Iintsholongwane zeMonoclonal: ziyintoni kwaye kutheni zinceda ukunyanga izifo

Umxholo

• Imizekelo yee-antibodies ze-monoclonal
• 1. I-Trastuzumab
• 2. IDenosumab
• 3. I-Obinutuzumab
• 4. Ustequinumab
• 5. IPertuzumab
• Ungazithatha njani ii-Antibodies zeMonoclonal

Iintsholongwane zeMonoclonal ziiproteni ezisetyenziswa ngamajoni omzimba ukuchonga kunye nokuthomalalisa imizimba yamanye amazwe, enokuba ziintsholongwane, intsholongwane okanye iiseli zesisu. Ezi proteni zithe ngqo, njengoko zibona ithagethi ethile, ebizwa ngokuba yi-antigen, eya kubakho kwiiseli zangaphandle emzimbeni. Qonda indlela amajoni omzimba asebenza ngayo.

Iintsholongwane zeMonoclonal, ezinjenge-denosumab, i-obinutuzumab okanye i-ustequinumab, umzekelo, ziveliswa elebhu, zihlala zifana nezo zifunyanwa emzimbeni womntu, eziza kunceda umzimba ukuba ulwe nezifo ezithile. Ke, kuxhomekeke kwi-anti-monoclonal antibody esetyenzisiweyo, la mayeza anokusetyenziselwa ukunyanga izifo ezinzulu ezinje nge-osteoporosis, leukemia, plaque psoriasis okanye ezinye iintlobo zomhlaza, ezinje ngomhlaza wamabele okanye wethambo, umzekelo.

Imizekelo yee-antibodies ze-monoclonal

Eminye imizekelo yee-antibodies ze-monoclonal zibandakanya:

1. I-Trastuzumab

Le anti-monoclonal antibody, ithengiswa njenge-Herceptin, yaphuhliswa ngobunjineli bemfuza, kwaye yahlasela ngokukodwa iprotein ekhoyo kubantu abanomhlaza othile webele kunye nesisu. Ke, eli chiza libonakalisiwe kunyango lomhlaza webele kwinqanaba lokuqala okanye nge-metastasis kunye nomhlaza wesisu kwinqanaba eliphezulu.

2. IDenosumab

Ithengiswe njengeProlia okanye iXgeva, ine-anti-monoglonal IgG2 antibody, ephazamisa ukusebenza kweprotein ethile eyenza amathambo omelele, ukunciphisa amathuba okophuka. Ke, iDenosumab ibonakalisiwe kunyango lokulahleka kwamathambo, i-osteoporosis, umhlaza wamathambo okanye umhlaza kwinqanaba eliphambili kunye neethambo zemastastase (ethe yasasazeka emathanjeni).

3. I-Obinutuzumab

Yaziwa nangorhwebo njengeGazyva, inezakhi zayo zomzimba ezithi ziqonde kwaye zibophe ngokuthe ngqo kwiprotein ye-CD20, efumaneka kumphezulu weeseli ezimhlophe zegazi okanye ii-lymphocyte ze-B. Iyakwazi ukumisa ukukhula okungaqhelekanga kweeseli ezimhlophe ezibangela esi sifo.

4. Ustequinumab

Eliyeza linokwaziwa njengorhwebo njengeStelara kwaye lenziwe ngabantu IgG1 monoclonal antibody, ethintela iiproteni ezithile ezinoxanduva lokubangela i-psoriasis. Ke, eli chiza libonakalisiwe kunyango lwe-psoriasis yamacwecwe.

5. IPertuzumab

Ikwabizwa ngokuba yiPerjeta, yenziwe ngamachiza omzimba omninzi abophelela umntu ekukhuleni kwesidermal factor 2 receptor, ekhoyo kwezinye iiseli zomhlaza, icothisa okanye imise ukukhula kwayo. Ke, iPerjeta ibonakalisiwe kunyango lomhlaza wamabele.

Ungazithatha njani ii-Antibodies zeMonoclonal

Amayeza aneMonoclonal Antibodies kufuneka athathwe kuphela phantsi kwengcebiso yezonyango, njengohlobo losulelo oluza kusetyenziswa kunye needosi ezinconyelwayo zixhomekeke kwingxaki ekufuneka inyangwe kunye nobukhali bayo.

Kwiimeko ezininzi, la mayeza asetyenziswa kunyango lomhlaza, kuba ngamayeza antineoplastic ekufuneka esetyenziswe ngokwemiyalelo ethile enikezwe ngugqirha kwaye efuna ukwenziwa ezibhedlele nasezikliniki.