Isikhokelo sakho kwi-Anti-Androgens

Umxholo

• Zisetyenziswa njani?
• Kubafazi
• Abafazi be-transgender kunye nabantu abangabhinqiyo
• Eyamadoda
• Zeziphi ezinye eziqhelekileyo?
• IFlutamide
• I-Spironolactone
• ICyproterone
• Zithini iziphumo ebezingalindelekanga?
• Umgca wezantsi

Yintoni i-anti-androgens?

I-Androgens zihomoni ezilawula ukukhula kweempawu zesondo. Ngokwesiqhelo, abantu abazalwa benempawu zesini samadoda banamanqanaba aphezulu e-androgens. Abantu abazalwe benempawu zabasetyhini banamanqanaba asezantsi e-androgens. Endaweni yoko, banamanqanaba aphezulu e-estrogens.

Amachiza e-anti-androgen asebenza ngokuthintela iziphumo ze-androgens, ezinje nge testosterone. Benza oku ngokuzibophelela kwiiproteni ezibizwa ngokuba yi-androgen receptors. Zibopha ezi receptors ukuze ii-androgens zingakwazi.

Kukho iintlobo ezininzi ze-anti-androgens. Zihlala zithathwa kunye namanye amayeza okanye ngexesha leenkqubo ezithile zotyando.

Zisetyenziswa njani?

I-anti-androgens inokusetyenziswa okuninzi, ukusuka ekulawuleni umhlaza wedlala lobudoda ukunciphisa ukunciphisa iinwele zobuso ezingafunekiyo.

Kubafazi

Bonke abantu basetyhini ngokwendalo bavelisa inani elincinci le-androgens. Nangona kunjalo, abanye abantu basetyhini bavelisa ngaphezulu kunabanye.

Umzekelo, abasetyhini abane-polycystic ovary syndrome (i-PCOS) banamanqanaba aphezulu e-androgen. Oku kunokubangela ukukhula okungaphezulu kweenwele, amabala, kunye neengxaki ze-ovulation. I-anti-androgens inokunceda ukunciphisa ezi zimpawu kubafazi abane-PCOS.

Ezinye iimeko ezibangela amanqanaba aphezulu e-androgens kwabasetyhini kubandakanya:

• iadrenal hyperplasia
• amathumba ovari
• amathumba adrenal

I-anti-androgens inokunceda ukulawula ezi meko kunye nokuthintela iingxaki ezibangelwa ngamanqanaba aphezulu e-androgen kwabasetyhini. Ezi ngxaki zibandakanya:

• isifo seswekile
• cholesterol ephezulu
• igazi elonyukayo
• isifo sentliziyo

Abafazi be-transgender kunye nabantu abangabhinqiyo

Kubantu abaguqukayo, ii-anti-androgens zinokunceda ekuthinteleni ezinye zeempawu zobudoda ze testosterone. Banokunciphisa ezinye iimpawu zobudoda, ezinje:

• impandla eyindoda
• ukukhula kweenwele ebusweni
• ukulungiswa kwasekuseni

Ama-anti-androgens asebenza kakhulu kubafazi be-transgender xa bethathwe nge-estrogen, eyona hormone iphambili yabasetyhini. Ukongeza ekuvuseleleni ukukhula kweempawu zobufazi, ezinje ngamabele, i-estrogen ikwacutha ngokungangqalanga amanqanaba e testosterone. Ukuthatha i-anti-androgens nge-estrogen kunokunceda kuzo zombini ukucinezela iimpawu zobudoda kunye nokukhuthaza ezabasetyhini.

Kubantu abachonga njengezinto ezingafunekiyo, ukuthatha ii-anti-androgens zodwa kunokunceda ukunciphisa iimpawu zomzimba wobudoda.

Eyamadoda

I-Androgens ivuselela ukukhula komhlaza kwi-Prostate. Ukunciphisa amanqanaba e-androgen, okanye ukukhusela i-androgens ekufikeleleni kwiiseli zomhlaza, kunokunceda ukunciphisa umhlaza. Isenokunciphisa amathumba akhoyo.

Kumanqanaba ayo okuqala, iiseli zomhlaza webala le-Prostate zixhomekeke kwii-androgens ukondla ukukhula kwazo. Umsebenzi we-anti-androgens ngokuthintela i-androgens ekubambeni ukuya kwi-androgen receptors kwiiseli zomhlaza webala. Oku kulamba iiseli zomhlaza ze-androgens abazidingayo ukuze zikhule.

Nangona kunjalo, i-anti-androgens ayimisi imveliso ye-androgen. Zisoloko zisetyenziswa ngokudibanisa nezinye iindlela zonyango, ezinje ngokuhlinzwa okanye ukuthathwa kwemichiza. Ezi ndibaniselwano zikwabizwa ngokuba:

• ukudityaniswa kwe-androgen
• Gcwalisa i-androgen blockade
• Iyonke i-androgen blockade

Zeziphi ezinye eziqhelekileyo?

Zininzi ii-anti-androgens ezikhoyo, nganye inokusetyenziswa okwahlukileyo okwahlukileyo. Nanku ukukhangela kwezinye zezona ziqhelekileyo.

IFlutamide

I-Flutamide luhlobo lwe-anti-androgen esetyenziselwa amanye amayeza ukunyanga iintlobo ezithile zomhlaza webele. I-Flutamide iyabophelela kwii-androgen receptors kwiiseli zomhlaza webele, ezithi zithintele ii-androgens ekubambeni ziye kwii-receptors. Oku kuthintela i-androgens ekukhuthazeni ukukhula komhlaza wesifo seprotate.

I-Spironolactone

I-Spironolactone (Aldactone) luhlobo lwe-anti-androgen esele isetyenziselwa ukunyanga induna yehomoni kunye neenwele zomzimba ezigqithileyo. Ukutshintsha kwabantu kunokuthatha ukunciphisa iimpawu zobudoda. Nangona bukhona ubungqina obuncinci bokuxhasa ukusetyenziswa kwayo, ikwenzele nemeko yempandla yomfazi.

ICyproterone

ICyproterone yenye ye-anti-androgens yokuqala. Kukunye namanye amayeza ukunyanga abasetyhini abane-PCOS. Ikwabonakalisiwe kumanqanaba e testosterone kunye nemveliso yeoyile ebangela induna.

Inokusetyenziselwa ukunciphisa iimpawu zobudoda kubafazi be-transgender. Nangona kunjalo, ngenxa yeziphumo zayo ebezingalindelekanga, akukhethwa ngokubanzi.

Zithini iziphumo ebezingalindelekanga?

I-anti-androgens inokuvelisa uluhlu lweziphumo ebezingalindelekanga, kuxhomekeke kwidosi kunye nohlobo oluthathayo.

Ezinye iziphumo ezinokubakho zibandakanya:

• isini esisezantsi
• umngcipheko okhulayo woxinzelelo
• i-enzyme zesibindi eziphakamileyo
• ukunciphisa iinwele zobuso nezomzimba
• umngcipheko ophezulu wokukhubazeka kokuzalwa ukuba uthathwe ngexesha lokukhulelwa
• hepatitis
• ukwenzakala kwesibindi
• Ukungasebenzi kakuhle kwe-erectile
• urhudo
• ukuthamba kwebele
• kushushu
• isitenxo sexesheni
• irhashalala
• Ukuchasana ne-androgen, oko kuthetha ukuba amayeza ayayeka ukusebenza

Ugqirha wakho unokukunceda ukhethe i-anti-androgen efanelekileyo ngokufanelekileyo kwiimfuno zakho kwaye iza neziphumo ebezingalindelekanga ezimbalwa.

Umgca wezantsi

I-anti-androgens inokusetyenziswa okuninzi kwamadoda, kwabasetyhini, nakubantu kuguquko kwisini, kokubini bebodwa kunye nokudibana namanye amayeza kunye nonyango. Nangona kunjalo, ii-anti-androgens ngamachiza anamandla anokubangela iziphumo ebezingalindelekanga ezibi. Sebenza nogqirha wakho ukulinganisa i-pros and cons of taking anti-androgens.