Uvavanyo lweMfuza loMhlaza weSifuba seMastastatic: Imibuzo yokubuza ugqirha wakho

Umxholo

• Yintoni uvavanyo lwemfuzo? Kwenziwa njani?
• Ngaba kufuneka ndenze uvavanyo lwemfuza kumhlaza webele we-metastatic?
• Ngaba uvavanyo lwemfuza ludlala njani kwindima yam yonyango lomhlaza wamabele?
• Kutheni le nto utshintsho lwezofuzo luchaphazela unyango? Ngaba ezinye iinguqulelo ‘zimbi’ kunezinye?
• Yintoni uguquko lwePIK3CA? Inyangwa njani?
• Ndifundile ngezilingo zeklinikhi zomhlaza webele we-metastatic. Ukuba ndiyafaneleka, ngaba ezi zikhuselekile?
• Ngaba bukhona ubungozi kuvavanyo lwemvelo?
• Kuya kuthatha ixesha elingakanani ukufumana iziphumo kuvavanyo lwemfuzo?
• Iziphumo ziya kunikwa njani kum? Ngubani oza kuhamba neziphumo kunye nam kwaye zithetha ntoni?

Yintoni uvavanyo lwemfuzo? Kwenziwa njani?

Ukuvavanywa kwemfuza luhlobo lovavanyo lwelabhoratri olunikezela ngolwazi olukhethekileyo malunga nokuba umntu unento engaqhelekanga kwiijeni zabo, ezinje ngenguquko.

Uvavanyo lwenziwa elebhu, ngesiqhelo ngesampulu yegazi lesigulana okanye iiseli zomlomo.

Olunye utshintsho kwimfuza lunxulunyaniswe nomhlaza othile, njenge I-BRCA1 okanye I-BRCA2 Imfuza kumhlaza wamabele.

Ngaba kufuneka ndenze uvavanyo lwemfuza kumhlaza webele we-metastatic?

Ukuvavanywa kwemfuza kunokuba luncedo kuye nabani na onomhlaza wamabele, kodwa ayimfuneko. Nabani na unokuvavanywa ukuba uyafuna. Iqela lakho le-oncology linokukunceda wenze isigqibo.

Abantu abahlangabezana neekhrayitheriya ezithile kunokwenzeka ukuba babe nokutshintsha kwemfuza. Oku kubandakanya:

• ndingaphantsi kweminyaka engama-50 ubudala
• ukuba nembali yosapho eyomeleleyo yomhlaza wamabele
• ukuba nomhlaza wamabele kuwo omabini amabele
• ukuba nesifo somhlaza webele esiphindwe kathathu

Kukho iindlela ezizodwa zonyango kwizigulana ezinomhlaza wamabele ezivavanya ukuguqulwa kwemfuza, ke qiniseka ukubuza malunga novavanyo lofuzo.

Ngaba uvavanyo lwemfuza ludlala njani kwindima yam yonyango lomhlaza wamabele?

Unyango lomhlaza webele lulungiselelwe umntu ngamnye, kubandakanya abo banemastastatic. Kwizigulana ze-metastatic ezine-mutations, kukho iindlela ezizodwa zonyango.

Umzekelo, unyango olukhethekileyo njenge-PI3-kinase (PI3K) inhibitors ziyafumaneka kubantu abanokutshintsha kwemfuza PIK3CA yemfuza ukuba badibana neenqobo ezithile zokufumana i-hormone.

I-PARP inhibitors lukhetho kubantu abanomhlaza webele we-metastatic nge I-BRCA1 okanye I-BRCA2 Ukutshintsha kwemfuza. Uvavanyo lwezonyango kolu nyango luyaqhubeka. Ugqirha wakho angakuxelela ukuba ungumgqatswa.

Kutheni le nto utshintsho lwezofuzo luchaphazela unyango? Ngaba ezinye iinguqulelo ‘zimbi’ kunezinye?

Iimpawu ezithile ezinxulunyaniswa notshintsho kwimfuza zinokujoliswa kunyango olwahlukileyo olwaziwayo ukuba nefuthe kwisiphumo.

Iinguqu ezahlukeneyo zemfuza zinxulunyaniswa nemingcipheko eyahlukeneyo. Enye ayisiyonto "imbi" kunenye, kodwa utshintsho lwakho oluthile luchaphazela ngokuthe ngqo unyango oza kulufumana.

Yintoni uguquko lwePIK3CA? Inyangwa njani?

PIK3CA yimfuza ebalulekileyo ekusebenzeni kweseli. Ukungaqhelekanga (okt, utshintsho) kwimfuza akuvumeli ukuba kusebenze ngokufanelekileyo. Izifundo zibonise ukuba olu tshintsho luqhelekile kubantu abanomhlaza wamabele. Kuyacetyiswa ukuba abantu abathile, kubandakanya abo banesifo somhlaza webele we-metastatic, benze uvavanyo lofuzo ukuvavanya olu tshintsho.

Ukuba unayo, unokuba ngumgqatswa kunyango ekujoliswe kulo njenge-PI3K inhibitor, ejonga ngqo unobangela wotshintsho.

Ndifundile ngezilingo zeklinikhi zomhlaza webele we-metastatic. Ukuba ndiyafaneleka, ngaba ezi zikhuselekile?

Uvavanyo lwezonyango lukhetho olufanelekileyo kubantu abaninzi abanesifo somhlaza webele. Ulingo lwenzelwe ukuphendula imibuzo ebalulekileyo malunga nonyango olungcono. Banokunikezela ngokufikelela okukhethekileyo kwiiprotokholi onokuthi ungabinakho ukufumana ngenye indlela.

Kunokubakho umngcipheko kuvavanyo lweklinikhi. Imingcipheko eyaziwayo kufuneka kwabelwane nawe ngaphambi kokuqala. Emva kokuba unolwazi ngokupheleleyo malunga nesifundo kunye nobungozi baso, kufuneka unike imvume ngaphambi kokuba uqale. Iqela lokulinga livavanya umngcipheko rhoqo kwaye labelane ngalo naluphi na ulwazi olutsha.

Ngaba bukhona ubungozi kuvavanyo lwemvelo?

Kukho umngcipheko kuvavanyo lwemfuza ngokwabantu abanikwa ulwazi olunzulu malunga nenqanaba lofuzo lwabo. Oku kunokubangela uxinzelelo lweemvakalelo.

Kukho kwakhona iingxaki zemali ngokuxhomekeke kwi-inshurensi yakho. Kuya kufuneka ukuba uthathele ingqalelo ukuba uyakuchaza njani ulwazi kumalungu osapho lwakho. Iqela lakho lokukhathalela linokunceda kwesi sigqibo.

Iziphumo zovavanyo ezifanelekileyo zisenokubonisa ukuba ufuna isicwangciso sonyango esibanzi.

Kuya kuthatha ixesha elingakanani ukufumana iziphumo kuvavanyo lwemfuzo?

Ngumbono olungileyo ukuba uxoxe ngokuvavanywa kwemfuza nogqirha wakho kwangoko emva kokuchongwa kuba iziphumo zithatha ixesha ukuzenza.

Uninzi lovavanyo lwemfuza luthatha iiveki ezi-2 ukuya kwezi-4 ukufumana iziphumo.

Iziphumo ziya kunikwa njani kum? Ngubani oza kuhamba neziphumo kunye nam kwaye zithetha ntoni?

Ngokwesiqhelo, ugqirha oyalele uvavanyo okanye ugqirha wemfuzo uya kuhamba nawe ngeziphumo. Oku kunokwenziwa buqu okanye ngomnxeba.

Kukwacetyiswa ngesiqhelo ukubona umcebisi wemfuza ukuphonononga iziphumo zakho ngakumbi.

Ugqirha Michelle Azu ngugqirha oqinisekisiweyo webhodi ojolise kutyando lwebele kunye nezifo zesifuba. Ugqirha Azu waphumelela kwiDyunivesithi yaseMissouri-Columbia ngo-2003 nogqirha wakhe. Ngoku usebenza njengomlawuli weenkonzo zotyando lwebele eNew York-Presbyterian / Hospital Lawrence. Usebenza njengoprofesa oncedisayo kwiziko i-Columbia University Medical Centre kunye neRutgers School yezeMpilo kaRhulumente. Ngexesha lakhe lokuphumla, uGqirha Azu uyakonwabela ukuhamba nokufota.