I-CBD yeFibromyalgia

Umxholo

• Uphando nge-CBD ye-fibromyalgia
• Izifundo zangaphambili
• Ufundo lwe-2019 lwesiDatshi
• Isifundo se-2019 sakwa-Israeli
• Ukhetho lonyango lwe-CBD
• Iziphumo ebezingalindelekanga ze-CBD
• Imbonakalo

Ukuqonda i-cannabidiol (CBD)

I-Cannabidiol (i-CBD) sisixhobo semichiza esenziwe nge-cannabis. I-CBD ayisebenzi ngengqondo, ngokungafaniyo ne-tetrahydrocannabinol (THC), enye imveliso ye-cannabis.

I-CBD icingelwa ukuba isebenze ii-serotonin receptors. Idlala indima:

• ukuqonda intlungu
• ukugcina ubushushu bomzimba
• ukunciphisa ukudumba

Ngokwezifundo zamva nje, i-CBD nayo:

• kunceda ukunciphisa iimpawu zoxinzelelo
• inokuthintela iimpawu zengqondo yengqondo

Ezi zibonelelo zezinto ezenza ukuba i-CBD ibe lolunye unyango olunomdla ekuphazamiseni iintlungu ezinje nge-fibromyalgia.

Uphando nge-CBD ye-fibromyalgia

I-Fibromyalgia sisifo esinganyangekiyo sentlungu ebangela iintlungu ze-musculoskeletal ukongeza:

• ukudinwa
• ukuphuthelwa
• imiba yokuqonda

Ichaphazela ikakhulu abasetyhini, kwaye okwangoku akukho nyango lwaziwayo ngale meko. Nangona kunjalo, iinketho zonyango ziyafumaneka ezijolise kulawulo lweentlungu.

I-CBD isetyenziselwe ukunciphisa iimpawu zentlungu engapheliyo kunye nokunciphisa ukudumba. Inikwe njengenye indlela yokuthatha imigqaliselo ye-opioid enokuba ngumlutha.

Nangona kunjalo, uLawulo lwezoKutya kunye neDrug (i-FDA) alwamkelanga i-CBD njengonyango kunyango lwe-fibromyalgia okanye uninzi lweemeko. Iyeza elisekwe kwi-CBD elise-Epidiolex, unyango lokuxhuzula, kuphela kwemveliso ye-CBD evunyiweyo kwaye ilawulwa yi-FDA.

Okwangoku akukho zifundo zipapashiweyo kwi-fibromyalgia ejonga iziphumo ze-CBD ngokwayo. Nangona kunjalo, olunye uphando lujonga iziphumo ze-cannabis, ezinokuthi ziqulethe ii-cannabinoids ezininzi, kwi-fibromyalgia.

Iziphumo ziye zaxutywa. Izifundo ezingakumbi zabantu ziyafuneka.

Izifundo zangaphambili

Kufunyenwe ukuba i-CBD inokusetyenziselwa ukunciphisa iintlungu ze-neuropathic. Abaphandi bagqiba kwelokuba ii-cannabinoids ezinjenge-CBD zinokuba sisixhobo esisebenzayo kwezinye iintlungu zentlungu.

Uphononongo luka-2011 lujonge abantu abangama-56 abane-fibromyalgia. Uninzi lwabathathi-nxaxheba yayingabafazi.

Amalungu ophando ayenamaqela amabini:

• Elinye iqela lalinamalungu angama-28 abathathi-nxaxheba ababengabasebenzisi be-cannabis.
• Iqela lesibini lalinabathathi-nxaxheba abangama-28 ababengabasebenzisi be-cannabis. Ubuninzi bokusetyenziswa kwe-cannabis, okanye inani le-cannabis abayisebenzisileyo, lahlukile.

Kwiiyure ezimbini emva kokusebenzisa i-cannabis, abasebenzisi be-cannabis bafumana izibonelelo ezinje:

• iintlungu ezincitshisiweyo kunye nokuqina
• ukwanda kokulala

Babenamanqaku aphezulu empilo engqondo kunabo bangasebenzisi.

Ufundo lwe-2019 lwesiDatshi

Isifundo se-2019 saseDatshi sijonge umphumo we-cannabis kubafazi be-20 abane-fibromyalgia. Ngaphezulu kwesifundo, umntu ngamnye othathe inxaxheba ufumene iintlobo ezine zentsangu:

• inani elingachazwanga lendidi ye-placebo, ebingenayo i-CBD okanye i-THC
• I-200 milligrams (mg) yeentlobo ngexabiso eliphezulu zombini i-CBD kunye ne-THC (iBediol)
• I-200 mg yeentlobo ngexabiso eliphezulu le-CBD kunye nexabiso eliphantsi le-THC (iBedrolite)
• I-100 mg yeentlobo ngexabiso eliphantsi le-CBD kunye nexabiso eliphezulu le-THC (iBedrocan)

Abaphandi bafumanise ukuba amanqaku eentlungu ezizenzekelayo zabantu abasebenzisa iindidi ze-placebo zazifana neempawu zentlungu ezizenzekelayo yabantu abasebenzisa ezinye zeentlobo ze-non-placebo.

Nangona kunjalo, iBediol, ephezulu kwi-CBD kunye ne-THC, yazisa isiqabu kwinani elikhulu labantu kunaleyo yayenziwe yi-placebo. Kubangele ukunciphisa iipesenti ezingama-30 zentlungu ezenzekelayo kwi-18 kwabathathi-nxaxheba abangama-20. Indawo ye-placebo ibangele ukuncipha kwe-30 yeepesenti yokubandezeleka okuzenzekelayo kubathathi-nxaxheba be-11.

Ukusetyenziswa kweBediol okanye iBedrocan, zombini iintlobo eziphezulu ze-THC, ziphucule kakhulu imingcele yoxinzelelo xa ithelekiswa ne-placebo.

I-Bedrolite, ephezulu kwi-CBD kwaye iphantsi kwi-THC, ayibonisanga bungqina bokuba nakho ukukhulula iintlungu ezizenzekelayo okanye ezikhutshiweyo.

Isifundo se-2019 sakwa-Israeli

Kuphononongo lakwa-Israeli lwango-2019, amakhulu abantu abane-fibromyalgia baqwalaselwa ngaphezulu kweenyanga ezi-6. Kubathathi-nxaxheba, iipesenti ezingama-82 yayingabafazi.

Abathathi-nxaxheba abafundayo bafumana isikhokelo kubahlengikazi ngaphambi kokuba bathathe i-cannabis yonyango. Abongikazi banikezela ngengcebiso malunga:

• Iintlobo ezili-14 ze-cannabis ezazifumaneka
• iindlela zokuhambisa
• iidosi

Bonke abathathi-nxaxheba baqala ngedosi esezantsi ye-cannabis, kwaye iidosi zonyuswa ngokuthe ngcembe ngexesha lokufunda. Umyinge ovunyiweyo we-cannabis uqalile kwi-670 mg ngosuku.

Kwiinyanga ezi-6, i-median evunyiweyo ye-cannabis yayiyi-1,000 mg ngosuku. Umyinge ovunyiweyo ophakathi we-THC yayiyi-140 mg, kwaye idosi evunyiweyo ye-CBD yayiyi-39 mg ngosuku.

Abaphandi bavumile ukuba isifundo besinemiqathango. Umzekelo, babenako ukulandela malunga neepesenti ezingama-70 zabathathi-nxaxheba. Ukusetyenziswa kweentlobo ezininzi ezahlukeneyo kwenza ukuba kube nzima ukuthelekisa iziphumo ze-CBD ezizityebi kunye ne-THC.

Nangona kunjalo, bagqibe kwelokuba unyango lwe-cannabis lwalunyango olukhuselekileyo nolusebenzayo lwe-fibromyalgia.

Ekuqaleni kophononongo, iipesenti ezingama-52.5 zabathathi-nxaxheba, okanye abantu abayi-193, bachaza inqanaba lentlungu njengaphezulu. Ukulandelwa kweenyanga ezi-6, kuphela yi-7.9 yepesenti yabo baphendulayo, okanye abantu be-19, baxela amanqanaba aphezulu entlungu.

Ukhetho lonyango lwe-CBD

Ukuba ufuna ukuphepha ukusebenza kwentsangu ngengqondo, unokufumana iimveliso ze-CBD eziqulethe kuphela inani le-THC. Ukuba uhlala kwindawo apho intsangu yolonwabo okanye yezomthetho isemthethweni, unokufumana iimveliso ze-CBD ezinokuxinana okuphezulu kwe-THC.

Nangona zinezibonelelo ngokwahlukeneyo, i-CBD kunye ne-TCH kusenokwenzeka ukuba zisebenza kakuhle xa zidityanisiwe. Iingcali zibhekisa kolu manyano, okanye ukuhlangana, njenge "mpembelelo yeqela."

I-CBD ikwasebenza ngokuchasene ne-receptors ekujolise kuyo i-THC ukunciphisa iziphumo ezibi zentsangu, ezinje ngeparanoia kunye noxinzelelo.

Ungayidla i-CBD ngeendlela ezininzi, kubandakanya:

• Ukutshaya okanye ukuqhuma. Ukuba ufuna ukuthomalalisa iintlungu ezikhawulezileyo, ukutshaya i-CBD ene-cannabis yeyona ndlela ikhawulezayo yokunciphisa iimpawu. Iziphumo zinokufikelela kwiiyure ezi-3. Ukutshaya okanye ukutshiza kukuvumela ukuba ungene ngaphakathi ngqo kwi-CBD kwisityalo se-cannabis, ukufunxa imichiza kwigazi lakho nasemiphungeni.
• Ukutya. Ukutya kukutya okuphekwe ngesityalo se-cannabis, okanye ioyile okanye ibhotolo efakwe i-cannabis. Kuya kuthatha ixesha elide ukufumana ukukhululeka kweempawu, kodwa iziphumo zokutya zinokuhlala ukuya kuthi ga kwiiyure ezingama-6.
• Izicatshulwa zeoyile. Iioyile zinokusetyenziswa ngokwezihloko, zithathwe ngomlomo, okanye zinyibilike phantsi kolwimi kwaye zingene kwizicubu zomlomo.
• Imixholo. Iioyile ze-CBD zinokufakwa kwiikhrim okanye ii-balms ze-topical kwaye zisetyenziswe ngqo kulusu. Ezi mveliso ze-CBD zinokuba lukhetho olusebenzayo lokunciphisa ukudumba kunye nokunceda ngeentlungu zangaphandle.

Kukho iingozi zokuphefumla ngokutshaya okanye ukutshaya intsangu. Abantu abane-asthma okanye iimeko zemiphunga akufuneki basebenzise le ndlela.

Kuya kufuneka uphinde ulandele imiyalelo yedosi ngononophelo, ngakumbi ngokutya, ukunqanda iziphumo ebezingalindelekanga zokuthatha kakhulu.

Iziphumo ebezingalindelekanga ze-CBD

I-Cannabidiol icingelwa ukuba ikhuselekile kwaye ineziphumo ebezingalindelekanga ezincinci. Nangona kunjalo, abanye abantu baye bafumana le miphumo ilandelayo emva kokusebenzisa i-CBD:

• ukudinwa
• urhudo
• utshintsho lokutya
• utshintsho lobunzima

Isifundo kwiimpuku ezinxulumene nokutya kwe-CBD kwityhefu yesibindi. Nangona kunjalo, ezinye iimpuku kolu phononongo zanyanzeliswa ngenani elikhulu le-CBD ngohlobo lwe-CBD etyebileyo ye-cannabis.

Ukudibana kweziyobisi kunokwenzeka nge-CBD. Lumka kubo ukuba ngoku uthatha ezinye izongezo okanye amayeza.

I-CBD, njengegrapefruit, ikwaphazamisa ii-cytochromes P450 (CYPs). Eli qela le-enzymes libalulekile kwimetabolism yeziyobisi.

Imbonakalo

Abaphandi basahlola ukuba ngaba i-CBD inokunyanga ngokufanelekileyo ukuphazamiseka okungapheliyo. Izifundo ezithe kratya ziyafuneka. Kukho amabali empumelelo, kodwa i-CBD ayivunyelwanga yi-FDA ye-fibromyalgia. Kwakhona, uphando alukasibonisi iziphumo zexesha elide ze-CBD emzimbeni.

Kuze kube yinto eyaziwayo, unyango lwendabuko lwe-fibromyalgia luyacetyiswa.

Ukuba uthatha isigqibo sokusebenzisa iimveliso ze-CBD kulawulo lweentlungu, qiniseka ukudibana nogqirha kuqala. Banokukunceda ukuba uphephe iziphumo ebezingalindelekanga okanye unxibelelwano oluyingozi namayeza akho kunye nonyango.