Amaxwebhu athi iPilisi eNtsha eVunyiweyo ye-FDA yokuNyanga i-Endometriosis inokuba sisiTshintsho somdlalo

Umxholo

• U-Orilissa uyinyanga njani i-endometriosis pain?
• Zithini iziphumo ebezingalindelekanga?
• Eyona nto ibalulekileyo?
• Uphengululo lwe

Kwangoko kule veki, uLawulo lwezoKutya kunye noLawulo lweeMithi luvumile ichiza elitsha elinokwenza ukuba ukuhlala ne-endometriosis kube lula ngaphezulu kwepesenti ye-10 yabasetyhini abaphila nesifo esibuhlungu, kwaye ngamanye amaxesha esiba buthathaka.(Inxulumene: U-Lena Dunham wayenayo i-Hysterectomy epheleleyo yokuMisa i-Endometriosis Pain)

Ukuhlaziya ngokukhawuleza: "I-Endometriosis sisifo esichaphazela abantu ababhinqileyo abanenzala apho ulusu lwesibeleko lukhula ngaphandle kwesibeleko," utshilo uSanjay Agarwal, MD, unjingalwazi wezokubelekisa, isifo gynecology, kunye nesayensi yokuzala kwi-UC San Diego Health. "Iimpawu zinokwahluka kakhulu kodwa zihlala zinxulunyaniswa namaxesha abuhlungu kunye neentlungu xa usabelana ngesondo-ezi mpawu zinokuba mbi." (I-Endometriosis nayo inokubangela ukungachumi. Ekuqaleni kwalo nyaka, uHalsey wavula malunga nokuqanda amaqanda akhe nge-23 ngenxa ye-endometriosis yakhe.)

Njengoko i-endometriosis ichaphazela abasetyhini abazizigidi ezingama-200 kwihlabathi liphela, oogqirha basenolwazi oluncinci ngokothusayo malunga nokuba yintoni ebangela izilonda ezibuhlungu. "Asiqinisekanga ukuba kutheni abanye abantu basetyhini beyiphuhlisa kwaye abanye bengayiphuhlisi okanye kutheni kwabanye abantu basetyhini inokuba yimeko enobungozi kwaye kwabanye inokuba sisimo esibuhlungu kakhulu," utshilo uZev Williams, MD, Ph.D ., oyintloko yeCandelo le-Reproductive Endocrinology kunye ne-Infertility kwi-Columbia University Medical Centre.

Yintoni oogqirha abayaziyo kukuba "i-estrogen idla ngokwenza isifo kunye neempawu zibe nzima," utshilo uGqr. Agarwal, yiyo loo nto i-endometriosis ihlala ibangela amaxesha abuhlungu kakhulu. Ngumjikelo okhohlakeleyo, wongeza uGqirha Williams. "Izilonda zibangela ukudumba, okubangela ukuba umzimba uvelise i-estrogen, ebangela ukudumba okungakumbi, njalo njalo," ucacisa. (Idibeneyo: UJulianne Hough Uthetha ngokuBambana kwakhe ne-Endometriosis)

"Enye yeenjongo zonyango ukuzama ukuphula loo mjikelo ngokusebenzisa amayeza anciphisa ukudumba okanye ubukho be-estrogen," utshilo uGqirha Williams. "Kwixesha elidlulileyo, senze oku ngezinto ezifana neepilisi zokulawula ukuzalwa ezigcina amanqanaba e-estrogen yowesifazane aphantsi okanye ngokusebenzisa amayeza afana ne-Motrin, achasene ne-inflammatories."

Olunye unyango luyindlela yokumisa umzimba ekuveliseni i-estrogen eninzi kwindawo yokuqala-indlela esele yenziwe ngenaliti, utshilo uGqirha Williams. Le yindlela kanye u-Orilissa, iyeza elitsha elivunywe yi-FDA, lisebenza-ngaphandle kwefomu yepilisi yemihla ngemihla.

Oogqirha bathi ipilisi, evunyiweyo yi-FDA ekuqaleni kwale veki kwaye kulindeleke ukuba ifumaneke ekuqaleni kuka-Agasti, inokuba ngumdlalo otshintshayo kubafazi abane-endometriosis ephakathi. "Le yinto enkulu kwihlabathi lezempilo yabasetyhini," utshilo uGqirha Agarwal. “Ubuchule obutsha kwicandelo le-endometriosis khange bubekho amashumi eminyaka, kwaye iindlela zonyango esizenzayo bezingumngeni,” utshilo. Ngelixa ichiza liindaba ezimnandi, ixabiso lezigulana ezingekho kwi-inshurensi alikho. Ukunikezelwa kweziyobisi iiveki ezine kuya kuxabisa i-845 yeedola ngaphandle kwe-inshurensi IChicago Tribune.

U-Orilissa uyinyanga njani i-endometriosis pain?

"Ngokwesiqhelo ingqondo ibangela ii-ovari zenze i-estrogen, evuselela ulwelwesi lwesibeleko-kunye ne-endometriosis izilonda-ukuba zikhule," ucacisa uGqirha Williams, othe wadibana nenkampani yeziyobisi emva kwe-Orilissa njengoko yayiphuhliswa. U-Orilissa ucinezela ngobunono i-endometriosis ebangela i-estrogen "ngokuthintela ubuchopho ekuthumeleni isiginali kwi-ovary ukuba ivelise i-estrogen, utshilo.

Njengoko amanqanaba e-estrogen ephela, kunjalo neentlungu ze-endometriosis. Kuvavanyo lweklinikhi oluvavanyiweyo lwe-FDA luka-Orilissa, olubandakanya phantse abafazi abayi-1,700 abaneentlungu ezilinganayo ukuya kwinzala ye-endometriosis, iyeza lanciphisa kakhulu iintlobo ezintathu zentlungu ye-endometriosis: iintlungu zemihla ngemihla, iintlungu zexesha, kunye nentlungu ngexesha lokwabelana ngesondo.

Zithini iziphumo ebezingalindelekanga?

Unyango lwangoku lwe-endometriosis luhlala luza neziphumo ebezingalunganga njengokuphuma gazi okungaqhelekanga, amabala, ukutyeba, kunye noxinzelelo. "Ngenxa yokuba eli chiza litsha licinezela i-estrogen ngobunono, akufuneki libe nobungakanani obufanayo beziphumo ebezingalindelekanga ezinokubakho kwamanye amayeza, utshilo uGqirha Agarwal, owayengumphandi weklinikhi kwinkqubo yokufunda.

Uninzi lweziphumo ebezingalindelekanga zincinci-kodwa ngenxa yokuba ibangela ukwehla kwe-estrogen, i-Orilissa inokubangela iimpawu ezinjengokuyeka ukuya exesheni njengokukhanya okutshisayo, nangona iingcali zisithi akukho bungqina bokuba inokukukhaba kwi-menopause kwangoko.

Umngcipheko ophambili kukuba ichiza linokubangela ukwehla kwethambo. Ngapha koko, i-FDA icebisa ukuba ichiza kufuneka lithathwe kuphela ubuninzi beminyaka emibini, nakwidosi esezantsi. UGqirha Williams uthi: "Inkxalabo yokuncipha kwethambo kukuba kungakhokelela kuqhekeko," utshilo uGqirha Williams. "Oku kubaluleke kakhulu kubafazi xa bengaphantsi kweminyaka engama-35 kwaye bakwiminyaka yokwakha ubuninzi beethambo zabo." (Iindaba ezimnandi: Ukuzivocavoca kunokunceda ukugcina ukuxinana kwamathambo kunye nokunciphisa i-osteoporosis.)

Ke, ngaba oko kuthetha ukuba u-Orilissa sisibonelelo seminyaka emibini kuphela esona sikhulu? Kanjalo. Nje ukuba uyeke iyeza, iingcali zithi iintlungu ziya kuqala ukubuya kancinci. Kodwa neminyaka emibini engenazintlungu ibalulekile. "Injongo yolawulo lwamahomoni kuzama ukulibazisa ukukhula kwezilonda ze-endometriosis ukukhulula iimpawu kwaye mhlawumbi uthintele isidingo sotyando okanye ukulibaziseka xa kufuneka utyando," kusho uGqr Williams.

Emva kokuba ulisebenzisile ixesha lakho lokuthatha iyeza, uninzi lwamaxwebhu anokucebisa ukuba ubuyele kunyango olufana nolawulo lokuzalwa ukuze uncede ukuphelisa ukubuyela kwakhona, utshilo uGqirha Williams.

Eyona nto ibalulekileyo?

U-Orilissa akayimbumbulu yomlingo, kwaye ayilonyango lwe-endometriosis (ngelishwa, akukho namnye). Kodwa ipilisi esandula ukwamkelwa ibonisa inyathelo elikhulu kunyango, ngakumbi abasetyhini abajongana neentlungu ezibi, utshilo uGqirha Agarwal. "Eli lixesha elinomdla kakhulu kubasetyhini abane-endometriosis."

Uphengululo lwe