IiLupus Anticoagulants

Umxholo

• Zithini iimpawu zelupus anticoagulants?
• Ukungabikho komtshato
• Iimeko ezihambelanayo
• Ndivavanywa njani i-lupus anticoagulants?
• Uvavanyo lwe-PTT
• Olunye uvavanyo lwegazi
• Zinyangwa njani i-lupus anticoagulants?
• Amayeza okucoca igazi
• IiSteroids
• Utshintshiselwano ngePlasma
• Ukuyeka amanye amayeza
• Utshintsho kwindlela yokuphila
• Ukwenza umthambo rhoqo
• Yeka ukutshaya kwaye ulinganisele ukusela kwakho
• Yehla emzimbeni
• Nciphisa ukutya okutyayo okune-vitamin K
• Yintoni imbonakalo?

Yintoni i-lupus anticoagulants?

I-Lupus anticoagulants (LAs) luhlobo lwe-antibody eveliswa ngamajoni omzimba wakho. Ngelixa uninzi lweentsholongwane luhlasela isifo emzimbeni, ii-LAs zihlasela iiseli ezisempilweni kunye neeproteni zeseli.

Bahlasela i-phospholipids, eziyinxalenye ebalulekileyo yeembumba zeseli. Ii-LAs zinxulunyaniswa nokuphazamiseka kwenkqubo yomzimba yokuzikhusela eyaziwa ngokuba yi-antiphospholipid syndrome.

Zithini iimpawu zelupus anticoagulants?

Ii-LAs zinokunyusa umngcipheko wamahlwili egazi. Nangona kunjalo, ii-antibodies zinokubakho kwaye zingakhokeleli kwihlwili.

Ukuba uhlakulela i-clot yegazi kwenye yeengalo zakho okanye imilenze, iimpawu zingabandakanya:

• ukudumba engalweni okanye emlenzeni
• ububomvu okanye ukutshintsha kombala engalweni okanye emlenzeni
• ubunzima bokuphefumla
• intlungu okanye ukuba ndindisholo engalweni okanye emlenzeni

Igazi elixineneyo kwindawo yentliziyo yakho okanye imiphunga kunokubangela:

• iintlungu zesifuba
• ukubila okugqithisileyo
• ubunzima bokuphefumla
• ukudinwa, isiyezi, okanye zombini

Ukugqobhoza kwegazi esiswini sakho okanye kwizintso kunokukhokelela ku:

• isisu esibuhlungu
• intlungu yethanga
• isicaphucaphu
• urhudo okanye isitulo segazi
• ifiva

Amahlwili egazi angabeka ubomi emngciphekweni ukuba awanyangwa kwangoko.

Ukungabikho komtshato

Amagqabantshintshi egazi amancinci abangelwa zii-LAs anokunyanzelisa ukukhulelwa kwaye enze ukuphuphuma kwesisu. Ukuphuphuma kwesisu okuninzi kunokuba ngumqondiso we-LAs, ngakumbi ukuba zenzeka emva kwekota yokuqala.

Iimeko ezihambelanayo

Phantse isiqingatha sabantu abane-LAs banesifo se-autoimmune lupus.

Ndivavanywa njani i-lupus anticoagulants?

Ugqirha wakho unokuyalela ukuvavanywa kwee-LAs ukuba unegazi elichazekileyo okanye unezisu ezininzi.

Akukho luvavanyo lunye olunceda oogqirha bafumane ngokuqinisekileyo ii-LAs. Uvavanyo lwegazi oluninzi luyafuneka ukumisela ukuba ii-LAs zikhona na kwigazi lakho. Ukuphinda uvavanyo kuyafuneka ngokuhamba kwexesha ukuqinisekisa ubukho babo. Kungenxa yokuba ezi ntsholongwane zinokubonakala nosulelo, kodwa hamba nje usulelo lusombulukile.

Uvavanyo lunokubandakanya:

Uvavanyo lwe-PTT

Ixesha lovavanyo lwe-thromboplastin (PTT) lilinganisela ixesha elithatha igazi lakho ukuba livale. Inokuveza kwakhona ukuba igazi lakho liqukethe ii-anticoagulant antibodies. Nangona kunjalo, ayizukuveza ukuba unazo na ii-LAs ngokuthe ngqo.

Ukuba iziphumo zakho zovavanyo zibonisa ubukho beantibheliantibulant antibodies, kuyakufuneka uphinde uphindwe ubonwe. Ukuzama kwakhona kwenzeka ngesiqhelo kwiiveki ezili-12.

Olunye uvavanyo lwegazi

Ukuba uvavanyo lwakho lwe-PTT lubonisa ubukho beentsholongwane ze-anticoagulant, ugqirha wakho unokuyalela ezinye iintlobo zovavanyo lwegazi ukukhangela imiqondiso yezinye iimeko zonyango. Olu vavanyo lunokubandakanya:

• Uvavanyo lwe-anticardiolipin antibody
• ixesha lokunqanda i-kaolin
• ulungelelwaniso lwezinto zokuqina
• Lungisa uvavanyo lwe venus kaRussell (DRVVT)
• I-LA-ethe-ethe PTT
• beta-2 glycoprotein 1 uvavanyo lomzimba

Lonke olu luvavanyo lwegazi olunomngcipheko omncinci. Unokuziva ulunywa kancinci xa inaliti igqobhoza ulusu lwakho. Ingaziva ibuhlungu emva koko. Kukho umngcipheko omncinci wosulelo okanye ukopha, njengalo naluphi na uvavanyo lwegazi.

Zinyangwa njani i-lupus anticoagulants?

Asinguye wonke umntu ofumana isifo kwi-LAs efuna unyango. Ukuba awunayo impawu kwaye awuzange ube namahlwili egazi ngaphambili, ugqirha wakho unokumisela ukuba akukho nyango okwangoku, ukuba uziva uphilile.

Izicwangciso zonyango ziya kwahluka kumntu ngamnye.

Unyango lwezonyango lwe-LAs lubandakanya:

Amayeza okucoca igazi

La mayeza anceda ukuthintela amahlwili egazi ngokucinezela ukuveliswa kwesibindi sakho sevithamin K, ehambisa ukujiya kwegazi. Abacoci gazi abaqhelekileyo baquka iiheparin kunye newarfarin. Ugqirha wakho unokumisela i-aspirin. Eli chiza lithintela ukusebenza kweplatelet endaweni yokucinezela imveliso yeevithamini K.

Ukuba ugqirha wakho ucebisa abancinci begazi, igazi lakho liya kuvavanywa ngamaxesha athile ubukho be-cardiolipin kunye ne-beta-2 glycoprotein 1 antibodies. Ukuba iziphumo zakho zovavanyo zibonisa ukuba ii-antibodies azisekho, unokukwazi ukuyeka iyeza lakho. Nangona kunjalo, oku kufuneka kwenziwe kuphela ngokubonisana nogqirha wakho.

Abanye abantu abane-LAs kufuneka bathathe abacoci gazi kangangeenyanga ezimbalwa. Abanye abantu kufuneka bahlale kumayeza abo ixesha elide.

IiSteroids

Ii-Steroids, ezinje nge-prednisone kunye ne-cortisone, zinokuthintela inkqubo yakho yomzimba yokulwa izifo ze-LA antibodies.

Utshintshiselwano ngePlasma

Ukutshintshiselana ngePlasma yinkqubo apho umatshini wahlulahlula iplasma yakho-enee-LAs-ukusuka kwezinye iiseli zegazi. Iplasma equlethe ii-LAs ithathelwa indawo yiplasma, okanye into ebambela iplasma, engenazo ii-antibodies. Le nkqubo ikwabizwa ngokuba yi-plasmapheresis.

Ukuyeka amanye amayeza

Amanye amayeza aqhelekileyo anokubangela i-LA. La mayeza aquka:

• iipilisi zokulawula inzala
• I-ACE inhibitors
• ikwinine

Thetha nogqirha wakho malunga nalo naliphi na iyeza olithathayo ukumisela ukuba kunokubangela ii-LAs. Ukuba kunjalo, wena nogqirha wakho ninokuxoxa ukuba ngaba kukhuselekile na kuwe ukuyeka ukusebenzisa.

Utshintsho kwindlela yokuphila

Kukho utshintsho olulula kwindlela onokuyenza enokukunceda ukuba ulawule ii-LAs, nokuba awuthathi na amayeza kwimeko yakho. Oku kubandakanya:

Ukwenza umthambo rhoqo

Ukuzivocavoca nokunyakaza kwandisa ukuhamba kwegazi. Oku kuthetha ukuba kunceda nokuthintela ukujiya kwegazi. Fumana indlela oyithandayo yokwenza umthambo kwaye uyenze rhoqo. Akunyanzelekanga ukuba ibe nzima. Ukuthatha nje ukuhamba ngokukhawuleza yonke imihla kunokukhuthaza ukuhamba kwegazi.

Yeka ukutshaya kwaye ulinganisele ukusela kwakho

Ukuyeka ukutshaya kubaluleke kakhulu ukuba unayo i-LAs. Inikotini ibangela ukuba imithambo yegazi yakho ityikitywe, ekhokelela ekunqandeni.

Uvavanyo lwezonyango lubonakalisile ukuba ukusetyenziswa gwenxa kotywala kukwanxulunyaniswa nokwakheka kwegazi.

Yehla emzimbeni

Iiseli ezinamafutha zivelisa izinto ezinokuthintela amahlwili egazi ekunyibilikeni njengoko kufanelekile. Ukuba utyebe kakhulu, igazi lakho linokuthwala uninzi lwezi zinto.

Nciphisa ukutya okutyayo okune-vitamin K

Ukutya okuninzi okunevithamini K eninzi kukulungele ngenye indlela, kodwa kuyanceda ekwenzeni amahlwili egazi.

Ukuba ukwigreyina yokutya, ukutya ukutya okunevithamini K eninzi kuyaphikisana nonyango lwakho. Ukutya okunotyebi ku-vitamin K kubandakanya:

• ibrokholi
• ilethasi
• ispinatshi
• i-asparagus
• iziqhamo
• iparsley
• ikhaphetshu

Yintoni imbonakalo?

Kwiimeko ezininzi, kokubamba kwegazi kunye neempawu ze-LAs kunokulawulwa ngonyango.

Ngokwe-2002 yokuphononongwa, abasetyhini abanyangwa i-antiphospholipid syndrome-ihlala ine-aspirin yedosi ephantsi kunye ne-heparin-banethuba elinama-70 eepesenti lokukhulelwa ngempumelelo ukuya kuthi ga kwixesha.