I-Herceptin-Unyango lomhlaza webele

Umxholo

• Yenzelwe ntoni
• Kusetyenziswa kwanjani
• 1. Umhlaza webele
• 2. Umhlaza wesisu
• Iziphumo ebezingalindelekanga ezinokwenzeka

I-Herceptin sisiyobisi esisekwe kwii-antibodies ze-monoclonal, ezivela kwilabhoratri yaseRoche, esebenza ngokuthe ngqo kwiseli yomhlaza kwaye iyasebenza ngokuchasene nezinye iintlobo zomhlaza.

Eli yeza linexabiso elimalunga ne-10 lamawaka reais kwaye liyafumaneka kwi-SUS-Sistema Único de Saúde.

Yenzelwe ntoni

I-Herceptin ibonakalisiwe kunyango lwabantu abanomdlavuza webele we-metastatic, umhlaza wamabele wokuqala kunye nomhlaza wesisu oqhubela phambili.

Kusetyenziswa kwanjani

I-Herceptin kufuneka ilawulwe yingcali yezempilo:

1. Umhlaza webele

Ukuba isetyenziswe ngeveki, idosi yokuqala yokulayisha ye-4 mg / kg yesisindo somzimba kufuneka ilawulwe njengokufakwa ngaphakathi ngaphakathi kwimizuzu engama-90. Iidosi ezilandelayo zeveki nganye kufuneka zibe yi-2 mg / kg yesisindo somzimba, esinokuqhutywa ukumiliselwa kwimizuzu engama-30.

Ukuba isetyenziswe rhoqo kwiiveki ezi-3, idosi yokuqala yokulayisha yi-8 mg / kg ubunzima bomzimba, ilandelwa ngu-6 mg / kg ubunzima bomzimba, rhoqo kwiiveki ezi-3, kwi-infusions ezihlala malunga nemizuzu engama-90. Ukuba le dosi inyamezeleke kakuhle, ixesha lokufakwa lingancitshiswa libe yimizuzu engama-30.

Eli yeza linokuqhutywa ngokudibeneyo ne-paclitaxel okanye i-docetaxel.

2. Umhlaza wesisu

Eli yeza kufuneka lisetyenziswe rhoqo kwiiveki ezi-3 kwaye idosi yokuqala yokuhlaselwa yi-8 mg / kg yesisindo somzimba, ilandelwe yi-6 mg / kg yesisindo somzimba, ekufuneka iphindaphindwe rhoqo kwiiveki ezintathu, kwi-infusions ehlala malunga nemizuzu engama-90. Ukuba le dosi inyamezelwe kakuhle, ixesha lokufakwa lingancitshiswa libe yimizuzu engama-30.

Iziphumo ebezingalindelekanga ezinokwenzeka

Iziphumo eziqhelekileyo ezinokuthi zenzeke ngexesha lonyango kunye ne-Herceptin zi-nasopharyngitis, usulelo, i-anemia, i-thrombocytopenia, i-febrile neutropenia, ukunciphisa ukubalwa kweeseli ezimhlophe zegazi, ukunciphisa okanye ukonyusa ubunzima, ukunciphisa ukutya, ukungalali, isiyezi, intloko, i-paresthesia, i-hypoesthesia, ukunciphisa incasa , ukukrazula, i-conjunctivitis, i-lymphedema, ukutshisa okutshisayo, ukuphefumula okufutshane, i-epistaxis, ukukhwehlela, impumlo kunye neentlungu zomlomo kunye ne-pharynx.

Ukongeza, urhudo, ukugabha, isicaphucaphu, iintlungu esiswini, ukungagayeki kakuhle, ukuqhina, i-stomatitis, i-erythema,irhashalala, ukulahleka kweenwele, ukuphazamiseka kweenzipho kunye nentlungu yomzimba.

Ngubani ongafanele asebenzise

Esi sixhobo akufuneki sisetyenziswe kubantu abagulayo nakweliphi na icandelo lefomula, abasetyhini abakhulelweyo nabancancisayo.

Eli yeza alikavavanywa ebantwaneni, kulutsha, kubantu abadala nakubantu abanokukhubazeka kwezintso okanye i-hepatic, kwaye kufuneka lisetyenziswe ngononophelo.