Yintoni iVogt-Koyanagi-Harada syndrome

Umxholo

• Yintoni ebangela
• Iimpawu ezinokwenzeka
• Unyango lwenziwa njani

IVogt-Koyanagi-Harada Syndrome sisifo esinqabileyo esichaphazela izicwili eziqukethe ii-melanocytes, ezinje ngamehlo, inkqubo ye-nervous system, indlebe kunye nolusu, ezibangela ukudumba kwi-retina yamehlo, zihlala zinxulunyaniswa neengxaki zesikhumba kunye nokuva.

Esi sifo senzeka ikakhulu kubantu abadala abakwiminyaka engama-20 ukuya kwengama-40, kwaye abasetyhini bachaphazeleka kakhulu. Unyango lubandakanya ukulawulwa kwe-corticosteroids kunye nee-immunomodulators.

Yintoni ebangela

Isizathu sesi sifo asikaziwa, kodwa kukholelwa ukuba sisifo somzimba, apho kukho ubundlobongela kumphezulu wee-melanocyte, ezikhuthaza ukusabela okukruthayo kunye nokuqaqamba kwee-lymphocyte T.

Iimpawu ezinokwenzeka

Iimpawu zesi sifo zixhomekeke kwinqanaba okulo:

Inqanaba leprodromal

Kule nqanaba, iimpawu zenkqubo efanayo neempawu ezinjengomkhuhlane ziyavela, zihamba kunye neempawu zemithambo-luvo ezihlala iintsuku ezimbalwa kuphela. Ezona mpawu zixhaphakileyo ngumkhuhlane, intloko ebuhlungu, meningism, isicaphucaphu, isiyezi, iintlungu ezibheke ngamehlo, i-tinnitus, ukuba buthathaka kwezihlunu ngokubanzi, ukukhubazeka okukodwa kwelinye icala lomzimba, ubunzima bokuchaza amagama ngokuchanekileyo okanye ukuqonda ulwimi, i-photophobia, ukukrazula, ulusu kunye nentloko hypersensitivity.

Inqanaba lesifo

Kule nqanaba, ukubonakaliswa kwe-ocular kubonakala phambili, njengokuvuvukala kwe-retina, ukunciphisa umbono kunye nokugqitywa kwe-retina. Abanye abantu banokufumana iimpawu zokuvalelwa njenge-tinnitus, iintlungu kunye nokuphazamiseka ezindlebeni.

Isigaba esingapheliyo

Kweli nqanaba, iimpawu ze-ocular kunye ne-dermatological, ezinje nge-vitiligo, ukumiswa kweenkophe, amashiya anokuhlala kwiinyanga ukuya kwiminyaka. IVitiligo ithambekele ekuhanjisweni ngokulinganayo ngaphezulu kwentloko, ubuso kunye nesiqu, kwaye inokuhlala isigxina.

Inqanaba lokuphindaphinda

Okwangoku abantu banokuphucula ukudumba okungapheliyo kwiretina, cataract, glaucoma, choroidal neovascularization kunye ne-subretinal fibrosis.

Unyango lwenziwa njani

Unyango lubandakanya ukulawulwa kweedosi eziphezulu ze-corticosteroids ezinje nge-prednisone okanye i-prednisolone, ngakumbi kwisigaba esibuhlungu sesi sifo, ubuncinci iinyanga ezi-6. Olu nyango lunokubangela ukuxhathisa kunye nokungasebenzi kwesibindi kwaye kwezi meko kunokwenzeka ukuba ukhethe ukusetyenziswa kwe-betamethasone okanye i-dexamethasone.

Kubantu ekusenokwenzeka ukuba iziphumo ebezingalindelekanga ze-corticosteroids zisebenzise iidosi ezisebenzayo ezinqabileyo, ii-immunomodulators ezinje ngecyclosporine A, methotrexate, azathioprine, tacrolimus okanye adalimumab ezinokusetyenziswa neziphumo ezilungileyo.

Kwiimeko zokuchasana ne-corticosteroids kunye nabantu abangayiphenduliyo kunyango lwe-immunomodulatory, i-immunoglobulin efakwa ngaphakathi ingasetyenziswa.