Ngaba iGlucosamine iyasebenza? Izibonelelo, Isisombululo kunye neempembelelo zecala

Umxholo

• Yintoni iGlucosamine?
• Ngamana unokunciphisa ukuvuvukala
• Ixhasa Amalungu Asempilweni
• Rhoqo isetyenziselwa ukunyanga amathambo kunye nokudibana okuhlangeneyo
• Olunye usetyenziso lweGlucosamine
• ICystitis yangaphakathi
• Izifo zesifo sokudumba (IBD)
• Multiple Sclerosis (MS)
• Iglaucoma
• Indibaniselwano yeTemporomandibular (TMJ)
• Ngaba iyasebenza ngokwenene?
• Umthamo kunye neefom zokuXhasa
• Imingcipheko enokubakho kunye neziphumo ebezingalindelekanga
• Umgca osezantsi

I-Glucosamine yimolekyuli eyenzeka ngokwendalo emzimbeni wakho, kodwa ikwayindlela yokutya eyaziwayo.

Eyona nto isetyenziselwa ukunyanga iimpawu zethambo kunye nokudibana ngokudibeneyo, ikwasetyenziselwa ukujolisa kwezinye izifo ezininzi.

Eli nqaku liphonononga izibonelelo ze-glucosamine, idosi kunye neziphumo ebezingalindelekanga.

Yintoni iGlucosamine?

I-Glucosamine yindalo eyenzeka ngokwendalo echazwa njenge-amino iswekile (1).

Isebenza njengebhlokhi yokwakha yeemolekyuli ezahlukeneyo ezisebenzayo emzimbeni wakho kodwa ibonwa ikakhulu ekuphuhliseni nasekugcineni intlala ngaphakathi kwamalungu akho (1).

I-Glucosamine ikwafumaneka kwezinye izilwanyana nakwezinye izicubu ezingengobantu, kubandakanya oonokrwece, amathambo ezilwanyana kunye nefungi. Iifom zokongeza ze-glucosamine zihlala zenziwe ngale mithombo yendalo (2).

I-Glucosamine ihlala isetyenziselwa ukunyanga kunye nokuthintela ukuphazamiseka ngokudibeneyo, njenge-osteoarthritis. Ingathathwa ngomlomo okanye ifakwe kumxholo okwi-cream okanye kwisalve (2).

I-Glucosamine yinkomfa yemichiza eyenzeka ngokwendalo kwizicubu zomntu nezilwanyana. Ebantwini, iyanceda ukwenza intlala kwaye ihlala isetyenziswa njengesongezo sokutya ukunyanga ukuphazamiseka ngokudibeneyo njenge-osteoarthritis.

Ngamana unokunciphisa ukuvuvukala

I-Glucosamine ihlala isetyenziselwa ukunyanga iimpawu zeemeko ezahlukeneyo zokudumba.

Nangona iindlela ze-glucosamine zingaqondwa kakuhle, kubonakala ngathi kunciphisa ngokulula ukudumba.

Olunye uvavanyo lwetyhubhu yovavanyo lubonakalise ifuthe elibalulekileyo lokuchasana xa i-glucosamine yayifakwa kwiiseli ezichaphazelekayo ekwakhiweni kwethambo ().

Uninzi lophando kwi-glucosamine lubandakanya kwangaxeshanye ukuxhasa i-chondroitin - ikhompawundi efanayo ne-glucosamine, ekwabandakanyeka kwimveliso yomzimba wakho kunye nokugcinwa kwe-cartilage esempilweni (4).

Isifundo esingaphezulu kwama-200 abantu abadibanise izongezo ze-glucosamine kwi-28% kunye ne-24% yokunciphisa kwiimpawu ezithile ze-biochemical of inflammation: i-CRP kunye ne-PGE. Nangona kunjalo, ezi ziphumo zazingabalulekanga ngokwezibalo ().

Kubalulekile ukuba uqaphele ukuba isifundo esifanayo sifumene ukuncipha kwama-36% kwaba bamakishi abachaphazelayo kubantu abathatha i-chondroitin. Esi siphumo, enyanisweni, sibalulekile ().

Olunye uphononongo lonyusa ezo ziphumo. Gcina ukhumbula ukuba uninzi lwabathathi-nxaxheba abathatha i-chondroitin nabo banika ingxelo ngaxeshanye bencedisa nge-glucosamine.

Ke, kuhlala kungacaci ukuba ngaba iziphumo ziqhutywa yi-chondroitin yodwa okanye indibaniselwano yazo zombini izongezo ezithathiweyo kunye ().

Ekugqibeleni, uphando oluthe kratya luyafuneka kwindima yeglucosamine ekunciphiseni amanqaku okumakisha emzimbeni wakho.

Indlela i-glucosamine esebenza ngayo kunyango lwezifo ayiqondakali kakuhle, kodwa olunye uphando lubonisa ukuba lunokunciphisa ukudumba-ngakumbi xa kusetyenziswa ecaleni kwezongezo ze-chondroitin.

Ixhasa Amalungu Asempilweni

I-Glucosamine ikhona ngokwendalo emzimbeni wakho. Enye yeendima zayo eziphambili kukuxhasa ukukhula okunempilo kwezihlunu phakathi kwamalungu akho (1).

I-articular cartilage luhlobo lwethishu emhlophe egudileyo egubungela iziphelo zamathambo akho apho ahlangana khona ukuze enze amalungu.

Olu hlobo lwethishu-kunye nolwelo lokuthambisa olubizwa ngokuba yi-synovial fluid-luvumela amathambo ukuba ahambe ngokukhululekileyo komnye, ukunciphisa ukungqubana kunye nokuvumela intshukumo engenazintlungu kumalungu akho.

I-Glucosamine inceda ukwenza iikhompawundi zeekhemikhali ezichaphazelekayo ekudalweni kwe-articular cartilage kunye ne-synovial fluid.

Olunye uphononongo lubonisa ukuba i-glucosamine eyongezelelweyo inokukhusela izicubu ezidibeneyo ngokuthintela ukonakala kwentlala.

Olunye uphononongo oluncinci lwabahamba ngeebhayisikile ezingama-41 lufumanise ukuba ukongeza ukuya kuthi ga kwi-3 gram yeglucosamine yemihla ngemihla kuncitshiswe ukonakala kwe-collagen emadolweni nge-27% xa kuthelekiswa ne-8% kwiqela le-placebo ().

Olunye uphononongo oluncinci lufumene umyinge owehliswe kakhulu wokuqhekeka kwe-collagen ukuya kumakishi we-collagen-synthesis kumalungu adibeneyo abadlali bebhola ekhatywayo aphathwe nge-3 gram yeglucosamine mihla le kwithuba leenyanga ezintathu ().

Ezi ziphumo zibonisa ukhuseleko ngokudibeneyo lwe-glucosamine. Nangona kunjalo, uphando olongezelelweyo luyafuneka.

I-Glucosamine ibandakanyeka kuphuhliso lwezicubu ezibalulekileyo ekusebenzeni ngokufanelekileyo. Ngelixa ezinye izifundo ziyimfuneko, olunye uphando lubonisa ukuba i-glucosamine eyongezelelweyo inokuwakhusela amalungu akho kumonakalo.

Rhoqo isetyenziselwa ukunyanga amathambo kunye nokudibana okuhlangeneyo

Izongezelelo zeGlucosamine zihlala zithathwa ukunyanga iimeko ezahlukeneyo zethambo kunye nokudibana.

Le molekyuli ifundelwe ngokukodwa amandla ayo okunyanga iimpawu kunye nokuqhubela phambili kwesifo okunxulunyaniswa ne-osteoarthritis, i-rheumatoid arthritis kunye ne-osteoporosis.

Izifundo ezininzi zibonisa ukuba ukongeza imihla ngemihla nge-glucosamine sulphate inokunika unyango olusebenzayo, lwexesha elide lwe-osteoarthritis ngokubonelela ukunciphisa okukhulu kwintlungu, ukugcinwa kwendawo edibeneyo kunye nokucothiswa kwesifo (,, 10, 11).

Olunye uphononongo lubonakalise ukunciphisa amanqaku e-rheumatoid arthritis (RA) kwiimpuku eziphathwe ngeendlela ezahlukeneyo ze-glucosamine (,).

Ngokuchasene noko, isifundo esinye sabantu asibonisanga naluphi na utshintsho olukhulu kuqhubekeko lwe-RA kunye nokusetyenziswa kweglucosamine. Nangona kunjalo, abathathi-nxaxheba bafunda ingxelo ephuculwe kakhulu kulawulo lweempawu ().

Olunye uphando lwangaphambili kwiimpuku ezine-osteoporosis zikwabonisa ukubakho kosetyenziso olongezelelekileyo lwe-glucosamine yokuphucula amandla ethambo ().

Ngelixa ezi ziphumo zikhuthaza, uphando olongezelelekileyo lomntu luyafuneka ukuqonda iindlela kunye nezona zicelo zibalaseleyo zeglucosamine kwizifo ezidibeneyo kunye nethambo.

Nangona i-glucosamine isetyenziswa rhoqo ukunyanga iimeko ezahlukeneyo zethambo kunye nokudibana, uphando ngakumbi ngeziphumo zalo luyafuneka.

Olunye usetyenziso lweGlucosamine

Nangona abantu besebenzisa i-glucosamine ukunyanga iintlobo ezahlukeneyo zezifo ezingapheliyo, idatha yesayensi yokuxhasa usetyenziso oluncinci.

ICystitis yangaphakathi

I-Glucosamine iphakanyiswa ngokubanzi njengonyango lwe-cystitis (IC), imeko enxulunyaniswa nokusilela kwi-glycosaminoglycan.

Ngenxa yokuba i-glucosamine sisandulela sale khompawundi, ithiyori ukuba isongezelelo se-glucosamine sinokunceda ukulawula i-IC ().

Ngelishwa, idatha ethembekileyo yesayensi yokuxhasa le ithiyori iyasilela.

Izifo zesifo sokudumba (IBD)

Njenge-cystitis yangaphakathi, isifo sesisu esivuthayo (IBD) sinxulunyaniswa nokusilela kwi-glycosaminoglycan ().

Uphando oluncinci kakhulu luxhasa umbono wokuba i-glucosamine inokunyanga i-IBD. Nangona kunjalo, uphononongo lweempuku nge-IBD lubonise ukuba ukongeza nge-glucosamine kunokunciphisa ukudumba ().

Ekugqibeleni, uphando olongezelelekileyo luyafuneka ukuze kufikelelwe kwisigqibo esichanekileyo.

Multiple Sclerosis (MS)

Eminye imithombo ibanga ukuba i-glucosamine inokuba lunyango olusebenzayo lwe-multiple sclerosis (MS). Nangona kunjalo, ukuxhasa uphando kuyasilela.

Olunye uphononongo luvavanye isiphumo sokusebenzisa i-glucosamine sulphate ecaleni kwonyango lwesiko lokubuyela kwakhona kwi-MS. Iziphumo azibonisanga mpembelelo ibalulekileyo kwinqanaba lokuphinda ubuye okanye ukuqhubela phambili kwesifo ngenxa yeglucosamine ().

Iglaucoma

I-Glaucoma kukholelwa ukuba iyanyangeka nge-glucosamine.

Olunye uphando lwakwangoko lubonisa ukuba i-glucosamine sulphate inokukhuthaza impilo yamehlo ngokunciphisa ukudumba kunye nefuthe le-antioxidant kwi-retina yakho).

Ngokuchasene noko, olunye uphando oluncinci lubonise ukuba ukungenisa kakhulu i-glucosamine kunokulimaza abantu abane-glaucoma ().

Ngokubanzi, idatha yangoku ayihambelani.

Indibaniselwano yeTemporomandibular (TMJ)

Eminye imithombo ibanga ukuba i-glucosamine lunyango olusebenzayo lwe-TMJ, okanye ilunga le-temporomandibular. Nangona kunjalo, uphando lokuxhasa eli bango alonelanga.

Olunye uphononongo oluncinci lubonise ukuncipha okukhulu kwintlungu kunye neempawu zokukrala, kunye nokunyusa ukuhamba kwemihlathi kubathathi-nxaxheba abafumana isongezelelo esidibeneyo se-glucosamine sulphate kunye ne-chondroitin ().

Olunye uphononongo oluncinci alubonakalisanga siphumo sexesha lifutshane lesongezelelo se-glucosamine hydrochloride yabantu abane-TMJ. Nangona kunjalo, ukuphuculwa okubalulekileyo kulawulo lweentlungu zexesha elide kwaxelwa ().

Ezi ziphumo zokufunda ziyathembisa kodwa aziboneleli ngedatha eyaneleyo yokuxhasa nasiphi na isigqibo esichazayo. Uphando olungakumbi luyafuneka.

Ngelixa i-glucosamine ihlala ithathwa njengonyango olusebenzayo kwiimeko ezahlukeneyo, akukho datha ichanekileyo kwifuthe layo.

Ngaba iyasebenza ngokwenene?

Nangona amabango abanzi enziwa malunga nefuthe le-glucosamine kwizifo ezininzi, uphando olukhoyo luxhasa kuphela ukusetyenziswa kwalo kuluhlu oluncinci lweemeko.

Okwangoku, obona bungqina bunamandla buxhasa ukusetyenziswa kwe-glucosamine sulphate kunyango lwexesha elide lweempawu ze-osteoarthritis. Oko kwathethi, ayinakusebenzela wonke umntu ().

Ngokwedatha ekhoyo, mancinci amathuba okuba lunyango olusebenzayo kwezinye izifo okanye iimeko zokuvuvukala.

Ukuba ucinga ukusebenzisa i-glucosamine, gcina engqondweni umgangatho wesongezelelo osikhethileyo - njengoko oku kunokwenza umahluko kwindlela ekuchaphazela ngayo.

Kwamanye amazwe-kubandakanya i-US-kukho umgaqo omncinci kakhulu wezongezo zokutya. Ke ngoko, iilebheli zinokukhohlisa (2).

Kuhlala kulunge kakhulu ukujonga isatifikethi somntu wesithathu ukuqinisekisa ukuba ufumana kanye le nto uyihlawulayo. Abavelisi bazimisele ukuba iimveliso zabo zivavanyelwe ukucoceka ngumntu wesithathu bahlala benemigangatho ephezulu.

I-ConsumerLab, i-NSF yamanye amazwe kunye ne-US Pharmacopeia (USP) ziinkampani ezimbalwa ezizimeleyo ezibonelela ngeenkonzo zokuqinisekiswa. Ukuba ubona enye yeelogo zabo kwisongezelelo sakho, kusenokwenzeka ukuba zikumgangatho olungileyo.

Uninzi lophando luxhasa ukusetyenziswa kweglucosamine-sulfate kuphela yokulawula iimpawu ze-osteoarthritis. Kunqabile ukuba kusebenze kwezinye izicelo.

Umthamo kunye neefom zokuXhasa

Umthamo oqhelekileyo we-glucosamine yi-1,500 mg ngosuku, onokuyithatha kube kanye okanye ngeedosi ezincinci kuyo yonke imihla (2).

Izongezo zeGlucosamine zenziwe kwimithombo yendalo- ezinje ngeqokobhe leentlanzi okanye isikhunta-okanye senziwe elebhu.

Izongezo zeGlucosamine ziyafumaneka ngeendlela ezimbini (1):

• Iswekile yeglucosamine
• I-Glucosamine hydrochloride

Ngamaxesha athile, i-glucosamine sulphate iyathengiswa ngokudibanisa ne-chondroitin sulfate.

Uninzi lwedatha yesayensi lubonisa ukusebenza okuphezulu kweglucosamine sulphate okanye i-glucosamine sulphate edityaniswe ne-chondroitin.

I-Glucosamine ihlala ichithwe kwi-1,500 mg ngosuku. Kwiifom ezikhoyo, i-glucosamine sulphate - kunye okanye ngaphandle kwe-chondroitin- yeyona inokwenzeka.

Imingcipheko enokubakho kunye neziphumo ebezingalindelekanga

Isongezelelo seGlucosamine sinokukhuseleka kubantu abaninzi. Nangona kunjalo, kukho umngcipheko okhoyo.

Iziphumo ezinokubakho ezichaseneyo zibandakanya (1):

• Isicaphucaphu nokugabha
• Urhudo
• Isitshisa
• Intlungu zesisu

Akufanele uthathe i-glucosamine ukuba ukhulelwe okanye uncancisa ngenxa yokunqongophala kobungqina obuxhasa ukhuseleko lwayo.

I-Glucosamine inokulwenza mandundu ulawulo lweswekile yegazi kubantu abanesifo seswekile, nangona lo mngcipheko uphantsi. Ukuba unesifo seswekile okanye uthatha amayeza eswekile, thetha nogqirha wakho ngaphambi kokuba uthathe i-glucosamine (2).

I-Glucosamine inokukhuseleka kubantu abaninzi. Olunye uxinzelelo lwesisu esincinci luxeliwe. Ukuba unesifo seswekile, i-glucosamine inokulwenza mandundu ulawulo lwakho lweswekile egazini.

Umgca osezantsi

I-Glucosamine ikhona ngokwendalo emzimbeni wakho kwaye idlala indima ebalulekileyo kuphuhliso kunye nokugcinwa kwamalungu asempilweni.

Nangona i-glucosamine isetyenziselwa ukunyanga izifo ezahlukeneyo zokudibanisa, zamathambo kunye nokuvuvukala, ezinjenge-IBD, i-cystitis yangaphakathi kunye ne-TMJ, uninzi lophando luxhasa ukusebenza kwayo kolawulo lweempawu ze-osteoarthritis zexesha elide.

Kubonakala kukhuselekile kubantu abaninzi kumthamo we-1,500 mg ngosuku kodwa kunokubangela iziphumo ebezingalindelekanga.

Ukuba ukhangele isiqabu se-osteoarthritis, ukuthatha isongezelelo se-glucosamine kunokufanelekile ukuba uqikelele, kodwa qiniseka ukuba uthethe nogqirha wakho kuqala.