I-Hepatitis C Uhlobo lwe-2: Yintoni onokuyilindela

Umxholo

• Kutheni kubalulekile ukuba ndine-genotype 2?
• Unyangwa njani i-hepatitis C genotype 2?
• Glecaprevir kunye nepibrentasvir (Mavyret)
• ISofosbuvir kunye nevelpatasvir (Epclusa)
• IDaclatasvir (iDaklinza) kunye nesofosbuvir (Sovaldi)
• Zinyangwa njani ezinye ii-genotypes
• Zeziphi iingxaki ezinokubakho?
• Imbonakalo

Ushwankathelo

Nje ukuba ufumane ukuxilongwa kwe-hepatitis C, kwaye ngaphambi kokuba uqale unyango, uyakufuna olunye uvavanyo lwegazi ukumisela uhlobo lwentsholongwane. Kukho ii-genotypes ezithandathu ezime kakuhle (iintlobo) ze-hepatitis C, kunye nangaphezulu kwama-subtypes angama-75.

Uvavanyo lwegazi lubonelela ngolwazi oluthe ngqo malunga nokuba ingakanani intsholongwane okwangoku kwigazi lakho.

Olu vavanyo aluyi kuphinda luphindwe ngenxa yokuba i-genotype ayitshintshi. Nangona ingaqhelekanga, kunokwenzeka ukuba wosulelwe ngaphezu kwesinye se-genotype. Oku kubizwa ngokuba yi-superinfection.

E-United States, malunga ne-13 ukuya kwi-15 ekhulwini labantu abane-hepatitis C bane-genotype 2. IGenotype 1 yiyo kwaye ichaphazela ukuya kwiipesenti ezingama-75 zabantu abane-hepatitis C.

Ukwazi uhlobo lwakho lwe-genotype kunefuthe kwizindululo zonyango.

Kutheni kubalulekile ukuba ndine-genotype 2?

Ukwazi ukuba unayo i-genotype 2 inikezela ngolwazi olubalulekileyo malunga nokhetho lwakho lonyango kunye nokuba kungenzeka njani ukuba lusebenze.

Ngokusekwe kwi-genotype, oogqirha banokunciphisa ukuba loluphi unyango olunokuthi lusebenze kwaye kufuneka uthathe ixesha elingakanani. Oku kunokukuthintela ekuchitheni ixesha kunyango olungelulo okanye ukuthatha amayeza ixesha elide kunokuba kufuneka.

Ezinye ii-genotypes zisabela ngendlela eyahlukileyo kunyango kunabanye. Kwaye kufuneka uthathe amayeza ixesha elingakanani ngokwahluka ngokuxhomekeke kuhlobo lwakho.

Nangona kunjalo, i-genotype ayikwazi ukuxelela oogqirha ukuba imeko iya kukhawuleza kangakanani, ukuba zimpawu ezinzima kangakanani iimpawu zakho, okanye ukuba isifo esibi siya kuba sisifo esingapheliyo.

Unyangwa njani i-hepatitis C genotype 2?

Akucaci ukuba kutheni, kodwa ebantwini bayalucacisa usulelo lwe-hepatitis C ngaphandle konyango. Kuba akukho ndlela yokwazi ukuba ngubani owela kolu luhlu, kusulelo olugqithisileyo, ugqirha wakho uya kuncoma ukulinda iinyanga ezi-6 ukunyanga intsholongwane, kuba inokucaca ngokuzenzekelayo.

I-Hepatitis C inyangwa ngamachiza antiviral acoca umzimba wakho kwintsholongwane kunye nokuthintela okanye ukunciphisa umonakalo kwisibindi sakho. Rhoqo, uya kuthatha indibaniselwano yamachiza amabini antiviral kwiiveki ezisibhozo okanye nangaphezulu.

Kukho ithuba elihle lokuba uya kuba nempendulo eqhubekayo ye-virologic (SVR) kunyango lweziyobisi zomlomo. Ngamanye amagama, iyanyangeka kakhulu. Ireyithi ye-SVR kuninzi lwenhlanganisela entsha yeziyobisi ze-hepatitis C iphezulu njengeipesenti ezingama-99.

Xa ukhetha iziyobisi kwaye uthatha isigqibo sokuba uza kuzithatha ixesha elingakanani, ugqirha wakho uya kuhlala ejonga ezi zinto zilandelayo:

• impilo yakho iyonke
• ingakanani intsholongwane ekhoyo kwinkqubo yakho (umthamo wentsholongwane)
• nokuba sele unayo i-cirrhosis okanye omnye umonakalo kwisibindi sakho
• ingaba sele unyangwe i-hepatitis C, kwaye loluphi unyango onalo

Glecaprevir kunye nepibrentasvir (Mavyret)

Unokumiselwa le ndibaniselwano ukuba umtsha kunyango okanye uphathwe i-peginterferon kunye ne-ribavirin okanye i-sofosbuvir kunye ne-ribavirin (i-RibaPack) kwaye ayikhange ikunyange. Idosi ngamacwecwe amathathu, kanye ngemini.

Uza kuthatha ixesha elingakanani amayeza:

• ukuba awunayo i-cirrhosis: iiveki ezi-8
• ukuba une-cirrhosis: iiveki ezili-12

ISofosbuvir kunye nevelpatasvir (Epclusa)

Olu dibaniso lolunye ukhetho kubantu abatsha kunyango, okanye abo bakhe banyangwa ngaphambili. Uya kuthatha ipilisi enye ngosuku ngeeveki ezili-12. Idosi iyafana, nokuba awunayo i-cirrhosis.

IDaclatasvir (iDaklinza) kunye nesofosbuvir (Sovaldi)

Le rejimeni yamkelwe kwi-hepatitis C genotype 3. Ayivunyelwanga ukunyanga i-genotype 2, kodwa oogqirha banokuyisebenzisa ngaphandle kwelebheli kubantu abathile abanolu hlobo lwe-genotype.

Idosi yipilisi enye yedaclatasvir kunye nethebhulethi enye ye-sofosbuvir kanye ngemini.

Uza kuthatha ixesha elingakanani amayeza:

• ukuba awunayo i-cirrhosis: iiveki ezili-12
• ukuba unesifo sokuqina kwesibindi: iiveki ezili-16 ukuya kwezi-24

Uvavanyo lwegazi olulandelelweyo luya kutyhila ukuba uphendula njani kunyango.

Qaphela: Ukusetyenziswa kwelebheli engekho kwilebula kuthetha ukuba ichiza elivunyiweyo yi-FDA ngenjongo enye lisetyenziselwa injongo eyahlukileyo engavunyelwanga. Nangona kunjalo, ugqirha usenokulisebenzisa iyeza ukulungiselela loo njongo. Kungenxa yokuba i-FDA ilawula ukuvavanywa kunye nokuvunywa kwamachiza, kodwa hayi indlela abagqirha abazisebenzisa ngayo iziyobisi ukunyanga izigulana zabo. Ke, ugqirha wakho unokuyalela ichiza kodwa bacinga ukuba kokona kulungileyo ukukhathalela kwakho. Funda ngakumbi malunga nokusetyenziswa kwelebheli emiselweyo

Zinyangwa njani ezinye ii-genotypes

Unyango lwe-genotypes 1, 3, 4, 5, kunye no-6 luxhomekeke kwizinto ezahlukeneyo ezinje ngomthamo wentsholongwane kunye nobungakanani bomonakalo wesibindi. IiGenotypes 4 no-6 aziqhelekanga, kwaye ii-genotypes 5 kunye no-6 zinqabile e-United States.

Amayeza antiviral angabandakanya la machiza okanye indibaniselwano kuwo:

• idaclatasvir (iDaklinza)
• I-elbasvir / grazoprevir (iZepatier)
• glecaprevir / pibrentasvir (Mavyret)
• I-ledipasvir / sofosbuvir (iHarvoni)
• ombitasvir / paritaprevir / ritonavir (Itekhnoloji)
• ombitasvir / paritaprevir / ritonavir kunye nedasabuvir (Viekira Pak)
• simeprevir (Olysio)
• isofosbuvir (Sovaldi)
• isofosbuvir / velpatasvir (Epclusa)
• isofosbuvir / velpatasvir / voxilaprevir (Yonkevi)
• mzantsiweb

Ubude bonyango bunokwahluka ngohlobo oluthile.

Ukuba umonakalo wesibindi unzulu ngokwaneleyo, ukufakelwa kwesibindi kunokucetyiswa.

Zeziphi iingxaki ezinokubakho?

IHepatitis C genotype 2 ihlala inyangeka. Kodwa usulelo olungapheliyo lunokukhokelela kwiingxaki ezinkulu.

Uninzi lwabantu abane-hepatitis C abanamava okanye iimpawu ezibuthathaka, nokuba isibindi sonakala.

Kwiinyanga ezintandathu zokuqala emva kokosuleleka ichazwa njengosulelo olunamandla lwe-hepatitis C. Oku kuyinyani nokuba unempawu okanye awunayo. Ngonyango, kwaye ngamanye amaxesha ngaphandle konyango, abantu abaninzi bayalususa usulelo ngeli xesha.

Akunakulindeleka ukuba ube nomonakalo omkhulu wesibindi ngexesha lesigaba esibuhlungu, nangona kwiimeko ezinqabileyo kunokwenzeka ukuba ufumane ukusilela kwesibindi.

Ukuba usenayo intsholongwane kwinkqubo yakho emva kweenyanga ezintandathu, unesifo esinganyangekiyo sesifo sehepatitis C. Nangona kunjalo, esi sifo ngokubanzi sithatha iminyaka emininzi ukuqhubela phambili. Iingxaki ezinzima zinokubandakanya i-cirrhosis, umhlaza wesibindi kunye nokusilela kwesibindi.

Izibalo zobunzima be-genotype 2 zodwa ziyasilela.

Kuzo zonke iintlobo ze-hepatitis C e-United States, uqikelelo lokuba:

• Ngama-75 ukuya kuma-85 kwabali-100 abantu abosulelekileyo abaza kuqhubekeka nosulelo olungapheliyo
• I-10 ukuya kwi-20 iya kuphuhlisa i-cirrhosis yesibindi kwisithuba seminyaka engama-20 ukuya kwengama-30

Nje ukuba abantu baphuhlise i-cirrhosis, baqhuba ukufumana umhlaza wesibindi unyaka nonyaka.

Imbonakalo

Kwangoko ufumana unyango, ngcono amathuba akho okuthintela ukonakala kwesibindi. Ukongeza kunyango lweziyobisi, uyakufuna uvavanyo lwegazi olulandelayo ukuze ubone ukuba isebenza njani.

Imbonakalo ye-hepatitis C genotype 2 iyathandeka kakhulu. Kuyinyani ngakumbi ukuba uqala unyango kwangoko, ngaphambi kokuba intsholongwane ibe nethuba lokonakalisa isibindi sakho.

Ukuba ucoca ngempumelelo i-hepatitis C genotype 2 kwinkqubo yakho, uya kuba nezixhobo zokulwa izifo eziza kukukhusela ekuhlaselweni kwixesha elizayo. Kodwa usenokosuleleka ngohlobo olwahlukileyo lwe-hepatitis okanye uhlobo olwahlukileyo lwe-hepatitis C.