Isikhokelo seNgxoxo ngoGqirha: Iingcebiso ngokuxoxa ngokuTshintsha kwePIK3CA kunye noGqirha wakho

Umxholo

• Yintoni uguquko lwePIK3CA?
• Ulufumana njani olu tshintsho?
• Ngaba utshintsho kum luchaphazela njani unyango lwam?
• Uguquko lwam luyichaphazela njani imbonakalo yam?
• Yise kude

Uvavanyo oluninzi lunokunceda ugqirha wakho ukuba afumane umhlaza webele we-metastatic, aqikelele ukuba uza kusebenza njani, kwaye ufumane olona nyango lusebenzayo kuwe. Uvavanyo lwe-Genetic lukhangela utshintsho kwiijeni, amacandelo e-DNA ngaphakathi kweeseli zakho ezilawula indlela osebenza ngayo umzimba wakho.

Olunye lotshintsho kwimfuza ugqirha anokuluvavanya PIK3CA. Funda ukuze ufunde ukuba olu tshintsho luchaphazela njani unyango kunye nembonakalo yakho.

Yintoni uguquko lwePIK3CA?

Inkqubo ye- PIK3CA Uhlobo lwemfuzo luphethe imiyalelo yokwenza iproteni ebizwa ngokuba yi-p110cy. Le protein ibalulekile kwimisebenzi emininzi yeseli, kubandakanya ukuxelela iiseli zakho ukuba kufuneka zikhule nini kwaye zahlule.

Abanye abantu banokuba notshintsho kule geni. PIK3CA Ukutshintsha kwemfuza kubangela ukuba iiseli zikhule ngokungalawulekiyo, ezinokubangela umhlaza.

PIK3CA Ukutshintsha kwemfuza kunxulunyaniswe nomhlaza wamabele, kunye nomhlaza wesibeleko, umphunga, isisu kunye nengqondo. Umhlaza webele kusenokwenzeka ukuba uvela kwindibaniselwano yotshintsho ukuya PIK3CA kunye nezinye izakhi zofuzo.

PIK3CA Utshintsho luchaphazela zonke i-cancer zomhlaza, kunye neepesenti ezingama-40 zabantu abane-estrogen receptor (ER) -i-positive, i-epidermal yokukhula kwe-factor factor 2 (HER2) -i-cancer ezingapheliyo.

I-ER-positive ithetha ukuba umdlavuza wakho webele ukhula ngokuphendula kwi-hormone estrogen. I-HER2-negative kuthetha ukuba awunazo iiproteni ze-HER2 ezingaqhelekanga kumphezulu weeseli zomhlaza wamabele.

Ulufumana njani olu tshintsho?

Ukuba une-ER-positive, umhlaza webele we-HER2-negative, ugqirha onyanga umhlaza wakho unokukuvavanya PIK3CA Ukutshintsha kwemfuza. Ngo-2019, i-FDA yamkela uvavanyo olubizwa ngokuba yitherascreen ukufumana utshintsho kwi PIK3CA Uhlobo.

Olu vavanyo lusebenzisa isampulu yegazi lakho okanye izicwili esifubeni sakho. Uvavanyo lwegazi lwenziwa njengalo naluphi na olunye uvavanyo lwegazi. Umongikazi okanye uchwepheshe uza kutsala igazi engalweni yakho ngenaliti.

Isampulu yegazi emva koko iya kwilebhu yohlalutyo. Umhlaza webele uchitha iziqwenga zeDNA yawo egazini. Ilebhu iya kuvavanya ifayile ye- PIK3CA yemfuza kwisampulu yegazi lakho.

Ukuba ufumana iziphumo ezingalunganga kuvavanyo lwegazi, kuya kufuneka ube ne-biopsy yokukuqinisekisa. Ugqirha wakho uya kususa isampuli yethishu ebeleni lakho ngexesha lotyando oluncinci. Isampuli yethishu ke iya elebhu, apho amagcisa avavanya kuyo PIK3CA Ukutshintsha kwemfuza.

Ngaba utshintsho kum luchaphazela njani unyango lwam?

Ukuba nefayile ye- PIK3CA Utshintsho lunokuthintela umhlaza wakho ekuphenduleni kunye nonyango lwehomoni olusetyenziselwa ukunyanga umhlaza webele we-metastatic. Ikwathetha ukuba ungumgqatswa weyeza elitsha elibizwa ngokuba yialpelisib (Piqray).

I-Piqray yi-PI3K inhibitor. Sisisiyobisi sokuqala ngohlobo lwaso. I-FDA yamkele uPiqray ngoMeyi 2019 ukuba anyange abantu ababhinqileyo abasemva kwamadoda kunye nabesilisa abanezilonda zamabele PIK3CA Utshintsho kwaye bane-HR-positive kunye ne-HER2-negative.

Ukuvunywa kwakusekwe kwiziphumo zesifundo se-SOLAR-1. Ityala lalibandakanya abasetyhini abangama-572 kunye namadoda ane-HR-positive kunye ne-HER2-negative cancer cancer. Umhlaza wabathathi-nxaxheba uqhubekile nokukhula kwaye usasazeka emva kokuba bephathwe nge-aromatase inhibitor njenge-anastrozole (Arimidex) okanye i-letrozole (Femara).

Abaphandi bafumanise ukuba ukuthatha iPiqray kuphucule ixesha abantu abaphila ngaphandle komhlaza wamabele wabo usiba mandundu. Kubantu abathathe iyeza, umhlaza wabo awuzange uqhubeke kangangeenyanga ezili-11, xa kuthelekiswa nomyinge weenyanga ezi-5.7 kubantu abangakhange bathathe iPiqray.

I-Piqray idityaniswe nonyango lwehormone fulvestrant (Faslodex). Ukuthatha amachiza amabini kunye kuyabanceda ukuba basebenze ngcono.

Uguquko lwam luyichaphazela njani imbonakalo yam?

Ukuba unayo PIK3CA Utshintsho, awunakuphendula kwiziyobisi ezisetyenziselwa ukunyanga umhlaza webele we-metastatic. Ukanti ukwaziswa kwePiqray kuthetha ukuba ngoku kukho ichiza elijolise ngokukodwa ekuguqukeni kwemfuza.

Abantu abathatha iPiqray kunye neFaslodex baphila ixesha elide ngaphandle kokuqhubela phambili kwesifo xa kuthelekiswa nabo bangalithathiyo eli chiza.

Yise kude

Ukwazi eyakho PIK3CA ubume bemfuza bunokuba luncedo ukuba umhlaza wakho awuphuculanga okanye ubuyile emva konyango. Buza ugqirha wakho ukuba kuya kufuneka uvavanyelwe le geni. Ukuba ngaba uvavanyo luthi unayo, unyango olutsha lunokunceda ukuphucula indlela ojonga ngayo.