Isikhokelo esilula kwiNkqubo ye-Endocannabinoid

Umxholo

• Ingaba isebenza kanjani?
• I-Endocannabinoids
• Ii-endocannabinoid receptors
• Iintsholongwane
• Yintoni imisebenzi yayo?
• Isebenza njani i-THC ne-ECS?
• Ngaba i-CBD inxibelelana njani ne-ECS?
• Kuthekani ngokusilela kwe-endocannabinoid?
• Umgca wezantsi

Inkqubo ye-endocannabinoid (ECS) yinkqubo entsonkothileyo yokubonisa iiseli ezichongwe kwii-1990s zokuqala ngabaphandi abaphonononga i-THC, into eyaziwayo ye-cannabinoid. Ii-cannabinoids yimixube efumaneka kwi-cannabis.

Iingcali zisazama ukuqonda ngokupheleleyo i-ECS. Kodwa ukuza kuthi ga ngoku, siyazi ukuba idlala indima kulawulo lwemisebenzi kunye neenkqubo, kubandakanya:

• lala
• imo
• ukutya
• imemori
• ukuzala nokuzala

I-ECS ikhona kwaye iyasebenza emzimbeni wakho nokuba awusebenzisi i-cannabis.

Funda ukuze ufunde ngakumbi nge-ECS kubandakanya ukuba isebenza njani kwaye inxibelelana njani ne-cannabis.

Ingaba isebenza kanjani?

I-ECS ibandakanya izinto ezintathu eziphambili: i-endocannabinoids, ii-receptors, kunye nee-enzymes.

I-Endocannabinoids

I-Endocannabinoids, ekwabizwa ngokuba zii-cannabinoids ezingapheliyo, ziimolekyuli ezenziwe ngumzimba wakho. Ziyafana ne-cannabinoids, kodwa ziveliswa ngumzimba wakho.

Iingcali zichonge ii-endocannabinoids eziphambili ukuza kuthi ga ngoku:

• anandamide (AEA)
• I-2-arachidonoylglyerol (2-AG)

Oku kunceda ukugcina imisebenzi yangaphakathi isebenza kakuhle. Umzimba wakho uvelisa njengoko kufuneka, usenza kube nzima ukwazi ukuba ngawaphi amanqanaba ahlukeneyo nganye nganye.

Ii-endocannabinoid receptors

Ezi zinto zifunyanwa emzimbeni wakho. I-Endocannabinoids ibophelela kubo ukuze ibonakalise ukuba i-ECS kufuneka ithathe inyathelo.

Zimbini izinto eziphambili ze-endocannabinoid receptors:

• Ii-receptors ze-CB1, ezifumaneka ikakhulu kwinkqubo ye-nervous system
• Ii-receptors ze-CB2, ezifumaneka ikakhulu kwinkqubo yakho yemithambo-luvo, ngakumbi iiseli zomzimba

I-Endocannabinoids inokubopha kuyo nayiphi na i-receptor. Iziphumo ezibangela ukuxhomekeka apho i-receptor ikhoyo kwaye yeyiphi i-endocannabinoid ebopha kuyo.

Umzekelo, i-endocannabinoids inokujolisa kwii-CB1 receptors kwithambo lomgogodla ukuze uthomalalise iintlungu. Abanye banokubopha kwi-CB2 receptor kwiiseli zakho zomzimba ukubonisa ukuba umzimba wakho ufumana ukudumba, uphawu oluqhelekileyo lokuphazamiseka komzimba.

Iintsholongwane

Ii-enzyme zinoxanduva lokophula i-endocannabinoids nje ukuba benze umsebenzi wabo.

Zimbini ii-enzymes eziphambili ezinoxanduva loku:

• i-asidi ye-asidi i-amide hydrolase, eyaphula i-AEA
• I-monoacylglycerol acid lipase, ehlala ichitha i-2-AG

Yintoni imisebenzi yayo?

I-ECS inzima, kwaye iingcali azikacacisi ukuba isebenza njani okanye yonke imisebenzi yayo enokubakho.

iqhagamshele i-ECS kwezi nkqubo zilandelayo:

• ukutya kunye nokwetyisa
• imetabolism
• iintlungu ezingapheliyo
• ukudumba kunye nezinye iimpendulo zomzimba
• imo
• ukufunda nokukhumbula
• ulawulo lweemoto
• lala
• Umsebenzi weenkqubo zentliziyo
• ukwakheka kwezihlunu
• ukulungiswa kwamathambo kunye nokukhula
• ukusebenza kwesibindi
• inkqubo yenkqubo yokuzala
• uxinzelelo
• ulusu kunye nomsebenzi we-nerve

Yonke le misebenzi inegalelo kwi-homeostasis, ebhekisa kuzinzo kwimeko-bume yangaphakathi. Umzekelo, ukuba amandla angaphandle, njengentlungu yokwenzakala okanye umkhuhlane, alahle i-homeostasis yomzimba wakho, i-ECS yakho iyakhaba ukunceda umzimba wakho ubuyele ekusebenzeni kwawo okufanelekileyo.

Namhlanje, iingcali zikholelwa ekubeni kugcinwe i-homeostasis ukuba yeyona ndima iphambili ye-ECS.

Isebenza njani i-THC ne-ECS?

I-Tetrahydrocannabinol (THC) yenye yeempawu eziphambili ze-cannabinoids ezifumaneka kwi-cannabis. Yikhompawundi ekufumana "phezulu."

Kanye emzimbeni wakho, i-THC inxibelelana ne-ECS yakho ngokuzibophelela kwii-receptors, njengee-endocannabinoids. Inamandla ngokuyinxalenye kuba inokubopha kuzo zombini i-CB1 kunye ne-CB2 receptors.

Oku kuyivumela ukuba ibe noluhlu lweziphumo emzimbeni nasengqondweni yakho, ezinye zinqweneleka ngakumbi kunabanye. Umzekelo, i-THC inokunceda ukunciphisa iintlungu kwaye ikhuthaze umdla wakho wokutya. Kodwa inokubangela paranoia kunye noxinzelelo kwezinye iimeko.

Iingcali ngoku zijonge iindlela zokuvelisa zokwenziwa ze-THC iinnabinoids ezinxibelelana ne-ECS ngeendlela eziluncedo kuphela.

Ngaba i-CBD inxibelelana njani ne-ECS?

Enye i-cannabinoid enkulu efumaneka kwi-cannabis yi-cannabidiol (i-CBD). Ngokungafaniyo ne-THC, i-CBD ayikwenzi ukuba "uphezulu" kwaye ngokwesiqhelo ayibangeli ziphumo zibi.

Iingcali aziqinisekanga ngokupheleleyo ukuba i-CBD inxibelelana njani ne-ECS. Kodwa bayazi ukuba ayibopheleli kwi-CB1 okanye kwi-CB2 receptors ngendlela i-THC eyenzayo.

Kunoko, abaninzi bakholelwa ukuba kusebenza ngokuthintela i-endocannabinoids ukuba ingaphuli. Oku kuvumela ukuba babe nefuthe elingaphezulu emzimbeni wakho. Abanye bakholelwa ukuba i-CBD iyabopha kwi-receptor engekafumaneki okwangoku.

Ngelixa iinkcukacha zendlela esebenza ngayo zisephantsi kwengxoxo, uphando lubonisa ukuba i-CBD inokunceda ngentlungu, isicaphucaphu, kunye nezinye iimpawu ezinxulumene neemeko ezininzi.

Kuthekani ngokusilela kwe-endocannabinoid?

Ezinye iingcali zikholelwa kwithiyori eyaziwa ngokuba kukusilela kwe-endocannabinoid (CECD). Le ithiyori icebisa ukuba amanqanaba asezantsi e-endocannabinoid emzimbeni wakho okanye ukungasebenzi kakuhle kwe-ECS kunokuba negalelo kuphuhliso lweemeko ezithile.

Ukuphononongwa ngaphezulu kweminyaka eli-10 yophando ngalo mbandela ucebisa ukuba ithiyori ingachaza ukuba kutheni abanye abantu bephuhlisa i-migraine, i-fibromyalgia, kunye nesifo sengqondo sesibindi.

Akukho nanye kwezi meko enesizathu esicacileyo. Bahlala bexhathisa kunyango kwaye ngamanye amaxesha kwenzeka ecaleni komnye nomnye.

Ukuba i-CECD idlala naluphi na uhlobo kule ndima, ekujoliseni i-ECS okanye imveliso ye-endocannabinoid inokuba sisitshixo esilahlekileyo kunyango, kodwa uphando oluninzi luyafuneka.

Umgca wezantsi

I-ECS idlala indima enkulu ekugcineni iinkqubo zakho zangaphakathi zizinzile. Kodwa kusekuninzi esingakwaziyo ngayo. Njengoko iingcali zikhulisa ukuqonda okungcono kwe-ECS, ekugqibeleni inokubamba isitshixo ekuphatheni iimeko ezininzi.