I-infliximab, isisombululo esifanelekileyo

Umxholo

• Izilumkiso ezibalulekileyo
• Isilumkiso se-FDA:
  
• Ezinye izilumkiso
• Yintoni infliximab?
• Kutheni isetyenziswa
• Ingaba isebenza kanjani
• Iziphumo ebezingalindelekanga ze-infliximab
• Iziphumo eziqhelekileyo ezichaphazelekayo
• Iziphumo ebezingalindelekanga ezimandundu
• I-infliximab inokusebenzisana namanye amayeza
• Izilumkiso ze-infliximab
• Isilumkiso somzimba
• Izilumkiso zabantu abaneemeko ezithile zempilo
• Izilumkiso kwamanye amaqela
• Ungayithatha njani i-infliximab
• Thatha njengoko kuyalelwe
• Ukuqwalaselwa okubalulekileyo kokuthatha i-infliximab
• Ukuhamba
• Uvavanyo lwezonyango kunye nokubeka iliso
• Ngaphambi kogunyaziso

Amagqabantshintshi e-infliximab

1. Isisombululo esingena ngenaliti ye-infliximab siyafumaneka njengamachiza anegama lophawu. Ayifumaneki kuhlobo oluqhelekileyo. Amagama eBrand: Remicade, Inflectra, Renflexis.
2. I-infliximab iza kwisisombululo esinokufakwa inaliti sokusetyenziswa njengokufakwa ngaphakathi.
3. Isisombululo esingena ngenaliti ye-infliximab sisetyenziselwa ukunyanga isifo sikaCrohn, isifo sezilonda, isifo samathambo, i-ankylosing spondylitis, i-psoriatic arthritis, kunye ne-plaque psoriasis.

Izilumkiso ezibalulekileyo

Isilumkiso se-FDA:

• Eli chiza linezilumkiso zebhokisi emnyama. Ezi zezona zilumkiso zinzima ezivela kuLawulo lokutya kunye noLawulo lweziyobisi (FDA). Isilumkiso sebhokisi emnyama silumkisa oogqirha kunye nezigulana malunga neziphumo zeziyobisi ezinokuba yingozi.
• Umngcipheko wesilumkiso esibi: I-infliximab inokunciphisa amandla omzimba wakho wokulwa izifo. Abanye abantu baba nosulelo olunzulu ngelixa bethatha eli chiza. Oku kunokubandakanya isifo sephepha (i-TB) okanye olunye usulelo olubangelwa ziintsholongwane, zintsholongwane, okanye ukungunda. Musa ukuthatha i-infliximab ukuba unayo nayiphi na intsholongwane ngaphandle kokuthetha nogqirha wakho kuqala. Ugqirha wakho unokukujonga iimpawu zosulelo ngaphambi, ngexesha, nasemva konyango lwakho nge-infliximab. Ugqirha wakho usenokukuvavanya ukuba une-TB ngaphambi kokuba uqalise i-infliximab.
• Umngcipheko wesilumkiso somhlaza: Eli yeza lonyusa umngcipheko we-lymphoma, umhlaza womlomo wesibeleko, kunye nezinye iintlobo zomhlaza. Abantu abangaphantsi kweminyaka eyi-18, abantu abadala abancinci abangamadoda, kwaye abo banesifo sikaCrohn okanye isifo sezilonda esibuhlungu sinokuba sesichengeni sokuba nomhlaza. Thetha nogqirha wakho ukuba ngaba unalo naluphi na uhlobo lomhlaza. Ugqirha wakho unokufuna ukunyanga amayeza akho.

Ezinye izilumkiso

• Isilumkiso somonakalo wesibindi: I-infliximab inokulimaza isibindi sakho. Tshela ugqirha wakho ukuba unempawu zomonakalo wesibindi, ezinje:
  • ubumthubi besikhumba sakho okanye ezimhlophe zamehlo akho
  • umchamo omnyama-mnyama
  • iintlungu kwicala lasekunene lesisu sakho
  • ifiva
  • ukudinwa kakhulu
• Umngcipheko wesifo esifana nelupus: I-Lupus sisifo esichaphazela amajoni akho omzimba. Iimpawu zingabandakanya iintlungu zesifuba ezingapheliyo, ukuphefumla okufutshane, iintlungu ezidibeneyo, kunye nokudumba kwizidlele zakho okanye iingalo eziba mandundu elangeni. Ugqirha unokuthatha isigqibo sokuyeka i-infliximab ukuba uvelisa ezi mpawu.
• Isilumkiso sokugonya: Musa ukufumana isitofu sokugonya esiphilayo ngelixa uthatha i-infliximab. Lindela ubuncinci iinyanga ezintathu emva kokumisa i-infliximab ukufumana isitofu sokugonya esiphilayo. Imizekelo yokugonya okuphilayo kubandakanya isitofu sokuthintela umkhuhlane sempumlo, imasisi, uqwilikana, kunye nokuthintela irubella, kunye nenkukhu yenkukhu okanye yokuthintela isifo. Isitofu sokugonya esiphilayo sinokungakukhuseli ngokupheleleyo kwesi sifo ngelixa uthatha eli chiza. Ukuba ungaphantsi kweminyaka eyi-18, qiniseka ukuba zonke izitofu zihlaziyiwe ngaphambi kokuqala i-infliximab.
• Impendulo ezimandla emva kwesilumkiso sokufakwa. Impendulo ezimandla ezichaphazela intliziyo yakho, isingqisho sentliziyo, kunye nemithambo yegazi zinokuvela ngaphakathi kweeyure ezingama-24 zokuqala kokufakwa kwesiyobisi. Ezi mpendulo zinokubandakanya ukubetha kwentliziyo, okunokubulala. Ukuba unempawu ezinje ngesiyezi, iintlungu esifubeni, okanye ukubetha kwentliziyo kwisithuba seeyure ezingama-24 zokufakwa kwakho, tsalela umnxeba kwangoko.

Yintoni infliximab?

I-infliximab sisiyobisi esimiselweyo. Iyafumaneka njengesisombululo esitofwayo.

I-infliximab iyafumaneka njengegama leziyobisi igama elithi Remicade, Inflectra, kunye neRenflexis. (I-Inflectra kunye ne-Renflexis zii-biosimilars. * * I-Infliximab ayifumaneki kuhlobo oluqhelekileyo.

I-infliximab inokudityaniswa ne-methotrexate xa isetyenziselwa ukunyanga isifo samathambo.

I-biosimilar luhlobo lweziyobisi zebhayoloji. I-Biologics yenziwe kumthombo webhayoloji, njengeeseli eziphilayo. I-biosimilar iyafana negama lophawu lwebhayiloji, kodwa ayisiyiyo ikopi ngqo. (Iyeza elenziwe lafana nalawo aveliswe ngumenzi, kwelinye icala, liyikopi ngqo yesiyobisi esenziwe ngemichiza. Uninzi lweziyobisi zenziwe ngemichiza.)

I-biosimilar inokumiselwa ukuba inyange ezinye okanye zonke iimeko ezenziwa ngegama lophawu lweziyobisi, kwaye kulindeleke ukuba zibe neziphumo ezifanayo kwisigulana. Kule meko, i-Inflectra kunye ne-Renflexis ziinguqulelo ezifanayo ze-Remicade.

Kutheni isetyenziswa

I-infliximab isetyenziselwa ukunyanga:

• Isifo sikaCrohn (xa ungaphendulanga kwamanye amayeza)
• ulcerative colitis (xa ungaphendulanga kwamanye amachiza)
• i-rheumatoid arthritis (esetyenziswa kunye ne-methotrexate)
• i-ankylosing spondylitis
• isifo samathambo
• ixesha elide kunye ne-plaque psoriasis (esetyenziswa xa ufuna ukunyanga umzimba wakho uphela okanye xa olunye unyango lungakulungelanga)

Ingaba isebenza kanjani

Eli yeza lisebenza ngokuthintela isenzo seprotein emzimbeni wakho obizwa ngokuba yi-tumor necrosis factor-alpha (TNF-alpha). I-TNF-alpha yenziwa ngamajoni omzimba wakho. Abantu abaneemeko ezithile bane-TNF-alpha eninzi kakhulu. Oku kunokubangela ukuba amajoni omzimba ahlasele amalungu asempilweni omzimba. I-infliximab inokuthintela umonakalo obangelwe yi-TNF-alpha kakhulu.

Iziphumo ebezingalindelekanga ze-infliximab

Isisombululo esingenabungozi se-infliximab asibangeli ukozela, kodwa sinokubangela ezinye iziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo eziqhelekileyo eziqhelekileyo ezinokuthi zenzeke nge-infliximab zibandakanya:

• izifo zokuphefumula, ezinje ngezifo zesinus kunye nomqala obuhlungu
• intloko ebuhlungu
• ukukhohlela
• isisu esibuhlungu

Iziphumo ebezingalindelekanga ezincinci zinokuhamba zingaphelanga iintsuku okanye iiveki ezimbalwa. Thetha nogqirha wakho okanye usokhemesti ukuba banzima kakhulu okanye abahambi.

Iziphumo ebezingalindelekanga ezimandundu

Shayela ugqirha wakho ngokukhawuleza ukuba unemiphumo emibi. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka. Iziphumo ebezingalindelekanga ezimandundu kunye neempawu zazo zinokubandakanya oku kulandelayo:

• Ukumelwa yintliziyo. Iimpawu zingabandakanya:
  • ingxaki yokuphefumla
  • ukudumba kwamaqatha okanye iinyawo
  • ukukhawuleza ukutyeba
• Iingxaki zegazi. Iimpawu zingabandakanya:
  • ukugruzuka okanye ukopha ngokulula kakhulu
  • umkhuhlane ongapheliyo
  • ijonge kakhulu
• Iingxaki zenkqubo. Iimpawu zingabandakanya:
  • utshintsho lombono
  • ubuthathaka beengalo zakho okanye imilenze
  • Ukuba ndindisholo okanye ukubetha komzimba wakho
  • ukuxhuzula
• Ukuphendula okungafunekiyo / ukunyanzeliswa. Ingakho ukuya kuthi ga kwiiyure ezimbini emva kokufakwa kwe-infliximab. Iimpawu zingabandakanya:
  • irhashalala
  • ukurhawuzelela
  • urhwebo
  • ukudumba kobuso bakho, imilebe, okanye ulwimi
  • umkhuhlane okanye ukubanda
  • iingxaki zokuphefumla
  • iintlungu zesifuba
  • uxinzelelo lwegazi oluphezulu okanye oluphantsi (unesiyezi okanye uziva utyhafile)
• Ukulibaziseka komzimba. Iimpawu zingabandakanya:
  • intlungu yesihlunu okanye edibeneyo
  • ifiva
  • irhashalala
  • intloko ebuhlungu
  • umqala obuhkungu
  • ukudumba kobuso okanye izandla
  • kunzima ukugwinya
• Unyango. Iimpawu zingabandakanya:
  • bomvu, amabala anamaxolo okanye amaqhuma aphakanyisiweyo kulusu
• Usulelo. Iimpawu zingabandakanya:
  • umkhuhlane okanye ukubanda
  • ukukhohlela
  • umqala obuhkungu
  • intlungu okanye ingxaki yokudlulisa umchamo
  • Ndiziva ndidiniwe
  • ulusu olufudumeleyo, olubomvu, okanye olubuhlungu

Iphepha elichazayo ukuba awusenanto oyifunayo: Injongo yethu kukukunika olona lwazi lufanelekileyo nolukhoyo ngoku. Nangona kunjalo, ngenxa yokuba iziyobisi zichaphazela umntu ngamnye ngokwahlukileyo, asinakuqinisekisa ukuba olu lwazi lubandakanya zonke iziphumo ebezingalindelekanga ezinokubakho. Olu lwazi aluthathi ndawo yengcebiso yezonyango. Soloko uxoxa ngeziphumo ebezingalindelekanga ezinokwenzeka kunye nomboneleli wezempilo oyaziyo imbali yakho yezonyango.

I-infliximab inokusebenzisana namanye amayeza

Isisombululo esingenayo i-infliximab sinokusebenzisana namanye amayeza, amayeza, okanye iivithamini onokuthi uzithathe. Umboneleli wakho wezempilo uya kujonga ukuhlangana kunye namayeza akho akhoyo. Njalo qiniseka ukuxelela ugqirha wakho malunga nawo onke amayeza, imifuno, okanye iivithamini ozithathayo.

Iphepha elichazayo ukuba awusenanto oyifunayo: Injongo yethu kukukunika olona lwazi lufanelekileyo nolukhoyo ngoku. Nangona kunjalo, ngenxa yokuba iziyobisi zinxibelelana ngokwahlukileyo kumntu ngamnye, asinakuqinisekisa ukuba olu lwazi lubandakanya lonke unxibelelwano olunokwenzeka. Olu lwazi aluthathi ndawo yengcebiso yezonyango. Soloko uthetha nomboneleli wakho wezempilo malunga nokunxibelelana okunokubakho nawo onke amayeza amiselweyo, iivithamini, amayeza kunye nezongezo, kunye neziyobisi ezingaphaya kwekhawunta ozithathayo.

Izilumkiso ze-infliximab

Eli chiza liza nezilumkiso ezininzi.

Isilumkiso somzimba

I-infliximab inokubangela ukusabela kakubi. Le mpendulo inokwenzeka ngelixa ufumana unyango okanye ukuya kuthi ga kwiiyure ezimbini emva. Iimpawu zingabandakanya:

• Imihlathi (ebomvu, ephakanyisiweyo, iipatches ezinobungozi zesikhumba)
• ingxaki yokuphefumla
• iintlungu zesifuba
• uxinzelelo lwegazi oluphezulu okanye oluphantsi. Iimpawu zoxinzelelo lwegazi oluphantsi zibandakanya:
  • isiyezi
  • ndiziva ndidiniwe
  • ingxaki yokuphefumla
  • umkhuhlane kunye nokugodola

Ngamanye amaxesha i-infliximab inokubangela ukuphendula okungahambi kakuhle. Impendulo zinokwenzeka kwiintsuku ezi-3 ukuya kwezi-12 emva kokufumana inaliti yakho. Tshela ugqirha wakho ngoko nangoko ukuba unayo nayiphi na le miqondiso yokuphendula okungahambi kakuhle komzimba:

• ifiva
• irhashalala
• intloko ebuhlungu
• umqala obuhkungu
• intlungu yesihlunu okanye edibeneyo
• ukudumba kobuso bakho nezandla
• ingxaki yokuginya

Izilumkiso zabantu abaneemeko ezithile zempilo

Kubantu abanesifo: Xelela ugqirha wakho ukuba unalo naluphi na uhlobo losulelo, nokuba lincinci, njengokusikwa okuvulekileyo okanye isilonda esikhangeleka sosulelekile. Umzimba wakho unokuba nexesha elinzima ukulwa nosulelo ngelixa uthatha i-infliximab.

Kubantu abanesifo sephepha (TB): I-infliximab ichaphazela amajoni akho omzimba kwaye ingenza kube lula kuwe ukuba ufumane i-TB. Ugqirha wakho usenokukuvavanyela i-TB ngaphambi kokuba aqale iyeza.

Kubantu abane-hepatitis B: Ukuba uphethe intsholongwane ye-hepatitis B, inokusebenza ngelixa usebenzisa i-infliximab. Ukuba intsholongwane iyaphinda isebenze, kuyakufuneka uyeke ukuthatha iyeza kwaye unyange usulelo. Ugqirha wakho angenza uvavanyo lwegazi ngaphambi kokuba uqale unyango, ngexesha lonyango, kunye neenyanga ezimbalwa emva konyango nge-infliximab.

Kubantu abaneengxaki zegazi: I-infliximab inokuchaphazela iiseli zakho zegazi. Tshela ugqirha wakho malunga naziphi na iingxaki onazo ngegazi lakho ngaphambi kokuba uqale ukuthatha i-infliximab.

Kubantu abaneengxaki zenkqubo ye-nervous: I-infliximab inokwenza ukuba ezinye iingxaki zenkqubo ye-neva zibe nzima ngakumbi. Yisebenzise ngononophelo ukuba une-multiple sclerosis okanye i-Guillain-Barre syndrome.

Kubantu abanesifo sentliziyo: Eli yeza linokwenza ukuba ukusilela kwentliziyo kubhebhetheke. Biza ugqirha wakho ngoko nangoko ukuba ufumana iimpawu zokwehluleka kwentliziyo. Iimpawu zinokubandakanya ukuphefumla kancinci, ukudumba kwamaqatha okanye iinyawo, kunye nokufumana ubunzima ngesiquphe. Kuya kufuneka uyeke ukuthatha i-infliximab ukuba ukusilela kwentliziyo yakho kuya kusiba mandundu.

Izilumkiso kwamanye amaqela

Abafazi abakhulelweyo: I-infliximab luluhlobo lokukhulelwa lodidi B. Oko kuthetha izinto ezimbini:

1. Ukufundwa kwesiyobisi kwizilwanyana ezikhulelweyo akubonakalisanga mngcipheko kwimveku engekazalwa.
2. Akukho zifundo zaneleyo zenziwe kwabasetyhini abakhulelweyo ukubonisa ukuba ichiza libeka umngcipheko kwimveku engekazalwa.

Tshela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. I-infliximab kufuneka isetyenziswe ngexesha lokukhulelwa kuphela ukuba isibonelelo esinokubakho siqinisekisa ubungozi obunokubakho kwimveku.

Biza ugqirha wakho ukuba ukhulelwe ngelixa uthatha eli chiza.

Kubafazi abancancisayo: Ayaziwa ukuba eli chiza lidlula kubisi lwebele. Ukuba i-infliximab idluliselwe emntwaneni wakho ngobisi lwakho lwebele, inokubangela iziphumo ebezingalindelekanga ezibi.

Wena kunye nogqirha wakho unokufuna ukugqiba ukuba ngaba uya kuthatha i-infliximab okanye uncelise.

Kubantu abadala: Unokuba semngciphekweni omkhulu wosulelo olubi ngelixa uthatha i-infliximab ukuba ungaphezulu kweminyaka engama-65.

Kubantwana: I-infliximab ayiboniswanga ukuba ikhuselekile kwaye iyasebenza kwisifo sikaCrohn okanye isifo sezilonda kubola kubantu abangaphantsi kweminyaka emi-6.

Ukhuseleko kunye nokusebenza kwe-infliximab yezinye iimeko azimiselwanga kubantu abangaphantsi kweminyaka eli-18.

Ungayithatha njani i-infliximab

Ugqirha wakho uya kugqiba umyinge olungele wena ngokusekwe kwimeko kunye nobunzima bakho. Impilo yakho ngokubanzi inokuchaphazela idosi yakho. Xelela ugqirha wakho ngazo zonke iimeko zempilo onazo phambi kokuba ugqirha okanye umongikazi akunike amayeza. Uya kunikwa i-infliximab ngenaliti ebekwe emthanjeni (IV okanye ukufakwa ngaphakathi) engalweni.

Uya kufumana idosi yakho yesibini kwiiveki ezimbini emva kwedosi yakho yokuqala. Iidosi zinokusasazeka ngakumbi emva koko.

Iphepha elichazayo ukuba awusenanto oyifunayo: Injongo yethu kukukunika olona lwazi lufanelekileyo nolukhoyo ngoku. Nangona kunjalo, ngenxa yokuba iziyobisi zichaphazela umntu ngamnye ngokwahlukileyo, asinakuqinisekisa ukuba olu luhlu lubandakanya zonke iidosi ezinokubakho. Olu lwazi aluthathi ndawo yengcebiso yezonyango. Soloko uthetha nogqirha wakho okanye usokhemesti malunga needosi ezikulungeleyo.

Thatha njengoko kuyalelwe

I-infliximab isetyenziselwa unyango lwexesha elide. Kuza nomngcipheko omkhulu ukuba awuyithathi njengoko kumiselwe.

Ukuba awuyithathi kwaphela: Ukuba awuthathi i-infliximab, imeko yakho inokungaphucuki kwaye isenokuba mandundu.

Ukuba uyeka ukuyithatha: Imeko yakho inokuba mandundu ukuba uyeka ukuthatha i-infliximab.

Ukuba uthatha kakhulu: Ngumboneleli wezempilo kuphela ekufuneka elungiselele amayeza kwaye akunike. Ukuthatha iziyobisi kakhulu akunakulindeleka. Nangona kunjalo, qiniseka ukuxoxa ngedosi yakho nogqirha wakho kutyelelo ngalunye.

Yintoni omele uyenze xa uphosa idosi: Kubalulekile ukuba ungaphoswa yidosi yakho. Shayela ugqirha wakho ukuba awukwazi ukugcina ixesha lakho lokuqeshwa.

Ungaxela njani ukuba ichiza liyasebenza: Iimpawu zakho kufuneka zibe ngcono. Kwisifo sikaCrohn kunye ne-ulcerative colitis, unokuba neempawu ezimbalwa zokuqhambuka. Kwi-arthritis, unako ukuhamba kwaye wenze imisebenzi ngokulula.

Ukuqwalaselwa okubalulekileyo kokuthatha i-infliximab

Gcina ezi ngqwalaselo engqondweni ukuba ugqirha wakho ukumisela i-infliximab kuwe.

Ukuhamba

Ukuhamba kunokuchaphazela ishedyuli yakho yeedosi. I-infliximab inikwa ngumboneleli wezempilo esibhedlele okanye eklinikhi. Ukuba ucwangcisa ukuhamba, thetha nogqirha wakho malunga nezicwangciso zakho zokuhamba kwaye ubone ukuba ziya kuyichaphazela na ishedyuli yakho yedosi.

Uvavanyo lwezonyango kunye nokubeka iliso

Ngaphambi kunye nonyango lwakho ngeli chiza, ugqirha wakho unokwenza uvavanyo lokujonga impilo yakho. Olu vavanyo lunokubandakanya:

• Uvavanyo lwesifo sephepha (TB): Ugqirha wakho usenokukuvavanyela i-TB ngaphambi kokuba aqale i-infliximab kwaye akuqwalasele ngokusondeleyo iimpawu neempawu ngelixa usithatha.
• Uvavanyo losulelo lwe-Hepatitis B: Ugqirha wakho angenza uvavanyo lwegazi ukukhangela intsholongwane ye-hepatitis B ngaphambi kokuba uqale unyango kwaye ngelixa ufumana i-infliximab. Ukuba unayo intsholongwane ye-hepatitis B, ugqirha wakho uya kwenza iimvavanyo zegazi ngexesha lonyango kunye neenyanga ezimbalwa emva kwonyango.
• Olunye uvavanyo: Olu vavanyo lunokubandakanya:
  • uvavanyo lwegazi ukukhangela usulelo
  • Uvavanyo lomsebenzi wesibindi

Ngaphambi kogunyaziso

Iinkampani ezininzi zeinshurensi zifuna ukugunyazwa kwangaphambili kwesi siyobisi. Oku kuthetha ukuba ugqirha wakho uyakufuna ukufumana imvume kwinkampani yeinshurensi ngaphambi kokuba inkampani yakho yeinshurensi ihlawule amayeza.

Iphepha elichazayo ukuba awusenanto oyifunayo: I-Healthline yenze yonke imizamo yokuqinisekisa ukuba lonke ulwazi luchanekile, lubanzi kwaye luhlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi.Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.