I-interferon yabantu i-alfa 2A: yeyantoni kwaye uyithatha njani

Umxholo

• Kusetyenziswa kwanjani
• 1. I-leukemia yeseli yeenwele
• 2. I-myeloma eninzi
• 3. Non-Hodgkin's lymphoma
• 4. I-leukemia enganyangekiyo
• 5. I-hepatitis B engapheliyo
• 6. I-hepatitis C ebuhlungu nehlala ihleli
• 7. I-Condylomata acuminata
• Ngubani ongafanele asebenzise
• Iziphumo ebezingalindelekanga ezinokwenzeka

I-alpha 2a ye-recombinant yabantu ye-alpha 2a yiprotein eboniswe kunyango lwezifo ezinjenge-leukemia enoboya obuninzi, i-myeloma eninzi, i-non-Hodgkin's lymphoma, i-myeloid leukemia engapheliyo, i-hepatitis B engapheliyo, i-hepatitis C engapheliyo kunye ne-acuminate condyloma.

Eliyeza licingelwa ukuba lisebenza ngokuthintela ukuphindaphindeka kwentsholongwane kunye nokumodareyitha impendulo yomzimba womninimzi, ngaloo ndlela kusenziwa isenzo sokuthintela ukungasebenzi kwentsholongwane.

Kusetyenziswa kwanjani

I-interferon yabantu i-alfa 2A kufuneka ilawulwe ngugqirha kwezonyango, oya kuyazi indlela yokulungiselela ichiza. Umthamo uxhomekeke kwisifo esiza kunyangwa:

1. I-leukemia yeseli yeenwele

Idosi yemihla ngemihla yeyeza yi-3 MIU kangangeeveki ezili-16 ukuya kwezingama-20, inikwe inaliti yangaphakathi okanye yesikhumba. Kunganyanzeleka ukuba unciphise idosi okanye ukuphindaphinda kwenaliti ukuze umisele eyona dosi inyamezelwayo. Idosi yesondlo ecetyiswayo yi-3 MIU, kathathu ngeveki.

Xa iziphumo ebezingalindelekanga zinzima, kunganyanzeleka ukuba unqumle idosi kwisiqingatha kwaye ugqirha kufuneka amisele ukuba umntu lowo kufuneka aqhubeke na unyango emva kweenyanga ezintandathu zonyango.

2. I-myeloma eninzi

Idosi ekucetyiswa ukuba iphindaphindwe phakathi kwabantu i-alfa 2A yi-3 MIU, kathathu ngeveki, ilawulwa njenge-intramuscular or subcutaneous injection. Ngokwempendulo kunye nokunyamezelana komntu, idosi inokunyuswa ngokuthe chu ukuya kwi-9 MIU, kathathu ngeveki.

3. Non-Hodgkin's lymphoma

Kwiimeko zabantu abane-non-Hodgkin's lymphoma, ichiza linokulawulwa kwiiveki ezi-4 ukuya kwezi-6 emva kwekhemotherapy kwaye idosi ekhuthazwayo yi-3 MIU, kathathu ngeveki ubuncinci iiveki ezili-12, ngaphantsi. Xa ilawulwa ngokudibeneyo ne-chemotherapy, idosi ekhuthazwayo yi-6 MIU / m2, ilawulwa ngendlela engeyiyo okanye kwi-intramuscularly ngeentsuku ezingama-22 ukuya kuma-26 zekhemotherapy.

4. I-leukemia enganyangekiyo

Idosi ye-interferon yabantu i-alfa 2A inokunyuka ngokuthe ngcembe ukusuka kwi-3 MIU yonke imihla kangangeentsuku ezintathu ukuya kwi-6 MIU yonke imihla kangangeentsuku ezintathu ukuya kuthi ga kwithagethi ekujoliswe kuyo ye-9 MIU yonke imihla kude kube sekupheleni kwonyango. Emva kweeveki ezisi-8 ukuya kwezi-12 zonyango, izigulana ezinempendulo ye-haematological zinokuqhubeka nonyango kude kube kuphendulwe ngokupheleleyo okanye kwiinyanga ezili-18 ukuya kwiminyaka emi-2 emva kokuqala unyango.

5. I-hepatitis B engapheliyo

Idosi ekucetyiswa ukuba yenziwe ngabantu abadala yi-5 MIU, kathathu ngeveki, ilawulwa ngendlela engeyiyo kwiinyanga ezi-6. Kubantu abangaphenduliyo kwi-interferon alpha 2A yabantu emva kwenyanga enye yonyango, ukunyuka kwethamo kunokuba yimfuneko.

Ukuba, emva kweenyanga ezintathu zonyango, akukho mpendulo ivela kwisigulana, ukupheliswa kwonyango kufuneka kuthathelwe ingqalelo.

6. I-hepatitis C ebuhlungu nehlala ihleli

Idosi ephakanyisiweyo ye-interferon yabantu i-alfa 2A kunyango yi-3 ukuya kwi-5 MIU, kathathu ngeveki, ilawulwa ngendlela engaphantsi okanye intramuscularly iinyanga ezintathu. Idosi yesondlo ecetyiswayo yi-3 MIU, kathathu ngeveki iinyanga ezi-3.

7. I-Condylomata acuminata

Umthamo ocetyiswayo kukusetyenziswa kwesikhumba okanye kwi-intramuscular ye-1 MIU ukuya kwi-3 MIU, amaxesha ama-3 ngeveki, iinyanga ezi-1 ukuya kwezi-2 okanye i-1 MIU esetyenziswe kwisiseko sesiza esichaphazelekayo kwezinye iintsuku, kwiiveki ezintathu ezilandelelanayo.

Ngubani ongafanele asebenzise

Eli yeza akufuneki lisetyenziswe kubantu abane-hypersensitive kuwo nawaphi na amacandelo akhoyo kwifomula, ngokugula okanye imbali yesifo sentliziyo, sezintso okanye sesibindi.

Ukongeza, akufuneki isetyenziswe nakwabasetyhini abakhulelweyo okanye abancancisayo, ngaphandle kokuba kucetyiswa ngugqirha.

Iziphumo ebezingalindelekanga ezinokwenzeka

Iziphumo ebezingalindelekanga eziqhelekileyo ezinokuthi zenzeke ngokusetyenziswa kweli yeza ziimpawu ezinje ngomkhuhlane, njengokudinwa, umkhuhlane, ukugodola, iintlungu zemisipha, intloko ebuhlungu, iintlungu ezidibeneyo, ukubila, phakathi kwabanye.