Umbhali: Roger Morrison
Umhla Wokudalwa: 17 Eyomsintsi 2021
Hlaziya Umhla: 1 Eyekhala 2024
Anonim
What You Need to Know About Aubagio®
Ividiyo: What You Need to Know About Aubagio®

Umxholo

Yintoni iAubagio?

I-Aubagio ligama lonyango elichaza amayeza. Isetyenziselwa ukunyanga iifom ezibuyayo ze-multiple sclerosis (MS) kubantu abadala. I-MS sisifo apho amajoni akho omzimba ahlasela inkqubo ye-nervous system.

I-Aubagio iqulethe ichiza i-teriflunomide, eyi-pyrimidine synthesis inhibitor. Amachiza akweli klasi anceda ukukhusela iiseli zokhuselo lomzimba ekubeni zande ngokukhawuleza. Eli nyathelo linceda ukunciphisa ukudumba (ukudumba).

I-Aubagio iza njengecwecwe oliginyeyo. Iyeza lifumaneka ngamandla amabini: 7 mg kunye 14 mg.

I-Aubagio yafaniswa ne-placebo (akukho lonyango) kwizilingo ezine zeklinikhi. Abantu abathathe iAubagio babene:

  • ukubuyela umva kancinci (ukuvutha kwakhona)
  • ukuqhubela phambili kokukhubazeka (ukukhubazeka kwabo emzimbeni akubanga kubi ngokukhawuleza)
  • umngcipheko osezantsi wezilonda ezintsha (izicwili ezibomvu) kwingqondo

Ngolwazi oluthe ngqo kwezi zifundo, jonga icandelo le- "Aubagio uses".

I-Aubagio generic

I-Aubagio okwangoku ifumaneka kuphela njengegama lonyango.


I-Aubagio iqulethe isithako esisebenzayo se-teriflunomide. Kwi-2018, uLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) livume uhlobo oluqhelekileyo lwe-teriflunomide, kodwa ayikafumaneki okwangoku.

Iziphumo ebezingalindelekanga zeAubagio

I-Aubagio inokubangela iziphumo ebezingalindelekanga ezinobulali okanye ezinobuzaza. Olu luhlu lulandelayo luqulathe ezinye zeziphumo ebezingalindelekanga ezinokubakho ngelixa uthatha iAubagio. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Ngolwazi oluthe kratya malunga neziphumo ebezingalindelekanga zeAubagio, thetha nogqirha wakho okanye usokhemesti. Banokukunika iingcebiso malunga nendlela yokujongana nayo nayiphi na imiphumo emibi.

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo eziqhelekileyo ezichaphazelekayo ze-Aubagio zingabandakanya:

  • intloko ebuhlungu
  • i-alopecia (ukunciphisa iinwele okanye ukulahleka kweenwele)
  • kunciphise amanqanaba e-phosphate
  • ukuhla kwamanqanaba eeseli ezimhlophe zegazi
  • isicaphucaphu
  • urhudo
  • ukonyuka kwamanqanaba ee-enzyme zesibindi (kunokuba luphawu lomonakalo wesibindi)
  • ukwanda koxinzelelo lwegazi
  • ukuba ndindisholo okanye ukubetha ezandleni okanye ezinyaweni
  • intlungu edibeneyo

Uninzi lweziphumo ebezingalindelekanga zinokuhamba zingaphelanga iintsuku okanye iiveki ezimbalwa. Ukuba zinzima kakhulu okanye azihambi, thetha nogqirha wakho okanye usokhemesti.


Iziphumo ebezingalindelekanga ezimandundu

Shayela ugqirha wakho ngokukhawuleza ukuba unemiphumo emibi. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Iziphumo ebezingalindelekanga ezimandundu kunye neempawu zazo zinokubandakanya oku kulandelayo:

  • Ukunyanga komzimba. Iimpawu zingabandakanya:
    • ukudumba ebusweni okanye ezandleni
    • ukurhawuzelela okanye urticaria
    • ukudumba okanye ukurhawuzelela umlomo okanye umqala
    • ukuqina kwesifuba
    • ingxaki yokuphefumla
  • Umonakalo wesibindi, kubandakanya ukusilela kwesibindi. Iimpawu zeengxaki zesibindi zingabandakanya:
    • isicaphucaphu
    • ukugabha
    • iintlungu esiswini sakho
    • Ukuphelelwa ngumdla wokutya
    • ukudinwa
    • umchamo omnyama
    • ubumthubi besikhumba sakho okanye ezimhlophe zamehlo akho
  • Amanqanaba asezantsi eeseli ezimhlophe zegazi. Iimpawu zingabandakanya:
    • ifiva
    • ukudinwa
    • iintlungu zomzimba
    • Ukugodola
    • isicaphucaphu
    • ukugabha
  • Ukuphendula kakubi kolusu. Iimpawu zingabandakanya:
    • I-Stevens-Johnson syndrome (izilonda ezibuhlungu emlonyeni wakho, emqaleni, emehlweni, okanye kwizitho zangasese)
    • ukugruzuka okungachazwanga okanye ukopha
    • ukudumba
    • iblister okanye isikhumba esixobukayo
    • izilonda emlonyeni wakho, amehlo, impumlo, okanye umqala
  • Igazi elonyukayo. Iimpawu zingabandakanya:
    • intloko ebuhlungu
    • ukudinwa okanye ukudideka
    • utshintsho lombono
    • ukubetha kwentliziyo ngokungaqhelekanga
  • Iingxaki zokuphefumla, kubandakanya isifo semiphunga esiphakathi. Iimpawu zingabandakanya:
    • ukuqhawukelwa ngumphefumlo
    • ukukhohlela kunye okanye ngaphandle komkhuhlane

Iinkcukacha zesiphumo

Unokuzibuza ukuba zenzeka kangaphi iziphumo ebezingalindelekanga ngeli chiza, okanye nokuba ngaba ezinye iziphumo ebezingalindelekanga zinxulumene nalo. Nazi ezinye iinkcukacha kwezinye zeziphumo ebezingalindelekanga ezinokubangelwa okanye ezingabangelwa zezi ziyobisi.


Ukuphendula ngokuchaseneyo

Njengokuba kuninzi lweziyobisi, abanye abantu banokuphendula emva kokuthatha i-Aubagio. Iimpawu zokuphendula kancinci kunokubandakanya:

  • irhashalala
  • ukucheba

Impendulo eyingozi kakhulu inqabile kodwa inokwenzeka. Iimpawu zokungaziphathi kakuhle zinokubandakanya:

  • i-angioedema (ukudumba phantsi kolusu lwakho, ubukhulu becala kwiinkophe zakho, imilebe, izandla, okanye iinyawo)
  • ukudumba kolwimi lwakho, umlomo, okanye umqala
  • ingxaki yokuphefumla
  • ubomvu okanye uxobuka ulusu

Biza ugqirha wakho ngoko nangoko ukuba unesifo esibi kwiAubagio. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Iingxaki zolusu / irhashalala

I-Aubagio inokubangela ukusabela okukhulu kolusu. Ezi zibandakanya isifo sikaStevens-Johnson, esingxamisekileyo kwezonyango. Kubangela izilonda ezibuhlungu emlonyeni wakho, emqaleni, emehlweni, okanye kwilungu langasese.

Kwaxelwa ukuba umntu omnye owathatha iAubagio wavelisa ityhefu yepermermal necrolysis (TEN), eyayibulalayo. I-TEN yiStevens-Johnson syndrome echaphazela ngaphezulu kwe-30% yomzimba wakho. Iqala njengokuqunjelwa okubuhlungu kunye neempawu ezinje ngomkhuhlane, emva koko kube namadyungudyungu.

Ukuba ulusu lwakho luyaxobuka okanye lube bomvu, ludumbe, okanye lube namaqhubu, xelela ugqirha ngoko nangoko. Ukuba une-Stevens-Johnson syndrome okanye i-TEN, unokufuna ukuba ulaliswe esibhedlele.

Umonakalo wesibindi

Kwezilingo zeklinikhi, malunga neepesenti ezi-6 zabantu abathathe i-Aubagio babenyuse amanqanaba ee-enzyme zesibindi. Phantse iipesenti ezi-4 zabantu ababene-placebo (akukho lonyango) babenyuse amanqanaba e-enzyme yesibindi.

I-Aubagio inokunyusa amanqanaba ee-enzyme zesibindi, ezinokuba luphawu lweengxaki zesibindi ezinzulu. Tshela ugqirha wakho ukuba unayo nayiphi na le mpawu:

  • isicaphucaphu
  • ukugabha
  • iintlungu esiswini sakho
  • Ukuphelelwa ngumdla wokutya
  • ukudinwa
  • umchamo omnyama
  • ubumthubi besikhumba sakho okanye ezimhlophe zamehlo akho

Ngaphambi kokuba uqale ukuthatha iAubagio, ugqirha wakho uya kukunika uvavanyo lwegazi ukujonga ukusebenza kwesibindi. Baza kuphinda bakunike iimvavanyo zenyanga ngelixa uthatha iAubagio ukubona ukuba isibindi sakho sisebenza njani.

Ukulahleka kweenwele

Esinye seziphumo ebezingalindelekanga eziqhelekileyo zeAubagio yialopecia (ukucheba iinwele okanye ukulahleka kweenwele).

Kwizilingo zeklinikhi, malunga ne-13% yabantu abathathe i-Aubagio babene-alopecia. Uninzi lwabantu lwaluneempawu zealopecia kwiinyanga ezintathu zokuthatha ichiza. IAlopecia yahlala ngaphantsi kweenyanga ezintandathu ngokomndilili. Iziphumo ebezingalindelekanga zezethutyana, kwaye uninzi lwamatyala aphuculwe njengoko abantu beqhubeka nokuthatha iAubagio.

Ukuba uthatha iAubagio kwaye ukhathazekile malunga nokulahleka kweenwele, thetha nogqirha wakho.

Urhudo

Urhudo sisiphumo esibi secala laseAubagio.

Kwizilingo zeklinikhi, malunga neepesenti ezili-14 zabantu abathathe i-Aubagio banesifo sohudo. Oku kwafaniswa ne-8% yabantu ababene-placebo (akukho lunyango). Uninzi lweziganeko zorhudo zazinobulali ukuya kumodareyitha kwaye zahamba zodwa.

Ukunyanga urhudo oluncinci, sela amanzi amaninzi okanye izisombululo ze-electrolyte ukunceda umzimba wakho ukuba ubuyisele ulwelo olulahlekileyo. Ukuba urhudo lwakho luhlala iintsuku ezininzi, tsalela ugqirha wakho. Banokucebisa ngeendlela zokunciphisa iimpawu zakho.

I-PML (hayi isiphumo esisecaleni)

Ukuqhubela phambili kwe-leukoencephalopathy ye-multifocal (PML) asiyompembelelo esecaleni ye-Aubagio. I-PLM sisifo esihlasela inkqubo ye-nervous system yakho.

Kwimeko yengxelo, umntu omnye wakhulisa i-PML emva kokutshintshela kwi-Aubagio esuka kwi-natalizumab, iyeza elisetyenziselwa ukunyanga i-multiple sclerosis (MS). I-natalizumab yeziyobisi inesilumkiso esibhokisiweyo esivela kuLawulo lokutya kunye noLawulo lweziyobisi (i-FDA) ngokubhekisele kumngcipheko okhulayo we-PML. Isilumkiso esibhokisi sisilumkiso esinzulu esivela kwi-FDA. Yazisa oogqirha kunye nezigulana malunga neziphumo zeziyobisi ezinokuba yingozi.

Akunakwenzeka ukuba i-Aubagio ibangele ukuba umntu aphuhlise i-PML. Kungenzeka ukuba i-natalizumab ibangele.

Ukuba utshintshela kwi-Aubagio emva kokuthatha i-natalizumab, ugqirha wakho uza kukujonga kwi-PML.

Ukudinwa (hayi isiphumo esisecaleni)

Ukukhathala (ukungabikho kwamandla) akuyona into echaphazelekayo ye-Aubagio. Nangona kunjalo, ukudinwa luphawu oluqhelekileyo lwe-multiple sclerosis (MS). Ukukhathala kungabonakalisa ukonakala kwesibindi.

Ukuba unomdla malunga nokudinwa ngelixa uthatha iAubagio, thetha nogqirha wakho. Banokuphonononga izizathu ezinokubakho kwaye bacebise ngeendlela zokuphucula amandla akho.

Ukwehla kobunzima okanye ukutyeba (hayi isiphumo esisecaleni)

Ukwehla kobunzima kunye nokuzuza ubunzima yayingezizo iziphumo ebezingalindelekanga ze-Aubagio kwizifundo zeklinikhi. Ngekhe ulahle okanye utyebe ngelixa uthatha iAubagio.

Nangona kunjalo, enye yeempawu eziqhelekileyo ze-multiple sclerosis (MS) kukukhathala (ukungabikho kwamandla). Xa inqanaba lakho lamandla liphantsi, usenokungasebenzi. Oku kunokukhokelela ekubeni utyebe. Ukuba unoxinzelelo, unokutya ukutya kakhulu okanye okuncinci, oku kunokubangela ukutyeba okanye ukunciphisa umzimba.

Ukuba unomdla malunga notshintsho kubunzima bakho, thetha nogqirha wakho. Banokucebisa ngeengcebiso zokutya eziluncedo okanye bacebise isazi sokutya ukuze uncede uqiniseke ukuba ufumana isondlo esifanelekileyo.

Umhlaza (hayi isiphumo esisecaleni)

Ukuthatha amayeza achaphazela amajoni akho omzimba, anje ngeAubagio, anokunyusa umngcipheko womhlaza. Nangona kunjalo, izilingo zeklinikhi zeAubagio azange zichaze ukwanda kwenani labantu abaphuhlise umhlaza.

Ukuba unomdla wokuba nomhlaza, thetha nogqirha wakho.

Uxinzelelo (hayi isiphumo esisecaleni)

Uxinzelelo asiyompembelelo esecaleni yeAubagio. Nangona kunjalo, uxinzelelo luphawu oluqhelekileyo lwe-MS.

Ukuba unempawu zokudakumba, yazisa ugqirha wakho. Amachiza amaninzi okulwa noxinzelelo afumanekayo anokunceda ukunciphisa iimpawu zakho.

Iindleko zeAubagio

Njengawo onke amayeza, iindleko zeAubagio ziyahluka.

Ixabiso eliya kuhlawula liya kuxhomekeka kwi-inshurensi yakho, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Uncedo lwezezimali

Ukuba ufuna inkxaso yemali ukuhlawulela iAubagio, uncedo luyafumaneka. IGenzyme Corporation, umenzi weAubagio, ibonelela ngeNkqubo yokuHlawula ngokuHanjiswa kweAubagio. Ngolwazi oluthe kratya kunye nokufumanisa ukuba uyilungele na inkxaso, tsalela umnxeba ku-855-676-6326 okanye undwendwele iwebhusayithi yenkqubo.

I-Aubagio isebenzisa

Ulawulo lokutya kunye neziyobisi (i-FDA) livuma amayeza amiselweyo anje ngeAubagio ukunyanga iimeko ezithile.

IAubagio yeMS

I-Aubagio ivunyiwe yi-FDA ukuba inyange abantu abadala abanefom ebuyayo ye-multiple sclerosis (MS). I-MS sisifo esinganyangekiyo (sexesha elide) esibangela ukuba amajoni akho omzimba ahlasele i-myelin (umaleko ongaphandle) kwimithambo-luvo emehlweni akho, kwingqondo nasemqolo. Oku kudala izicwili ezibomvu, ezenza ukuba kube nzima kwingqondo yakho ukuthumela imiyalezo kwamanye amalungu omzimba wakho.

Kuvavanyo lweklinikhi, ngaphezulu kwabantu abayi-1 000 ababenokubuyela umva nge-MS (i-flare-ups) bathatha i-Aubagio okanye i-placebo (akukho nyango). Kwiqela le-Aubagio, i-57% yabo bahlala bengenakho ukubuyela umva ngelixa besebenzisa iziyobisi. Oku kwafaniswa ne-46% yeqela le-placebo. Abantu abathathe i-Aubagio nabo banama-31% ambalwa okubuya kwakhona kunabantu abathathe indawo ye-placebo.

Uvavanyo olufanayo lweklinikhi lubonise ukuba, xa kuthelekiswa neqela le-placebo, abantu abathathe i-Aubagio:

  • inye kuphela ebuyela umva rhoqo kwiminyaka emithandathu ngelixa uthatha iyeza
  • ukuqhubela phambili kokukhubazeka (ukukhubazeka kwabo emzimbeni akubanga kubi ngokukhawuleza)
  • izilonda ezintsha ezimbalwa (izicwili ezibomvu) kwingqondo

Olunye uphononongo luvavanye ukuba isebenza njani iAubagio:

  • Kwilingo elinye leklinikhi, malunga neepesenti ezingama-72 zabantu abathathe i-Aubagio bahlala bengenakho ukubuyela umva ngexesha lokufunda. Oku kwafaniswa ne-62% yabantu abathathe i-placebo.
  • Izifundo ezibini zeklinikhi zijonge abantu abane-MS ebuyela umva. Kwisifundo esinye, abo bathathe i-Aubagio babephindaphinda iipesenti ezingama-31% kunabantu abathathe i-placebo. Kwesinye isifundo, elo nani lalingama-36%.
  • Kwizilingo zeklinikhi, ubuncinci i-80% yabantu abathathe i-Aubagio babengenaqhubekeko ekukhubazekeni kwabo. Oku kuthetha ukuba ukukhubazeka kwabo emzimbeni akubanga kubi ngokukhawuleza. Uninzi lwaba bantu, oku kuye kwaqhubeka ukuya kuthi ga kwiminyaka eyi-7.5.

Kwesinye isifundo seklinikhi, abantu bathathe iAubagio kwi-14-mg okanye i-7-mg doses. Abaphandi bafumanise ukuba xa kuthelekiswa nabantu abathathe i-placebo:

  • I-80% yabantu kwiqela lethamo le-14-mg babenezilonda ezintsha ezimbalwa
  • I-57% yabantu kwiqela lethamo le-7-mg babenezilonda ezintsha ezimbalwa

I-Aubagio kunye notywala

Akukho nxibelelwano lwaziwayo phakathi kweAubagio kunye notywala. Nangona kunjalo, ukusela utywala ngelixa uthatha iAubagio kunokunyusa umngcipheko wezinye iziphumo ebezingalindelekanga, ezinje:

  • isicaphucaphu
  • urhudo
  • intloko ebuhlungu

Ukusela kakhulu utywala ngelixa uthatha i-Aubagio kunokunyusa umngcipheko wokulimala kwesibindi.

Ukuba uthatha iAubagio, thetha nogqirha wakho malunga nokuba kukhuselekile na ukusela utywala.

Unxibelelwano lweAubagio

I-Aubagio inokusebenzisana namanye amayeza. Iyakwazi ukusebenzisana nezibonelelo ezithile kunye nokutya.

Unxibelelwano olwahlukileyo kunokubangela iziphumo ezahlukeneyo. Umzekelo, unxibelelwano oluthile lunokuphazamisa ukusebenza kakuhle kwesiyobisi. Olunye unxibelelwano lunokunyusa inani leziphumo ebezingalindelekanga okanye lubenze banzima ngakumbi.

I-Aubagio kunye namanye amayeza

Apha ngezantsi luluhlu lwamayeza anokusebenzisana neAubagio. Olu luhlu alunazo zonke iziyobisi ezinokusebenzisana neAubagio.

Ngaphambi kokuba uthathe iAubagio, thetha nogqirha wakho kunye nosokhemesti. Baxelele ngawo onke amayeza kagqirha, ekhawuntareni, kunye nezinye iziyobisi ozithathayo. Baxelele malunga nazo naziphi na iivithamini, amayeza esintu kunye nezixhasi ozisebenzisayo. Ukwabelana ngolu lwazi kunokukunceda uphephe unxibelelwano olunokubakho.

Ukuba unemibuzo malunga nokunxibelelana kweziyobisi okunokuchaphazela, buza ugqirha wakho okanye usokhemesti.

Ukugonywa kweAubagio kunye nomkhuhlane

Kukhuselekile ukufumana umkhuhlane xa uthatha iAubagio. Isitofu sokugonya somkhuhlane asisebenzi, oko kuthetha ukuba senziwe ngentsholongwane ebuleweyo.

Isitofu sokugonya esiphilayo, kwelinye icala, seso sinohlobo olubuthathaka lwentsholongwane. Ukuba amajoni omzimba abuthathaka, uyacetyiswa ngokuchasene nokufumana izitofu zokuphila. Kungenxa yokuba kwizihlandlo ezinqabileyo kakhulu, izitofu zokuphila zingatshintsha zibuyele kwintsholongwane enamandla abangela isifo. Ukuba oku kuyenzeka, abantu abanamajoni omzimba abuthathaka banokuba nomngcipheko ophezulu kakhulu wokuphuhlisa isifo ekufanele ukuba sisithintele isitofu sokugonya.

Ukuba uthatha iAubagio, akufanele ufumane izitofu zokuphila. I-Aubagio inokuwenza buthathaka amajoni akho omzimba, ke ngoko ukufumana isitofu sokugonya esiphilayo kunokukubeka emngciphekweni wokugula ekufanele ukuba ukukhusele.

Ukuba unemibuzo malunga nokufumana izitofu ngelixa uthatha iAubagio, thetha nogqirha wakho.

I-Aubagio kunye neeflunomide

I-Arava (leflunomide) sisiyobisi esisetyenziselwa ukunyanga isifo samathambo (RA). Ukuthatha i-Aubagio nge-leflunomide kunokunyusa inani le-Aubagio emzimbeni wakho. Oku kungonakalisa isibindi sakho. Musa ukuthatha i-Aubagio kunye ne-leflunomide kunye.

Ukuba uthatha iArava kwaye kufuneka uthathe iAubagio, thetha nogqirha wakho. Banokucebisa ngolunye uhlobo lwamayeza eRA.

I-Aubagio kunye ne-warfarin

Ukuthatha i-Aubagio nge-warfarin kunokwenza ukuba i-warfarin isebenze kancinci (ayisebenzi nasemzimbeni wakho). Ngenxa yoko, igazi lakho linokukwazi ukugquma.

Ukuba uthatha i-warfarin, thetha nogqirha wakho. Baza kuvavanya igazi lakho ngaphambi nangexesha lonyango lwakho kunye neAubagio.

I-Aubagio kunye ne-immunosuppressants

Amayeza athile, anjengeziyobisi zomhlaza, anokuwenza buthathaka amajoni akho omzimba. Babizwa ngokuba ngama-immunosuppressants. I-Aubagio inokuwenza buthathaka amajoni akho omzimba. Ukuba uthatha iyeza lomhlaza kunye neAubagio, amajoni akho omzimba anokungabi namandla ngokwaneleyo okulwa neentsholongwane. Oku kunokunyusa umngcipheko wosulelo.

Imizekelo yala mayeza ibandakanya:

  • bendamustine (Bendeka, Treanda, Belrapzo)
  • cladribine (iMavenclad)
  • erlotinib (iTarceva)

Ukuba uthatha ichiza lomhlaza okanye elinye ichiza elicinezela amajoni akho omzimba, thetha nogqirha wakho. Banokucinga ngokutshintsha isicwangciso sakho sonyango.

I-Aubagio kunye nezinto zokucwangcisa zomlomo

Izinto zokucwangcisa ngomlomo (iipilisi zolawulo lokuzalwa) ngamayeza anceda ukuthintela ukukhulelwa. Ukuthatha iAubagio ngeepilisi ezithile zolawulo lokuzalwa kunganyusa amanqanaba omzimba wakho wehomoni kwiipilisi zolawulo lokuzalwa. Oku kunokubangela ukungalingani kumanqanaba akho ehomoni.

Imizekelo yala mayeza ibandakanya:

  • i-ethinyl estradiol
  • levonorgestrel (Cwangcisa B inyathelo elinye, iMirena, Skyla)
  • i-ethinyl estradiol / levonogestrel (iLutera, Vienva)

Ukuba uthatha iipilisi zolawulo lokuzalwa, thetha nogqirha wakho. Banokucebisa uhlobo olungayi kusabela ngamandla ngeAubagio.

I-Aubagio kunye neyeza lokunciphisa amayeza

Ukuthatha iAubagio ngamayeza athile anciphisa i-cholesterol anokunyusa amanqanaba ala mayeza emzimbeni wakho. Oku kunokubangela ukwanda kweziphumo ebezingalindelekanga ezivela kumayeza e-cholesterol.

Imizekelo yala mayeza ibandakanya:

  • atorvastatin (Lipitor)
  • ipravastatin (Pravachol)
  • Isimvastatin (iZocor, iFloLipid)
  • rosuvastatin

Ukuba uthatha iyeza ukunciphisa i-cholesterol yakho, thetha nogqirha wakho. Baza kujonga umyinge weyeza ngalinye kwaye baqinisekise ukuba bakhuselekile ukuthatha kunye.

I-Aubagio kunye nezinye iziyobisi

I-Aubagio inokusebenzisana namayeza amaninzi ahlukeneyo. Kwaye amanye ala mayeza anokuchaphazela indlela esebenza ngayo iAubagio. Kungenxa yokuba umzimba wakho uhambisa umzimba (uyaphula) iAubagio kunye nezinye iziyobisi ngendlela efanayo. Xa amayeza ephulwe kunye, ngamanye amaxesha banokunxibelelana.

I-Aubagio inokubangela ukuba umzimba wakho uphule amachiza ngokukhawuleza okanye kancinci.Oku kunganyusa okanye kunciphise amanqanaba ala machiza emzimbeni wakho. Ukuba inyusa amanqanaba, inokuphakamisa umngcipheko weziphumo ebezingalindelekanga. Ukuba kunciphisa amanqanaba, iyeza alinakusebenza ngokunjalo.

Imizekelo yala mayeza ibandakanya:

  • amioquine
  • sifiso
  • I-Bacillus Calmette-Guerin (i-BCG)
  • elagolix (Orilissa)
  • ingca
  • natalizumab (iTysabri)
  • ipazopanib (Votrient)
  • ipimecrolimus (Elidel)
  • i-revefenacin (Yupelri)
  • I-tacrolimus yeengxoxo
  • topotecan (IHycamtin)
  • yobawiso

Ukuba uthatha naliphi na kula mayeza, thetha nogqirha wakho. Baza kujonga amanqanaba ala machiza emzimbeni wakho ngelixa uthatha iAubagio.

Umthamo weAubagio

Umthamo we-Aubagio ogqirha ugqirha wakho aya kuxhomekeka kwizinto ezininzi. Oku kunokubandakanya:

  • uhlobo kunye nobunzima bemeko oyithathayo iAubagio
  • iminyaka yakho
  • uhlobo lweAubagio oyithathayo
  • ezinye iimeko zonyango onokuba nazo

Ngokuqhelekileyo, ugqirha wakho uya kukuqala kwiqondo eliphantsi. Ke baya kuyilungisa ngokuhamba kwexesha ukufikelela kumthamo olungele wena. Ekugqibeleni baya kumisela idosi encinci enika isiphumo esifunekayo.

Olu lwazi lulandelayo luchaza iidosi eziqhelekileyo ezisetyenziswayo okanye ezicetyiswayo. Nangona kunjalo, qiniseka ukuthatha idosi ekumisela ugqirha wakho. Ugqirha wakho uya kumisela eyona idosi ilungele iimfuno zakho.

Iifom zamachiza kunye namandla

I-Aubagio iza njengecwecwe oliginyeyo. Itholakala kumandla amabini: 7 mg kunye ne-14 mg.

Umyinge weendlela zokubuyela umva ze-MS

Ugqirha wakho unokukuqala nge-7 mg, kanye ngemini. Ukuba le dosi yokuqala ayisebenzi kuwe, banokwandisa idosi ukuya kwi-14 mg, kanye ngemini.

Kuthekani ukuba ndiphose idosi?

Ukuba uphosa idosi, thabatha idosi yakho oyiphosileyo kwakamsinya nje emva kokuba ukhumbule. Ukuba ukufutshane nexesha ledosi yakho elandelayo, tsiba idosi ephosiweyo kwaye ubuyele kwixesha lakho eliqhelekileyo. Musa ukuthatha amanani amabini ngexesha elinye okanye nayiphi na idosi eyongezelelweyo.

Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?

I-Aubagio yenzelwe ukuba isetyenziswe njengonyango lwexesha elide lokuphinda ubuye kwiifom ezininzi ze-sclerosis. Ukuba wena nogqirha ugqibe ukuba i-Aubagio ikhuselekile kwaye iyasebenza kuwe, uya kuyithatha ixesha elide. Qiniseka ukuba uthatha amayeza ngokuchanekileyo njengoko ugqirha ekuxelele.

Ezinye iindlela zeAubagio

Amanye amachiza akhoyo anokunyanga iindlela zokubuyela umva kwi-multiple sclerosis (MS). Abanye banokukulungela ngcono kunabanye. Ukuba unomdla wokufumana enye indlela eya eAubagio, thetha nogqirha wakho ukuze ufunde ngakumbi ngamanye amayeza anokukusebenzela.

Imizekelo yezinye iziyobisi ezingasetyenziselwa ukunyanga iifom zokubuyela umva ze-MS zibandakanya:

  • ii-beta interferons (Rebif, Avonex)
  • ocrelizumab (Ocrevus)
  • idimethyl fumarate (Tecfidera)
  • I-glatiramer acetate (iCopaxone)
  • fingolimod (iGilenya)
  • natalizumab (iTysabri)
  • alemtuzumab (Lemtrada)
  • yitshitshiso

IAubagio vs iTecfidera

Usenokuzibuza ukuba iAubagio ithelekiswa njani namanye amayeza amiselweyo ukuze asetyenziswe ngokufanayo. Apha sijonga indlela iAubagio kunye neTecfidera ezifanayo kunye ezahlukeneyo.

Izithako

I-Aubagio iqulethe isithako esisebenzayo se-teriflunomide. Yeyiklasi ye-pyrimidine synthesis inhibitor yeklasi.

I-Tecfidera iqulethe into esebenzayo eyahlukileyo, i-dimethyl fumarate. Yeyakho iklasi yokunyanga isifo.

Sebenzisa

Ulawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) luvumile zombini iAubagio kunye neTecfidera ukunyanga iifom ezibuyayo ze-multiple sclerosis (MS).

Iifom zeziyobisi kunye nolawulo

I-Aubagio iza njengecwecwe. Uyithatha ngomlomo (uyayiginya) kanye ngemini.

I-Tecfidera iza njengecapsule. Uyithatha ngomlomo (uyayiginya) kabini ngemini.

Iziphumo kunye neengozi

Umsebenzi weAubagio kunye neTecfidera ngeendlela ezahlukeneyo kodwa baneziphumo ebezingalindelekanga ezifanayo. Imizekelo yeziphumo ebezingalindelekanga eziqhelekileyo nezibi kwicala ngalinye leziyobisi zidweliswe apha ngezantsi.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeAubagio, kunye neTecfidera, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Inokwenzeka ngeAubagio:
    • i-alopecia (ukunciphisa iinwele okanye ukulahleka kweenwele)
    • ukonyuka kwamanqanaba ee-enzyme zesibindi (kunokuba luphawu lomonakalo wesibindi)
    • intloko ebuhlungu
    • kunciphise amanqanaba e-phosphate
    • ukuba ndindisholo okanye ukubetha ezandleni okanye ezinyaweni
    • intlungu edibeneyo
  • Inokwenzeka ngeTecfidera:
    • ukucoca (ukufudumala nokubomvu kwesikhumba sakho)
    • irhashalala
    • iintlungu esiswini sakho
  • Inokwenzeka kunye neAubagio kunye neTecfidera:
    • isicaphucaphu
    • urhudo

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeAubagio, kunye neTecfidera, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Inokwenzeka ngeAubagio:
    • Olunye ulusu olunzulu, njengoStevens-Johnson syndrome (izilonda ezibuhlungu emlonyeni wakho, emqaleni, emehlweni, okanye kwilungu lobufazi)
    • ukwanda koxinzelelo lwegazi
  • Inokwenzeka ngeTecfidera:
    • I-leukoencephalopathy eqhubekayo ye-multifocal (PML), isifo sentsholongwane yenkqubo ye-nervous system
  • Inokwenzeka kunye neAubagio kunye neTecfidera:
    • ukulimala kwesibindi
    • ukusilela kwesibindi
    • amanqanaba asezantsi eeseli ezimhlophe zegazi
    • negazi lakho kakhulu

Ukusebenza ngempumelelo

I-Multiple sclerosis (MS) kuphela kwemeko yokuba ii-Aubagio kunye neTecfidera zisetyenziselwa ukunyanga.

Uphononongo lweklinikhi ngokuthelekisa ngokuthe ngqo ukusebenza kweAubagio kunye neTecfidera kunyango lwe-MS. Abaphandi bajonge kwimagneti ye-magnetic resonance imaging (MRI) yabantu abasebenzisa iziyobisi. Kubantu abathathe i-Aubagio, i-30% yayinezilonda ezitsha okanye ezinkulu (izicwili ezibomvu). Oku kwafaniswa ne-40% yabantu abathathe iTecfidera.

La mayeza mabini ayesebenza ngokufanayo. Nangona kunjalo, xa ujonga indlela amachiza abuchaphazele ngayo ubuchopho ngokubanzi, i-Aubagio yayineziphumo ezingcono kuneTecfidera.

Oko kwathethi, kuba bekukho abantu abangama-50 kuphela kolu phando, uphando olongezelelekileyo luyafuneka ukwenza uthelekiso oluchanekileyo phakathi kwezi ziyobisi zimbini.

Iindleko

I-Aubagio kunye neTecfidera zombini zineziyobisi ezinamagama. Azinazo iifom zohlobo oluqhelekileyo. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokwengqikelelo yeGoodRx.com, iTecfidera ngokubanzi ixabisa ngaphezulu kweAubagio. Indleko ozihlawulela iziyobisi ziya kuxhomekeka kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

IAubagio vs.Gilenya

Ukongeza kwiTecfidera (ngentla), iGileyadi ikwasetyenziselwa ukunyanga isifo sokuqina kwemithambo. Apha sijonga indlela iAubagio kunye neGilenya ezifanayo kunye ezahlukeneyo.

Sebenzisa

Ulawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) luvumile zombini iAubagio kunye neGilenya ukuba inyange abantu abadala ngeendlela eziphindaphindayo zesifo sokuqina kwemithambo. Kodwa u-Gilenya ukwamkelwe ukuba anyange i-MS kubantwana abaneminyaka eli-10 ubudala.

I-Aubagio iqulethe isithako esisebenzayo se-teriflunomide. I-Gilenya iqulethe into eyahlukileyo esebenzayo, i-fingolimod hydrochloride. La mayeza mabini akakho kwiklasi enye yeziyobisi, ke ayasebenza ngeendlela ezahlukeneyo zokunyanga i-MS.

Iifom zeziyobisi kunye nolawulo

I-Aubagio iza njengecwecwe oliginyeyo. Uthatha iyeza kanye ngemini. I-Gilenya iza njengepilisi oyiginyeyo. Uthatha iyeza kanye ngemini.

Iziphumo kunye neengozi

Umsebenzi weAubagio kunye neGilenya ngeendlela ezahlukeneyo kodwa baneziphumo ebezingalindelekanga ezifanayo. Imizekelo yeziphumo ebezingalindelekanga eziqhelekileyo nezibi kwicala ngalinye leziyobisi zidweliswe apha ngezantsi.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeAubagio, kunye neGilenya, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Inokwenzeka ngeAubagio:
    • i-alopecia (ukunciphisa iinwele okanye ukulahleka kweenwele)
    • isicaphucaphu
    • ukuba ndindisholo okanye ukubetha ezandleni okanye ezinyaweni
    • intlungu edibeneyo
    • kunciphise amanqanaba e-phosphate
  • Inokwenzeka kunye neGilenya:
    • iintlungu esiswini sakho
    • umkhuhlane
    • umqolo obuhlungu
    • ukukhohlela
  • Inokwenzeka kunye neAubagio kunye neGilenya:
    • urhudo
    • Amanqanaba okwanda kwee-enzyme zesibindi (ezinokuba luphawu lomonakalo wesibindi)
    • intloko ebuhlungu

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeAubagio, kunye neGilenya, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Inokwenzeka ngeAubagio:
    • iimpendulo zesikhumba ezinzulu, ezinjengeStevens-Johnson syndrome (izilonda ezibuhlungu emlonyeni wakho, emqaleni, emehlweni, okanye kwizitho zangasese)
    • iziphene zokuzalwa
    • amanqanaba asezantsi eeseli ezimhlophe zegazi
    • negazi lakho
  • Inokwenzeka kunye neGilenya:
    • umhlaza wolusu
    • iingxaki zombono
    • ukudideka ngequbuliso
  • Inokwenzeka kunye neAubagio kunye neGilenya:
    • ukwanda koxinzelelo lwegazi
    • iingxaki zokuphefumla
    • ukulimala kwesibindi
    • ukusilela kwesibindi

Ukusebenza ngempumelelo

Kwisifundo seklinikhi, iAubagio ngokuthelekiswa ngokuthe ngqo ne-Gilenya kubantu abane-multiple sclerosis (MS). Abantu abathathe iGilenya babephindaphinda i-0.18 MS rhoqo ngonyaka, ngelixa abantu abathathe i-Aubagio babephindaphinda i-0.24 MS rhoqo ngonyaka. Kodwa la machiza mabini ayesebenza ngokufanayo ekunciphiseni ukuqhubela phambili kokukhubazeka. Oku kuthetha ukuba ukukhubazeka komzimba akubanga kubi ngokukhawuleza.

Iindleko

IAubagio kunye neGilenya zombini zineziyobisi ezinamagama. Azinazo iifom zohlobo oluqhelekileyo. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokwengqikelelo yeGoodRx.com, i-Gilenya ngokubanzi ixabisa ngaphezulu kweAubagio. Indleko ozihlawulela iziyobisi ziya kuxhomekeka kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Indlela yokuthatha iAubagio

Kuya kufuneka uthathe iAubagio njengoko ugqirha wakho okanye umboneleli wezempilo ekuxelela njalo.

Ixesha

Thatha iAubagio kanye ngemini malunga nexesha elifanayo yonke imihla.

Ukuthatha iAubagio ngokutya

Ungathatha iAubagio kunye okanye ngaphandle kokutya. Ukuthatha la mayeza kunye nokutya akuyi kuchaphazela indlela elisebenza ngayo ichiza emzimbeni wakho.

Ngaba iAubagio inokuchotshozwa, ihlafunwe, okanye yahlulwe?

Akukhuthazwa ukuba iAubagio ichithwe, yahlulwe, okanye ihlafunwe. Akukhange kubekho zifundo zenziweyo ukufumanisa ukuba ngaba ukwenza ezi zinto kungatshintsha indlela esebenza ngayo iAubagio emzimbeni.

Iyeza elisebenzayo eAubagio, teriflunomide, yaziwa ngokuthwala incasa ekrakra, ke kuyacetyiswa kakhulu ukuba uthathe iAubagio iphelele.

Zeziphi iimvavanyo endizakuzidinga ngaphambi kokuqala unyango?

Ngaphambi kokuba uthathe iAubagio, ugqirha wakho uya kuqhuba iimvavanyo ukuqinisekisa ukuba ichiza likhuselekile kuwe. Oku kubandakanya:

  • Uvavanyo lwegazi ukubona ukuba isibindi sakho siphilile ngokwaneleyo.
  • Uvavanyo lwesikhumba sephepha (TB) okanye uvavanyo lwegazi ukukhangela i-TB.
  • Inani elipheleleyo legazi ukujonga izifo, kubandakanya i-leukoencephalopathy eqhubekayo. (Jonga icandelo le "Iinkcukacha zeziphumo ebezingalindelekanga" apha ngasentla ukufunda okungakumbi malunga ne-PML.)
  • Uvavanyo lokukhulelwa. Akufanele uthathe iAubagio ukuba ukhulelwe.
  • Uvavanyo lwegazi. Ukuthatha i-Aubagio kunokunyusa uxinzelelo lwegazi, ukuze ugqirha abone ukuba sele unoxinzelelo lwegazi oluphezulu.
  • Imagnetic resonance imaging (MRI) ngaphambi kwaye ngelixa uthatha iAubagio. Ugqirha wakho uya kujonga ingqondo yakho kulo naluphi na utshintsho kwizilonda (izicwili ezibomvu).

Ngelixa uthatha iAubagio, ugqirha wakho uya kukunika uvavanyo lwegazi lwenyanga ukuze ujonge isibindi sakho. Kananjalo baya kugcina uxinzelelo lwegazi.

Usebenza njani uAubagio

I-Multiple sclerosis (MS) sisifo esinganyangekiyo (sexesha elide). Ibangela ukuba amajoni akho omzimba ahlasele i-myelin (umaleko ongaphandle) kwimithambo-luvo emehlweni akho, kwingqondo nasemqolo. Oku kudala izicwili ezibomvu, ezenza ukuba kube nzima kwingqondo yakho ukuthumela imiyalezo kula malungu omzimba wakho.

I-Aubagio isebenza ngokwahlukileyo kwamanye amayeza e-MS. Yiyo kuphela i-pyrimidine synthesis inhibitor yokunyanga i-MS.

Indlela esebenza ngayo iAubagio ayiqondakali ngokupheleleyo. Kucingelwa ukuba iteriflunomide, ichiza elisebenzayo eAubagio, libhloka i-enzyme ethile. Amaseli omzimba afuna le enzyme ukuze iphindaphinde ngokukhawuleza. Xa i-enzyme ivaliwe, iiseli zomzimba azinako ukusasaza kwaye zihlasele i-myelin.

Kuthatha ixesha elingakanani ukusebenza?

I-Aubagio iqala ukusebenza kwangoko emva kokuba uyithathile. Nangona kunjalo, awunakuwubona umohluko kwiimpawu zakho nasemva kokuba ichiza liqale ukusebenza. Kungenxa yokuba iyasebenza ukunceda ukuthintela ukubuyela umva kunye nezilonda ezintsha, zizenzo ezinokuthi zingabonakali ngokuthe ngqo.

UAubagio kunye nokukhulelwa

Ukuthatha iAubagio xa ukhulelwe kunokubangela iziphene zokuzalwa ezinkulu. Musa ukulithatha eli chiza ukuba ukhulelwe. Ukuba unokukhulelwa kwaye awusebenzisi ulawulo lokuzalwa oluthembekileyo, akufuneki uthathe iAubagio.

Ukuba ukhulelwe ngelixa usebenzisa iAubagio, yeka ukuthatha ichiza kwaye uxelele ugqirha ngoko nangoko. Xelela ugqirha wakho ukuba ufuna ukukhulelwa kungaphelanga iminyaka emibini. Kule meko, banokukuqala ngonyango ukuze ususe iAubagio ngokukhawuleza kwinkqubo yakho (jonga "imibuzo eqhelekileyo malunga neAubagio" apha ngezantsi).

I-Aubagio inokuhlala egazini ixesha elide, mhlawumbi ukuya kuthi ga kwiminyaka emibini emva kokuyeka unyango. Ekuphela kwendlela yokwazi ukuba iAubagio isese kwinkqubo yakho kukwenza uvavanyo lwegazi. Sebenza nogqirha wakho ukuze kuvavanywe amanqanaba akho ukuqinisekisa ukuba ukukhulelwa kukhuselekile. Ude uyazi ukuba iAubagio iphumile kwinkqubo yakho, kubalulekile ukugcina usebenzisa ulawulo lokuzalwa.

Unokubhalisela irejista eyanceda ukuqokelela ulwazi malunga namava akho. Iirejista zokuvezwa kokukhulelwa zinceda oogqirha bafunde ngakumbi malunga nokuba amachiza athile abachaphazela njani abantu ababhinqileyo kunye nokukhulelwa kwabo. Ukubhalisa, tsalela umnxeba 800-745-4447 kwaye ucofe ukhetho 2.

Ukuba unomdla malunga nokukhulelwa ngelixa uthatha iAubagio, thetha nogqirha wakho. Banokucebisa ngeendlela ezifanelekileyo zolawulo lokuzalwa.

Kwamadoda: Amadoda athatha i-Aubagio kufuneka asebenzise ngokufanelekileyo ukukhulelwa. Kuya kufuneka baxelele ugqirha ukuba iqabane labo liceba ukukhulelwa.

I-Aubagio kunye nokuncancisa

Ayaziwa nokuba i-Aubagio idlula ubisi lwebele.

Ngaphambi kokuba uthathe iAubagio, xelela ugqirha wakho ukuba uncelisa umntwana wakho okanye ucwangcise ukuncancisa. Banokuxoxa nawe ngomngcipheko kunye nezibonelelo zokuthatha ichiza ngelixa uncancisa.

Imibuzo eqhelekileyo malunga neAubagio

Nazi iimpendulo kwimibuzo ebuzwa rhoqo malunga neAubagio.

Ngaba iAubagio i-immunosuppressant?

I-Aubagio ayihlelwa njenge-immunosuppressant, kodwa isenokuwenza buthathaka amajoni akho omzimba. Ukuba amajoni akho omzimba awanamandla ngokwaneleyo okulwa neentsholongwane, kunokwenzeka ukuba ufumane usulelo.

Ukuba unomdla malunga nosulelo olunokwenzeka ngelixa uthatha iAubagio, thetha nogqirha wakho.

Ndiyenza njani "into yokuhlamba" yeAubagio?

Ukuba uthatha iAubagio kwaye ukhulelwe okanye ufuna ukukhulelwa, xelela ugqirha wakho ngoko nangoko. Banokusebenzela ukususa ngokukhawuleza iAubagio emzimbeni wakho.

I-Aubagio inokuhlala kwinkqubo yakho ukuya kuthi ga kwiminyaka emibini emva kokuba uyekile ukuyithatha. Ukufumanisa ukuba usenayo iAubagio kwinkqubo yakho, kuyakufuneka wenze uvavanyo lwegazi.

Ukuze "uhlambe," okanye ususe ngokukhawuleza, iAubagio, ugqirha wakho uya kukunika icholestyramine okanye ipowder yamalahle esebenzayo.

Ngaba ndifanele ndisebenzise ulawulo lokuzalwa ngelixa ndithatha iAubagio?

Ewe kufuneka usebenzise izinto zokuthintela ukukhawula (uthintelo lokuzalwa) ngelixa uthatha iAubagio.

Ukuba ungumfazi onokukhulelwa, ugqirha wakho uya kukunika uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango lwe-Aubagio. Kubalulekile ukuba ungakhulelwa ngelixa uthatha iAubagio kuba ichiza linokubangela iziphene zokuzalwa.

Amadoda athatha i-Aubagio kufuneka asebenzise ngokufanelekileyo ukukhulelwa. Kuya kufuneka baxelele ugqirha ukuba iqabane labo liceba ukukhulelwa.

Ngaba iAubagio ibangela ukugungxula?

Hayi. Izifundo ze-Aubagio azange zichaze ukugungxwa (ukufudumala nokubomvu kulusu lwakho) njengempembelelo esecaleni yokuthatha iyeza.

Nangona kunjalo, ukugungxula kunokuba sisiphumo esisecaleni samanye amayeza anyanga i-multiple sclerosis (MS), enje ngeTecfidera.

Ngaba ndiza kuba neziphumo zokurhoxa xa ndiyeka ukuthatha iAubagio?

Iziphumo zokurhoxa azange zichazwe kwizifundo zeAubagio. Ke akunakulindeleka ukuba ube neempawu zokurhoxa xa uyeka unyango lwe-Aubagio.

Nangona kunjalo, iimpawu zakho ze-multiple sclerosis (MS) zinokuya zisiba mbi xa uyeka ukuthatha i-Aubagio. Oko kunokubonakala ngathi yimpendulo yokurhoxa, kodwa ayisiyiyo into efanayo.

Ungayeki ukuthatha iAubagio ngaphandle kokuthetha nogqirha wakho kuqala. Banokukunceda ulawule nakuphi na ukonyuka kweempawu zakho ze-MS.

Ngaba iAubagio inokubangela umhlaza? Ngaba inxulunyaniswa nokufa?

Kwizifundo zeklinikhi zeAubagio, umhlaza wawungenguye umphumo wecala owenzekileyo. Nangona kunjalo, kwimeko yengxelo, umfazi one-multiple sclerosis wenza i-follicular lymphoma emva kokuthatha i-Aubagio iinyanga ezisibhozo. Ingxelo ayizange ibange ukuba i-Aubagio yayingunobangela womhlaza, kodwa ayizange ikhuphe loo nto.

Kwizifundo zeklinikhi yaseAubagio, abantu abane babulawa ziingxaki zentliziyo. Oku kwakungabantu abamalunga nama-2 600 abathatha ichiza. Kodwa akuzange kuboniswe ukuba ukuthatha i-Aubagio kubangele oku kufa.

Izilumkiso zeAubagio

Eli chiza liza nezilumkiso ezininzi.

Izilumkiso ze-FDA

Eli chiza linezilumkiso zebhokisi. Isilumkiso esibhokisi sisilumkiso esinzulu esivela kuLawulo lokutya kunye noLawulo lweziyobisi (FDA). Yazisa oogqirha kunye nezigulana malunga neziphumo zeziyobisi ezinokuba yingozi.

  • Umonakalo omkhulu wesibindi. I-Aubagio inokubangela iingxaki zesibindi ezinzima, kubandakanya ukusilela kwesibindi. Ukuthatha i-Aubagio kunye nezinye iziyobisi ezinokuchaphazela isibindi sakho kunokunyusa inani le-Aubagio emzimbeni wakho. Oku kungonakalisa isibindi sakho. Elinye lala machiza yiArava (leflunomide), emiselwe ukunyanga isifo samathambo. Ugqirha wakho uya kukunika uvavanyo lwegazi ngaphambi kwaye ngelixa uthatha iAubagio ukujonga isibindi sakho.
  • Umngcipheko weziphene zokuzalwa. Ukuba ukhulelwe, akufuneki uthathe iAubagio kuba inokubangela iziphene zokuzalwa ezinkulu. Ukuba unokukhulelwa kwaye awusebenzisi ulawulo lokuzalwa oluthembekileyo, akufuneki uthathe iAubagio. Ukuba ukhulelwa ngelixa uthatha iAubagio, yeka ukuyithatha kwaye uxelele ugqirha wakho ngoko nangoko.

Ezinye izilumkiso

Ngaphambi kokuba uthathe iAubagio, thetha nogqirha wakho malunga nembali yakho yezempilo. I-Aubagio isenokungakulungeli ukuba uneemeko ezithile zonyango. Oku kubandakanya:

  • Isifo sesibindi. I-Aubagio inokubangela ukonakala kwesibindi. Ukuba unesifo sesibindi, iAubagio inokuyenza mandundu.
  • Ukuphendula kwangaphambili. Gwema ukuthatha i-Aubagio ukuba unayo impendulo yokugula:
    • zibaunidide
    • ngocomocide
    • naziphi na ezinye izithako eAubagio

Ukugqithisa kweAubagio

Kukho ulwazi olulinganiselweyo malunga nokusebenzisa ngaphezulu komthamo ocetyiswayo weAubagio.

Kufuneka wenze ntoni xa uthe wagqithisa?

Ukuba ucinga ukuba uthathe iAubagio kakhulu, biza ugqirha wakho. Ungabiza uMbutho waseMelika wamaZiko oLawulo lweTyhefu ku-800-222-1222 okanye usebenzise isixhobo esikwi-Intanethi. Kodwa ukuba ucinga ukuba unonyango olungxamisekileyo, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko.

Ukuphelelwa lixesha kweAubagio, ukugcinwa kunye nokulahlwa

Xa ufumana iAubagio kwikhemesti, usokhemesti uya kongeza umhla wokuphelelwa kwileyibhile esebhotileni. Lo mhla uqhelekile ukuba ube ngunyaka omnye ukusukela kumhla wokuhambisa kwabo amayeza.

Umhla wokuphelelwa unceda ekuqinisekiseni ukusebenza kwamayeza ngeli xesha. Isimo sangoku soLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) kukuphepha ukusebenzisa amayeza aphelelwe lixesha. Ukuba awusebenzisanga iyeza elidlulileyo kumhla wokuphelelwa kwalo, thetha nosokhemesti wakho malunga nokuba unganako na ukuyisebenzisa.

Ukugcina

Ukuhlala ixesha elingakanani iyeza lihlala lilungile kunokuxhomekeka kwizinto ezininzi, kubandakanya ukuba uligcina phi kwaye phi na iyeza.

Gcina iipilisi zeAubagio kubushushu begumbi phakathi kwama-68 ° F kunye nama-77 ° F (20 ° C nama-25 ° C).

Ukulahla

Ukuba akusafuneki uthathe iAubagio kwaye unamayeza aseleyo, kubalulekile ukuba uyilahle ngokukhuselekileyo. Oku kunceda ukuthintela abanye, kubandakanya abantwana kunye nezilwanyana zasekhaya, ekubeni bathathe iyeza ngengozi. Kuyanceda ukugcina ichiza lingonzakalisi okusingqongileyo.

Iwebhusayithi ye-FDA ibonelela ngeengcebiso ezininzi eziluncedo ngokulahla amayeza. Unokucela ikhemesti yakho ukuba ikwazi ukuba ulahla njani na amayeza akho.

Ulwazi lobungcali lweAubagio

Olu lwazi lulandelayo lubonelelwe ngoochwephesha kunye nabanye abaqeqeshi bezempilo.

Uphawu

I-Aubagio ibonakalisiwe ukuba inyange abantu ngeendlela eziphindaphindayo ze-multiple sclerosis (MS).

Indlela yokusebenza

I-Aubagio iqulethe isithako esisebenzayo se-teriflunomide. I-Teriflunomide inqanda i-enzyme ye-mitochondrial ebizwa ngokuba yi-dihydroorotate dehydrogenase, ebandakanyeka kwi-de novo pyrimidine synthesis. I-Aubagio inokusebenza ngokunciphisa inani lee-lymphocyte ezisebenzayo kwinkqubo ye-nervous system.

I-Pharmacokinetics kunye ne-metabolism

Emva kolawulo lomlomo, uxinzelelo oluphezulu lwenzeka kwisithuba seeyure ezine. I-Aubagio ikakhulu iphantsi kwe-hydrolysis kwaye inyanzeliswa kwimetabolites ezincinci. Iindlela zesekondari zemetabolism zibandakanya ukudibanisa, ioksijini, kunye ne-N-acetylation.

I-Aubagio yi-CYP1A2 inducer kwaye inqanda i-CYP2C8, i-efflux yokuhambisa umhlaza webele weprotein (BCRP), i-OATP1B1, kunye ne-OAT3.

I-Aubagio inobomi obunesiqingatha seentsuku ezili-18 ukuya kwezi-19 kwaye ubukhulu becala ikhutshiwe kwilindle (malunga nama-38%) kunye nomchamo (malunga nama-23%).

Ukungqinelana

I-Aubagio iyaphikiswa kwizigulana ezi:

  • ukukhubazeka okukhulu kwesibindi
  • Imbali ye-hypersensitivity to teriflunomide, leflunomide, okanye naliphi na elinye icandelo leziyobisi
  • Ukusetyenziswa ngokuhambelana kunye ne-leflunomide
  • ukubakho kokukhulelwa ngaphandle kokusebenzisa izinto zokucwangcisa okanye ukhulelwe

Ukugcina

I-Aubagio kufuneka igcinwe kubushushu begumbi phakathi kwama-68 ° F kunye nama-77 ° F (20 ° C nama-25 ° C).

Ukuziphendulela: Iindaba zezoNyango namhlanje zenze zonke iinzame zokuqinisekisa ukuba zonke iinkcukacha zichanekile, zibanzi kwaye zihlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi. Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.

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