Yenza ntoni i-Gamma Aminobutyric Acid (GABA)?

Umxholo

• Kutheni le nto abantu bethatha izongezelelo zeGABA?
• Zisebenza kangakanani izongezo zeGABA?
• Ixhala
• Igazi elonyukayo
• Ukuphuthelwa
• Uxinzelelo kunye nokudinwa
• Zithini iziphumo ebezingalindelekanga zeGABA ezongezelelweyo?
• Umgca wezantsi

Sibandakanya iimveliso esicinga ukuba ziluncedo kubafundi bethu. Ukuba uthenga amakhonkco kweli phepha, sinokufumana ikhomishini encinci. Nantsi inkqubo yethu.

Yintoni i-GABA?

I-Gamma aminobutyric acid (GABA) yinto eyenzeka ngokwemvelo kwi-amino acid esebenza njenge-neurotransmitter kwingqondo yakho. I-Neurotransmitters isebenza njengabathunywa bemichiza. I-GABA ithathwa njenge-neurotransmitter engathinteliyo ngenxa yokuba ibhloka, okanye inqanda, imiqondiso ethile yobuchopho kunye nokunciphisa umsebenzi kwinkqubo yovalo.

Xa i-GABA incamathele kwiprotein kwingqondo yakho eyaziwa njenge-GABA receptor, ivelisa isiphumo sokuthomalalisa. Oku kunokunceda kwiimvakalelo zoxinzelelo, uxinzelelo kunye noloyiko. Inokukunceda ukunqanda ukuxhuzula.

Ngenxa yezi zinto, i-GABA ikwasisibonelelo esithandwayo kule minyaka idlulileyo. Oku kungenxa yokuba ayifumaneki kwimithombo emininzi yokutya. Ukutya kuphela okuqulethe i-GABA zizinto ezinotyiweyo, ezinje nge-kimchi, miso, kunye ne-tempeh.

Kodwa zisebenza njani ezi zongezelelo? Funda ukuze ufunde ngakumbi malunga nesayensi emva kwezibonelelo ezinokubakho zezongezo zeGABA.

Kutheni le nto abantu bethatha izongezelelo zeGABA?

Ukuthotywa kwendalo kwe-GABA kwingqondo kukhokelele kumabango angenakubalwa malunga nokusetyenziswa kwezongezo ze-GABA ukunciphisa uxinzelelo. Uxinzelelo oluninzi lunxulunyaniswa nokungalali kakuhle, amajoni omzimba abuthathaka, kunye nomngcipheko ophezulu woxinzelelo, phakathi kwezinye izinto. Nanku ukujonga ngokuthe ngqo kwimiphumo yoxinzelelo emzimbeni wakho.

Ukongeza, abantu abaneemeko ezithile zonyango banokuba namanqanaba asezantsi e-GABA. Ezinye zeemeko zibandakanya:

• iingxaki zokubanjwa
• iingxaki zokuhamba, ezifana nesifo sika-Parkinson
• ingqalelo yokungahambi kakuhle kwi-hyperactivity
• ixhala
• ukuphazamiseka kovalo
• iingxaki zemood, ezinje ngoxinzelelo

Abanye abantu abanezi meko bathabatha izongezo ze-GABA ukunceda ukulawula iimpawu zabo. Ngelixa oku kunengqiqo kwithiyori, akukabikho bungqina bungako bokubonisa ukuba izongezo ze-GABA zinokunceda kwezi meko, ngaphandle koxinzelelo.

Zisebenza kangakanani izongezo zeGABA?

Akukho nto ingako iyaziwayo malunga nokusebenza kwezixhobo zeGABA. Ngapha koko, iingcali azi ukuba ingakanani i-GABA efikelela kwingqondo xa isetyenziswe njengesongezo okanye ukutya. Kodwa abanye bacebisa ukuba yimali encinci kuphela.

Nanku ukukhangela kolunye uphando emva kokusetyenziswa kweGABA.

Ixhala

Ngokwenqaku lika-2006, zimbini izifundo ezincinci kakhulu ezifumanise ukuba abathathi-nxaxheba abathathe isongezelelo se-GABA babeneemvakalelo ezandayo zokuphumla ngexesha lomsitho oxinzelelekileyo kunabo bathatha i-placebo okanye i-L-theanine, enye into eyaziwayo. Inqaku liyaphawula ukuba iziphumo zokuphumla zaziva ngaphakathi kweyure yokuthatha isongezelelo.

Igazi elonyukayo

Olunye uphando oluncinci, oludala luvavanye ukusetyenziswa kweemveliso ezine-GABA zokwehlisa uxinzelelo lwegazi.

Kwisifundo esinye ukusukela ngo-2003, ukusetyenziswa kwemihla ngemihla kwemveliso yobisi enegwele equlethe i-GABA yanciphisa uxinzelelo lwegazi kubantu abanoxinzelelo oluphezulu lwegazi emva kweeveki ezimbini ukuya kwezine. Oku kwafaniswa ne-placebo.

Uphononongo olwenziwe ngo-2009 lwafumanisa ukuba ukuthatha i-GABA ene-Chlorella isongezo kabini ngemini kunciphise uxinzelelo lwegazi kwabo bane-hypertension.

Ukuphuthelwa

Kwisifundo esincinci se-2018, abathathi-nxaxheba abathathe i-GABA iyure ngaphambi kokuba balale baziva belele ngokukhawuleza kunabo bathatha indawo ye-placebo. Baye baxela ukuphucula umgangatho wokulala kwiiveki ezine emva kokuqala unyango.

Njengolunye uphononongo oluninzi olujonga iziphumo ze-GABA ezongezelelekileyo ebantwini, olu phononongo lwaluluncinci kakhulu, linabathathi-nxaxheba abangama-40 kuphela.

Uxinzelelo kunye nokudinwa

Isifundo sika-2011 eJapan sivavanye iziphumo zesiselo esinama-25 mg okanye ama-50 mg we-GABA kubathathi-nxaxheba abangama-30. Zombini iziselo zazinxulunyaniswa namanyathelo ancitshisiweyo okudinwa engqondweni nasemzimbeni ngelixa besenza umsebenzi wokusombulula iingxaki. Kodwa ke isiselo esine-50 mg sibonakala sisebenza kancinci.

Olunye uphononongo ukusukela ngo-2009 lufumanise ukuba ukutya itshokholethi ene-28 mg ye-GABA kunciphise uxinzelelo kubathathi-nxaxheba benza umsebenzi wokusombulula iingxaki. Kwesinye isifundo, ukuthatha iicapsule eziqukethe i-100 mg ye-GABA kunciphise amanyathelo oxinzelelo kubantu abagqibezayo umsebenzi wovavanyo lwengqondo.

Iziphumo zazo zonke ezi zifundo zivakala zithembisa. Kodwa uninzi lwezi zifundo zazincinci kwaye uninzi lwazo luphelelwe lixesha. Ezinkulu, kufuneka ixesha elide lokufunda ukuze kuqondwe ngokupheleleyo izibonelelo zeGABA zokuncedisa.

Zithini iziphumo ebezingalindelekanga zeGABA ezongezelelweyo?

Iziphumo ezinokubakho zezongezo ze-GABA azifundiswanga kakuhle, ke kunzima ukwazi ukuba ulindele ntoni.

Ezinye iziphumo ebezingalindelekanga ezichaziweyo zibandakanya:

• isisu esimoshakele
• intloko ebuhlungu
• ukozela
• ubuthathaka bemisipha

Kuba i-GABA inokwenza ukuba abanye abantu bayozele, akufuneki uqhube okanye usebenze oomatshini emva kokuthatha i-GABA de ube uyazi ukuba ikuchaphazela njani.

Akucaci nokuba i-GABA iyasebenzisana nawaphi na amayeza okanye ezinye izongezo. Ukuba ufuna ukuzama i-GABA, cinga ukuthetha nodokotela kuqala. Qinisekisa ukubaxelela malunga naluphi na amayeza okanye amayeza owathethayo, kubandakanya amayeza kunye nezinye izongezo. Banokukunika umbono ongcono wokunxibelelana okunokubukela ngelixa uthatha iGABA.

Umgca wezantsi

I-GABA inendima ebalulekileyo kwimizimba yethu njengomthunywa weekhemikhali. Kodwa xa isetyenziswa njengesongezelelo, indima yayo ayicacanga ncam. Olunye uphando lubonisa ukuba kunokuba yinto onokukhetha ukuyenza ukunciphisa uxinzelelo, ukudinwa, unxunguphalo kunye nokuqaqanjelwa sisisu. Kodwa uninzi lwezi zifundo zincinci, ziphelelwe lixesha, okanye zombini. Ubungqina obungakumbi buyafuneka ukuqonda ngcono izibonelelo ezinokubakho zokuthatha i-GABA.

Izongezo ze-GABA, onokuzithenga kwi-Intanethi, kunokuba kufanelekile ukuba udubule ukuba ujonga uxinzelelo lwendalo. Kodwa musa ukuxhomekeka kuyo ukuba inyange naziphi na iimeko ezisisiseko, kubandakanya unxunguphalo olukhulu, ukuphazamiseka kokubanjwa, okanye uxinzelelo oluphezulu lwegazi.