I-Baricitinib: yeyantoni, ungayithatha njani kunye neziphumo ebezingalindelekanga

Umxholo

• Yenzelwe ntoni
• Ngaba i-baricitinib iyacetyiswa kunyango lwe-COVID-19?
• Indlela yokuthatha
• Iziphumo ebezingalindelekanga ezinokwenzeka
• Ngubani ongafanele asebenzise

I-Baricitinib sisixhobo esinciphisa ukuphendula kwamajoni omzimba, ukunciphisa isenzo se-enzymes ezikhuthaza ukudumba kunye nokubonakala komonakalo odibeneyo kwimeko ye-rheumatoid arthritis. Ngale ndlela, eliyeza liyakwazi ukunciphisa ukudumba, ukukhulula iimpawu zesi sifo ezinjengeentlungu kunye nokudumba kwamalungu.

Eli chiza livunyiwe ngu-Anvisa ukuba lisetyenziswe kwi-rheumatoid arthritis, enegama lezorhwebo i-Olumiant kwaye linokuthengwa ezikhemisti kuphela ngommiselo, ngohlobo lweepilisi ze-2 okanye ze-4 mg.

Yenzelwe ntoni

IBaricitinib iboniswa ukunciphisa iintlungu, ukuqina kunye nokudumba kwesifo samathambo, ukongeza ekunciphiseni ukuqhubela phambili kwethambo kunye nomonakalo odibeneyo.

Eli yeza linokusetyenziswa lilodwa okanye lidibene ne-methotrexate, kunyango lwe-rheumatoid arthritis.

Ngaba i-baricitinib iyacetyiswa kunyango lwe-COVID-19?

I-Baricitinib igunyaziswe e-United States kuphela ukuba inyange usuleleko nge-coronavirus entsha orhanelwa ngayo okanye iqinisekiswe ngovavanyo lwebhubhoratri, xa isetyenziswa ngokudibanisa ne-remdesivir, eyi-antiviral. I-Remdesivir igunyazisiwe yi-Anvisa yezifundo zovavanyo zeCovid-19.

Olunye uphononongo lubonakalisile ukuba eli chiza linokunceda ukuthintela ukungena kwe-coronavirus kwiiseli kunye nokunciphisa ixesha lokubuyisela kunye nokufa kwabantu kumodareyitha ukuya kwimo enzima, kubantu abadala abasesibhedlele kunye nabantwana abangaphezulu kweminyaka emibini ubudala abafuna ioksijini, umatshini wokungenisa umoya okanye ioksijini yangaphakathi. Jonga zonke iziyobisi ezivunyiweyo kunye nezifundwayo zeCovid-19.

Ngokuka-Anvisa, ukuthengwa kwe-baricitinib ekhemesti kusavumelekile, kodwa kuphela kubantu abanemigqaliselo yonyango yesifo samathambo.

Indlela yokuthatha

IBaricitinib kufuneka ithathwe ngomlomo ngokweengcebiso zonyango, kanye ngemini, ngaphambi okanye emva kokondla.

Ithebhulethi kufuneka isoloko ithathwa ngaxeshanye, kodwa xa kukho ukulibala, idosi kufuneka ithathwe ngokukhawuleza nje ukuba ukhumbule kwaye ulungelelanise iishedyuli ngokwale dosi yokugqibela, uqhubeke nonyango ngokwamaxesha amiselweyo. Sukuyiphinda kabini idosi ukwenza idosi ekhohliweyo.

Ngaphambi kokuba uqale unyango nge-baricitinib, ugqirha kufuneka acebise ukuba wenze iimvavanyo ukuqinisekisa ukuba awunaso isifo sephepha okanye ezinye izifo.

Iziphumo ebezingalindelekanga ezinokwenzeka

Ezinye zeempembelelo eziqhelekileyo ezinokuthi zenzeke ngexesha lokunyanga nge-baricitinib zi-reactionergic kwizinto zepilisi, isicupucu okanye ukwanda kwengozi yokusuleleka okubandakanya isifo sofuba, i-fungal, ibhaktheriya okanye ukusuleleka kwintsholongwane njenge-herpes simplex okanye i-herpes zoster.

Ukongeza, i-baricitinib inokunyusa umngcipheko wokuba ne-lymphoma, i-vein thrombosis okanye i-pulmonary embolism.

Kuyacetyiswa ukuba uyeke ukusebenzisa kwaye ufune uncedo lwezonyango kwangoko ukuba iimpawu zokungabikho komzimba kwi-baricitinib zivela, njengobunzima bokuphefumla, imvakalelo yokuxinana emqaleni, ukudumba emlonyeni, ulwimi okanye ubuso, okanye isifuba, okanye ukuba uthatha I-baricitinib kwiidosi ezinkulu kunezo zicetyiswayo ekulandeleni iimpawu kunye neempawu zeziphumo ebezingalindelekanga.

Ngubani ongafanele asebenzise

I-Baricitinib akufuneki isetyenziswe ngabafazi abakhulelweyo okanye abancancisayo, kwimeko yesifo sephepha okanye usulelo lokungunda olunjenge-candidiasis okanye i-pneumocystosis.

Eli yeza kufuneka lisetyenziswe ngononophelo kubantu abaneengxaki zokunqanda igazi, kubandakanya abantu abadala, abantu abatyebe kakhulu, abantu abanembali ye-thrombosis okanye i-embolism okanye abantu abaza kuba nohlobo oluthile lotyando kwaye kufuneka babenamandla. Ukongeza, ulumkiso kufuneka lusetyenziswe nakwimeko yabantu abanesifo esingasebenzi kakuhle sesibindi okanye sezintso, i-anemia okanye abantu abanamajoni omzimba abuthathaka, abanokufuna uhlengahlengiso lwedosi ngugqirha.