Ngaba i-Psoriasis sisifo esiZenzekelayo?

Umxholo

• Ushwankathelo
• Ukuqonda izifo ezenzekelayo
• Iimeko eziqhelekileyo zokuzimela
• I-Psoriasis njengesifo sokuzimela
• Unyango olujolise kumajoni omzimba
• Iziyobisi ezindala
• Ibhayoloji
• Abachasi be-TNF
• I-biologics entsha
• I-Psoriasis kunye nomngcipheko kwezinye iimeko ezizimeleyo
• Imbonakalo

Ushwankathelo

I-Psoriasis yimeko yesikhumba ekruthayo ebonakaliswa ziimpawu ezibomvu ezinokurhawuzelela zolusu ezigqunywe ngezikali ezimhlophe zesilivere. Yimeko engapheliyo. Iimpawu zinokuza zihambe, kwaye zinokubakho kubukhali.

I-Psoriasis yimeko eqhelekileyo, ichaphazela phantse iipesenti ezi-3 zabemi behlabathi. Bamalunga ne-7.4 yezigidi abantu eUnited States abane-psoriasis.

Oyena nobangela we-psoriasis awuqinisekanga. Kucingelwa ukuba yindibaniselwano yemfuza, izinto zokusingqongileyo, kunye nenkqubo yomzimba yokuzikhusela.

Ngokusekwe kuphando olwenziwe kule minyaka imbalwa idlulileyo, i-psoriasis ngokubanzi yahlelwa njengesifo sokuzimela. Oku kuthetha ukuba amajoni akho omzimba, abizwa ngokuba zii-T seli, ahlasela ngempazamo iiseli zakho zolusu njengabahlaseli bangaphandle. Oku kubangela ukuba iiseli zolusu lwakho zande ngokukhawuleza, zikhokelela kulusu lwe-psoriasis yolusu.

Ayingabo bonke abaphandi abacinga ukuba i-psoriasis sisifo esibuhlungu. Abanye bayavuma ukuba i-psoriasis yimeko yokulamla omzimba. Kodwa ithiyori yabo kukuba iziphumo ze-psoriasis zihambelana nokusabela okungaqhelekanga okunxulumene nofuzo kwiintsholongwane.

Ukuqonda izifo ezenzekelayo

Ngokwesiqhelo amajoni akho omzimba ayaziqonda iiseli zakho kwaye angazihlaseli. Izifo ezizimeleyo xa amajoni akho omzimba ehlasela ngempazamo iiseli ezisempilweni ngokungathi zingaphandle kwabahlaseli abahlasela umzimba wakho.

Kukho izifo ezingaphezu kwama-100 ezizimeleyo. Ezinye izifo ezizimeleyo zibandakanya inxalenye enye yomzimba wakho- njengesikhumba sakho kwi-psoriasis. Eminye yinkqubo, ibandakanya umzimba wakho uphela.

Ziziphi zonke iingxaki zokuzimela komzimba ezifanayo kukuba zibangelwa kukudityaniswa kwemfuza kunye nemeko yokusingqongileyo.

Ngokuchanekileyo indlela imfuza kunye nezinto ezisingqongileyo ezinxibelelana ngayo ukubangela izifo ezininzi ezahlukeneyo sisihloko sophando oluqhubekayo.

Kuze kube ngoku, yintoni eyaziwayo kukuba abantu abane-genetic predisposition to autoimmunity banokuba namaxesha ama-2 ukuya kwama-5 ithuba lokuphuhlisa isifo se-autoimmune njengabantu abangenayo i-genetic predisposition.

Iqela lemfuza elibandakanyekayo libizwa ngokuba yimbali yokuhambelana, eyaziwa ngokuba yi-HLA. I-HLA yahlukile kuye wonke umntu.

Isimo semfuza sokuzimelela komzimba sinokuhamba kwiintsapho, kodwa amalungu osapho anokuhlakulela ukuphazamiseka okungafaniyo nokuzimela. Kwakhona, ukuba unesifo esisodwa se-autoimmune, unomngcipheko ophezulu wokufumana enye.

Akukho nto eyaziwayo malunga nezinto ezithile zokusingqongileyo ezibangela isifo somzimba kumntu onesifo semvelo sokuzimela.

Iimeko eziqhelekileyo zokuzimela

Nazi ezinye zeengxaki eziqhelekileyo zokuzimela komzimba:

• isifo se-celiac (impendulo kwi-gluten)
• uhlobo lweswekile 1
• izifo zesisu ezivuthayo, kubandakanya iCrohn's
• I-lupus (systemic lupus erythematosus, echaphazela ulusu, izintso, amalungu, ingqondo kunye namanye amalungu)
• rheumatoid arthritis (ukudumba kwamalungu)
• Isifo seSjögren's (ukoma emlonyeni wakho, emehlweni nakwezinye iindawo)
• i-vitiligo (ukulahleka kwe-pigment yesikhumba, ebangela amabala amhlophe)

I-Psoriasis njengesifo sokuzimela

Uninzi lwezazinzulu namhlanje lukholelwa ukuba i-psoriasis sisifo esizimele. Kudala kwaziwa ukuba amajoni omzimba ayabandakanyeka kwi-psoriasis. Kodwa indlela echanekileyo ayiqinisekanga.

Kule minyaka ingamashumi amabini idlulileyo, uphando luye lwafumanisa ukuba izakhi zofuzo kunye namaqela emfuza anxulumene ne-psoriasis kwabelwana ngawo kunye nokuphazamiseka okuzenzekelayo komzimba. Uphando luye lwafumanisa ukuba iziyobisi ezisebenza ngokuchasene nokunyanga komzimba zisebenza ngokunyanga ngokutsha kwi-psoriasis. La machiza asebenza ngokucinezela amajoni omzimba ahlasela izicwili ezisempilweni.

Uphando luyaqhubeka kwindima yeeseli ze-immune system kwi-psoriasis. Iiseli ze-T "ngamajoni" amajoni omzimba aqhele ukulwa nezifo. Xa iiseli ze-T zitshisa ngomlilo kwaye endaweni yoko zihlasela ulusu olusempilweni, zikhupha iiproteni ezikhethekileyo ezibizwa ngokuba zii-cytokines. Oku kubangela ukuba iiseli zolusu zande kwaye zakheke kulusu lwakho, kukhokelela kwizilonda ze-psoriatic.

Inqaku lika-2017 linike ingxelo ngophando olutsha oluchonge ukusebenzisana kweeseli ezithile ze-T kunye nee-interleukins esele zaziwa ukuba ziyabandakanyeka kuphuhliso lwe-psoriasis. Njengoko iinkcukacha ezizodwa zisaziwa, kunokuba nakho ukuphuhlisa unyango ekujoliswe kulo.

Unyango olujolise kumajoni omzimba

Unyango lwe-psoriasis luxhomekeke kuhlobo kunye nokuba qatha kwale meko, impilo yakho ngokubanzi, kunye nezinye izinto.

Nazi iindlela ezahlukeneyo zonyango ezijolise ngqo kwinkqubo yomzimba yokuzikhusela ebangela ukudumba. Ezi zihlala zisetyenziswa xa iimpawu zakho ze-psoriasis zimodareyitha kakhulu. Qaphela ukuba amachiza amatsha abiza kakhulu.

Iziyobisi ezindala

Amachiza amabini amadala asetyenziselwa ukucinezela amajoni omzimba kunye neempawu ezicacileyo ze-psoriasis yi-methotrexate kunye ne-cyclosporine. Zombini ziyasebenza, kodwa zineziphumo ebezingalindelekanga eziyityhefu xa zisetyenziswa ixesha elide.

Ibhayoloji

Abachasi be-TNF

Ukujolisa kweziyobisi kutshanje yinto ebangela ukudumba okubizwa ngokuba yi-tumor necrosis factor (TNF). I-TNF yi-cytokine eyenziwe ngamalungu omzimba afana neeseli zeT. La machiza matsha abizwa ngokuba ngabaphikisi be-TNF.

Amachiza e-anti-TNF ayasebenza, kodwa angaphantsi kune-biologics entsha. Iziyobisi ezichasene ne-TNF zibandakanya:

• adalimumab (Humira)
• I-etanercept (i-Enbrel)
• infliximab (I-Remicade)
• isatifikethi sepgol (Cimzia)

I-biologics entsha

Ukujolisa kwe-biologics kutsha nje kunye nokubhloka kweeseli ze-T kunye neendlela ze-interleukin ezichaphazelekayo kwi-psoriasis. I-biologics ezintathu ezijolise kwi-IL-17 zivunyiwe ukusukela ngo-2015:

• secukinumab (iCosentyx)
• ixekizumab (iTaltz)
• brodalumab (uSiliq)

Amanye amachiza ajonge ukuvimba enye indlela ye-interleukin (I-23 kunye ne-IL-12):

• ustekinuman (Stelara) (IL-23 kunye ne-IL-12)
• guselkumab (Tremfya) (IL-23)
• Itildrakizumab-asmn (Ilumya) (IL-23)
• I-risankizumab-rzaa (i-Skyrizi) (IL-23)

Ezi biologics zingqineke zikhuselekile kwaye zisebenza ngokufanelekileyo.

I-Psoriasis kunye nomngcipheko kwezinye iimeko ezizimeleyo

Ukuba nesifo esinye se-autoimmune esifana ne-psoriasis sikubeka ekuphuhliseni esinye isifo. Umngcipheko uyonyuswa ukuba i-psoriasis yakho inzima.

Amaqela ohlobo oluchaza ukuba uphuhlise isifo sokuzimela komzimba afanayo kwiintlobo ezahlukeneyo zezifo ezizimele. Ezinye zeenkqubo zokukrala kunye nemeko yokusingqongileyo ziyafana.

Ezona ngxaki ziphambili zomzimba ezinxulumene ne-psoriasis zezi:

• i-psoriatic arthritis, echaphazela iipesenti ezingama-30 ukuya kuma-33 zabantu abane-arthritis
• irheumatoid Arthritis
• isifo se-celiac
• Isifo sikaCrohn kunye nezinye izifo zamathumbu
• isifo sokugubhuka
• lupus (systemic lupus erythematosus okanye SLE)
• isifo se-thyroid
• Isifo sikaSjögren
• ukulahleka kweenwele okuzenzekelayo (alopecia areata)
• pemphigoid

I-psoriasis ine-rheumatoid arthritis.

Ubudlelwane be-psoriasis kwezinye izifo ezizimeleyo sisihloko sesifundo esiqhubekayo. Kwakhona kufundwa ngumbutho we-psoriasis kunye namazinga aphezulu okufa kwezi zifo.

Imbonakalo

Imbonakalo yabantu abane-psoriasis intle kakhulu. Le meko ayinakunyangeka, kodwa unyango lwangoku lunokugcina iimpawu ziphantsi kolawulo.

Uphando lwezonyango luyaqhubeka nokufumanisa ngakumbi malunga nezizathu ze-psoriasis kunye nokunye ukuphazamiseka komzimba. Oku kufumanisa kutsha kunceda ekuphuhliseni amachiza amatsha ajolise ngqo kuthintele izifo.

Umzekelo, amanye amachiza amatsha ajolise kwi-interleukin-23 ngoku akwizilingo zeklinikhi. Ezinye iindlela ezintsha zinokuthi ziphume kuphando oluqhubekayo malunga nokuphazamiseka okuzenzekelayo ngokubanzi.

Thetha nogqirha wakho malunga nokuthatha inxaxheba kuvavanyo lweklinikhi oluqhubekayo kunye nophuhliso olutsha. Unokufuna kwakhona ukujoyina iqela lenkxaso ye-psoriasis / iPSA kwi-Intanethi.