Umbhali: Randy Alexander
Umhla Wokudalwa: 28 Utshazimpuzi 2021
Hlaziya Umhla: 20 Eyenkanga 2024
Anonim
Further Prescribing Considerations for Glecaprevir/Pibrentasvir (Mavyret (G/P))
Ividiyo: Further Prescribing Considerations for Glecaprevir/Pibrentasvir (Mavyret (G/P))

Umxholo

Yintoni iMavyret?

I-Mavyret sisiyobisi esisetyenziswa kunyango lwe-hepatitis C (HCV). Le ntsholongwane ichaphazela isibindi sakho kwaye ibangele ukudumba.

I-Mavyret ingasetyenziselwa ngabantu abanazo naziphi na iintlobo ezintandathu ze-HCV ezingenayo i-cirrhosis (ukusilela kwesibindi) okanye abo bahlawule (c) i-cirrhosis. I-Mavyret inokusetyenziselwa ukunyanga uhlobo lwe-HCV 1 kubantu abakhe banyangwa ngaphambili (kodwa banganyangeki) ngolunye uhlobo lwamayeza.

I-Mavyret ivunyiwe ukuba isetyenziswe kubantu abadala. Ikwavunyiwe ukuba isetyenziswe kubantwana abaneminyaka eli-12 nangaphezulu, okanye abo banobunzima obungama-45 eekhilogremu (malunga neepawundi ezingama-99).

I-Mavyret iza njengecwecwe elinye elinamayeza amabini antiviral: glecaprevir (100 mg) kunye ne-pibrentasvir (40 mg). Kuthathwa ngomlomo kube kanye ngosuku.

Ukusebenza ngempumelelo

Kwezilingo zeklinikhi, abantu abadala abane-HCV (iintlobo 1, 2, 3, 4, 5, kunye no-6) abangazange banyangelwe intsholongwane banikwa iMavyret. Kula bantu, i-98% ukuya kwi-100% yanyangwa emva kweeveki ezisi-8 ukuya kwezi-12 zonyango. Kwezi zifundo, ukunyangwa kwakuthetha ukuba uvavanyo lwegazi lwabantu, olwenziwa kwiinyanga ezintathu emva konyango, alubonisanga zimpawu zosulelo lwe-HCV emzimbeni wabo.


Ngolwazi oluthe kratya malunga nokusebenza, jonga icandelo le "Ukusebenza" phantsi kwe "Mavyret yehepatitis C" engezantsi.

Ukuvunywa kwe-FDA

I-Mavyret yamkelwe yi-Food and Drug Administration (i-FDA) ngo-Epreli 2017 ukunyanga intsholongwane engapheliyo ye-hepatitis C (iintlobo 1, 2, 3, 4, 5, kunye no-6) kubantu abadala.

Ngo-Epreli 2019, i-FDA yandisa imvume yamachiza ukubandakanya ukusetyenziswa kwayo ebantwaneni. Kuvunyelwe ukusetyenziswa kubantwana abaneminyaka eyi-12 nangaphezulu, okanye abo banobunzima obungama-45 kg (malunga ne-99 lbs.).

Mavyret generic

I-Mavyret ifumaneka kuphela njengonyango lwegama lophawu. Okwangoku ayifumaneki ngendlela eqhelekileyo.

IMavyret inezithako ezibini ezisebenzayo zeziyobisi: i-glecaprevir kunye ne-pibrentasvir.

Iindleko zeMavyret

Njengawo onke amayeza, indleko zeMavyret ziyahluka. Ukufumana amaxabiso akhoyo eMavyret kwindawo yakho, jonga iGoodRx.com.

Iindleko ozifumanayo kwi-GoodRx.com yinto onokuyihlawula ngaphandle kwe-inshurensi. Ixabiso langempela oza kulihlawula lixhomekeke kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.


Uncedo lwezezimali kunye neinshurensi

Ukuba ufuna inkxaso yemali ukuhlawula i-Mavyret, okanye ukuba ufuna uncedo lokuqonda i-inshurensi yakho, uncedo luyafumaneka.

UAbbvie, umvelisi weMavyret, unikezela ngenkqubo ebizwa ngokuba yiMavyret Patient Support, enokuthi incede ekunciphiseni iindleko zamachiza. Ngolwazi oluthe kratya kunye nokufumanisa ukuba uyilungele na inkxaso, tsalela umnxeba ku-877-628-9738 okanye undwendwele iwebhusayithi yenkqubo.

Iziphumo ebezingalindelekanga zeMavyret

I-Mavyret inokubangela iziphumo ebezingalindelekanga ezinobulali okanye ezinobuzaza. Olu luhlu lulandelayo luqulathe ezinye zeziphumo ebezingalindelekanga ezinokubakho ngelixa uthatha uMavyret. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Ngolwazi oluthe kratya malunga neziphumo ebezingalindelekanga zeMavyret, thetha nogqirha okanye usokhemesti. Banokukunika iingcebiso malunga nendlela yokujongana nayo nayiphi na imiphumela emibi enokuthi ikhathaze.

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo eziqhelekileyo eziqhelekileyo zeMavyret zingabandakanya:

  • intloko ebuhlungu
  • ndiziva ndidiniwe
  • isicaphucaphu
  • urhudo
  • Inqanaba le-bilirubin ephezulu (uvavanyo lwelebhu olujonga ukusebenza kwesibindi)

Uninzi lweziphumo ebezingalindelekanga zinokuhamba zingaphelanga iintsuku okanye iiveki ezimbalwa. Ukuba zinzima kakhulu okanye azihambi, thetha nogqirha wakho okanye usokhemesti.


Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ezibi kakhulu ezivela kuMavyret aziqhelekanga, kodwa zinokwenzeka. Shayela ugqirha wakho ngokukhawuleza ukuba unemiphumo emibi. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Iziphumo ebezingalindelekanga ezimandundu, ekuxoxwa ngazo apha ngezantsi “kwiinkcukacha zeziphumo ebezingalindelekanga,” zibandakanya oku kulandelayo:

  • Ukuvuselelwa kwentsholongwane ye-hepatitis B (ukuvutha kwentsholongwane, ukuba sele ingaphakathi komzimba wakho)
  • negazi lakho kakhulu

Iinkcukacha zesiphumo

Unokuzibuza ukuba zenzeka kangaphi ezinye iziphumo ebezingalindelekanga ngeli chiza, okanye nokuba ngaba ezinye iziphumo ebezingalindelekanga zinxulumene nayo. Nazi ezinye iinkcukacha kwezinye zeziphumo ebezingalindelekanga ezinokubangelwa okanye ezingabangelwa zezi ziyobisi.

Ukuphendula ngokuchaseneyo

Njengokuba kuninzi lweziyobisi, abanye abantu banokuphendula emva kokuthatha iMavyret. Ayaziwa ngokuqinisekileyo ukuba kangaphi abantu abathatha eli chiza benokungabikho komzimba. Iimpawu zokuphendula kancinci kunokubandakanya:

  • irhashalala
  • ukucheba
  • ukucoca (ukufudumala nokubomvu kwesikhumba sakho)

Impendulo eyingozi kakhulu inqabile kodwa inokwenzeka. Iimpawu zokungaziphathi kakuhle kunokubandakanya:

  • ukudumba phantsi kolusu lwakho, ikakhulu kwiinkophe zakho, imilebe, izandla, okanye iinyawo
  • ukudumba kolwimi lwakho, umlomo, okanye umqala
  • ingxaki yokuphefumla okanye ukuthetha

Biza ugqirha wakho ngoko nangoko ukuba uneempendulo ezimbi kuMavyret. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Ukurhawuzelela

Unokufumana ukurhawuzelela ngelixa usebenzisa iMavyret.Kwezilingo zeklinikhi, abanye abantu babarhawuzela ngelixa babethatha eli chiza. Ukurhawuzela kuhlala kwenzeka kuphela kubantu abathatha ichiza abanesifo sezintso esinganyangekiyo kunye ne-hepatitis C virus (HCV). Kweli qela, malunga neepesenti ezili-17 zabantu baxele ukurhawuzelela njengeziphumo ebezingalindelekanga.

Ukurhawuzelela ngamanye amaxesha luphawu olubangelwa yi-HCV. Ukutshiza kwenzeka malunga neepesenti ezingama-20 zabantu abane-HCV. Olu phawu kusenokwenzeka ukuba lubangelwe kukwakhiwa kwekhemikhali ebizwa ngokuba yibilirubin emzimbeni wakho. Ukurhawuzelela okubangelwa yi-HCV kunokuba kwindawo enye okanye kungaba kuwo wonke umzimba wakho.

Ukuba unenkxalabo malunga nokuba nolusu olurhawuzayo ngelixa uthatha iMavyret, thetha nogqirha wakho. Banokucebisa ngeendlela zokunceda ukunciphisa eli cala ngelixa usebenzisa ichiza.

Ukuphinda kusebenze iHepatitis B

Unokuba nomngcipheko okhulayo we-hepatitis B virus (HBV) yokuvuselela (i-flare-up) ngelixa uthatha iMavyret.

Unyango lweMavyret lwonyusa umngcipheko wokuvuselelwa kwe-HBV kubantu abane-HBV kunye ne-HCV. Kwiimeko ezinzima, ukuvuselelwa kwakhona kwe-HBV kunokubangela ukusilela kwesibindi okanye nokufa.

Iimpawu zokuvuselelwa kwe-HBV zinokubandakanya:

  • iintlungu kwicala lasekunene lesisu sakho
  • isitulo esikhanyayo
  • ndiziva ndidiniwe
  • ubumthubi besikhumba sakho okanye ezimhlophe zamehlo akho

Ngaphambi kokuba uqale uMavyret, ugqirha wakho uya kuvavanya i-HBV. Ukuba unayo i-HBV, unokufuna ukunyangwa ngaphambi kokuba uqale ukuthatha iMavyret. Okanye ugqirha wakho unokucebisa ukuvavanywa ngexesha lonyango lwakho lweMavyret ukubeka esweni ukulungiswa kwe-HBV kunye nokunyanga imeko xa kufuneka njalo.

Utshintsho lobunzima (hayi isiphumo esisecaleni)

Ukuphulukana nobunzima kunye nokufumana ubunzima akuzange kuxelwe njengeziphumo ebezingalindelekanga zeMavyret ngexesha lovavanyo lweklinikhi. Nangona kunjalo, iMavyret inokubangela isicaphucaphu, esinokuthi sikhokelele ekulahlekeni kobunzima kwabanye abantu. Ukuba uziva uburhabaxa ngelixa uthatha eli chiza, kunokwenzeka ukuba utye ukutya okuncinci, okunokubangela ukunciphisa umzimba.

Ukuba unenkxalabo malunga nokufumana ubunzima okanye ukunciphisa umzimba ngelixa uthatha iMavyret, thetha nogqirha wakho. Banokukunceda ucwangcise ukutya okusempilweni ngexesha lonyango lwakho.

Ukudumba kolusu (hayi isiphumo esisecaleni)

Ukuqubuka kolusu akuzange kuchazwe njengempembelelo yecala leMavyret ngexesha lovavanyo lweklinikhi. Nangona kunjalo, i-HCV ngokwayo ngamanye amaxesha inokubangela irhashalala. Oku kunokuphazanyiswa sisiphumo secala leziyobisi. Ukukhawuleza okubangelwa yi-HCV kunokubakho naphi na emzimbeni wakho, kubandakanya ubuso bakho, isifuba okanye iingalo. Kananjalo kunokukwenza uzive urhawuzelela.

Ukuba unerhashalala ngelixa usebenzisa uMavyret, thetha nogqirha wakho. Banokucebisa ngeendlela zokunciphisa iimpawu zakho kwaye bacebise unyango ukuba luyafuneka.

Iziphumo ebezingalindelekanga ebantwaneni

Ngexesha lezifundo zeklinikhi, iziphumo ebezingalindelekanga ezibonwe ebantwaneni (abaneminyaka eli-12 ukuya kweli-17 ubudala) ukuthatha iMavyret bezifana neziphumo ebezingalindelekanga ezibonwe kubantu abadala besebenzisa iziyobisi. Kwezi zifundo, akukho bantwana bayeka unyango ngenxa yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichazwe kubantwana zibandakanya:

  • ndiziva ndidiniwe
  • isicaphucaphu
  • intloko ebuhlungu
  • Inqanaba le-bilirubin ephezulu (uvavanyo lwelebhu olujonga ukusebenza kwesibindi)

Ukuba ukhathazekile malunga neziphumo ebezingalindelekanga ezenzeka emntwaneni usebenzisa iMavyret, thetha nogqirha wakho. Banakho ukucebisa ngeendlela zokunciphisa ezi ziphumo bezingalindelekanga ngexesha lonyango.

Umthamo weMavyret

Olu lwazi lulandelayo luchaza iidosi eziqhelekileyo ezisetyenziswayo okanye ezicetyiswayo. Nangona kunjalo, qiniseka ukuthatha idosi ekumisela ugqirha wakho. Ugqirha wakho uya kumisela eyona idosi ilungele iimfuno zakho.

Iifom zamachiza kunye namandla

IMavyret iza njengecwecwe elithathwa ngomlomo. Ithebhulethi nganye ine-100 mg ye-glecaprevir kunye ne-40 mg ye-pibrentasvir.

Isisombululo se-hepatitis C

Umyinge weMavyret wentsholongwane engapheliyo ye-hepatitis C (HCV) iipilisi ezintathu ezithathwa ngomlomo kanye ngosuku. Eli chiza kufuneka lithathwe kunye nokutya. Kufuneka kwakhona ithathwe malunga nexesha elifanayo yonke imihla.

Ugqirha wakho uya kugqiba ukuba uthathe ixesha elingakanani ukuthatha iMavyret. Esi sigqibo sixhomekeke kunyango lwe-HCV oludlulileyo.

Ubude bonyango lomntu ngamnye buyahluka, kodwa uninzi lwabantu luthatha iMavyret naphina ukusuka kwiiveki ezisibhozo ukuya kwiiveki ezili-16. Ubude obuqhelekileyo bonyango lweMavyret lulandelayo:

  • Ukuba awukaze uphathwe i-HCV, kwaye awunayo i-cirrhosis (ukusilela kwesibindi), uya kunyangwa iiveki ezisi-8.
  • Ukuba awuzange unyange i-HCV, kwaye ubuyekeze i-cirrhosis (ethambileyo), uya kunyangwa iiveki ezili-12.
  • Ukuba ukhe wanyangwa i-HCV ngaphambili, kwaye unyango lwakho belungasebenzi (khange lunyange usulelo lwakho), ubude bonyango lwakho noMavyret bunokwahluka. Inokuhlala naphi na kwiiveki ezisibhozo ukuya kwiiveki ezili-16. Ubude obude bonyango lwakho buya kuxhomekeka kunyango lwe-HCV obelusebenzisa ngaphambili.

Ukuba unemibuzo malunga nokuba uza kuthatha ixesha elingakanani ukuthatha iMavyret, thetha nogqirha wakho. Banokucebisa ngesona sicwangciso sonyango silungileyo kuwe.

Idosi yabantwana

Umthamo wabantwana beMavyret uyafana nabantu abadala: iipilisi ezintathu ezithathwa ngomlomo (ngokutya) kube kanye ngosuku. Umthamo wabantwana usebenza kubantwana:

  • iminyaka eli-12 ukuya kweli-17, okanye
  • abo banobunzima obungama-45 kg (malunga neepawundi ezingama-99)

I-Mavyret ayamkelwa okwangoku ukuba isetyenziswe kubantwana abangaphantsi kweminyaka eli-12 ubudala okanye kwabo banobunzima obungaphantsi kwe-45 kg.

Kuthekani ukuba ndiphose idosi?

Ukuba uphoswa ithamo leMavyret, nantsi into ekufuneka uyenzile:

  • Ukuba kungaphantsi kweeyure ezili-18 ukusuka xa bekufanele ukuba uthathe i-Mavyret, qhubeka uthathe idosi yakho ngokukhawuleza xa ukhumbula. Emva koko, thatha idosi yakho elandelayo ngexesha eliqhelekileyo.
  • Ukuba ngaphezulu kweeyure ezili-18 ukususela xa kufanele ukuba uthathe iMavyret, tsiba nje idosi leyo. Unokuthatha idosi yakho elandelayo ngexesha eliqhelekileyo.

Ukukunceda uqiniseke ukuba awuphosi idosi, zama ukuseta isikhumbuzi kwifowuni yakho. Ixesha leyeza linokuba luncedo, nalo.

Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?

Ubude bexesha oya kuyidinga ukuthatha iMavyret buxhomekeke kwizinto ezimbalwa. Oku kubandakanya ukuba ngaba ukhe wanyangwa i-HCV ngaphambili, kwaye ukuba ngaba unesibindi esibindayo (i-cirrhosis).

Ngokwesiqhelo, unyango lweMavyret luhlala naphi na ukusuka kwiiveki ezi-8 ukuya kwezi-16. Ihlala ingapheli iiveki ezili-16.

Mavyret kunye notywala

UMavyret akanalo naluphi na unxibelelwano olwaziwayo notywala. Nangona kunjalo, akufuneki usele utywala ukuba unentsholongwane ye-hepatitis C (HCV). Utywala buyenza mandundu i-HCV, enokuthi ikhokelele ekuqobekeni ngamandla (i-cirrhosis) kwisibindi sakho.

Ukuba usela utywala, kwaye ukhathazekile malunga nendlela yokuyeka ukusela, thetha nogqirha wakho.

Eminye iMavyret

Amanye amachiza akhoyo anokunyanga intsholongwane engapheliyo ye-hepatitis C (HCV). Abanye banokukulungela ngcono kunabanye. Ukuba unomdla wokufumana enye indlela kuMavyret, thetha nogqirha wakho. Banokukuxelela ngamanye amayeza anokukusebenzela.

Olunye unyango, oluqukethe indibaniselwano yamachiza antiviral ukunyanga i-HCV, kubandakanya oku kulandelayo:

  • ledipasvir kunye nesofosbuvir (Harvoni)
  • isofosbuvir kunye nevelpatasvir (Epclusa)
  • I-velpatasvir, i-sofosbuvir, kunye ne-voxilaprevir (Vosevi)
  • I-elbasvir kunye negrazoprevir (iZepatier)
  • simeprevir (Olysio) kunye nesofosbuvir (Sovaldi)

Nangona bengezi njengesiyobisi esidibeneyo, uSimeprevir (Olysio) kunye nesofosbuvir (Sovaldi) banokuthi bathathwe kunye ukunyanga i-HCV.

UMavyret ngokuchasene neHarvoni

Unokuzibuza ukuba uMavyret uthelekisa njani namanye amayeza amiselwe ukusetyenziswa okufanayo. Apha sijonga indlela uMavyret noHarvoni abafana ngayo kwaye bahlukile.

Malunga

I-Mavyret iqulethe iziyobisi i-glecaprevir kunye ne-pibrentasvir. IHarvoni iqulethe iziyobisi ledipasvir kunye nesofosbuvir. Zombini iMavyret kunye neHarvoni ziqulathe indibaniselwano ye-antivirals, kwaye bakudidi olunye lwamayeza.

Sebenzisa

I-Mavyret yamkelwe ukunyanga intsholongwane engapheliyo ye-hepatitis C (HCV) kubantu abadala. Ikwavunyiwe ukuba isetyenziswe kubantwana abaneminyaka eli-12 nangaphezulu, okanye abo banobunzima obungama-45 kg, malunga ne-99 lbs.

I-Mavyret isetyenziselwa ukunyanga zonke iintlobo (1, 2, 3, 4, 5, kunye no-6) ze-HCV ebantwini:

  • ngaphandle kwesibindi (i-cirrhosis), okanye kulabo abane-cirrhosis ngaphandle kwempawu
  • abafumene ukufakelwa isibindi okanye izintso
  • abane-HIV

I-Mavyret inokusetyenziselwa ukunyanga uhlobo lwe-HCV 1 kubantu abakhe banyangwa ngaphambili (kodwa banganyangeki) ngolunye uhlobo lwamayeza.

I-Harvoni ivunyiwe ukuba inyange i-HCV kubantu abadala. Ingasetyenziselwa ukunyanga ezi ntlobo zilandelayo ze-HCV:

  • iintlobo 1, 2, 5, okanye 6 kubantu abangenaso isibindi (i-cirrhosis), okanye kulabo abane-cirrhosis ngaphandle kwempawu
  • Chwetheza 1 kubantu abane-cirrhosis eneempawu zale meko (kwaba bantu, iHarvoni kufuneka idityaniswe ne-ribavirin)
  • Chwetheza u-1 okanye u-4 kubantu abafumene ukufakelwa isibindi, kwaye abanaso isibindi, okanye banesiva esibindayo ngaphandle kweempawu (kwaba bantu, iHarvoni kufuneka idityaniswe ne-ribavirin)

IHarvoni ikwavunyiwe ukuba isetyenziswe kubantwana abaneminyaka eli-12 nangaphezulu, okanye abo banobunzima obungama-35 kg, malunga ne-77 lbs. Ingasetyenziswa kwaba bantwana balandelayo:

  • abo baneentlobo ze-HCV 1, 4, 5, okanye 6
  • abantwana ngaphandle kwesibindi (i-cirrhosis), okanye abo bane-cirrhosis kodwa abangenazo iimpawu

Iifom zeziyobisi kunye nolawulo

IMavyret iza njengeepilisi, ezithathwa ngomlomo (ngokutya) kube kanye ngosuku. Ihlala inikezelwa kangangesithuba se-8, i-12, okanye i-16 iiveki ngokuxhomekeke kwimbali yakho yonyango kunye nokuba siqine kangakanani isifo sesibindi sakho.

IHarvoni iza neepilisi, ezithathwa ngomlomo (kunye okanye ngaphandle kokutya) kanye ngemini. Ihlala inikwa ngaphezulu kwesithuba se-8, 12, okanye i-24 iiveki kuxhomekeke kwimbali yonyango kunye nemeko yesibindi sakho.

Iziphumo kunye neengozi

UMavyret noHarvoni awanazo iziyobisi ezifanayo, kodwa bayinxalenye yodidi olufanayo lwamayeza. La mayeza anokubangela iziphumo ebezingalindelekanga ezifanayo kunye nezinye iziphumo ebezingalindelekanga. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho neMavyret, kunye neHarvoni, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Inokwenzeka neMavyret:
    • urhudo
    • Inqanaba le-bilirubin ephezulu (uvavanyo lwelebhu olujonga ukusebenza kwesibindi)
  • Ngaba kunokwenzeka ngeHarvoni:
    • ndiziva ndibuthathaka
    • ukulala (kunzima ukulala)
    • ukukhohlela
    • ndiziva ndicaphukile
  • Inokwenzeka kunye noMavyret noHarvoni:
    • intloko ebuhlungu
    • ndiziva ndidiniwe
    • isicaphucaphu

Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ebezingalindelekanga ezinokubakho zombini kunye noMavyret kunye neHarvoni (xa zithathwa ngokwahlukeneyo) zibandakanya oku kulandelayo:

  • Ukuvuselelwa kwentsholongwane ye-hepatitis B (ukuvutha kwentsholongwane, ukuba sele ingaphakathi komzimba wakho)
  • negazi lakho kakhulu

Ukusebenza ngempumelelo

Bobabini uMavyret noHarvoni bavunyelwe ukunyanga intsholongwane engapheliyo ye-hepatitis C (HCV). Nangona kunjalo, elinye iyeza linokusebenza ngakumbi kunelinye, kuxhomekeke kuhlobo lwe-HCV onayo kunye nokuba unesibindi sokunqongophala kwesibindi (i-cirrhosis).

La machiza khange athelekiswe ngokuthe ngqo kwizifundo zeklinikhi. Kodwa izifundo ezahlukileyo zifumanise ukuba zombini iMavyret kunye neHarvoni ziyasebenza ekunyangeni i-HCV.

Iindleko

UMavyret noHarvoni bobabini banegama leziyobisi. Okwangoku azikho iintlobo zohlobo oluthile lwamayeza. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokwengqikelelo yeGoodRx.com, iMavyret kunye neHarvoni ngokubanzi zibiza malunga nokufanayo. Elona xabiso uzakuhlawula ngalo naliphi na ichiza lixhomekeke kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

IMavyret vs.Epclusa

Unokuzibuza ukuba uMavyret uthelekisa njani namanye amayeza amiselwe ukusetyenziswa okufanayo. Apha sijonga indlela uMavyret no-Epclusa abafana ngayo kwaye bahlukile.

Malunga

I-Mavyret iqulethe iziyobisi i-glecaprevir kunye ne-pibrentasvir. I-Epclusa iqulethe iziyobisi zevelpatasvir kunye nesofosbuvir. Zombini iMavyret kunye ne-Epclusa ziqulethe indibaniselwano yamachiza antiviral, kwaye bakudidi olunye lwamayeza.

Sebenzisa

I-Mavyret yamkelwe ukunyanga intsholongwane engapheliyo ye-hepatitis C (HCV) kubantu abadala. Ikwavunyiwe ukuba isetyenziswe kubantwana abaneminyaka eli-12 nangaphezulu, okanye abo banobunzima obungama-45 kg, malunga ne-99 lbs.

I-Mavyret isetyenziselwa ukunyanga zonke iintlobo (1, 2, 3, 4, 5, kunye no-6) ze-HCV ebantwini:

  • ngaphandle kwesibindi (i-cirrhosis), okanye kulabo abane-cirrhosis ngaphandle kwempawu
  • abafumene ukufakelwa isibindi okanye izintso
  • abane-HIV

I-Mavyret inokusetyenziselwa ukunyanga uhlobo lwe-HCV 1 kubantu abakhe banyangwa ngaphambili (kodwa banganyangeki) ngolunye uhlobo lwamayeza.

NjengoMavyret, i-Epclusa ikwavunyiwe ukunyanga i-HCV engapheliyo ebangelwa zizo zonke iintlobo zentsholongwane (iintlobo 1, 2, 3, 4, 5, kunye no-6). Isetyenziswa kubantu abadala abangenawo amanxeba esibindi (i-cirrhosis), okanye kwabo banesibetho sesibindi abangenazimpawu zemo.

I-Epclusa inokusetyenziswa nakwabantu abadala abane-cirrhosis abaneempawu zeso sifo.

I-Epclusa ayivunyelwanga ukuba isetyenziswe ebantwaneni.

Iifom zeziyobisi kunye nolawulo

IMavyret iza njengeepilisi, ezithathwa ngomlomo (ngokutya) kube kanye ngosuku. Ihlala inikezelwa kangangesithuba se-8, i-12, okanye i-16 iiveki ngokuxhomekeke kwimbali yakho yonyango kunye nokuba siqine kangakanani isifo sesibindi sakho.

I-Epclusa iza neepilisi, ezithathwa ngomlomo kube kanye ngosuku. I-Epclusa ingathathwa kunye okanye ngaphandle kokutya. Ihlala inikwa kangangexesha leeveki ezili-12.

Iziphumo kunye neengozi

UMavyret no-Epclusa abanazo iziyobisi ezifanayo kubo. Nangona kunjalo, bakudidi olunye lwamayeza. Ke ngoko, omabini la mayeza anokubangela iziphumo ezifanayo. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho neMavyret, kunye ne-Epclusa, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Inokwenzeka neMavyret:
    • urhudo
    • Inqanaba le-bilirubin ephezulu (uvavanyo lwelebhu olujonga ukusebenza kwesibindi)
  • Inokwenzeka nge-Epclusa:
    • ndiziva ndibuthathaka
    • ukulala (kunzima ukulala)
  • Inokwenzeka kunye neMavyret kunye ne-Epclusa:
    • intloko ebuhlungu
    • ndiziva ndidiniwe
    • isicaphucaphu

Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ebezingalindelekanga ezinokubakho zombini kunye noMavyret kunye ne-Epclusa (xa zithathwa ngokwahlukeneyo) zibandakanya oku kulandelayo:

  • Ukuvuselelwa kwentsholongwane ye-hepatitis B (ukuvutha kwentsholongwane, ukuba sele ingaphakathi komzimba wakho)
  • negazi lakho kakhulu

Ukusebenza ngempumelelo

UMavyret no-Epclusa bobabini basetyenziselwa ukunyanga zonke iintlobo ezintandathu ze-HCV ezinganyangekiyo. Ugqirha wakho unokucebisa ukuba uthathe i-Epclusa okanye iMavyret kuxhomekeke kuhlobo lwe-HCV onayo kunye nemeko yesibindi sakho.

La machiza khange athelekiswe ngokuthe ngqo kwizifundo zeklinikhi. Kodwa izifundo ezahlukileyo zifumanise ukuba zombini iMavyret kunye ne-Epclusa ziyasebenza ekunyangeni i-HCV.

Iindleko

UMavyret noEpclusa bobabini baneziyobisi. Okwangoku azikho iintlobo zohlobo oluthile lwamayeza. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokwengqikelelo yeGoodRx.com, iMavyret kunye ne-Epclusa ngokubanzi zibiza malunga nokufanayo. Elona xabiso uzakuhlawula ngalo naliphi na ichiza lixhomekeke kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

I-Mavyret ye-hepatitis C

Ulawulo lokutya kunye neziyobisi (i-FDA) livuma amayeza amiselweyo anje ngeMavyret ukunyanga iimeko ezithile.

I-Mavyret ivunyiwe yi-FDA ukunyanga izifo ezingapheliyo ezibangelwa yintsholongwane ye-hepatitis C (HCV). Le ntsholongwane ichaphazela isibindi sakho kwaye ibangele ukudumba, okunokuthi ngamanye amaxesha kukhokelele ekuqhekekeni kwesibindi (okubizwa ngokuba yi-cirrhosis). I-HCV inokubangela iimpawu ezinje:

  • ubumthubi besikhumba sakho kunye namhlophe wamehlo akho
  • ulwelo olwakhiweyo esiswini sakho
  • ifiva
  • iingxaki zexesha elide, ezinje ngokusilela kwesibindi

I-HCV isasazeka ngegazi elosuleleke yintsholongwane. Ukuhanjiswa (ukusasazeka) kwenzeka kakhulu kubantu ababelana ngeenaliti ezisetyenzisiweyo. NgokwamaZiko oLawulo lweNtsholongwane kunye noThintelo lweZifo (i-CDC), ngo-2016 malunga ne-2.4 yezigidi zabantu e-United States babephethwe yi-hepatitis C.

I-Mavyret yamkelwe ukunyanga i-HCV kubantu abadala. Ikwavunyiwe ukuba isetyenziswe kubantwana abaneminyaka eli-12 nangaphezulu, okanye abo banobunzima obungama-45 kg, malunga ne-99 lbs. Isetyenziselwa ukunyanga zonke iintlobo zeHCV (1, 2, 3, 4, 5, kunye 6) ebantwini:

  • ngaphandle kwesibindi (i-cirrhosis), okanye kulabo abane-cirrhosis ngaphandle kwempawu (ezibizwa ngokuba yi-cirrhosis)
  • abafumene ukufakelwa isibindi okanye izintso
  • abane-HIV

I-Mavyret inokusetyenziselwa ukunyanga uhlobo lwe-HCV 1 kubantu abakhe banyangwa ngaphambili (kodwa banganyangeki) ngolunye uhlobo lwamayeza.

Ukusebenza ngempumelelo

Kwezilingo zeklinikhi, abantu abadala abane-HCV (iintlobo 1, 2, 3, 4, 5, kunye no-6) abangazange banyangelwe intsholongwane banikwa iMavyret. Kula bantu, iipesenti ezingama-98 ukuya kwi-100% baphiliswa kwiiveki ezisibhozo ukuya kwezi-12 zonyango. Kwezi zifundo, ukunyangwa kwakuthetha ukuba uvavanyo lwegazi lwabantu, olwenziwa kwiinyanga ezintathu emva konyango, alubonisanga zimpawu zosulelo lwe-HCV emzimbeni wabo.

Kubo bonke abantu kwizifundo (abo babekhe banyangelwa i-HCV ngaphambili kunye nabo bebengekabikho), phakathi kwe-92% kunye ne-100% baphiliswa i-HCV. Iziphumo zahluka ngokuxhomekeka ekubeni abantu babekhe baphathwa ngaphambili kunye nohlobo lwe-HCV ababenayo.

Uvavanyo lwezonyango luye lwafanisa iMavyret nokudibanisa ezinye iziyobisi ezibizwa ngokuba yi-sofosbuvir (Sovaldi) kunye ne-daclatasvir (Daklinza). Olunye uphononongo lujonge abantu abane-HCV yohlobo lwe-3, abangazange baphathwe ngaphambili. Aba bantu babengenaso isibindi (cirrhosis).

Emva kweeveki ezili-12, ama-95.3% abantu abathatha i-Mavyret babonwa njengonyango (babengenayo intsholongwane ye-HCV kuvavanyo lwegazi). Kulabo bathatha i-sofosbuvir kunye ne-daclatasvir, i-96.5% yayineziphumo ezifanayo.

Mavyret yabantwana

I-Mavyret ivunyiwe ukunyanga i-HCV kubantwana abaneminyaka eli-12 nangaphezulu, okanye kwabo banobunzima obungama-45 kg, malunga ne-99 lbs.

Unxibelelwano lweMavyret

UMavyret unokusebenzisana namanye amayeza. Iyakwazi ukusebenzisana nezibonelelo ezithile.

Unxibelelwano olwahlukileyo kunokubangela iziphumo ezahlukeneyo. Umzekelo, unxibelelwano oluthile lunokuphazamisa ukusebenza kakuhle kwesiyobisi. Olunye unxibelelwano lunokunyusa iziphumo ebezingalindelekanga okanye lubenze bube nzima ngakumbi.

Mavyret kunye namanye amayeza

Apha ngezantsi kukho uluhlu lwamayeza anokusebenzisana noMavyret. Olu luhlu alunazo zonke iziyobisi ezinokuthi zinxibelelane noMavyret.

Ngaphambi kokuba uthathe uMavyret, thetha nogqirha wakho kunye nosokhemesti. Baxelele ngawo onke amayeza kagqirha, ekhawuntareni, kunye nezinye iziyobisi ozithathayo. Baxelele malunga nazo naziphi na iivithamini, amayeza esintu kunye nezixhasi ozisebenzisayo. Ukwabelana ngolu lwazi kunokukunceda uphephe unxibelelwano olunokubakho.

Ukuba unemibuzo malunga nokunxibelelana kweziyobisi okunokuchaphazela, buza ugqirha wakho okanye usokhemesti.

IMavyret kunye necarbamazepine (Tegretol)

Ukuthatha i-carbamazepine kunye neMavyret kunokunciphisa inani leMavyret emzimbeni wakho. Oku kunokubangela ukuba iyeza lingasebenzi ngokunjalo, elinokukhokelela ekubeni intsholongwane yakho ye-hepatitis C (HCV) inganyangwa ngokupheleleyo. Kubalulekile ukunqanda ukuthatha i-carbamazepine kunye neMavyret kunye.

IMavyret kunye newarfarin (Coumadin)

Ukuthatha i-warfarin neMavyret kunokutshintsha inqanaba le-warfarin emzimbeni wakho. Oku kunokukhokelela kutshintsho kwigazi lakho, kubangele ukuba libhitye kakhulu okanye libe lukhulu kakhulu. Ukuba oku kuyenzeka, unokuba semngciphekweni weengxaki ezithile, njengokuphuma kwegazi okanye ukuba namahlwili egazi.

Ukuba uthatha iMavyret nge-warfarin, kubalulekile ukuba kwenziwe uvavanyo lwegazi rhoqo ukujonga ubukhulu begazi lakho. Ukuba ufuna ukuthatha la mayeza kunye, ugqirha wakho uya kukucebisa ngeendlela zokukunceda ukuqinisekisa ukhuseleko lwakho ngexesha lonyango.

IMavyret kunye nedigoxin (Lanoxin)

Ukuthatha iMavyret nge-digoxin kunokunyusa amanqanaba e-digoxin emzimbeni wakho. Oku kunokubangela iimpawu ezinje:

  • isicaphucaphu
  • ukugabha
  • urhudo
  • isingqisho sentliziyo esingaqhelekanga

Ukuba uthatha i-digoxin ngelixa usebenzisa iMavyret, ugqirha wakho unokufuna ukunciphisa idosi yakho ye-digoxin. Oku kuya kunceda ukukhusela amanqanaba akho e-digoxin ekuphakameni kakhulu kwaye abangele iziphumo ebezingalindelekanga. Ugqirha wakho unokujonga amanqanaba akho e-digoxin kuvavanyo lwegazi rhoqo kunesiqhelo ngelixa uthatha iMavyret.

IMavyret kunye nedabigatran (Pradaxa)

Ukuthatha iMavyret nge-dabigatran kwandisa amanqanaba e-dabigatran emzimbeni wakho. Ukuba eli nqanaba liphezulu kakhulu, uya kuba nengozi eyonyukayo yokopha okanye yokugruzuka. Unokuziva ubuthathaka. Ezi mpawu ngamanye amaxesha zinokuba nzulu.

Ukuba uthatha i-dabigatran ngelixa usebenzisa i-Mavyret, ugqirha wakho unokufuna ukunciphisa idosi ye-dabigatran. Oku kuya kunceda ukuthintela ezi mpawu ekubeni zenzeke.

IMavyret kunye nerifampin (Rifadin)

Ukuthatha iMavyret ngerifampin kunciphisa amanqanaba eMavyret emzimbeni wakho. Ukuba inqanaba leMavyret emzimbeni wakho lehlile, ichiza alinakusebenza kakuhle ukunyanga i-HCV. Kuya kufuneka uphephe ukuthatha iMavyret kunye neRifampin ngaxeshanye.

I-Mavyret kunye namayeza athile okulawula ukuzalwa

Olunye unyango lwamayeza luqukethe iziyobisi ezibizwa ngokuba yi-ethinyl estradiol. Ukuthatha eli chiza ngokudibeneyo neMavyret kunokunyusa amanqanaba omzimba wakho we-enzyme yesibindi ebizwa ngokuba yi-alanine aminotransferase (ALT). Ukunyusa amanqanaba e-ALT kunokwenza ukuba iimpawu zakho ze-hepatitis zibe mbi.

Kuyacetyiswa ukuba ungasebenzisi ulawulo lokuzalwa oluqukethe i-ethinyl estradiol ngelixa uthatha iMavyret.

Imizekelo yeepilisi zolawulo lokuzalwa eziqukethe i-ethinyl estradiol ibandakanya:

  • I-levonorgestrel kunye ne-ethinyl estradiol (i-Lessina, i-Levora, i-Seasonique)
  • desogestrel kunye ne-ethinyl estradiol (Apri, Kariva)
  • norethindrone kunye ne-ethinyl estradiol (iBalziva, iJunel, iLoestrin / iLoestrin Fe, iMicrogestin / iMicrogestin Fe)
  • I-norgestrel kunye ne-ethinyl estradiol (i-Cryselle, iLo / i-Ovral)
  • I-drospirenone kunye ne-ethinyl estradiol (Loryna, Yaz)
  • norgestimate kunye ne-ethinyl estradiol (Ortho Tri-Cyclen / Ortho Tri-Cyclen Lo, Sprintec, Tri-Sprintec, TriNessa)

Olu ayilo luhlu lupheleleyo lweepilisi zolawulo lokuzalwa eziqulathe i-ethinyl estradiol. Ukuba awuqinisekanga ukuba ulawulo lwakho lokuzalwa lune-ethinyl estradiol kuyo, qiniseka ukubuza ugqirha wakho okanye usokhemesti.

Ezinye iindlela zolawulo lokuzalwa ngaphandle kweepilisi zine-ethinyl estradiol. Ezi ndlela zibandakanya isicwangcisi sokucwangcisa (iOrtho Evra) kunye neringi yelungu lobufazi (iNuvaRing).

Ukuba usebenzisa ulawulo lokuzalwa oluqukethe i-ethinyl estradiol, thetha nogqirha wakho ngezinye iindlela zokuthintela ukukhulelwa ngelixa uthatha iMavyret.

I-Mavyret kunye namayeza athile e-HIV

Amayeza athile e-HIV (abizwa ngokuba zii-antivirals) anokuchaphazela isixa seMavyret emzimbeni wakho. Imizekelo yamachiza antiviral anokutshintsha isixa seMavyret emzimbeni wakho kubandakanya:

  • atazanavir (Reyataz)
  • idarunavir (Prezista)
  • lopinavir kunye ne ritonavir (Kaletra)
  • i-ritonavir (iNorvir)
  • I-efavirenz (iSustiva)

I-Atazanavir akufuneki ithathwe kunye noMavyret. Ukuthatha la machiza kunye kunyusa inqanaba lomzimba wakho we-enzyme yesibindi ebizwa ngokuba yi-alanine aminotransferase (ALT). Ukunyusa amanqanaba e-ALT kunokwenza ukuba iimpawu zakho ze-hepatitis zibe mbi.

Ukuthatha iMavyret nge-darunavir, i-lopinavir, okanye i-ritonavir nayo ayikukhuthazwa. Kungenxa yokuba la machiza antiviral anokunyusa amanqanaba eMavyret emzimbeni wakho. Oku kunokukhokelela kwiziphumo ebezingalindelekanga ezivela kuMavyret.

Ukuthatha iMavyret nge-efavirenz kunciphisa amanqanaba eMavyret emzimbeni wakho. Oku kunokubangela ukuba uMavyret angasebenzi ngokunjalo. Kuya kufuneka uphephe ukusebenzisa i-efavirenz ngelixa uthatha iMavyret.

Mavyret kunye namayeza athile e-cholesterol

Ukuthatha iMavyret kunye namayeza athile e-cholesterol abizwa ngokuba zii-statins anokunyusa inqanaba le-statin emzimbeni wakho. Ukuba namanqanaba anyukayo ee-statins anyusa umngcipheko weziphumo ebezingalindelekanga (ezinjengeentlungu zomzimba) kwi-statin.

Imizekelo yemimiselo ibandakanya:

  • atorvastatin (Lipitor)
  • I-lovastatin (Mevacor)
  • Simvastatin (iZocor)
  • ipravastatin (Pravachol)
  • Irosuvastatin (Crestor)
  • ifluvastatin (Lescol)
  • ipitavastatin (Livalo)

Kuyacetyiswa ukuba ungathathi iMavyret ngokudibanisa neatorvastatin, lovastatin, okanye simvastatin. Ezi zi-statins zinomngcipheko ophezulu wokunyuka kweempembelelo xa zithathwa kunye noMavyret.

I-Pravastatin inokuthathwa kunye neMavyret ukuba ugqirha wakho ucebisa ukuba ufuna amayeza e-cholesterol. Idosi yakho yepravastatin iya kudinga ukwehliswa ngaphambi kokuba uqale ukuthatha iMavyret. Oku kuya kunceda ukunciphisa umngcipheko weziphumo ebezingalindelekanga ezivela kwi-statin.

Ukuba i-fluvastatin kunye ne-pitavastatin zithathwa kunye neMavyret, kuya kufuneka zinikwe idosi ephantsi enokubakho. Oku kunceda ukunciphisa umngcipheko wokuba nemiphumela emibi evela kwiimimiselo.

IMavyret kunye necyclosporine (iSandimmune)

I-Mavyret ayikhuthazwa ukuba isetyenziswe kubantu abathatha ngaphezulu kwe-100 mg ngosuku lwe-cyclosporine. Eli chiza lonyusa amanqanaba eMavyret emzimbeni wakho, onokuthi wandise umngcipheko weziphumo ebezingalindelekanga ezivela kuMavyret.

Ukuba uthatha i-cyclosporine, thetha nogqirha wakho malunga nokuba yeyiphi idosi ye-cyclosporine ekhuselekileyo kuwe.

Mavyret kunye ne-omeprazole (hayi ukudibana)

Akukho nxibelelwano lwaziwayo phakathi kwe-omeprazole kunye neMavyret. Ngamanye amaxesha i-Omeprazole inikwa abantu abathatha iMavyret ukuba banesicaphucaphu ngexesha lonyango. Ngamanye amaxesha, isicaphucaphu sibangelwa kukukhula kweasidi esiswini sakho. Ukuthatha i-omeprazole kuya kunceda ukunciphisa isixa seasidi esiswini sakho, esinokukunceda ukunciphisa eli cala.

Mavyret kunye ibuprofen (hayi ukudibana)

Akukho nxibelelwano lwaziwayo phakathi kwe-ibuprofen kunye neMavyret. I-Ibuprofen ingasetyenziselwa ukunyanga iintloko kubantu abathatha iMavyret. Intloko ziziphumo eziqhelekileyo ezinokubakho xa uthatha iMavyret. Ibuprofen inokunceda ukunciphisa iintlungu kunye nokuphazamiseka kwentloko.

Mavyret kunye nemifuno kunye nezongezelelo

UMavyret unokusebenzisana namanye amayeza kunye nezongezo, kubandakanya neSt.John's wort (eneenkcukacha ezingezantsi). Oku kunxibelelana kunokuchaphazela indlela iMavyret esebenza ngayo emzimbeni wakho.

Kuya kufuneka ujonge onke amayeza owathathayo (kubandakanya nawaphi na amayeza kunye nezongezo) nogqirha okanye usokhemesti ngaphambi kokuba uqale ukuthatha iMavyret.

Mavyret kunye neSt

Ukuthatha iwort yaseSt. John's kunye noMavyret kunokuwanciphisa kakhulu amanqanaba eMavyret emzimbeni wakho. Oku kunokubangela ukuba uMavyret angasebenzi kakuhle ekunyangeni usulelo lwakho lwe-hepatitis C. Kuyacetyiswa ukuba ungathathi iwort yaseSt.John ngelixa usebenzisa iMavyret.

Mavyret kunye nokukhulelwa

Akuzange kubekho zifundo ebantwini ezijonga ukuba ngaba iMavyret ikhuselekile ukuthatha ngexesha lokukhulelwa.

Kwizifundo zezilwanyana, akukho monakalo ubonwayo kwimveku enikwa oomama iMavyret ngexesha lokukhulelwa. Nangona kunjalo, iziphumo zezifundo zezilwanyana azihlali ziqikelela ukuba kuya kwenzeka ntoni ebantwini.

Ukuba ukhulelwe okanye unokukhulelwa ngelixa usebenzisa uMavyret, thetha nogqirha wakho. Banokuxoxa nawe ngomngcipheko kunye nezibonelelo zokusebenzisa eli chiza ngexesha lokukhulelwa.

Mavyret kunye nokuncancisa

Akuzange kubekho zifundo ebantwini ukuba bazi ukuba iMavyret idlulela kubisi lwebele, okanye ukuba inefuthe na kumntwana oncelisayo.

Kwizifundo zezilwanyana, uMavyret wayedlula kubisi lweempuku ezincancisayo. Nangona kunjalo, olu bisi aluzange lubangele monakalo kwizilwanyana ezilutyhilileyo. Gcina ukhumbula ukuba ezi ziphumo zinokwahluka ebantwini.

Ukuba uncelisa, okanye ucwangcisa ukuncancisa ngelixa uthatha uMavyret, thetha nogqirha wakho malunga nokuba le yindlela ekhuselekileyo. Banokucebisa ngezinye iindlela ezisempilweni zokondla umntwana wakho.

Uyithatha kanjani iMavyret

Kuya kufuneka uthathe uMavyret ngokwemiyalelo kagqirha wakho okanye yezempilo.

Nini ukuthatha

Ayinamsebenzi ukuba liliphi ixesha losuku okhetha ukuthatha ngalo iMavyret, kodwa kuya kufuneka ulithathe malunga nexesha elifanayo suku ngalunye. Oku kunceda amayeza asebenze ngendlela eyiyo ngaphakathi komzimba wakho.

Ukukunceda uqiniseke ukuba awuphosi idosi, zama ukuseta isikhumbuzi kwifowuni yakho. Ixesha leyeza linokuba luncedo, nalo.

Ukuthatha iMavyret ngokutya

I-Mavyret kufuneka ithathwe kunye nokutya. Oku kunceda umzimba wakho ukuba uwathathe ngcono amayeza.

Ngaba iMavyret inokutyunyuzwa, yahlulwe, okanye ihlafunwe?

Hayi, iMavyret akufuneki yahlulwe, ichithwe, okanye ihlafunwe. Amacwecwe enzelwe ukuginywa uphelele. Ukuqhekeza, ukutyumza, okanye ukuhlafuna kunganciphisa inani leziyobisi ezingena emzimbeni wakho. Oku kunokubangela ukuba uMavyret angasebenzi kakuhle ekunyangeni usulelo lwakho lwe-hepatitis C.

Isebenza njani iMavyret

UMavyret uvunyiwe ukuba anyange intsholongwane engapheliyo ye-hepatitis C (HCV). Le ntsholongwane ibangela usulelo emzimbeni wakho oluchaphazela isibindi sakho. I-HCV inokukhokelela kumonakalo omkhulu wesibindi ukuba ayinyangwa ngendlela eyiyo.

I-Mavyret iqulethe iziyobisi ezibini: i-glecaprevir kunye ne-pibrentasvir. Isebenza ngokumisa intsholongwane ye-hepatitis C ekuphindaphindeni (ukwenza intsholongwane engakumbi) ngaphakathi komzimba wakho. Ngenxa yokuba intsholongwane ayinako ukuphindaphindeka, izakufa ekugqibeleni.

Nje ukuba yonke intsholongwane ifile, kwaye ingasekho emzimbeni wakho, isibindi sakho singaqala ukuphola. UMavyret usebenza ukunyanga zonke iintlobo ezintandathu (1, 2, 3, 4, 5, kunye no-6) ze-HCV.

Kuthatha ixesha elingakanani ukusebenza?

Ngexesha lezifundo zeklinikhi, iipesenti ezingama-92 ukuya kwi-100 zabantu abane-HCV baphiliswa emva kokuthatha iMavyret ngobude bexesha labo elimiselweyo. Obu bude bexesha bususela kwi-8 ukuya kwi-16 iiveki.

Kwezi zifundo, ukunyangwa kwakuthetha ukuba uvavanyo lwegazi lwabantu, olwenziwa kwiinyanga ezintathu emva konyango, alubonisanga zimpawu zosulelo lwe-HCV emzimbeni wabo.

Imibuzo eqhelekileyo malunga noMavyret

Nazi iimpendulo kwimibuzo ebuzwa rhoqo malunga noMavyret.

Ndingamthatha uMavyret ukuba ndine-HIV kunye ne-hepatitis C?

Ewe ungayithatha iMavyret ukuba unayo intsholongwane kaGawulayo kunye ne-hepatitis C virus (HCV). Ukuba ne-HIV ayitshintshi indlela uMavyret asebenza ngayo emzimbeni wakho ukunyanga i-HCV.

Uphumelele kangakanani uMavyret ekunyangeni i-hepatitis C?

I-Mavyret ibonakaliswe ukuba iyasebenza kakhulu ekunyangeni isifo se-hepatitis C (HCV). Kwizilingo zeklinikhi, phakathi kwama-98% kunye ne-100% yabantu abathatha iMavyret baphiliswa kwi-HCV.

Kwezi zifundo, ukunyangwa kwakuthetha ukuba uvavanyo lwegazi lwabantu, olwenziwa kwiinyanga ezintathu emva konyango, alubonisanga zimpawu zosulelo lwe-HCV. Ipesenti yabantu abaphilisiweyo baxhomekeke kuhlobo lwe-HCV abanalo, kwaye loluphi uhlobo lonyango ababelusebenzisa ngaphambili.

Ukuba ndithathe olunye unyango lwe-hepatitis C, ndingasebenzisa iMavyret?

Ukuba ukhe wazama amanye amayeza kwi-hepatitis C yakho engakhange isebenze (ukunyanga usulelo lwakho), usenokusebenzisa iMavyret. Kuxhomekeka ekubeni zeziphi iziyobisi ozisebenzisileyo ngaphambili, ubude bonyango lwakho noMavyret bunokubakho ukusuka kwiiveki ezi-8 ukuya kwezi-16.

Ukuba unemibuzo malunga nokuba ungasebenzisa iMavyret, thetha nogqirha wakho.

Ngaba ndiza kufuna naluphi na uvavanyo ngaphambi okanye ngexesha lonyango lweMavyret?

Ngaphambi kokuba uqale unyango kunye noMavyret, ugqirha wakho uya kuvavanya igazi lakho kwintsholongwane ye-hepatitis B (HBV). Ukuba unayo i-HBV, inokuphinda isebenze kwakhona (i-flare up) ngexesha lonyango lweMavyret. Ukuvuselelwa kwe-HBV kunokubangela iingxaki zesibindi ezinzima, kubandakanya ukusilela kwesibindi kunye nokufa.

Ukuba unayo i-HBV, ugqirha wakho uya kukucebisa kuvavanyo lwegazi ngexesha lonyango lwakho lweMavyret ukujonga ukwenziwa kwakhona kwe-HBV. Kuya kufuneka unyangwe nge-HBV ngaphambi kokuba uqale ukuthatha iMavyret.

Ndingayisebenzisa iMavyret ukuba ndinesifo sesibindi?

Unokwazi, kodwa kuxhomekeke ekubeni sisibi kangakanani isifo sakho sokuqina kwesibindi (ukusilela kwesibindi).

I-Mavyret ingasetyenziselwa ukuba ubuyekeze i-cirrhosis (encinci). Ngale meko, isibindi sakho sinesikrelemnqa, kodwa awunazo naziphi na iimpawu zeso sifo kwaye isibindi sakho sisasebenza ngendlela eqhelekileyo.

I-Mavyret ayikavunywa ukuba isetyenziswe kubantu abane-cirrhosis ebolileyo. Ngale meko, isibindi sakho sinesikrelemnqa kwaye uneempawu zaloo meko. Iimpawu zingabandakanya:

  • ubumthubi besikhumba sakho okanye ezimhlophe zamehlo akho
  • ulwelo olongezelelekileyo esiswini sakho
  • Imithambo yegazi eyandisiweyo emqaleni wakho, enokubangela ukopha

Ukuba une-cirrhosis kodwa awuqinisekanga ukuba loluphi uhlobo, thetha nogqirha wakho.

Izikhuselo zeMavyret

Eli chiza liza neendlela ezininzi zokukhusela.

Isilumkiso se-FDA: intsholongwane ye-hepatitis B iyasebenza

Eli chiza linesilumkiso esibhokisiweyo. Esi sisilumkiso esibi kakhulu esivela kuLawulo lokutya kunye noLawulo lweziyobisi (FDA). Isilumkiso esinebhokisi silumkisa oogqirha kunye nezigulana malunga neziyobisi ezinokuba yingozi.

Unyango lweMavyret lwonyusa umngcipheko wentsholongwane ye-hepatitis B (HBV) (i-flare-up) kubantu abane-HBV kunye ne-hepatitis C virus (HCV). Kwiimeko ezinzima, ukuvuselelwa kwakhona kwe-HBV kunokubangela ukusilela kwesibindi okanye nokufa.

Ngaphambi kokuba uqale uMavyret, ugqirha wakho uya kuvavanya i-HBV. Ukuba unayo i-HBV, unokufuna ukunyangwa ngaphambi kokuba uqale ukuthatha iMavyret. Okanye ugqirha wakho unokucebisa ukuvavanywa ngexesha lonyango lwakho lweMavyret ukujonga ukuvuselelwa kwe-HBV.

Ezinye izilumkiso

Ngaphambi kokuba uthathe uMavyret, thetha nogqirha wakho malunga nembali yakho yezempilo. I-Mavyret isenokungakulungeli ukuba uneemeko ezithile zonyango. Oku kubandakanya:

  • Ukungaphumeleli kwesibindi. Ukuba unesibindi sokusilela, ukuthatha iMavyret kunokuba mandundu imeko yakho. Thetha nogqirha wakho ukuba unayo nayiphi na imbali yesifo sesibindi okanye ukusilela kwesibindi ngaphambi kokuqala unyango kunye noMavyret.
  • Ukusetyenziswa kwangoku kwe-atazanavir okanye i-rifampin. I-Mavyret mayingaze isetyenziswe ebantwini abathatha i-atazanavir okanye i-rifampin. Ukuthatha iMavyret kunye ne-rifampin kunye kunokunciphisa amanqanaba eMavyret emzimbeni wakho. Oku kunokwenza ukuba iMavyret ingasebenzi kakuhle kuwe. Ukuthatha i-atazanavir kunye neMavyret kunokunyusa isixa seMavyret emzimbeni wakho. Oku kunganyusa amanqanaba e-enzyme yesibindi (ebizwa ngokuba yi-alanine aminotransferase), enokuba yingozi. Jonga icandelo "lokunxibelelana noMavyret" ngolwazi oluthe kratya. Soloko uthetha nogqirha wakho malunga nawaphi na amayeza owathathayo ngaphambi kokuba uqale iMavyret.
  • Ukukhulelwa. Ayaziwa nokuba iMavyret inokuchaphazela ukukhulelwa okukhulayo. Kwizifundo zezilwanyana, uMavyret akazange abangele ingozi xa esetyenziswa ngexesha lokukhulelwa. Nangona kunjalo esi siphumo sinokwahluka ebantwini. Ngolwazi oluthe kratya, nceda ubone icandelo "leMavyret kunye nokukhulelwa" apha ngasentla.
  • Ukuncancisa. Ayaziwa ukuba iMavyret idlulela kubisi lwebele lomntu, okanye ukuba yenzakalisa umntwana oncelisayo. Kwizifundo zezilwanyana, uMavyret wayedlula kubisi lwebele, kodwa khange lubangele monakalo kwizilwanyana ezitya ubisi lwebele. Nangona kunjalo, esi siphumo sinokuhluka ebantwini. Ngolwazi oluthe kratya, nceda ubone icandelo elithi "Mavyret kunye nokuncancisa" apha ngasentla.

Phawula: Ngolwazi oluthe kratya malunga neziphumo ezibi ezinokubakho zeMavyret, jonga icandelo "leziphumo zeMavyret" apha ngasentla.

Ukugqithisa ngokweqile kweMavyret

Sebenzisa ngaphezulu komthamo ocetyiswayo weMavyret kunokukhokelela kwiziphumo ebezingalindelekanga ezibi. Ungaze uthathe ngaphezulu komthamo omiselwe ngugqirha wakho.

Kufuneka wenze ntoni xa uthe wagqithisa?

Ukuba ucinga ukuba uthathe kakhulu eli chiza, tsalela ugqirha wakho. Ungabiza uMbutho waseMelika wamaZiko oLawulo lweTyhefu ku-800-222-1222 okanye usebenzise isixhobo esikwi-Intanethi. Kodwa ukuba iimpawu zakho zinzima, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko.

Ukuphelelwa lixesha kweMavyret, ukugcinwa kunye nokulahlwa

Xa ufumana iMavyret ekhemesti, usokhemesti uya kongeza umhla wokuphelelwa kwileyibhile esebhotileni. Lo mhla uqhelekile ukuba ube ngunyaka omnye ukusukela kumhla wokuhambisa kwabo amayeza.

Umhla wokuphelelwa unceda ekuqinisekiseni ukusebenza kwamayeza ngeli xesha. Isimo sangoku soLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) kukuphepha ukusebenzisa amayeza aphelelwe lixesha. Ukuba awusebenzisanga iyeza elidlulileyo kumhla wokuphelelwa kwalo, thetha nosokhemesti wakho malunga nokuba unganako na ukuyisebenzisa.

Ukugcina

Ukuhlala ixesha elingakanani iyeza lihlala lilungile kunokuxhomekeka kwizinto ezininzi, kubandakanya ukuba uligcina phi kwaye phi na iyeza.

Iipilisi zeMavyret kufuneka zigcinwe kubushushu begumbi (ngaphantsi kwe-86 ° F / 30 ° C) kwisitya esitywinwe ngokuqinileyo, kude nokukhanya. Gwema ukugcina eli yeza kwiindawo ezinokuthi zifumane ubumanzi okanye zimanzi, njengakwigumbi lokuhlambela.

Ukulahla

Ukuba akusafuneki ukuba uthathe iMavyret kwaye unamayeza ashiyekileyo, kubalulekile ukuba ulahle ngokukhuselekileyo. Oku kunceda ukuthintela abanye, kubandakanya abantwana kunye nezilwanyana zasekhaya, ekubeni bathathe iyeza ngengozi. Kuyanceda ukugcina ichiza lingonzakalisi okusingqongileyo.

Iwebhusayithi ye-FDA ibonelela ngeengcebiso ezininzi eziluncedo ngokulahla amayeza. Unokucela ikhemesti yakho ukuba ikwazi ukuba ulahla njani na amayeza akho.

Ulwazi lobungcali kuMavyret

Olu lwazi lulandelayo lubonelelwe ngoochwephesha kunye nabanye abaqeqeshi bezempilo.

Iimpawu

I-Mavyret ibonakalisiwe kunyango lwe-hepatitis C engapheliyo (HCV) genotypes 1, 2, 3, 4, 5, kunye no-6. ikg.

Kufuneka isetyenziswe kuphela kwizigulana ngaphandle kwesibindi, okanye kwabo bane-cirrhosis ehlawulelweyo.

I-Mavyret ikwaboniswa kunyango losulelo lwe-genotype 1 hepatitis C kubantu abagula bangaphumeleli kunyango lwabo. Olu nyango lwangaphambili kufuneka lubandakanye i-HCV NS5A inhibitor okanye i-NS3 / 4A protease inhibitor.

I-Mavyret ayiboniswanga ukuba isetyenziswe kwizigulana ezingaphangeliyo kusilele ukusebenzisa i-HCV NS5A inhibitor kunye ne-NS3 / 4A protease inhibitor.

Indlela yokusebenza

I-Mavyret iqulethe i-glecaprevir kunye ne-pibrentasvir. La machiza asebenza ngokuthe ngqo amayeza alwa ne-HCV.

IGlecaprevir yi-NS3 / 4A protease inhibitor. Isebenza ngokujolisa kwi-NS3 / 4A protease, eyimfuneko kuphuhliso lwentsholongwane ye-hepatitis C.

IPibrentasvir yi-NS5A inhibitor. Ngokuthintela i-NS5A, i-pibrentasvir imisa ukuphindaphindeka kwentsholongwane ye-hepatitis C.

I-Mavyret iyasebenza ngokuchasene ne-hepatitis C virus genotypes 1, 2, 3, 4, 5, kunye no-6.

I-Pharmacokinetics kunye ne-metabolism

Kwisifundo esichaphazela abantu abangosulelekanga yi-HCV ababonwa njengabaphilileyo, ukufunxwa kweMavyret kwachaphazeleka kakhulu kukutya. Xa kuthathwa kunye nesidlo, ukufunxwa kwe-glecaprevir kunyuke nge-83% ukuya kwi-163%. Ukufunxwa kwepibrentasvir kunyuswe nge-40% ukuya kwi-53%. Ke ngoko, iMavyret icetyiswa ukuba ithathwe kunye nokutya ukuphucula ukufunxeka kwayo.

Ubuninzi beplasma ye-Mavyret yenzeka malunga neeyure ezi-5 emva kwethamo. Isiqingatha sobomi se-glecaprevir ziiyure ezingama-6, ngelixa isiqingatha sobomi bepibrentasvir iiyure ezili-13.

I-Mavyret ikakhulu ikhutshiwe ngendlela ye-biliary-fecal. Uninzi lwazo zombini i-glecaprevir kunye ne-pibrentasvir yiproteni eboshwe ngeplasma.

Ukungqinelana

I-Mavyret iyaphikiswa kwizigulana ezinesifo esibi se-hepatic, esichazwa njengenqaku loMntwana-Pugh C.

I-Mavyret ikwangqinelana kwizigulana ezithatha i-atazanavir okanye i-rifampin. Uxinzelelo lwe-Mavyret luyancipha kakhulu yi-rifampin, enokunciphisa okanye ukuthintela ukusebenza kwe-Mavyret. I-Mavyret akufuneki ithathwe kunye ne-atazanavir kuba indibaniselwano yamachiza inokunyusa amanqanaba e-alanine aminotransferase (ALT), ekhokelela kumngcipheko wokungaphumeleli kwesibindi.

Ukugcina

I-Mavyret kufuneka igcinwe ngaphakathi okanye ngaphantsi kwe-86 ° F (30 ° C) kwisitya esitywiniweyo nesomileyo.

Iphepha elichazayo ukuba awusenanto oyifunayo: Iindaba zezoNyango namhlanje zenze zonke iinzame zokuqinisekisa ukuba zonke iinkcukacha zichanekile, zibanzi kwaye zihlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi. Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.

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