Buza ingcali: Ukuqonda imeko yonyango lwe-Ankylosing Spondylitis

Umxholo

• Ngaba i-ankylosing spondylitis inokuphiliswa?
• Loluphi olona nyango luthembisayo kwizilingo zeklinikhi?
• Ndazi njani ukuba ndiyafaneleka ukulingwa?
• Zeziphi ezona nyango zintsha ze-ankylosing spondylitis?
• Luluphi unyango olongezelelekileyo olucebisayo? Loluphi uqeqesho olucebisayo?
• Ngaba utyando lukhethwa kunyango lwe-ankylosing spondylitis?
• Ulujonga njani unyango lwe-ankylosing spondylitis etshintsha kule minyaka ili-10 izayo?
• Ucinga ukuba yintoni into eza kulandela kunyango lwe-ankylosing spondylitis?
• Itekhnoloji yale mihla ilunceda njani unyango?

Ngaba i-ankylosing spondylitis inokuphiliswa?

Okwangoku, akukho lunyango lwe-ankylosing spondylitis (AS). Nangona kunjalo, uninzi lwezigulana ezine-AS zinokukhokelela kubomi obude, obunemveliso.

Ngenxa yexesha phakathi kokuqala kweempawu kunye nokuqinisekiswa kwesi sifo, ukuxilongwa kwangoko kubalulekile.

Ulawulo lwezonyango, unyango oluncedisayo, kunye nokuzilolonga okujolisiweyo kunokunika abaguli umgangatho ophucukileyo wobomi. Iimpembelelo ezintle zibandakanya ukukhululeka kwentlungu, ukwanda kokuhamba, kunye nokwanda kwamandla okusebenza.

Loluphi olona nyango luthembisayo kwizilingo zeklinikhi?

Olona vavanyo lweklinikhi luthembisayo ngabo bavavanya ukusebenza kunye nokhuseleko lwe-bimekizumab. Sisiyobisi esithintela zombini i-interleukin (IL) -17A kunye ne-IL-17F - iiproteni ezincinci ezinegalelo kwiimpawu ze-AS.

IFilgotinib (FIL) sisithintelo esikhethiweyo sikaJanus kinase 1 (JAK1), enye iprotein enengxaki. I-FIL okwangoku ikwinkqubo yonyango lwe-psoriasis, i-psoriatic arthritis, kunye ne-AS. Ithathwe ngomlomo kwaye inamandla kakhulu.

Ndazi njani ukuba ndiyafaneleka ukulingwa?

Ukufaneleka kwakho ukuthatha inxaxheba kuvavanyo lweklinikhi lwe-AS kuxhomekeke kwinjongo yesilingo.

Izilingo zinokufunda ngokusebenza kunye nokhuseleko lwamachiza ophando, ukuqhubela phambili kokubandakanyeka kwamathambo, okanye ikhosi yendalo yesi sifo. Ukuhlaziywa kweenqobo zokuqonda isifo ze-AS kuya kuba nefuthe kuyilo lweemvavanyo zeklinikhi kwixa elizayo.

Zeziphi ezona nyango zintsha ze-ankylosing spondylitis?

Iziyobisi zamva nje ze-FDA zonyango lwe-AS zezi:

• ustekinumab (Stelara), IL12 / 23 inhibitor
• tofacitinib (Xeljanz), isithinteli seJAK
• secukinumab (Cosentyx), IL-17 inhibitor kunye ne-human monoclonal antibody
• ixekizumab (Taltz), IL-17 inhibitor

Luluphi unyango olongezelelekileyo olucebisayo? Loluphi uqeqesho olucebisayo?

Unyango olongezelelekileyo endihlala ndicebisa ngalo lubandakanya:

• ukuphulula
• ukutshiza
• acupressure
• umthambo wehidrotherapy

Ukuzivocavoca okuthe ngqo kubandakanya:

• ukuzolula
• Ukuhlala eludongeni
• iiplanga
• I-chin tuck ikwisikhundla esiphindaphindayo
• ukuzolula inyonga
• imithambo yokuphefumla ngokunzulu kunye nokuhamba

Ukusetyenziswa kweendlela zeyoga kunye neeyunithi zokuhambisa amandla ombane (TENS) ziyakhuthazwa.

Ngaba utyando lukhethwa kunyango lwe-ankylosing spondylitis?

Uqhaqho lunqabile kwi-AS. Ngamanye amaxesha, esi sifo siqhubela phambili siye kuphazamisa imisebenzi yemihla ngemihla ngenxa yeentlungu, ukusikelwa umda kokuhamba, kunye nobuthathaka. Kule meko, kunokucetyiswa utyando.

Kukho iinkqubo ezimbalwa ezinokunciphisa iintlungu, ukuzinzisa umqolo, ukuphucula ukuma komzimba, kunye nokuthintela uxinzelelo lwe-nerve. Ukuhlanganiswa komgogodla, i-osteotomies, kunye ne-laminectomies ezenziwe ngabagqirha abanezakhono kakhulu kunokuba luncedo kwezinye izigulana.

Ulujonga njani unyango lwe-ankylosing spondylitis etshintsha kule minyaka ili-10 izayo?

Kukucinga kwam ukuba unyango luya kulungiswa ngokusekwe kwiziphumo ezithile zeklinikhi, iindlela zobugcisa eziphuculweyo, kunye nakuphi na ukubonakaliswa kwesi sifo.

AS iwela phantsi kwesambulela secandelo elibanzi lezifo ezibizwa ngokuba yi-spondyloarthropathies. Oku kubandakanya i-psoriasis, i-psoriatic arthritis, isifo samathumbu esivuthayo, kunye ne-spondyloarthropathy esebenzayo.

Kunokubakho umboniso we-crossover kwezi subsets kwaye abantu baya kuxhamla kwindlela ekujolise kuyo kunyango.

Ucinga ukuba yintoni into eza kulandela kunyango lwe-ankylosing spondylitis?

Iintlobo ezimbini zemfuza, i-HLA-B27 kunye ne-ERAP1, inokubandakanyeka kwinkcazo ye-AS. Ndicinga ukuba inyathelo elilandelayo kunyango lwe-AS luya kwaziswa ngokuqonda indlela abanxibelelana ngayo kunye nokunxulumana kwabo nezifo zesisu ezivuthayo.

Itekhnoloji yale mihla ilunceda njani unyango?

Inkqubela phambili ephambili kwi-nanomedicine. Obu buchwephesha busetyenziselwa ukunyanga ngempumelelo ezinye izifo ezinjenge-osteoarthritis kunye ne-rheumatoid arthritis. Ukuphuhliswa kweenkqubo zokuhambisa ezisekwe kwi-nanotechnology kunokuba lolongezo olunomdla kulawulo lwe-AS.

UBrenda B. Spriggs, MD, FACP, MPH, nguNjingalwazi wezonyango u-Emerita, i-UCSF, iRheumatology, umcebisi kwimibutho yezempilo emininzi kunye nombhali. Umdla wakhe ubandakanya ukubhengeza isigulana kunye nomnqweno wokubonelela ngobuchule bokubonisana nge-rheumatology koogqirha nakubantu abangagcinwanga kakuhle. Ungumbhali-mbhali we "Gxila kweyona Mpilo yakho iQhelekileyo: Isikhokelo esiSebenzayo kuKhathalelo lwezeMpilo olufanelekileyo."