ILatuda (lurasidone): yenzelwe ntoni, ungayithatha njani kunye neziphumo ebezingalindelekanga

Umxholo

• Yenzelwe ntoni
• Indlela yokuthatha
• Iziphumo ebezingalindelekanga ezinokwenzeka
• Ngubani ongafanelekanga ukuthatha

ILurasidone, eyaziwa ngegama lokurhweba iLatuda, lunyango kwiklasi ye-antipsychotic, esetyenziselwa ukunyanga iimpawu zesifo sengqondo kunye noxinzelelo olubangelwa kukuphazamiseka kwengqondo.

La mayeza asandula ukuvunywa ngu-Anvisa ayathengiswa ezikhemesti eBrazil, kwi-20mg, 40mg kunye ne-80mg yeepilisi, kwiipakethe zeepilisi ezisi-7, 14, 30 okanye ezingama-60, kwaye zinokufunyanwa okanye zi-odolwe kwii-pharmacy eziphambili. Njengoko iyi-antipsychotic, iLurasidone yinxalenye yodidi lwamachiza alawulwayo kwaye ithengiswa kuphela ngommiselo okhethekileyo kwiikopi ezimbini.

Yenzelwe ntoni

I-Lurasidone isetyenziselwa ukunyanga:

• ISchizophrenia, kubantu abadala nakwishumi elivisayo abaneminyaka eli-13 ukuya kweli-18 ubudala;
• Uxinzelelo olunxulunyaniswa nokuphazamiseka kwengqondo, kubantu abadala, njengeyeza elinye okanye ngokudibana nabanye, njenge-lithium okanye i-valproate.

Eli yeza liyi-antipsychotic, esebenza njenge-arhente ekhethiweyo yokuthintela iziphumo zedopamine kunye ne-monoamine, eyi-neurotransmitters yengqondo, ebalulekileyo ekuphuculeni iimpawu.

Nangona kunjalo, isebenza ngolunye uphuculo ngokunxulumene ne-antipsychotic ezindala, ezinje ngotshintsho oluncinci kwimetabolism, olunefuthe elincinci ekuzuzeni ubunzima kunye notshintsho kumanqatha omzimba kunye neprofayile yeglucose.

Indlela yokuthatha

Iipilisi zeLurasidone kufuneka zithathwe ngomlomo, kanye ngemini, kunye nesidlo, kwaye kuyacetyiswa ukuba zithathwe ngexesha elinye yonke imihla. Ukongeza, iipilisi kufuneka ziginywe ziphele, ukunqanda incasa yazo ekrakra.

Iziphumo ebezingalindelekanga ezinokwenzeka

Ezinye zeziphumo ebezingalindelekanga eziqhelekileyo zeLurasidone kukozela, ukungazinzi, isiyezi, intshukumo yokungazibandakanyi, ukulala, ukuphazamiseka, ixhala okanye ukutyeba.

Eminye imiphumo enokubakho kukuxhuzula, ukuncipha kwesidlo, ukungakhathali, ukungaboni kakuhle, i-tachycardia, utshintsho kuxinzelelo lwegazi, isiyezi okanye utshintsho kubalo lwegazi, umzekelo.

Ngubani ongafanelekanga ukuthatha

ILurasidone iyaphikiswa xa kukho:

• Hypersensitivity ukuya kwisithako esisebenzayo okanye nakweziphi na izinto ezincedisayo kwithebhulethi;
• Ukusetyenziswa kweziyobisi ezinamandla ze-CYP3A4, ezinje ngeBoceprevir, Clarithromycin, Voriconazole, Indinavir, Itraconazole okanye Ketoconazole, umzekelo;
• Ukusetyenziswa kwe-CYP3A4 eqinisa iziyobisi, ezinje ngeCarbamazepine, iPhenobarbital, Phenytoin, Rifampicin okanye iSt John's wort, umzekelo.

Ngenxa yokunxibelelana nefuthe lala mayeza, uluhlu lwamayeza olusetyenzisiweyo kufuneka luhlale luchazwa kugqirha ohamba nalo.

I-Lurasidone kufuneka isetyenziswe ngononophelo ngabantu abanezifo zezintso okanye ukumodareyitha isifo sesibindi, isifo sika-Parkinson, ukuphazamiseka kwentshukumo, isifo sentliziyo okanye ezinye izifo zemithambo-luvo. Ukongeza, eli yeza alikavavanywa kwizigulana esele zikhulile ezinesifo sengqondo esixhalabisayo okanye ebantwaneni, ke ukusetyenziswa kufuneka kuthintelwe kwezi meko.