I-Spironolactone (Aldactone)

Umxholo

• Yenzelwe ntoni
• Indlela yokuthatha
• 1. Uxinzelelo lwegazi olubalulekileyo
• 2. Ukungaphumeleli kwentliziyo
• 3. Isibindi sokuqina kwesibindi
• 4. Isifo seNephrotic Syndrome
• 5. I-Edema
• 6. IHypokalemia / hypomagnesaemia
• 7. Unyango lwangaphambi kokunyanga kwe-Hyperaldosteronism yaseprayimari
• 8. Uxinzelelo lwegazi
• Indlela yokusebenza
• Iziphumo ebezingalindelekanga ezinokwenzeka
• Ukungqinelana

I-Spironolactone, eyaziwa ngokuthengisa njenge-Aldactone, isebenza njenge-diuretic, ukwandisa ukupheliswa kwamanzi ngomchamo, kunye ne-antihypertensive, kwaye ingasetyenziselwa unyango lwexinzelelo oluphezulu lwegazi, ukuvuvukala okunxulumene neengxaki ekusebenzeni kwentliziyo okanye izifo kwesibindi kunye nezintso, i-hypokalemia okanye kunyango lwe-hyperaldosteronism, umzekelo.

Ngamanye amaxesha, eli chiza linokumiselwa unyango lwe-acne kunye nokuthintela ukulahleka kweenwele, nangona kunjalo ezi zicelo aziyonxalenye yeempawu eziphambili ze-spironolactone, kwaye azikhankanywanga kwiphakheji yokufaka.

I-Spironolactone inokuthengwa ezikhemesti, ngexabiso elimalunga ne-14 ukuya kwi-45 reais, kuxhomekeke ekubeni umntu ukhetha uphawu okanye uhlobo oluqhelekileyo, olufuna ukunikwa amayeza.

Yenzelwe ntoni

I-Spironolactone iboniswe ukuba:

• Uxinzelelo lwegazi olubalulekileyo;
• I-Edema ebangelwa yintliziyo, izintso okanye iingxaki zesibindi;
• I-ediopathic edema;
• Uncedo oluncedisayo kwixinzelelo lwegazi;
• Hypokalemia xa amanye amanyathelo ethathwa njengangafanelekanga okanye engonelanga;
• Uthintelo lwe-hypokalemia kunye ne-hypomagnesaemia kubantu abathatha i-diuretics;
• Ukuchongwa kunye nonyango lwehyperaldosteronism.

Funda ngezinye iintlobo ze-diuretics kwaye ufunde ukuba zisebenza njani.

Indlela yokuthatha

Umthamo uxhomekeke kwingxaki eza kunyangwa:

1. Uxinzelelo lwegazi olubalulekileyo

Umthamo oqhelekileyo yi-50 mg / ngosuku ukuya kwi-100 mg / ngemini, ethi ithi kwiimeko ezinganyangekiyo okanye ezinzima zinokunyuswa ngokuthe chu, ngeeveki ezimbini, ukuya kuthi ga kwi-200 mg / ngosuku. Unyango kufuneka luqhubeke ubuncinci iiveki ezimbini ukuqinisekisa impendulo eyoneleyo kunyango. Umthamo kufuneka uhlengahlengiswe njengoko kufuneka.

2. Ukungaphumeleli kwentliziyo

Ukucetyiswa ukuqala idosi yemihla ngemihla yi-100 mg kwidosi enye okanye eyahluliweyo, enokwahluka phakathi kwe-25 mg kunye ne-200 mg mihla le. Umthamo oqhelekileyo wolondolozo kufuneka umiselwe umntu ngamnye.

3. Isibindi sokuqina kwesibindi

Ukuba umlinganiselo we-potassium we-sodium / urinary mkhulu kune-1, idosi eqhelekileyo yi-100 mg / ngosuku. Ukuba lo mlinganiselo ungaphantsi kwe-1, idosi ekhuthazwayo yi-200 mg / ngosuku ukuya kwi-400 mg / ngosuku. Umthamo oqhelekileyo wolondolozo kufuneka umiselwe umntu ngamnye.

4. Isifo seNephrotic Syndrome

Idosi eqhelekileyo kubantu abadala yi-100 mg / ngosuku ukuya kwi-200 mg / ngosuku.

5. I-Edema

Umthamo oqhelekileyo yi-100 mg ngemini yabantu abadala kwaye malunga ne-3.3 mg nge-kg yesisindo esilawulwa kwithamo leqhezu. Umthamo kufuneka uhlengahlengiswe ngokusekwe kwimpendulo kunye nokunyamezeleka komntu ngamnye.

6. IHypokalemia / hypomagnesaemia

Umyinge we-25 mg / ngosuku ukuya kwi-100 mg / ngosuku kuyacetyiswa kunyango lwe-hypopotassemia kunye / okanye i-hypomagnesemia ebangelwa zii-diuretics, xa i-potassium yomlomo kunye / okanye izongezo zemagniziyam azonelanga.

7. Unyango lwangaphambi kokunyanga kwe-Hyperaldosteronism yaseprayimari

Xa ukuxilongwa kwe-hyperaldosteronism kusekwe kakuhle ngovavanyo oluchanekileyo, i-spironolactone inokulawulwa kwimithamo yemihla ngemihla ye-100 mg ukuya kwi-400 mg ukulungiselela uqhaqho.

8. Uxinzelelo lwegazi

Kufuneka isetyenziswe kuphela njengonyango oluncedisayo kwaye xa kukho ukugcinwa okugqithisileyo kwe-aldosterone, i-hypokalemia kunye ne-alkalosis ye-metabolic. Idosi yokuqala yi-100 mg / ngosuku, enokuthi inyuswe, xa kukho imfuneko, ngamakhefu eeveki ezimbini, ukuya kuthi ga kwi-400 mg / ngosuku.

Indlela yokusebenza

I-Spironolactone sisichasi esithile se-aldosterone, esisebenza ikakhulu kwindawo yokutshintshiselana nge-aldosterone kunye ne-potassium ion exchange, ebekwe kwi-distal echazwe kwi-tubule yezintso, ekhokelela ekwandisweni kokupheliswa kwesodiyamu kunye namanzi kunye nokugcinwa kokugcinwa kwe potassium.

Iziphumo ebezingalindelekanga ezinokwenzeka

Ezinye zeziphumo ebezingalindelekanga ze-spironolactone zinokubandakanya i-benign breast neoplasm, i-leukopenia, i-thrombocytopenia, ukuphazamiseka kwe-electrolyte, utshintsho kwi-libido, ukudideka, isiyezi, ukuphazamiseka kwamathumbu kunye nesicaphucaphu, ukusebenza kwesibindi okungaqhelekanga, isifo se-Steve-Johnson, i-epidermal necrolysis, irhashalala, iinwele ilahleko, hypertrichosis, ukurhawuzelela, urticaria, amaqhuma emilenzeni, ukusilela kwezintso ezibi, iintlungu zebele, ukuphazamiseka kokuya exesheni, i-gynecomastia kunye ne-malaise.

Ukungqinelana

I-Spironolactone akufuneki isetyenziswe ngabantu abanovelwano kakhulu kumalungu efomula, abantu abanesifo esingasebenziyo sezintso, ukukhubazeka okubonakalayo kokusebenza kwezintso, i-anuria, isifo sika-Addison, i-hyperkalaemia okanye abasebenzisa iyeza elibizwa ngokuba yi-eplerenone.