I-Angiokeratoma

Umxholo

• Zeziphi iintlobo ezahlukeneyo?
• Ziintoni iimpawu?
• Yintoni ebangela i-angiokeratoma?
• I-angiokeratoma ichongwa njani?
• Inyangwa njani?
• Yintoni imbonakalo yabantu abane-angiokeratoma?

Yintoni iAngokeroker?

I-Angiokeratoma yimeko apho amachaphaza amnyama, amnyama avela kulusu. Banokubonakala naphina emzimbeni wakho. Ezi zilonda zenzeka xa imithambo yegazi emincinci ekuthiwa yi-capillaries iyavuleka, okanye yande, kufutshane nomphezulu wolusu lwakho.

Ii-angiokeratomas zinokuziva zimbi ngakwicingo. Zivame ukuvela ngokwamaqela esiqwini:

• Ilungu lobudoda
• Isikram
• lobufazi
• ilebhu majora

Bangaphazanyiswa kukuqunjelwa, umhlaza wolusu, okanye imeko efana neentsumpa zokuzala okanye iherpes. Uninzi lwexesha, ii-angiokeratomas azinabungozi kwaye azidingi kunyangwa.

I-Angiokeratomas ngamanye amaxesha inokuba luphawu lweemeko ezisisiseko, ezinje ngesifo esingaqhelekanga semfuza esaziwa njengeFabry isifo (FD). Kuya kufuneka ubonane nonyango ukuze uthintele iingxaki.

Zeziphi iintlobo ezahlukeneyo?

Iindidi ze-angiokeratoma zibandakanya:

• I-angiokeratoma yodwa. Ezi zihlala zibonakala zodwa. Zifumaneka rhoqo kwiingalo nasemilenzeni yakho. Azinabungozi.
• I-Angiokeratoma yeFordyce. Oku kubonakala kulusu lwe-scrotum okanye i-vulva. Ngokuqhelekileyo zifumaneka kwi-scrotum kumaqoqo amakhulu. Olu hlobo lunokukhula kwilungu lobufazi labasetyhini abakhulelweyo. Azinabungozi, kodwa ziyathanda ukopha ukuba zikrwitshiwe.
• I-Angiokeratoma yeMibelli. Ezi ziphumo ezivela kwimithambo yegazi ehlanjululweyo esondele kakhulu kwi-epidermis, okanye uluhlu oluphezulu lwesikhumba sakho. Azinabungozi. Olu hlobo ludla ngokuqina kwaye lukhuni ekuhambeni kwexesha kwinkqubo eyaziwa ngokuba yi-hyperkeratosis.
• I-Angiokeratoma circumscriptum. Le yeyona fomu inqabileyo ebonakala ngokwamaqela kwimilenze yakho okanye kwisisu somzimba. Unokuzalwa ngolu hlobo. Ityekele ekubonakaleni ngokuhamba kwexesha, iba mnyama okanye ithathe iimilo ezahlukeneyo.
• I-Angiokeratoma corporis diffusum. Olu hlobo luphawu lwe-FD. Kungenzeka nangenye ingxaki ye-lysosomal, echaphazela indlela iiseli ezisebenza ngayo. Ezi meko zinqabile kwaye zinezinye iimpawu ezibonakalayo, njengokutsha kwezandla kunye neenyawo okanye iingxaki zombono. Ezi angiokeratomas zixhaphake kakhulu kumzimba ongezantsi. Banokubonakala naphina ukusuka ezantsi kwethumbu lakho ukuya emathangeni akho aphezulu.

Ziintoni iimpawu?

Ubume ngqo, ubungakanani, kunye nombala ziyahluka. Unokuba neempawu ezongezelelweyo ukuba unemeko ehambelana nayo, njenge-FD.

Ngokubanzi, ii-angiokeratomas zibonisa ezi mpawu zilandelayo:

• zibonakala njengamaqhuma amancinci ukuya kwaphakathi ukusuka kwi-1 millimeter (mm) ukuya kwi-5 mm okanye kwiijagged, iipateni ezinje ngentsumpa
• ndinobume obufana nedome
• uzive ungqindilili okanye ulukhuni umphezulu
• zibonise zodwa okanye ngokwamaqela nje ambalwa ukuya phantse kwikhulu
• zinombala omnyama, kubandakanya obomvu, bhlowu, bumfusa, okanye mnyama

Ii-Angiokeratomas ezivele zavela ukuba bomvu ngombala. Amabala ebeseluswini lwakho okwethutyana ahlala emnyama.

Ii-Angiokeratomas kwi-scrotum zinokubonakala kunye nobomvu kwindawo enkulu yesikram. I-Angiokeratomas kwi-scrotum okanye i-vulva inokuphaphaza ngokulula xa ikrwelwe kunaleyo kwamanye amalungu omzimba wakho.

Ukuba unemeko efana ne-FD ebangela ukuba i-angiokeratomas ivele, ezinye iimpawu onokufumana zona zibandakanya:

• i-acroparesthesias, okanye iintlungu ezandleni nasezinyaweni
• i-tinnitus, okanye isandi sokukhala ezindlebeni zakho
• ukukhanya kwe-corneal, okanye ukukhanya kwelifu kumbono wakho
• hypohidrosis, okanye ukungabi nokubila ngokufanelekileyo
• iintlungu esiswini kunye namathumbu
• ukuziva unomdla wokuzikhupha emva kokutya

Yintoni ebangela i-angiokeratoma?

Ii-angiokeratomas zibangelwa kukunaba kwemithambo yegazi kufutshane nomphezulu wolusu. Ii-angiokeratomas zodwa kusenokwenzeka ukuba zibangelwe kukonzakala okwakhe kwenzeka kwindawo ababonakala kuyo.

I-FD idluliselwa ezintsatsheni, kwaye inokubangela ii-angiokeratomas. Malunga ne-1 kuwo onke ama-40,000 ukuya kuma-60,000 amadoda ane-FD, ngokweSebe leLizwe lezeMpilo laseMelika laseMelika.

Ngaphandle kokudibana kwabo ne-FD kunye nezinye iimeko ze-lysosomal, akusoloko kucacile ukuba yintoni unobangela we-angiokeratomas. Izizathu ezinokubakho zibandakanya:

• uxinzelelo lwegazi, okanye uxinzelelo lwegazi oluphezulu kwimithambo ecaleni kwesikhumba
• ukuba imeko echaphazela imithambo yegazi yendawo, enje nge-inguinal hernia, i-hemorrhoids, okanye i-varicocele (xa imithambo isanda kwi-scrotum)

I-angiokeratoma ichongwa njani?

Ii-angiokeratomas zihlala zingenabungozi. Akusoloko ufuna ukubona ugqirha ukuze afumane isifo.

Kodwa ukuba uqaphela ezinye iimpawu, njengokuphuma rhoqo kwegazi okanye iimpawu ze-FD, jonga ugqirha wakho kwangoko ukuze ufumane isifo kunye nonyango. Unokufuna kwakhona ukubona ugqirha wakho ukuba ukrokrela ukuba indawo ekhangeleka ngathi yi-angiokeratoma inokuba ngumhlaza.

Ugqirha wakho uya kuthatha isampulu yeethishu ye-angiokeratoma ukuyifumanisa. Oku kwaziwa njenge-biopsy. Ngexesha lale nkqubo, ugqirha wakho unokususa, okanye asike, i-angiokeratoma kulusu lwakho ukuze uyisuse ukuze ihlolwe. Oku kunokubandakanya ugqirha wakho usebenzisa i-scalpel ukususa i-angiokeratoma kwisiseko sayo phantsi kolusu.

Ugqirha wakho unokucebisa uvavanyo lwe-GLA yemfuza ukubona ukuba unayo i-FD. I-FD ibangelwa lutshintsho kule geni.

Inyangwa njani?

I-Angiokeratomas ngokubanzi ayidingi kunyangwa ukuba awufumani kungahambi kakuhle okanye iintlungu. Unokufuna ukuba zisuswe ukuba zihlala zisopha okanye ngenxa yezizathu zokuthambisa. Kule meko, iindlela ezininzi zonyango ziyafumaneka:

• Ukuchongwa kombane kunye nonyango (ED & C). Ugqirha wakho uphazamisa indawo ejikeleze ii-angiokeratomas nge-anesthesia yendawo, emva koko usebenzisa i-cautery yombane kunye nezixhobo zokutshiza amabala kunye nokususa izicubu.
• Ukususwa kweLaser. Ugqirha wakho usebenzisa ii-lasers, ezinje nge-laser edayiweyo yedayi, ukutshabalalisa imithambo yegazi eyandisiweyo ebangela ii-angiokeratomas.
• ICryotherapy. Ugqirha wakho umisa ii-angiokeratomas kunye nezicubu ezijikelezileyo kwaye uzisuse.

Unyango lwe-FD lunokubandakanya amayeza, anje ngala:

• I-Agalsidase beta (Fabrazyme). Uya kufumana inaliti yesiqhelo yeFabrazyme ukunceda umzimba wakho ekwaphuleni amanqatha eseli akhelwe ngenxa yokulahleka kwe-enzyme ebangelwe kukutshintsha kwemfuza kwe-GLA.
• Neurontin (Gabapentin) okanye carbamazepine (Tegretol). La mayeza anokunyanga iintlungu zezandla neenyawo.

Ugqirha wakho unokucetyiswa ukuba ubone iingcali zentliziyo, izintso, okanye iimpawu zesifo se-FD, nazo.

Yintoni imbonakalo yabantu abane-angiokeratoma?

Ii-angiokeratomas azihlali zibangela inkxalabo. Yiya kugqirha wakho ukuba uphawula ukopha okanye ukwenzakala kwii-angiokeratomas, okanye ukuba ukrokrela ukuba kukho imeko engunobangela wokungonwabi okanye iintlungu.