Mefloquine: yintoni, iyintoni kunye neziphumo ebezingalindelekanga

Umxholo

• Yenzelwe ntoni
• Ngaba i-mefloquine ibonakalisiwe kunyango losulelo lwe-coronavirus?
• Kusetyenziswa kwanjani
• Ingaba isebenza kanjani
• Ngubani ongafanele asebenzise
• Iziphumo ebezingalindelekanga ezinokwenzeka

I-Mefloquine sisixhobo esibonisiweyo sothintelo se-malaria, kubantu abanenjongo yokuhamba baye kwiindawo apho kukho umngcipheko omkhulu wokuba nesi sifo. Ukongeza, inokusetyenziselwa ukunyanga isifo seengcongconi esibangelwa ziiarhente ezithile, xa zidityaniswe nelinye iyeza, elibizwa ngokuba yi-artesunate.

I-Mefloquine iyafumaneka ezikhemesti, kwaye inokuthengwa kuphela xa kunikwa amayeza.

Yenzelwe ntoni

I-Mefloquine ibonakalisiwe kuthintelo lwesifo seengcongconi, kubantu abanenjongo yokuhamba baye kwiindawo ezinesifo kwaye, xa inxulunyaniswa ne-artesunate, inokusetyenziselwa ukunyanga isifo seengcongconi esibangelwa ziiarhente ezithile.

Ngaba i-mefloquine ibonakalisiwe kunyango losulelo lwe-coronavirus?

Ukusetyenziswa kwe-mefloquine ukunyanga usulelo kwi-coronavirus entsha akukacetyiswa kuba, nangona ibonakalisile iziphumo ezithembisayo kunyango lwe-COVID-19^[1], izifundo ezongezelelweyo ziyafuneka ukungqina ukusebenza kwayo kunye nokhuseleko.

Ngaphaya koko, eRashiya, irejimeni yonyango olusebenzayo iyavavanywa, kunye ne-mefloquine edityaniswe namanye amachiza, kodwa ngaphandle kweziphumo eziqinisekileyo.

Ukuzinyanga ngokwakho kunye ne-mefloquine kuyacetyiswa ngokuchasene kwaye kuyingozi, kwaye kunokuba neziphumo ezibi empilweni.

Kusetyenziswa kwanjani

Eli yeza kufuneka lisetyenziswe ngomlomo, liphelele kunye neglasi yamanzi, ngexesha lokutya. Umthamo kufuneka ugqitywe ngugqirha, ngokusekwe kwisifo esithile, ubukhali kunye nokuphendula komntu kwichiza. Kunyango ebantwaneni, ugqirha kufuneka alungelelanise idosi kubunzima bakho.

Kubantu abadala, xa i-mefloquine isetyenziselwa ukuthintela isifo seengcongconi, kuyacetyiswa ukuba uqale unyango malunga neeveki ezi-2 ukuya kwezi-3 ngaphambi kohambo. Ke ngoko, ithebhulethi enye ye-250 mg ngeveki kufuneka ilawulwe, ihlala igcina le rejimeni ukuya kuthi ga kwiiveki ezi-4 emva kokubuya.

Ukuba akunakwenzeka ukuqala unyango lothintelo kwangoko, i-mefloquine ingaqalwa kwiveki enye ngaphambi kohambo, nangona kunjalo, kubalulekile ukuba wazi ukuba iziganeko ezibi kakhulu zihlala zenzeka de kube kwidosi yesithathu, enokubonakala sele kuhambo . Ngenye indlela, ungasebenzisa i-mefloquine kwithamo lokulayisha le-750 mg kwidosi enye kwaye emva koko uqalise irejimeni kwi-250 mg ngeveki.

Funda indlela yokuchonga iimpawu ze-malaria kunye nento omawuyenze.

Ingaba isebenza kanjani

I-Mefloquine isebenza kumjikelo wobomi be-asexual parasite, eyenzeka ngaphakathi kwiiseli zegazi, ngokwenziwa kwezakhiwo kunye neqela le-heme yegazi, ukuthintela ukungasebenzi kwazo sisidleleli. Izakhiwo ezenziweyo kunye neqela le-heme lasimahla linetyhefu kwi-parasite.

I-Mefloquine ayinanto yakwenza nokuchaphazela iifom zesibindi se-parasite, okanye ngokuchasene neentlobo zesondo.

Ngubani ongafanele asebenzise

I-Mefloquine iyaphikiswa kubantu abane-hypersensitivity kumacandelo efomula, kubantwana abangaphantsi kwe-5 kg ​​okanye ngaphantsi kweenyanga ezi-6, abasetyhini abakhulelweyo kwaye ngelixa uncancisa.

Akufanelekanga ukuba isetyenziswe kubantu abaneengxaki zezintso kunye nesibindi, imbali yonyango lwangoku lwe-halofantrine, imbali yokugula kwengqondo efana nokudakumba, ukuphazamiseka kwengqondo okuchaphazelayo okanye ukuxhalaba okukhulu kwe-neurosis kunye nokuhluthwa.

Iziphumo ebezingalindelekanga ezinokwenzeka

Ezinye zeziphumo ebezingalindelekanga ezinokubakho ngexesha lonyango lwe-mefloquine sisizungu, intloko ebuhlungu, isicaphucaphu, iintlungu esiswini kunye norhudo.

Ukongeza, nangona kunqabile ngakumbi, ukuqaqanjelwa sisisu, ukubona izinto ezingekhoyo, utshintsho kulungelelwaniso, utshintsho kwiimvakalelo, ukuphazamiseka, ubundlongondlongo kunye nokusabela kweparanoid nako kunokubakho.