Buza ingcali: Iimpawu okanye Iziphumo ebezingalindelekanga?

Umxholo

• 1. Nguwuphi umahluko ophambili phakathi kokungcangcazela kunye nedyskinesia?
• Ukungcangcazela kokuphumla kukaParkinson
• 2. Ngaba kukho iindlela ezibonakalayo zokwahlula inyikima kwi-dyskinesia?
• 3. Ziintoni iimpawu zedyskinesia ebangelwa ziziyobisi?
• Ukungcangcazela kweParkinson
• 4. Kutheni le nto ezinye iziyobisi zedyskinesia zibangelwa yiParkinson?
• 5. Ndingayilawula njani idyskinesia ebangelwa ziziyobisi? Yiyeke?
• I-dyskinesia ebangelwa sisiyobisi seParkinson
• 6. Zeziphi ezinye iingxaki zedyskinesia?

1. Nguwuphi umahluko ophambili phakathi kokungcangcazela kunye nedyskinesia?

Ingqumbo ebonwe sisifo sika-Parkinson yenye yeempawu ezibonakalayo zemeko. Yenye yeempawu zeemoto zikaParkinson ezibonisa ukuphucuka ngamayeza.

Kwelinye icala, i-dyskinesia ithambekele ekuboniseni kamva kwisifo njengempembelelo yexesha elide yamayeza asetyenziselwa ukunyanga iParkinson's. Ngamanye amaxesha kunokuba nzima ukuxelela ukuba iintshukumo ezingaqhelekanga ziyangcangcazela okanye iDyskinesia.

Ukungcangcazela kokuphumla kukaParkinson

Ngokwesiqhelo, ngeParkinson's, umntu uye wangcangcazela kukungcangcazela ngelixa izandla ziphumla okanye zixhaswe ngumzimba ngokuchasene nomxhuzulane emva koko ziphucule xa iingalo zihamba.

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2. Ngaba kukho iindlela ezibonakalayo zokwahlula inyikima kwi-dyskinesia?

Umahluko ophambili kukuba inyikima inesingqi ekuhambeni kwayo, ngakumbi ngokudibeneyo. IDyskinesia ayisiyongabalulekanga kuphela, kodwa ihlala iphazamisekile. Ingcangcazela enxulunyaniswa neParkinson's ihlala icinezelwa kukushukuma kunye nomsebenzi, ngelixa i-dyskinesia ingekho.

3. Ziintoni iimpawu zedyskinesia ebangelwa ziziyobisi?

Zenzeka ngokunyanga ixesha elide kunyango lwesifo sikaParkinson, ngakumbi i-levodopa (iSinemet, iDuopa). Sekude umntu abe nale meko kwaye kukudala ethatha amayeza (ngakumbi kwiidosi eziphezulu), umngcipheko omkhulu wokukhula kweedyskinesia ezibangelwa ziziyobisi.

Ukungcangcazela kweParkinson

Uxinzelelo, ukonwaba, kunye nenqanaba lokuphumla konke kuchaphazela ubungqongqo benyikima kaParkinson.

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4. Kutheni le nto ezinye iziyobisi zedyskinesia zibangelwa yiParkinson?

Akuqondwa ngokupheleleyo ukuba kutheni amayeza eParkinson abangela idyskinesia. Ngaphantsi kweemeko eziqhelekileyo, kukho ukukhuthaza okuqhubekayo kunye ne-dopamine. Kwi-Parkinson's, umqondiso we-dopamine uyasilela. Nangona kunjalo, amayeza ayilelwe ukubuyisela uphawu lwe-dopamine kwisiphumo se "pulses" ezingezizo ze-dopamine. Kucingelwa ukuba iimpembelelo ezinyukayo kunye nezantsi zesiginali ye-dopamine inoxanduva lwedyskinesia ebangelwa ziziyobisi.

5. Ndingayilawula njani idyskinesia ebangelwa ziziyobisi? Yiyeke?

Ukulawula idyskinesia ebangelwa ziziyobisi kunokuba ngumceli mngeni. Enye indlela esebenzayo kukunciphisa idosi yamayeza, ngakumbi i-levodopa. Nangona kunjalo, oku kunokubangela ukuba ezinye zeempawu zeemoto ezinxulumene neParkinson zibuyele.

Ukuqulunqwa okutsha kunye neendlela zokuhambisa amayeza zibonelela ngokukhutshwa okuzinzileyo kwesiyobisi kunye nokunceda ukunciphisa iimpawu zedyskinesia. Iifomula zokukhululwa ezizinzileyo kunye nokungena ngokuthe ngqo emathunjini yimizekelo yeendlela ezinjalo.

Izizukulwana ezitsha zamayeza angenayo i-levodopa, njenge-safinamide, igama le-Xadago (i-monoamine oxidase B inhibitor), kunye ne-opicapone (i-catechol-O-methyltransferase inhibitor) ikwabonakalise isithembiso ekwehliseni idyskinesia.

Utyando lwe-Parkinson's, olunje ngokuvuselela ingqondo okunzulu (DBS), kukwabangela ukunciphisa iimpawu zedyskinesia. Oku kunokuba kungenxa yokuba i-DBS ihlala inceda ukunciphisa isixa samayeza afunekayo eParkinson's.

I-dyskinesia ebangelwa sisiyobisi seParkinson

Ngokusetyenziswa ixesha elide kwamayeza kaParkinson, afana nelevodopa, umntu angakhula kukuphazamiseka kokuhamba, nokuba amayeza ayencede iimpawu zikaParkinson ekuqaleni kwesi sifo.

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6. Zeziphi ezinye iingxaki zedyskinesia?

Njengazo zonke iimpawu zesifo sika-Parkinson, idyskinesia inokuthintela imisebenzi yemihla ngemihla njengokutya nokusela. Nangona kunjalo, idyskinesia ngokwayo ayilulo uphawu lomngcipheko ophantsi. Ibonisa ukuqhubela phambili kwesi sifo.

Owona mngcipheko mkhulu ekuphuhliseni idyskinesia ebangelwa ngamachiza kukuba umntu unexesha elingakanani eparkinson. Xa i-dyskinesia ibonisa, inokuthetha ukuba umntu kungenzeka ukuba angaphenduli kangako kumayeza aqhelekileyo kule meko. Isenokuthetha ukuba kufuneka bahlengahlengise ishedyuli yabo yethamo okanye ukwenziwa kweziyobisi.

UGqirha Seunggu Jude Han unjingalwazi oncedisayo wotyando lwe-Oregon kwiYunivesithi yase-Oregon yezeMpilo kunye neSayensi ePortland, e-Oregon. Ebekwisikhundla sokuphononongwa kwezonyango kwiHealthline ukusukela nge2016 kwaye uphonononge ngaphezulu kwamanqaku angama-200.