuku ziintsuku ze-migraine.

Ukusebenza kwentloko ye-migraine

U-Ajovy ufunyenwe esebenza ngempumelelo ekuthinteleni iintlungu zentloko. Ngolwazi malunga nendlela u-Ajovy aqhube ngayo kwizifundo zeklinikhi, jonga ulwazi lokumisela iyeza.

I-American Headache Society icebisa ukuba kusetyenziswe i-Ajovy ukuthintela i-migraine entloko kubantu abadala abangakwaziyo ukunciphisa inani labo leentsuku ze-migraine ngokwaneleyo namanye amayeza. Ikwacebisa u-Ajovy kubantu abangakwaziyo ukuthatha amanye amayeza okuthintela migraine ngenxa yeziphumo ebezingalindelekanga okanye ukuhlangana kweziyobisi.

Iziphumo ebezingalindelekanga zika-Ajovy

I-Ajovy inokubangela iziphumo ebezingalindelekanga ezinobulali okanye ezinobuzaza. Olu luhlu lulandelayo luqulathe ezinye zeziphumo ebezingalindelekanga ezinokubakho ngelixa uthatha iAjovy. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Ngolwazi oluthe kratya malunga neziphumo ebezingalindelekanga ezinokubakho zeAjovy, okanye iingcebiso ngendlela yokujongana neziphumo ebezingalunganga, thetha nogqirha wakho okanye usokhemesti.

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo ebezingalindelekanga eziqhelekileyo zeAjovy kukusabela kwendawo yenaliti. Oku kunokubandakanya ezi ziphumo zilandelayo kwindawo otofa kuyo iziyobisi:

• bomvu
• ukucheba
• intlungu
• ukuthamba

Ukuphendula kwendawo yenaliti kuhlala kungabi nzima okanye kungapheli. Uninzi lweziphumo ebezingalindelekanga zinokunyamalala kwiintsuku nje ezimbalwa okanye kwiiveki ezimbalwa. Thetha nogqirha wakho okanye usokhemesti ukuba iziphumo ebezingalindelekanga zinzima kakhulu okanye azihambi.

Iziphumo ebezingalindelekanga ezimandundu

Akuqhelekanga ukuba nemiphumo emibi evela ku-Ajovy, kodwa kunokwenzeka. Iziphumo ezingathandekiyo eziphambili ze-Ajovy sisenzo esibi sokungabikho komzimba kwichiza. Jonga ngezantsi iinkcukacha.

Ukuphendula ngokuchaseneyo

Njengoninzi lweziyobisi, abanye abantu banokufumana into ebabuyayo emva kokuba bethathe iAjovy. Iimpawu zokuphendula kancinci kunokubandakanya:

• ukucheba
• irhashalala
• ukucoca (ukufudumala nokubomvu kwesikhumba sakho)

Ukuchasana kakhulu ne-Ajovy kunqabile. Iimpawu ezinokubakho zokungabikho komzimba zibandakanya:

• ukudumba kolwimi lwakho, umlomo, okanye umqala
• i-angioedema (ukudumba phantsi kolusu lwakho, ubukhulu becala kwiinkophe zakho, imilebe, izandla, okanye iinyawo)
• ingxaki yokuphefumla

Ukuba unesifo esibi kwi-Ajovy, tsalela ugqirha kwangoko. Ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unonyango olungxamisekileyo, tsalela umnxeba ku-911.

Iziphumo ebezingalindelekanga zexesha elide

U-Ajovy lunyango olusandula ukwamkelwa kwiklasi entsha yamachiza. Ngenxa yoko, kuncinci kakhulu uphando lwexesha elide kukhuseleko luka-Ajovy, kwaye kuncinci okwaziwayo malunga neziphumo zalo zexesha elide. Olona phando lude lweklinikhi (PS30) lwaseAjovy luthathe unyaka, kwaye abantu kolu phando khange baxele naziphi na iziphumo ezibi.

Impendulo yendawo yenaliti yayiyeyona nto ixhaphakileyo echaphazelekayo kwisifundo sonyaka wonke. Abantu baxele ezi ziphumo zilandelayo kwindawo apho kunikwe khona inaliti:

• intlungu
• bomvu
• ukopha
• ukucheba
• isikhumba esingqindilili okanye esiphakamileyo

Enye indlela eya ku-Ajovy

Kukho ezinye iziyobisi ezikhoyo ezinokukunceda ukuthintela intloko ebuhlungu. Ezinye zinokukulungela ngcono kunabanye. Ukuba ungathanda ukufumana enye indlela eya ku-Ajovy, thetha nogqirha wakho. Banokukunceda ufunde ngamanye amayeza anokukulungela.

Nayi eminye imizekelo yezinye iziyobisi ezivunyiweyo yi-FDA ukunceda ukuthintela iintloko zentloko:

• i-beta-blocker propranolol (Inderal, Inderal LA)
• i-neurotoxin onabotulinumtoxinA (Botox)
• amayeza athile okubanjwa, njenge-divalproex sodium (Depakote) okanye i-topiramate (Topamax, iTrokendi XR)
• enye i-peptide enxulumene nemfuza ye-calcitonin (CGRP) echasene ne-erenumab-aooe (Aimovig) kunye ne-galcanezumab-gnlm (Ubume)

Nayi eminye imizekelo yezinye iziyobisi ezinokusetyenziswa ngaphandle kwelebheli yokuthintela intloko ebuhlungu:

• amayeza athile okubanjwa, njenge-valproate sodium
• ezinye izidambisi zengqondo, ezinje nge-amitriptyline okanye venlafaxine (Effexor XR)
• ii-beta-blocker ezithile, ezinjenge-metoprolol (Lopressor, Toprol XL) okanye i-atenolol (Tenormin)

Abachasi be-CGRP

I-Ajovy luhlobo olutsha lwechiza elibizwa ngokuba yi-calcitonin enxulumene ne-peptide (CGRP) echasene nomzimba. Kwi-2018, i-FDA ivume i-Ajovy yokuthintela i-migraine headaches, kunye nabanye abachasi be-CGRP: Ubungqingili kunye neAimovig. Iyeza lesine (eptinezumab) kulindeleke ukuba livunywe kungekudala.

Indlela abasebenza ngayo

Abathathu abachasi be-CGRP abakhoyo ngoku basebenza ngeendlela ezahlukeneyo zokunceda ukukhusela iintlungu zentloko.

I-CGRP yiprotein emzimbeni wakho. Idibaniswe ne-vasodilation (ukwandiswa kwemithambo yegazi) kunye nokuvuvukala kwengqondo, enokubangela iintlungu zentloko ebuhlungu. Ukwenza ezi ziphumo kwingqondo, i-CGRP kufuneka ibophe (incamathisele) kwii-receptors zayo. Izamkeli ziimolekyuli kwiindonga zeeseli zengqondo yakho.

Umsebenzi we-Ajovy kunye ne-Emgality ngokuncamathela kwi-CGRP. Oku kuthintela i-CGRP ekuncamathiseleni kwii-receptors zayo. I-Aimovig, kwelinye icala, isebenza ngokudibanisa ii-receptors ngokwazo. Oku kugcina i-CGRP ekubeni iqhotyoshelwe kubo.

Ngokuthintela i-CGRP ekubeni inamathele kwi-receptor yayo, la machiza mathathu anceda ukuthintela i-vasodilation kunye nokudumba. Ngenxa yoko, banokukunceda ukukhusela i-migraine.

Icala ngecala

Le tshathi ithelekisa ulwazi malunga neAimovig, Ajovy, kunye ne-Emgality. Ezi zi yobisi zintathu ze-CGRP ezichasene nazo ezivunyiweyo ngoku ukukunceda ukukhusela i-migraine. (Ukufunda ngakumbi ngendlela i-Ajovy ethelekiswa ngayo nala machiza, jonga icandelo le- "Ajovy vs. nezinye iziyobisi" apha ngezantsi.)

Amaxabiso anokuhluka ngokuxhomekeka kwindawo okuyo, ikhemesti esetyenzisiweyo, i-inshurensi yakho, kunye neenkqubo zoncedo lomenzi.

Ajovy vs. namanye amachiza

Unokuzibuza ukuba i-Ajovy ithelekiswa njani namanye amayeza amiselwe ukusetyenziswa okufanayo. Apha ngezantsi kuthelekiswa phakathi kweAjovy kunye namayeza aliqela.

Ajovy vs Aimovig

I-Ajovy iqulethe ichiza le-fremanezumab, elilelona linye lomzimba. I-Aimovig iqulethe i-erenumab, ekwayiloo monoclonal antibody. Amachiza omzimba monoclonal ngamachiza enziwe kwiiseli zomzimba. Bayamisa umsebenzi weeproteni ezithile emzimbeni wakho.

Umsebenzi ka-Ajovy no-Aimovig ngeendlela ezahlukeneyo. Nangona kunjalo, bobabini bayamisa umsebenzi weprotein ebizwa ngokuba yi-calcitonin enxulumene ne-peptide (CGRP). I-CGRP ibangela i-vasodilation (ukwandiswa kwemithambo yegazi) kunye nokudumba kwingqondo. Ezi ziphumo zinokubangela iintlungu zentloko.

Ngokuthintela i-CGRP, i-Ajovy kunye ne-Aimovig kunceda ukuthintela i-vasodilation kunye nokudumba. Oku kunokukunceda ukukhusela i-migraine intloko.

Sebenzisa

U-Ajovy kunye no-Aimovig bobabini bavunyelwe yi-FDA ukuthintela iintloko zentloko kubantu abadala.

Iifom kunye nolawulo

Amachiza u-Ajovy kunye ne-Aimovig bobabini beza ngohlobo lwenaliti enikezwe phantsi kolusu lwakho (subcutaneous). Unokuzifaka ngokwakho iziyobisi ekhaya. Omabini la machiza anokuzifaka ngokwakho kwiindawo ezintathu: umphambili wamathanga akho, umva weengalo zakho ezingaphezulu, okanye isisu sakho.

I-Ajovy iza ngohlobo lwesirinji ekhethwe ngedosi enye. I-Ajovy inokunikezelwa ngenaliti enye ye-225 mg kanye ngenyanga. Ngenye indlela, inokunikwa njengezitofu ezintathu ze-675 mg ezilawulwa ngekota (kanye kwiinyanga ezintathu).

I-Aimovig iza ngohlobo lwe-autoinjector ekhethwe yidosi enye. Ihlala inikwa njenge-70-mg injection kanye ngenyanga. Kodwa i-140-mg yenyanga yethamo inokuba ngcono kwabanye abantu.

Iziphumo kunye neengozi

Umsebenzi ka-Ajovy kunye no-Aimovig ngeendlela ezifanayo kwaye ke oko kubangela iziphumo ebezingalindelekanga ezifanayo. Ikwabangela iziphumo ebezingalindelekanga ezahlukeneyo.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga eziqhelekileyo ezinokuthi zenzeke ngeAjovy, kunye neAimovig, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Inokwenzeka ngo-Ajovy:
  • akukho ziphumo ebezingalindelekanga eziqhelekileyo
• Ngaba kunokwenzeka ngeAimovig:
  • ukuqhina
  • izihlunu okanye izihlunu
  • usulelo oluphezulu lokuphefumla olufana nokubanda okuqhelekileyo okanye isifo sesono
  • Iimpawu ezinjengomkhuhlane
  • umqolo obuhlungu
• Inokwenzeka kunye neAjovy kunye neAimovig:
  • Ukuphendula kwendawo yenaliti njengentlungu, ukurhawuzelela, okanye ubomvu

Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ebezingalindelekanga eziphambili kwiAjovy kunye neAimovig kukungaziphathi kakuhle. Ukuphendula okunjalo akuqhelekanga, kodwa kunokwenzeka. (Ngolwazi oluthe kratya, jonga "Impendulo eyoyikisayo" kwicandelo "leziphumo ebezingalindelekanga ze-Ajovy" apha ngasentla).

Ukuphendula komzimba

Kuvavanyo lweklinikhi kuwo omabini la machiza, ipesenti encinci yabantu abanamava okuphendula komzimba. Le mpendulo yabangela ukuba imizimba yabo ivelise izilwa-buhlungu ezichasene neAjovy okanye iAimovig.

Ii-antibodies ziiproteni kumajoni omzimba ahlasela izinto zangaphandle emzimbeni wakho. Umzimba wakho unokwenza amajoni omzimba kuwo nawuphi na umcimbi wasemzini. Oku kubandakanya ii-antibodies ze-monoclonal. Ukuba umzimba wakho wenza ii-antibodies ku-Ajovy okanye i-Aimovig, amayeza anokungaphindi akusebenzele. Kodwa gcinani engqondweni ukuba ngenxa yokuba u-Ajovy no-Aimovig bavunywa ngo-2018, kusekutsha kakhulu ukuba sazi ukuba esi siphumo siqhele ukuba njani kwaye sinokuchaphazela njani indlela abantu abazisebenzisa ngayo ezi ziyobisi kwixa elizayo.

Ukusebenza ngempumelelo

La machiza awathelekiswa ngokuthe ngqo kuvavanyo lweklinikhi. Nangona kunjalo, izifundo zifumene iAjovy kunye neAimovig ukuba zisebenze ekukhuseleni zombini i-episodic kunye ne-chronic migraine headaches.

Ukongeza, izikhokelo zonyango lwe-migraine zicebisa ukuba ichiza linokukhetha kubantu abathile. Oku kubandakanya abantu abangakhange bakwazi ukunciphisa iintsuku zabo zenyanga ze-migraine ngokwaneleyo namanye amayeza. Babandakanya nabantu abangakwaziyo ukunyamezela amanye amayeza ngenxa yeziphumo ebezingalindelekanga okanye ukuhlangana kweziyobisi.

Iindleko

Iindleko zika-Ajovy okanye i-Aimovig zinokwahluka ngokuxhomekeke kwisicwangciso sonyango lwakho. Ukuthelekisa amaxabiso ala machiza, jonga iGoodRx.com. Elona xabiso uzakuhlawula ngalo naliphi na kula machiza liya kuxhomekeka kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Ajovy vs. Ubundlobongela

I-Ajovy iqulethe i-fremanezumab, eyi-anti-monoclonal antibody. Ubundlobongela buqulethe i-galcanezumab, ekwangumzimba omntu omnye. I-anti-monoclonal antibody luhlobo lweziyobisi ezenziwe kwiiseli zomzimba zomzimba. Imisa umsebenzi weeproteni ezithile emzimbeni wakho.

I-Ajovy kunye ne-Emgality zombini ziyekisa umsebenzi we-calcitonin enxulumene ne-peptide (CGRP). I-CGRP yiprotein emzimbeni wakho. Ibangela i-vasodilation (ukwandiswa kwemithambo yegazi) kunye nokudumba kwengqondo, okunokubangela iintlungu zentloko.

Ngokumisa i-CGRP ekusebenzeni, i-Ajovy kunye ne-Emgality zinceda ukuthintela i-vasodilation kunye nokudumba engqondweni. Oku kunokukunceda ukukhusela i-migraine intloko.

Sebenzisa

I-Ajovy kunye ne-Emgality zombini zivunyelwe yi-FDA ukuthintela iintloko zentloko kubantu abadala.

Iifom kunye nolawulo

I-Ajovy iza ngohlobo lwesirinji ekhethwe ngedosi enye. Ubundlobongela buza ngendlela yesirinji okanye ipeni.

Omabini la machiza atofelwe phantsi kolusu lwakho (ongama). Ungazitofa ngokwakho u-Ajovy kunye ne-Emgality ekhaya.

I-Ajovy inokuzitofela ngokwakho usebenzisa enye yeeshedyuli ezimbini ezahlukeneyo. Inokunikezelwa ngenaliti enye ye-225 mg kanye ngenyanga, okanye njengezitofu ezintathu ezahlukeneyo (iyonke eyi-675 mg) kube kanye kwiinyanga ezintathu. Ugqirha wakho uya kukhetha ishedyuli efanelekileyo.

Ukomelela kunikwa isitofu esinye se-120 mg, kube kanye ngenyanga. (Ithamo lenyanga yokuqala yidosi yenaliti ezimbini ezingama-240 mg.)

Zombini i-Ajovy kunye ne-Emgality zinokujova kwiindawo ezintathu ezinokubakho: umphambili wamathanga akho, umva weengalo zakho ezingaphezulu, okanye isisu sakho. Ukongeza, i-Emgality inokufakwa ngaphakathi kweempundu zakho.

Iziphumo kunye neengozi

I-Ajovy kunye ne-Emgality ngamachiza afanayo kwaye abangela iziphumo ezifanayo ezifanayo nezibi.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho nge-Ajovy, nge-Emgality, okanye ngamachiza omabini (xa ethathwe ngokwahlukeneyo).

• Inokwenzeka ngo-Ajovy:
  • akukho ziphumo ebezingalindelekanga eziqhelekileyo
• Inokwenzeka nge-Emgality:
  • umqolo obuhlungu
  • usulelo lweendlela zokuphefumla
  • umqala obuhkungu
  • usulelo lwesono
• Inokwenzeka nge-Ajovy kunye ne-Emgality:
  • Ukuphendula kwendawo yenaliti njengentlungu, ukuqaqamba, okanye ubomvu

Iziphumo ebezingalindelekanga ezimandundu

Ukusabela okungafunekiyo komzimba sisiphumo esibi esibi kwi-Ajovy kunye ne-Emgality. Akuqhelekanga ukufumana impendulo enjalo, kodwa kunokwenzeka. (Ngolwazi oluthe kratya, jonga "Impendulo eyoyikisayo" kwicandelo "leziphumo ebezingalindelekanga ze-Ajovy" apha ngasentla).

Ukuphendula komzimba

Kwizilingo ezahlukileyo zeklinikhi yamachiza i-Ajovy kunye ne-Emgality, ipesenti encinci yabantu ifumene ukuphendula komzimba. Ukuphendula komzimba wakho kubangele ukuba imizimba yabo yenze izilwa-buhlungu ezichasene neziyobisi.

Iintsholongwane ngamajoni omzimba ziiproteni ezihlasela into yangaphandle emzimbeni wakho. Umzimba wakho unokwenza ii-antibodies kuyo nayiphi na into yangaphandle. Oku kubandakanya ii-antibodies ze-monoclonal ezifana ne-Ajovy kunye ne-Emgality.

Ukuba umzimba wakho udala amajoni omzimba ku-Ajovy okanye kwi-Emgality, elo chiza alinakusebenzela wena.

Nangona kunjalo, kuselithuba kungekudala ukwazi ukuba inokwenzeka njani le nto inokwenzeka ngenxa yokuba i-Ajovy kunye ne-Emgality zivunyiwe kwi-2018. Kukwangoko ngokukhawuleza ukuba ingayichaphazela njani indlela abantu abawasebenzisa ngayo la mayeza mabini kwixesha elizayo.

Ukusebenza ngempumelelo

La machiza awathelekiswa ngokuthe ngqo kuvavanyo lweklinikhi. Nangona kunjalo, izifundo zifumene i-Ajovy kunye ne-Emgality ukuba zisebenze ekukhuseleni zombini i-episodic kunye ne-chronic migraine headaches.

Ukongeza, zombini i-Ajovy kunye ne-Emgality ziyacetyiswa zizikhokelo zonyango kubantu abangakwaziyo ukuthatha amanye amayeza ngenxa yeziphumo ebezingalindelekanga okanye ukuhlangana kweziyobisi. Ziyacetyiswa kwakhona kubantu abangakwaziyo ukunciphisa inani labo lokuqaqanjelwa yintloko rhoqo ngenyanga namanye amachiza.

Iindleko

Iindleko ze-Ajovy okanye ze-Emgality zinokwahluka ngokuxhomekeke kwisicwangciso sonyango. Ukuthelekisa amaxabiso ala machiza, jonga iGoodRx.com. Elona xabiso uzakuhlawula ngalo naliphi na kula machiza liya kuxhomekeka kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Ajovy vs.Botox

I-Ajovy iqulethe i-fremanezumab, eyi-anti-monoclonal antibody. I-anti-monoclonal antibody luhlobo lweziyobisi ezenziwe kwiiseli zomzimba zomzimba. U-Ajovy unceda ukukhusela i-migraine entloko ngokumisa umsebenzi weeproteni ezithile ezibangela ukuba uqaqanjelwe.

Esona sithako siphambili seBotox yi-onabotulinumtoxinA. Eli chiza liyinxalenye yeklasi yeziyobisi ezaziwa ngokuba zii-neurotoxins. IBotox isebenza ngokukhubaza okwethutyana izihlunu ekungenwe kuzo. Esi siphumo kwiimisipha sigcina imiqondiso yeentlungu ekubeni zitshintshiwe. Kucingelwa ukuba esi senzo sinceda ukukhusela iintlungu zentloko ngaphambi kokuba ziqale.

Sebenzisa

I-FDA ivume i-Ajovy ukuthintela isifo esinganyangekiyo okanye seepisodic migraine entloko kubantu abadala.

I-Botox ivunyiwe ukukhusela i-migraine engapheliyo kubantu abadala. IBotox ikwavunyiwe ukuba inyange iimeko ezininzi, kubandakanya:

• Ukuxhamla kwemisipha
• isinyi kakhulu
• ukubila okugqithisileyo
• Umlomo wesibeleko (intamo ejijekileyo)
• ukukhululeka kwenkophe

Iifom kunye nolawulo

U-Ajovy uza njengesirinji yedosi enye ekhethiweyo. Inikwa ngenaliti phantsi kolusu lwakho (subcutaneous) onokuzinika yona ekhaya, okanye umboneleli wezempilo akunike iofisi kagqirha wakho.

I-Ajovy inokunikwa kwenye yeeshedyuli ezimbini ezahlukeneyo: inaliti enye ye-225-mg kanye ngenyanga, okanye inaliti ezintathu ezahlukeneyo (zizonke ezingama-675 mg) kube kanye kwiinyanga ezintathu. Ugqirha wakho uya kukhetha ishedyuli efanelekileyo.

I-Ajovy inokufakwa kwiindawo ezintathu ezinokubakho: umphambili wamathanga akho, umva weengalo zakho ezingasentla, okanye isisu sakho.

I-Botox ikwanikwa njengesihlangu, kodwa ihlala inikwa kwiofisi kagqirha. Ingene kwi-muscle (intramuscular), ngokuqhelekileyo rhoqo kwiiveki ezili-12.

Iindawo apho iBotox ijojowe khona ibandakanya ibunzi lakho, ngasentla nasezindlebeni zakho, kufutshane neenwele zakho emazantsi entamo yakho, nasemva kwentamo namagxa akho. Kutyelelo ngalunye, ugqirha wakho uhlala ekunika inaliti ezincinci ezingama-31 kwezi ndawo.

Iziphumo kunye neengozi

I-Ajovy kunye neBotox zombini zisetyenziselwa ukuthintela iintloko zentloko, kodwa zisebenza ngeendlela ezahlukeneyo emzimbeni. Ke ngoko, baneziphumo ebezingalindelekanga ezifanayo, kwaye ezinye zahlukile.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngo-Ajovy, kunye neBotox, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Inokwenzeka ngo-Ajovy:
  • zimbalwa iziphumo ebezingalindelekanga eziqhelekileyo
• Ngaba kunokwenzeka ngeBotox:
  • Iimpawu ezinjengomkhuhlane
  • intloko ebuhlungu okanye ukuqaqanjelwa yintloko ebuhlungu
  • ijwabu leso
  • ukukhubazeka kwezihlunu zobuso
  • intlungu yentamo
  • ukuqina kwemisipha
  • iintlungu zemisipha kunye nobuthathaka
• Inokwenzeka kunye neAjovy kunye neBotox:
  • iimpendulo zesiza senaliti

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokuthi zenzeke nge-Ajovy, kunye ne-Xultophy, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Inokwenzeka ngo-Ajovy:
  • zimbalwa iziphumo ebezingalindelekanga ezimandundu
• Ngaba kunokwenzeka ngeBotox:
  • ukusasazeka kokukhubazeka kwimisipha ekufutshane
  • ingxaki yokuginya nokuphefumla
  • usulelo olubi
• Inokwenzeka kunye neAjovy kunye neBotox:
  • iimpendulo ezibi kakhulu

I-Botox inesilumkiso esibhokisi esivela kwi-FDA malunga nokusasazeka kokukhubazeka kwiimisipha ezikufuphi kulandela inaliti. Isilumkiso sebhokisi sisilumkiso esomeleleyo esifunwa yi-FDA. Yazisa oogqirha kunye nezigulana malunga neziphumo zeziyobisi ezinokuba yingozi.

Ukusebenza ngempumelelo

Iintlungu ezingapheliyo ze-migraine yimeko kuphela apho zombini i-Ajovy kunye neBotox zisetyenziselwa ukuthintela.

Izikhokelo zonyango zincoma u-Ajovy njengendlela enokwenzeka kubantu abangenako ukunciphisa inani labo le-migraine iintloko ngokwaneleyo kunye namanye amayeza. U-Ajovy ukwacetyiswa nabantu abangakwaziyo ukunyamezela ezinye iziyobisi ngenxa yeziphumo ebezingalindelekanga okanye ukuhlangana kweziyobisi.

I-American Academy ye-Neurology icebisa iBotox njengendlela yokonyango kubantu abaneentloko ezingapheliyo zentloko.

Izifundo zonyango azikathelekisi ngokuthe ngqo ukusebenza kweAjovy kunye neBotox. Kodwa izifundo ezahlukileyo zibonise zombini iAjovy kunye neBotox ukuba zisebenze ekuncedeni ukukhusela i-migraine engapheliyo.

Iindleko

Ixabiso lika-Ajovy okanye iBotox lingahluka ngokuxhomekeke kwisicwangciso sonyango. Ukuthelekisa amaxabiso ala machiza, jonga iGoodRx.com. Elona xabiso uzakuhlawula ngalo naliphi na kula machiza liya kuxhomekeka kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Iindleko zeAjovy

Njengawo onke amayeza, amaxabiso e-Ajovy ayahluka.

Ixabiso lakho liya kuxhomekeka kwi-inshurensi yakho, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Uncedo lwezezimali

Ukuba ufuna inkxaso yemali ukuhlawulela i-Ajovy, uncedo luyafumaneka.

I-Teva Pharmaceuticals, umenzi we-Ajovy, unesibonelelo sokonga esinokukunceda uhlawule kancinci i-Ajovy. Ngolwazi oluthe kratya kunye nokufumanisa ukuba uyafaneleka na, ndwendwela iwebhusayithi yenkqubo.

Umthamo we-Ajovy

Olu lwazi lulandelayo luchaza iidosi eziqhelekileyo ze-Ajovy. Nangona kunjalo, qiniseka ukuthatha idosi ekumisela ugqirha wakho. Ugqirha wakho uya kumisela eyona shedyuli ilungileyo.

Iifom zamachiza kunye namandla

U-Ajovy uza kwisirinji yethamo elinye eligcwalisiweyo. Isirinji nganye iqulethe i-225 mg ye-fremanezumab kwi-1.5 mL yesisombululo.

U-Ajovy unikezwa ngenaliti phantsi kolusu lwakho (ongama). Unokuzifaka ngokwakho iziyobisi ekhaya, okanye umboneleli wezempilo angakunika inaliti kwiofisi kagqirha wakho.

Umyinge wokuthintela intloko ebuhlungu

Zimbini iishedyuli zedosi ezicetyiswayo:

• inaliti enye engaphantsi kwama-225-mg inikwe inyanga nenyanga, okanye
• Iinaliti ezintathu ezinama-225-mg zangaphantsi ezinikezwe kunye (enye emva kwenye) kanye kwiinyanga ezintathu

Wena kunye nogqirha uya kugqiba ishedyuli efanelekileyo ye-dosing kuwe, ngokusekelwe kukhetho lwakho kunye nendlela yokuphila.

Kuthekani ukuba ndiphose idosi?

Ukuba uyalibala okanye uphose idosi, yenza idosi ngokukhawuleza nje ukuba ukhumbule.Emva koko, qhubeka kwakhona neshedyuli eqhelekileyo.

Umzekelo, ukuba ukwishedyuli yenyanga, cwangcisa idosi elandelayo kwiiveki ezine emva kwethamo lakho lokwenza. Ukuba ukwishedyuli yekota, lawula idosi elandelayo kwiiveki ezili-12 emva kwethamo lakho lokwenza.

Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?

Ukuba wena nogqirha ugqibe ukuba i-Ajovy ikhuselekile kwaye iyasebenza kuwe, ungasebenzisa ichiza ixesha elide ukuthintela iintlungu zentloko.

Ungamthatha njani u-Ajovy

I-Ajovy yinaliti enikezelwa phantsi kwesikhumba (sangaphantsi) kanye ngenyanga okanye kanye kwiinyanga ezintathu. Unokuziqhuba ngokwakho inaliti ekhaya, okanye umboneleli wezempilo akunike inaliti kwiofisi kagqirha wakho. Ukuqala kwakho ukufumana iyeza lika-Ajovy, umboneleli wakho wezempilo unokuchaza ukuba ungalitofa njani iyeza ngokwakho.

I-Ajovy iza njengethamo elinye, i-225-mg yesirinji ekhethiweyo. Isirinji nganye inedosi enye kuphela kwaye isetyenziselwa ukuba isetyenziswe kube kanye emva koko ilahlwe.

Apha ngezantsi kunolwazi ngendlela yokusebenzisa isirinji ekhethiweyo. Ngolunye ulwazi, ividiyo, kunye nemifanekiso yemiyalelo yenaliti, jonga iwebhusayithi yomenzi.

Ungayifaka njani inaliti

Ugqirha wakho uya kukumisela i-225 mg kanye ngenyanga, okanye i-675 mg kanye kwiinyanga ezintathu (ngekota). Ukuba umiselwe i-225 mg ngenyanga, uya kuzinika inaliti enye. Ukuba umiselwe i-675 mg ngekota, uya kuzinika inaliti ezintathu ezahlukeneyo enye emva kwenye.

Ukulungiselela ukujova

• Imizuzu engamashumi amathathu ngaphambi kokuba utofe iyeza, susa isirinji efrijini. Oku kuvumela ichiza ukuba lifudumale kwaye lize kubushushu begumbi. Gcina ikepusi kwisirinji de ube ukulungele ukusebenzisa isirinji. (I-Ajovy inokugcinwa kubushushu begumbi ukuya kuthi ga kwiiyure ezingama-24. Ukuba iAjovy igcinwe ngaphandle kwefriji kangangeeyure ezingama-24 ingasetyenziswanga, sukuyibuyisela kwifriji. Yilahle kwisitya sakho esibukhali.)
• Ungazami ukufudumeza isirinji ngokukhawuleza ngokuyihambisa ngemicrowave okanye ngokuhambisa amanzi ashushu ngaphezulu kwayo. Kwakhona, sukuyigungqisa isirinji. Ukwenza ezi zinto kunokwenza u-Ajovy akhuseleke kwaye asebenze.
• Xa ukhupha isirinji kwipakethe yayo, qiniseka ukuyikhusela ekukhanyeni.
• Ngelixa ulinde isirinji ukuba ifudumale ukuya kubushushu begumbi, fumana i-gauze okanye ibhola yomqhaphu, ukosula utywala, kunye nesikhongozeli sakho sokulahla. Qiniseka ukuba unenani elichanekileyo lesirinji yethamo lakho elimiselweyo.
• Jonga isirinji ukuqinisekisa ukuba ichiza alinamafu okanye liphelelwe lixesha. Umbane kufuneka ucace tyheli kancinane. Kulungile ukuba kukho amaqamza. Kodwa ukuba ulwelo lutshintshiwe okanye lusibekele, okanye ukuba kukho iziqwenga ezincinci eziqinileyo kulo, musa ukulusebenzisa. Kwaye ukuba kukho nakuphi na ukuqhekeka okanye ukuvuza kwisirinji, ungayisebenzisi. Ukuba kufuneka, nxibelelana nogqirha wakho malunga nokufumana entsha.
• Sebenzisa isepha namanzi ukuhlamba izandla, emva koko ukhethe indawo yenaliti yakho. Unokujova phantsi kolusu lwakho kwezi ndawo zintathu:
• umphambili wamathanga akho (ubuncinci iisentimitha ezimbini ngaphezulu kwedolo lakho okanye ii-intshi ezimbini ezantsi kwe-groin yakho)
• umva weengalo zakho ezingasentla
• isisu sakho (ubuncinci ii-intshi ezimbini kude nesisu sakho)
• Ukuba ufuna ukujova iyeza ngasemva kwengalo yakho, umntu othile unokufuna ukuba akufake iyeza.
• Sebenzisa ukosula utywala ukucoca indawo yenaliti oyikhethileyo. Qiniseka ukuba utywala bume ngokupheleleyo ngaphambi kokuba utofe ichiza.
• Ukuba uzifaka inaliti ezintathu, ungaziniki nayiphi na inaliti kwindawo enye. Ungaze utofe kwiindawo ezinemigruzuko, ebomvu, enezikrelemnqa, enamathambo, okanye ekunzima ukuyichukumisa.

Inaliti ye-Ajovy isirinji ekhethiweyo

1. Thatha ikepusi yenaliti kwisirinji uyilahle emgqomeni.
2. Cofa ngobunono ubuncinci i-intshi enye yolusu onqwenela ukulufaka.
3. Faka inaliti kulusu olukhanyiweyo kwi-angle ye-45 ukuya kwi-90 degrees.
4. Nje ukuba inaliti ifakwe ngokupheleleyo, sebenzisa ubhontsi wakho ukutyhala kancinci iplunger kude kuye kufika apho iya khona.
5. Emva kokufaka i-Ajovy, tsala inaliti ngqo ngaphandle kwesikhumba kwaye ukhulule ulusu. Ukuphepha ukuzincamathela, musa ukuphinda uyiphinde inaliti.
6. Cinezela ngobunono ibhola yomqhaphu okanye igalikhi kwindawo yenaliti imizuzwana embalwa. Musa ukurabha indawo.
7. Phosa isirinji esetyenzisiweyo kunye nenaliti kwisitya sakho sokulahla izixhobo ngokukhawuleza.

Ixesha

U-Ajovy kufuneka athathwe kube kanye ngenyanga okanye kube kanye kwiinyanga ezintathu (ngekota), kuxhomekeke kwinto ekuyalelwa ngugqirha. Ingathathwa nanini na emini.

Ukuba uphosa idosi, thatha iAjovy ngokukhawuleza nje ukuba ukhumbule. Idosi elandelayo kufuneka ibe yinyanga enye okanye iinyanga ezintathu emva kokuba uyithathile, kuxhomekeke kwishedyuli yethosi ekhuthazwayo. Isixhobo sokukhumbuza amayeza sinokukunceda ukhumbule ukuthatha iAjovy kwishedyuli.

Ukuthatha iAjovy ngokutya

I-Ajovy ingathathwa kunye okanye ngaphandle kokutya.

Isebenza njani iAjovy

U-Ajovy yintsholongwane yomntu omnye. Olu hlobo lwechiza yiprotein yomzimba yokuzikhusela eyenziwe elebhu. U-Ajovy usebenza ngokuphelisa umsebenzi weprotein ebizwa ngokuba yi-calcitonin enxulumene ne-peptide (CGRP). I-CGRP ibandakanyeka kwi-vasodilation (ukwandiswa kwemithambo yegazi) kunye nokudumba kwingqondo yakho.

I-CGRP ikholelwa ukuba idlala indima ephambili ekubangeleni iintloko zentloko. Ngapha koko, xa abantu beqala ukufumana intloko ebuhlungu, banamanqanaba aphezulu e-CGRP kwigazi labo. U-Ajovy unceda ukugcina intloko ebuhlungu be-migraine ukuqala ngokumisa umsebenzi we-CGRP.

Uninzi lwamayeza ekujolise kuwo (yenza) kwiikhemikhali ezininzi okanye kwiindawo zeeseli emzimbeni wakho. Kodwa i-Ajovy kunye nezinye ii-antibodies ze-monoclonal zijolise kuphela kwinto enye emzimbeni. Ngenxa yoko, kunokubakho ukuhlangana okuncinci kweziyobisi kunye neziphumo ebezingalindelekanga ku-Ajovy. Oku kunokukwenza ukhetho olufanelekileyo kubantu abangakwaziyo ukuthatha ezinye iziyobisi ngenxa yeziphumo ebezingalindelekanga okanye ukuhlangana kweziyobisi.

I-Ajovy isenokuba lukhetho olufanelekileyo kubantu abaye bazama ezinye iziyobisi, kodwa amayeza akenzanga ngokwaneleyo ukunciphisa inani labo leentsuku ze-migraine.

Kuthatha ixesha elingakanani ukusebenza?

Kungathatha iiveki ezimbalwa ngalo naluphi na utshintsho lwe-migraine olwenziwe ngu-Ajovy ukuba lubonakale. Kwaye kungathatha iinyanga ezininzi ukuze u-Ajovy asebenze ngokupheleleyo.

Iziphumo zovavanyo lweklinikhi zibonise ukuba abantu abaninzi abathathe i-Ajovy banamava eentsuku ezimbalwa zemigraine kwinyanga enye yokuthatha idosi yabo yokuqala. Ngaphezulu kweenyanga ezininzi, inani leentsuku ze-migraine liyaqhubeka ukwehla kubantu abakwisifundo.

Ajovy kunye notywala

Akukho nxibelelwano phakathi kwe-Ajovy kunye notywala.

Nangona kunjalo, kwabanye abantu, ukusela utywala ngelixa uthatha i-Ajovy kunokubonakala ngathi kwenza ukuba ichiza lingasebenzi kakuhle. Kungenxa yokuba utywala yinto ebangela ukuba abantu abaninzi babe nemagraine, kwaye neqondo elincinci lotywala linokubangela ukuba baqaqanjelwe yintloko.

Ukuba ufumanisa ukuba utywala bubangela iintlungu ezibuhlungu okanye iintlungu rhoqo, kufuneka uphephe iziselo ezinotywala.

Unxibelelwano ngoAjovy

U-Ajovy akabonakaliswanga ukuba unxibelelana namanye amayeza. Nangona kunjalo, kusabalulekile ukuba uthethe nogqirha wakho okanye usokhemesti ngayo nayiphi na imishanguzo kagqirha, iivithamini, izongezo, kunye namayeza owathengayo ngaphambi kokuba uqale iAjovy.

Ajovy kunye nokukhulelwa

Ayaziwa ukuba i-Ajovy ikhuselekile ukusebenzisa ngexesha lokukhulelwa. Xa u-Ajovy wanikwa abantu ababhinqileyo abakhulelweyo kwizifundo zezilwanyana, akukho bungozi baboniswa ukukhulelwa. Kodwa iziphumo zezifundo zezilwanyana azisoloko ziqikelela ukuba ichiza linokubachaphazela njani abantu.

Ukuba ukhulelwe okanye ucinga ngokukhulelwa, thetha nogqirha wakho. Banganceda ukufumanisa ukuba ngaba iAjovy lukhetho olufanelekileyo kuwe. Kuya kufuneka ulinde ukusebenzisa i-Ajovy de ungabe ukhulelwe.

Ajovy kunye nokuncancisa

Ayaziwa nokuba i-Ajovy iyadlula kubisi lomntu lwebele. Ke ngoko, akucaci nokuba ngaba i-Ajovy ikhuselekile ukuyisebenzisa ngelixa uncancisa.

Ukuba ucinga ngokuba nonyango lwe-Ajovy ngelixa uncancisa, thetha nogqirha wakho malunga nezibonelelo ezinokubakho kunye nemingcipheko. Ukuba uqala ukuthatha iAjovy, kuya kufuneka uyeke ukuncancisa.

Imibuzo eqhelekileyo malunga no-Ajovy

Nazi iimpendulo kwimibuzo ebuzwa rhoqo malunga no-Ajovy.

Ngaba iAjovy ingasetyenziselwa ukunyanga intloko ebuhlungu?

Hayi, iAjovy ayilonyango lweentloko zentloko. U-Ajovy unceda ukuthintela iintlungu zentloko ngaphambi kokuba ziqale.

Wahluke njani u-Ajovy kwezinye iziyobisi ze-migraine?

I-Ajovy yahlukile kuninzi lwamanye amachiza e-migraine kuba yenye yeyeza zokuqala ezenzelwe ukunceda ukuthintela iintlungu zentloko. I-Ajovy yinxalenye yodidi olutsha lwamachiza abizwa ngokuba yi-calcitonin enxulumene nopept peptide (CGRP) antagonists.

Uninzi lwamanye amayeza asetyenziselwa ukuthintela iintlungu zentloko zenzelwe iinjongo ezahlukeneyo, njengokunyanga ukuxhuzula, uxinzelelo, okanye uxinzelelo lwegazi. Uninzi lwezi ziyobisi zisetyenziselwa ngaphandle kwelebheli ukunceda ukuthintela iintlungu zentloko.

I-Ajovy ikwahlukile kuninzi lwamanye amayeza e-migraine kuba itofelwe kanye ngenyanga okanye kanye kwiinyanga ezintathu. Uninzi lwamanye amayeza asetyenziselwa ukuthintela iintlungu zentloko ziza njengethebhulethi ekufuneka uzithathe kube kanye ngosuku.

Elinye iyeza elineziyobisi yiBotox. IBotox nayo inaliti, kodwa uyifumana kube kanye kwiinyanga ezintathu kwiofisi kagqirha wakho. Unokuzifaka ngokwakho u-Ajovy ekhaya okanye umboneleli wezempilo akunike inaliti kwiofisi kagqirha wakho.

Kwakhona, iAjovy yi-monoclonal antibody, eluhlobo lwesiyobisi esenziwe kwiiseli zomzimba. Isibindi asiwaphuli la machiza, njengoko esenza njalo kwezinye iziyobisi ezisetyenziselwa ukuthintela iintlungu zentloko. Oku kuthetha ukuba i-Ajovy kunye nezinye ii-antibodies ze-monoclonal zinonxibelelwano oluncinci lweziyobisi kunamanye amayeza anceda ukuthintela iintlungu zentloko.

Ngaba iAjovy iyayinyanga intloko ebuhlungu?

Hayi, u-Ajovy akancedi ekunyangeni intloko ebuhlungu. Okwangoku, akukho ziyobisi zikhoyo ezinokunyanga iintlungu zentloko. Amachiza e-migraine akhoyo anokunceda ukunqanda okanye ukunyanga iintlungu zentloko.

Ukuba ndithatha iAjovy, ndingayeka ukuthatha amanye amayeza am okuthintela?

Oko kuxhomekeke. Impendulo yomntu wonke ku-Ajovy yahlukile. Ukuba ichiza linciphisa inani leentloko zakho zentloko ukuya kwinqanaba elinokulawulwa, kunokwenzeka ukuba ube nakho ukuyeka ukusebenzisa amanye amayeza othintelo. Kodwa xa uqala ukuthatha iAjovy, ugqirha wakho uya kuthi akunike kunye namanye amachiza othintelo.

Isifundo sonyango sifumanise ukuba i-Ajovy ikhuselekile kwaye iyasebenza ekusebenziseni namanye amayeza othintelo. Amanye amayeza anokukuyalela ugqirha wakho nge-Ajovy aquka i-topiramate (Topamax), ipropranolol (Inderal), kunye ne-anti-depressants ezithile. I-Ajovy inokusetyenziswa kwi-onabotulinumtoxinA (Botox).

Emva kokuba uzame i-Ajovy kangangeenyanga ezimbini ukuya kwezintathu, ugqirha wakho uya kuthetha nawe ukuze abone ukuba ichiza lisebenza njani kuwe. Ngelo xesha, nina nobabini ninokuthatha isigqibo sokuba niyeke ukuthatha amanye amayeza othintelo, okanye ukuba ninciphise idosi yamachiza.

Ukugqithisa iAjovy

Ukutofa idosi ezininzi ze-Ajovy kunokunyusa umngcipheko wokuphendula kwendawo yenaliti. Ukuba u-aleji okanye u-hypersensitive ku-Ajovy, unokuba semngciphekweni wokuphendula nzulu.

Iimpawu libanda

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• Intlungu ebuhlungu, ukurhawuzelela, okanye ubomvu kwindawo ekufuphi nenaliti
• ukugungxula
• urhwebo
• i-angioedema (ukudumba phantsi kolusu)
• ukudumba kolwimi, umqala, okanye umlomo
• ingxaki yokuphefumla

Kufuneka wenze ntoni xa uthe wagqithisa?

Ukuba ucinga ukuba uthathe kakhulu eli chiza, biza ugqirha wakho okanye ufune isikhokelo kuMbutho waseMelika wamaZiko oLawulo lweTyhefu e800-222-1222 okanye ngesixhobo sabo se-Intanethi. Kodwa ukuba iimpawu zakho zinzima, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko.

Izilumkiso zika-Ajovy

Ngaphambi kokuba uthathe u-Ajovy, thetha nogqirha wakho malunga nembali yakho yezempilo. Akufuneki uthathe i-Ajovy ukuba unembali yempembelelo ye-hypersensitivity ku-Ajovy okanye nasiphi na isithako sayo. Impendulo enzulu ye-hypersensitivity inokubangela iimpawu ezinje:

• irhashalala
• ukucheba
• ingxaki yokuphefumla
• i-angioedema (ukudumba phantsi kolusu)
• ukudumba kolwimi, umlomo nomqala

Ukuphelelwa nguAjovy

Xa u-Ajovy ekhutshwa kwikhemesti, usokhemesti uya kongeza umhla wokuphelelwa kwileyibhile kwisitya. Lo mhla uqhele ukuba ngunyaka omnye ukusukela kumhla wokukhutshwa kwamayeza.

Injongo yale mihla yokuphelelwa lixesha kukuqinisekisa ukusebenza kweyeza ngeli xesha. Isimo sangoku soLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) kukuphepha ukusebenzisa amayeza aphelelwe lixesha.

Kuhlala ixesha elingakanani iyeza lihlala lilungile kunokuxhomekeka kwizinto ezininzi, kubandakanya nokuba ligcinwa njani kwaye liphi iyeza.

Iisirinji zeAjovy kufuneka zigcinwe kwisikhenkcisi esikwisikhongozeli sokuqala ukuzikhusela ekukhanyeni. Zingagcinwa ngokukhuselekileyo kwifriji ukuya kwiinyanga ezingama-24, okanye kude kube lixesha lokuphela kwexesha elidweliswe kwisitya. Nje ukuba ukhutshwe kwifriji, isirinji nganye kufuneka isetyenziswe ngaphakathi kweeyure ezingama-24.

Ukuba awusebenzisanga iyeza elidlulileyo kumhla wokuphelelwa kwalo, thetha nosokhemesti wakho malunga nokuba unganako na ukuyisebenzisa.

Iphepha elichazayo ukuba awusenanto oyifunayo:Iindaba Zonyango Namhlanje wenze yonke imizamo yokuqinisekisa ukuba yonke ingcaciso ichanekile, ibanzi kwaye ihlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi. Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.