Irritable Bowel Syndrome vs Carcinoid Syndrome

Umxholo

• Zeziphi iimpawu eziphambili ze-MCT?
• Zithini iimpawu ze-IBS?
• Nguwuphi umahluko ophambili phakathi kwe-IBS kunye nee-MCT?
• Ubudala ekuchongeni
• Ukuhluza, ukuvutha, okanye ukuphefumla nzima
• Ukuhla ukusinda
• Ukuqhubeka kweempawu zesisu
• Ukuthatha

Oogqirha baba ngcono ekufumaneni isifo se-metastatic carcinoid tumors (MCTs). Nangona kunjalo, iimpawu ezahlukahlukeneyo ze-MCT ngamanye amaxesha zingakhokelela ekuxilongweni okungalunganga kunye nokunyanga okungalunganga, de kube i-tumor ye-carcinoid ibonakaliswe ukuba ibangele ezo mpawu. Ngokwe-National Organisation for Rare Disorders, ii-carcinoid tumors zihlala zichazwa gwenxa njenge-irritable bowel syndrome (IBS) okanye isifo sikaCrohn, okanye njengophawu lokuyeka ukuya exesheni kwabasetyhini.

Ukwazi umahluko phakathi kweempawu ze-carcinoid syndrome kunye ne-IBS kunokukunika umbono wokuba yeyiphi imeko onokuba nayo, kwaye kufuneka ubuze ugqirha wakho ukuba uqiniseke ngokuqinisekileyo.

Zeziphi iimpawu eziphambili ze-MCT?

Ngokutsho kwephephancwadi i-American Family Physician, uninzi lwezicubu ze-carcinoid azibangeli zimpawu. Rhoqo, ugqirha wotyando ufumanisa elinye lala mathumba ngelixa esenza utyando lomnye umba, njenge-pancreatitis ebukhali, ukuvaleka kwesisu somntu, okanye izifo ezichaphazela inzala yomfazi.

Amathumba e-carcinoid anokufihla inani lamahomoni achaphazela umzimba wakho, eyona nto ibaluleke kakhulu kwi-serotonin. Ukonyuka kwe-serotonin emzimbeni wakho kunokuvuselela isilonda sakho, kubangele iimpawu ezinjenge-IBS, ngakumbi isifo sorhudo. Ezinye iimpawu ezinxulumene nee-MCTs zibandakanya:

• ukugungxula
• iingxaki zentliziyo ezibangela ukubetha kwentliziyo ngokungaqhelekanga kunye notshintsho kuxinzelelo lwegazi, zihlala zinciphisa uxinzelelo lwegazi
• izihlunu ezihlangeneyo nezihlunu
• ukuvutha

Urhudo olunxulunyaniswa nee-MCTs zihlala zisiba mbi emva kokuba umntu etye ukutya okuqulethe into ebizwa ngokuba yi-tyramine. Ukutya okune-tyramine kubandakanya iwayini, itshizi, kunye netshokholethi.

Ixesha elingaphezulu, iimpawu zesisu ezinxulumene neMCTs zinokuba neziphumo ezibi ngakumbi. Oku kubandakanya ukwehla kobunzima kuba ilindle lidlula ngokukhawuleza emathunjini akho kangangokuba umzimba wakho awunalo ixesha lokufunxa izondlo. Ukuphelelwa ngamanzi emzimbeni kunye nokungondleki kunokubakho ngenxa yezizathu ezifanayo.

Zithini iimpawu ze-IBS?

I-IBS yimeko echaphazela amathumbu amakhulu, ibangela ukucaphuka rhoqo okunokukhokelela kwisisu esibuhlungu rhoqo. Imizekelo yeempawu ezinxulumene ne-IBS zibandakanya:

• ukuqhina
• ukuxinana
• urhudo
• irhasi
• isisu esibuhlungu

Abanye abantu abane-IBS banamava atshintshanayo okuqunjelwa kunye norhudo. Njenge-MCT, i-IBS ihlala isenziwa mandundu xa umntu esitya iintlobo ezithile zokutya, ezinje ngetshokholethi notywala. Okunye ukutya okwaziwayo ukudala iimpawu ze-IBS kubandakanya:

• Imifuno ebethelelayo enjenge-broccoli, icauliflower kunye neklabishi
• ukutya okuneziqholo
• ukutya okunamafutha aphezulu
• iimbotyi
• iimveliso zederi

I-IBS ayibangeli monakalo ngokwasemzimbeni emathunjini. Xa umntu eneempawu ezibi, ugqirha unokwenza i-biopsy yamathumbu abo ukukhangela ukonakala okanye isifo. Kulapho ugqirha anokufumanisa khona iMCT, ukuba ikho.

Nguwuphi umahluko ophambili phakathi kwe-IBS kunye nee-MCT?

Ukujonga iimpawu ze-IBS, kulula ukubona ukuba i-MCT inokuchazwa gwenxa njenge-IBS. Nangona kunjalo, izinto ezithile eziphambili zinokukhokelela kugqirha ekucebiseni ukuba avavanye uvavanyo lwe-MCT.

Ubudala ekuchongeni

Ngelixa umntu enokufumana i-IBS nakweyiphi na iminyaka, abantu ababhinqileyo abangaphantsi kweminyaka engama-45 kunokwenzeka ukuba bafumane i-IBS, ngokweKliniki yaseMayo. Ngokwahlukileyo, ubudala beminyaka umntu one-MCT uqala ukubona iimpawu ziphakathi kwe-50 kunye ne-60.

Ukuhluza, ukuvutha, okanye ukuphefumla nzima

Umntu one-MCT unokuba namava okuvuthwa kunye nohudo kwaye atshintshe ezi mpawu ukuya kwimiba eyahlukeneyo. Umzekelo, banokugxeka ukuvutha komkhuhlane kunye nohudo kwi-IBS. Nangona kunjalo, iimpawu ezinxulumene nee-MCTs azisoloko zigxile kwinkqubo enye emzimbeni womntu.

Ukwazi oku, kubalulekile ukuba uchaze zonke iimpawu ezingaqhelekanga okhe wahlangabezana nazo kugqirha wakho, nokuba zibonakala zingadibani. Umzekelo, kuya kufuneka wabelane ukuba awufumananga kuphela urhudo, kodwa nokugungxula, ukubila, okanye ukuphefumla ngokubanzi. Ngokukodwa, urhudo kunye nokugungxuka kwenzeka ngaxeshanye kwabo bane-MCT.

Ukuhla ukusinda

Ngelixa umntu one-IBS enokulahleka kwesisindo ngokunxulumene nohudo lwabo, olu phawu kunokwenzeka ukuba lwenzeke nge-MCTs okanye enye imeko ebaluleke ngakumbi. Ukwehla kwesisindo kuthathwa ngokuba "luphawu lweflegi ebomvu" ukuba oyena nobangela akuyiyo i-IBS, ngokweKliniki yaseMayo.

Ukuqhubeka kweempawu zesisu

Rhoqo, abo bane-MCT baya kufumana iimpawu ezahlukeneyo zesisu iminyaka emininzi ngaphandle kokuxilongwa. Ukuba iimpawu zakho aziphendulanga kunyango okanye kubonakala ngathi ziyaphucuka ngokupheliswa kwezinto eziqukethe ityramine ekudleni kwakho, oku kunokuba ngumqondiso wokucela ugqirha wakho ukuba aqhubeke emba ngakumbi.

Imizekelo yovavanyo lokufumanisa i-MCT ibandakanya:

• ukulinganisa umchamo wakho iiyure ezingama-24 ubukho be-5-HIAA, imveliso ephuma emzimbeni wakho eyaphula i-serotonin
• ukuvavanya igazi lakho kwi-chromogranin-A
• usebenzisa i-imaging scans, ezinje nge-CT okanye nge-MRI scan, ukuchonga indawo enokubakho ye-MCT

Ukuthatha

Ixesha eliqhelekileyo ukusuka ekuqaleni kweempawu ze-MCT zokuchonga isifo. Ngelixa oku kubonakala ngathi lixesha elide kakhulu, kubonisa ukuba kunzima kangakanani kwaye ngamanye amaxesha kunokuba nzima ukuxilonga i-MCT.

Ukuba unempawu ezidlulela ngaphaya kohudo, thetha nogqirha wakho malunga nokwenza i-MCT. Uninzi lwabantu abane-MCT abalufuni unyango de kube ithumba lisasazekile kwaye liqale ukubangela ezinye iimpawu. Kodwa ukuba uthatha amanyathelo ovavanyo olongezelelweyo kwangoko kwaye ugqirha wakho ufumanisa i-MCT, banokukwazi ukususa ithumba, kuthintele ukusasazeka.